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Molecular mechanisms by which microenvironmental niches regulate production of immune cells.

Planned Research

Project AreaAnalysis and synthesis of multi-dimensional immune organ network
Project/Area Number 24111003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University (2015-2016)
Kyoto University (2012-2014)

Principal Investigator

NAGASAWA Takashi  大阪大学, 生命機能研究科, 教授 (80281690)

Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥81,510,000 (Direct Cost: ¥62,700,000、Indirect Cost: ¥18,810,000)
Fiscal Year 2016: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2014: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2013: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2012: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Keywords免疫学 / 再生医学 / 発生・分化 / 微小環境
Outline of Final Research Achievements

All immune cells are generated from hematopoietic stem cells (HSCs) in the bone marrow. HSCs are in contact with and maintained by restricted microenvironments, termed niches; however, the identity of cells creating HSC niches has been a subject of longstanding debate. We identified a population of mesenchymal cells, termed CXCL12-abundant reticular (CAR) cells and revealed that CAR cells create a critical niche for HSCs and lympho-hematopoiesis. In this study, we found that the transcription factor Foxc1 was preferentially expressed in CAR cells in bone marrow and was essential for development and maintenance of the niche for lympho-hematopoiesis. In addition, there are numerous empty HSC niches available for engraftment and proliferation of HSCs in bone marrow, supporting the idea that CAR cells with long processes function as niches for lympho-hematopoiesis.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (63 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (29 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 27 results,  Open Access: 9 results,  Acknowledgement Compliant: 2 results) Presentation (27 results) (of which Int'l Joint Research: 2 results,  Invited: 27 results) Book (7 results)

  • [Journal Article] Numerous niches for hematopoietic stem cells remain empty during homeostasis.2017

    • Author(s)
      Shimoto, M., Sugiyama, T., Nagasawa, T.
    • Journal Title

      Blood

      Volume: 129 Issue: 15 Pages: 2124-2131

    • DOI

      10.1182/blood-2016-09-740563

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation2016

    • Author(s)
      Gomes, A. C., Hara, T., Lim, V. Y., Herndler-Brandstetter, D., Nevius, E., Sugiyama, T., Tani-ichi, S., Schlenner, S., Richie, E., Rodewald, H., Flavell, R. A., Nagasawa, T., Ikuta, K., and Pereira, J. P.
    • Journal Title

      Immunity

      Volume: 45 Issue: 6 Pages: 1219-1231

    • DOI

      10.1016/j.immuni.2016.11.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Chemokine Signaling Controls Integrity of Radial Glial Scaffold in Developing Spinal Cord and Consequential Proper Position of Boundary Cap Cells.2016

    • Author(s)
      Yan Zhu, Tomoko Matsumoto, Takashi Nagasawa, Fabienne Mackay, Fujio Murakami
    • Journal Title

      The Journal of neuroscience

      Volume: 35 Issue: 24 Pages: 9211-9224

    • DOI

      10.1523/jneurosci.0156-15.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice.2015

    • Author(s)
      Day, R.B., Bhattacharya, D., Nagasawa, T., Link, D.C.
    • Journal Title

      Blood.

      Volume: 125 Issue: 20 Pages: 3114-3117

    • DOI

      10.1182/blood-2015-02-629444

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The critical and specific transcriptional regulator of the microenvironmental niche for hematopoietic stem and progenitor cells.2015

    • Author(s)
      Omatsu, Y., Nagasawa, T.
    • Journal Title

      Curr. Opin. Hematol.

      Volume: 22 Issue: 4 Pages: 330-336

    • DOI

      10.1097/moh.0000000000000153

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCL12/SDF-1 and CXCR4.2015

    • Author(s)
      Nagasawa, T.
    • Journal Title

      Front Immunol.

      Volume: 6 Pages: 301-301

    • DOI

      10.3389/fimmu.2015.00301

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCL12 catches T-ALL at the entrance of the bone marrow.2015

    • Author(s)
      Sugiyama, T., Nagasawa, T.
    • Journal Title

      Trends Immunol.

      Volume: 36 Issue: 9 Pages: 504-506

    • DOI

      10.1016/j.it.2015.08.001

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells.2015

    • Author(s)
      Rodda, L.B., Bannard, O., Ludewig, B., Nagasawa, T., Cyster, J.G.
    • Journal Title

      J. Immunol.

      Volume: 195 Issue: 10 Pages: 4781-4791

    • DOI

      10.4049/jimmunol.1501191

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Myeloid cells stimulate their progenitors in an emergency.2015

    • Author(s)
      Sugiyama, T., Nagasawa, T.
    • Journal Title

      Immunity

      Volume: 42 Issue: 1 Pages: 13-14

    • DOI

      10.1016/j.immuni.2015.01.002

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice.2015

    • Author(s)
      Day, R.B., Bhattacharya, D., Nagasawa, T., Link, D.C.
    • Journal Title

      Blood

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation2014

    • Author(s)
      Omatsu Y, Seike M, Sugiyama T, Kume T, Nagasawa T.
    • Journal Title

      Nature

      Volume: 508 Issue: 7497 Pages: 536-540

    • DOI

      10.1038/nature13071

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position.2014

    • Author(s)
      Vogt, D., Hunt, R.F., Mandal, S., Sandberg, M., Silberberg, S.N., Nagasawa, T., Yang, Z., Baraban, S.C., Rubenstein, J.L.
    • Journal Title

      Neuron

      Volume: 82 Issue: 2 Pages: 350-364

    • DOI

      10.1016/j.neuron.2014.02.030

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4.2014

    • Author(s)
      Nagasawa, T.
    • Journal Title

      J. Mol. Med.

      Volume: 92 Issue: 5 Pages: 433-439

    • DOI

      10.1007/s00109-014-1123-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage.2014

    • Author(s)
      Ono, N.,Ono, W., Mizoguchi, T., Nagasawa, T., Frenette, P.S., Kronenberg, H.M.
    • Journal Title

      Dev. Cell.

