| Research Collaborator |
KANZAKI Makoto 東北大学, 大学院医工学研究科, 准教授
TACHIKAWA Masanori 東北大学, 大学院薬学研究科, 准教授
KANETAKA Hiroyasu 東北大学, 大学院歯学研究科, 准教授
TAKASHIMA Keisuke 東北大学, 大学院工学研究科, 助教
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| Budget Amount *help |
¥92,170,000 (Direct Cost: ¥70,900,000、Indirect Cost: ¥21,270,000)
Fiscal Year 2016: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2015: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2014: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2013: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2012: ¥31,590,000 (Direct Cost: ¥24,300,000、Indirect Cost: ¥7,290,000)
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| Outline of Final Research Achievements |
In order to develop a highly efficient and minimally invasive drug delivery method, the applications of plasmas generated in liquid to control of biological response have been proposed. In the beginning, it has been experimentally verified that micro-scale plasma was generated by applying a pulse voltage to coaxial type thin electrode and had the capability to enhance the cellular uptake of drugs and genes. Next, investigation of effects of separated plasma-derived stimuli on drug uptake showed that plasma-produced short-lived reactive species contribute to the drug uptake. Furthermore, it is clarified that relatively short-lived reactive species (i.e., deactivated within approximately 10 min) in plasma-irradiated saline induced physiologically relevant calcium ion influx through ion channel on cell membrane, which triggers activation of gene and drug uptake.
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