| Budget Amount *help |
¥51,610,000 (Direct Cost: ¥39,700,000、Indirect Cost: ¥11,910,000)
Fiscal Year 2014: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2013: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2012: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
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| Outline of Final Research Achievements |
In this study, we found that expression of CDKAL1 - one of susceptible genes for type 2 diabetes and obesity identified in genome-wide association studies - is regulated during adipocyte differentiation, hypertrophy and adiposity. Functionally, CDKAL1 works as a factor that suppresses adipocyte differentiation and lipid accumulation. Mechanistically, we found that CDKAL1 stimulates the Wnt/β-catenin pathway, which suppresses adipocyte differentiation. We also mapped a promoter region responsible for the suppression of adiponectin gene expression in adipocyte hypertrophy. A transcription factor named Heb1 binds and regulates transcription. Expression level of Heb1 itlsef is regulated by various metabolic stress signals in adipocytes.
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