| Budget Amount *help |
¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Outline of Final Research Achievements |
A disposition behavior of small molecules is integration of their interactions with biological organisms comprising of multi layers. in which the lowest events are molecular interactions. In this study, we established methods for systematically collecting information on interaction between small molecule drugs and ADME-related functional proteins and for analyzing their structure-activity relationship. Being exemplified by the prediction of enzyme induction-associated drug-drug interaction, a method for predicting effect of small molecule drugs on pharmacokinetics of other or its own molecules was also developed. We succeeded in reproducing the biological phenomena on an open platform for multi-level modeling and simulation of physiological system.
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