| Project Area | Plasma medical innovation |
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| Project/Area Number |
24108008
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
梶山 広明 名古屋大学, 医学(系)研究科(研究院), 准教授 (00345886)
丸山 彰一 名古屋大学, 医学(系)研究科(研究院), 准教授 (10362253)
水野 正明 名古屋大学, 医学部附属病院, 病院教授 (70283439)
豊國 伸哉 名古屋大学, 医学(系)研究科(研究院), 教授 (90252460)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUBOI Naotake 名古屋大学, 大学院医学系研究科, 准教授 (50566958)
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| Research Collaborator |
OKAZAKI Yasumasa 名古屋大学, 大学院医学系研究科, 講師 (30403489)
TANAKA Hiromasa 名古屋大学, 未来社会創造機構, 特任講師 (00508129)
AKIYAMA Shinichi 名古屋大学, 大学院医学系研究科, 特任講師 (20500010)
UTSUMI Fumi 名古屋大学, 医学部附属病院, 病院助教 (10749261)
KAMIMURA Yutaka 名古屋大学, 大学院医学系研究科, 医員
HASHIZUME Hiroshi 名古屋大学, 未来社会創造機構, 特任助教
WANG Yue 名古屋大学, 大学院医学系研究科, 研究員
SHI Lei 名古屋大学, 大学院医学系研究科, 研究員
ITHO Fumiya 名古屋大学, 大学院医学系研究科
Peng Yang 名古屋大学, 大学院医学系研究科
NAKAMURA Kae 名古屋大学, 大学院医学系研究科, 客員研究員
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥182,780,000 (Direct Cost: ¥140,600,000、Indirect Cost: ¥42,180,000)
Fiscal Year 2016: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2015: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2014: ¥35,100,000 (Direct Cost: ¥27,000,000、Indirect Cost: ¥8,100,000)
Fiscal Year 2013: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2012: ¥43,160,000 (Direct Cost: ¥33,200,000、Indirect Cost: ¥9,960,000)
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| Keywords | 大気圧非平衡プラズマ / プラズマ活性化溶液 / 癌治療 / 再生医療 / 卵巣癌 / 脳腫瘍 / 悪性中皮腫 / 脂肪幹細胞 / プラズマ活性化培養液 / プラズマ活性化リンゲル液 / プラズマ医療 / 癌 / がん治療 / 酸化ストレス / 卵巣がん / 脂肪由来間葉系幹細胞 / ROS / 大気圧プラズマ / フリーラジカル |
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| Outline of Final Research Achievements |
Non-thermal plasma has been focused on as a novel medical practice. There have been a number of reports showing the effect of non-thermal plasma on cell death of various cancers. We have succeeded in selective killing of ovarian cancer and glioblastoma brain tumor cells, which are difficult to achieve complete remission under the present therapies, using not only directly but also indirectly plasma referred to as plasma-activated liquids. We have also elucidated that the effects and mechanisms of non-thermal plasma on biological systems using mesothelioma. We have demonstrated that plasma-activated liquids might be more useful for advanced cancers with metastasis and micro-dissemination. On the other hand, for developing medical applications of non-thermal plasma, we have achieved a certain result for regenerative medicine using human adipose tissue-derived stromal cells we established.
These discoveries have led to the use of non-thermal plasma for alternative clinical applications.
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