      Volume: 29 Issue: 3 Pages: 330-339

    • DOI

      10.1016/j.devcel.2014.03.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones.2014

    • Author(s)
      Ono N, Ono W, Nagasawa T, Kronenberg HM.
    • Journal Title

      Nat. Cell. Biol.

      Volume: 16 Issue: 12 Pages: 1157-1167

    • DOI

      10.1038/ncb3067

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance.2013

    • Author(s)
      Casanova-Acebes, M.
    • Journal Title

      Cell

      Volume: 153 Issue: 5 Pages: 1025-1035

    • DOI

      10.1016/j.cell.2013.04.040

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure.2013

    • Author(s)
      Aronovich, A.
    • Journal Title

      Blood

      Volume: 122 Issue: 15 Pages: 2562-2571

    • DOI

      10.1182/blood-2012-08-447458

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow2013

    • Author(s)
      Devi S, Wang Y, Chew WK, Lima R, A-Gonzalez N, Mattar CN, Chong SZ, Schlitzer A, Bakocevic N, Chew S,
    • Journal Title

      J Exp Med

      Volume: 210 Issue: 11 Pages: 2321-2336

    • DOI

      10.1084/jem.20130056

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection2013

    • Author(s)
      Bannard O, Horton RM, Allen CD, An J, Nagasawa T, Cyster JG.
    • Journal Title

      Immunity

      Volume: 39 Issue: 5 Pages: 912-924

    • DOI

      10.1016/j.immuni.2013.08.038

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance2013

    • Author(s)
      Greenbaum, A., Hsu, Y.M., Day, R.B., Schuettpel,z L.G., Christopher, M.J., Borgerding, J.N., Nagasawa, T., *Link, D.C.
    • Journal Title

      Nature

      Volume: 495 Issue: 7440 Pages: 227-230

    • DOI

      10.1038/nature11926

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral Nerve-Derived CXCL12 and VEGF-A Regulate the Patterning of Arterial Vessel Branching in Developing Limb Skin2013

    • Author(s)
      Li, W., Kohara, H., Uchida, Y., James, J.M., Soneji, K., Cronshaw, D.G., Zou, Y.R., Nagasawa, T., *Mukouyama, Y.S.
    • Journal Title

      Dev. Cell

      Volume: Dev. Cell Issue: 4 Pages: 359-371

    • DOI

      10.1016/j.devcel.2013.01.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spi-B is critical for plasmacytoid dendritic cell function and development2012

    • Author(s)
      Sasaki, K. Hoshino, T. Sugiyama, C. Yamazaki, T. Yano, A. Iizuka, H. Hemmi, T. Tanaka, M. Saito, M. Sugiyama, Y. Fukuda, T. Ohta, K. Sato, A. Ainai, T. Suzuki, H. Hasegawa, N. Toyama-Sorimachi, H. Kohara, T. Nagasawa, T. Kaisho
    • Journal Title

      Blood

      Volume: 120 Issue: 24 Pages: 4733-4743

    • DOI

      10.1182/blood-2012-06-436527

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstitution of mouse spermatogonial stem cell niches in culture2012

    • Author(s)
      Kanatsu-Shinohara, M., Inoue, K., Takashima, S.,Takehashi, M.,Ogonuki, N., Morimoto, H., Nagasawa, T., Ogura, A. and Shinohara, T
    • Journal Title

      Cell Stem Cell

      Volume: 11(4) Issue: 4 Pages: 567-578

    • DOI

      10.1016/j.stem.2012.06.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system.2012

    • Author(s)
      Nishiyama, C., Uesaka, T., Manabe, T., Yonekura, Y., Nagasawa, T., Newgreen, D.F., Young, H.M., *Enomoto, H.
    • Journal Title

      Nat. Neurosci.

      Volume: 15(9) Issue: 9 Pages: 1211-1218

    • DOI

      10.1038/nn.3184

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Endothelial Antigen ESAM Monitors Hematopoietic Stem Cell Status between Quiescence and Self-Renewal.2012

    • Author(s)
      Sudo, T.
    • Journal Title

      J. Immunol.

      Volume: 189 Issue: 1 Pages: 200-210

    • DOI

      10.4049/jimmunol.1200056

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Constitutive Plasmacytoid Dendritic Cell Migration to the Splenic White Pulp Is Cooperatively Regulated by CCR7- and CXCR4-Mediated Signaling.2012

    • Author(s)
      Umemoto, E.
    • Journal Title

      J. Immunol.

      Volume: 189 Issue: 1 Pages: 191-199

    • DOI

      10.4049/jimmunol.1200802

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy.2012

    • Author(s)
      Murata, K.
    • Journal Title

      PLoS One.

      Volume: 7 Issue: 5 Pages: 237-44

    • DOI

      10.1371/journal.pone.0037163

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellul- ar matrix protein Tenascin-C is req- uired in the bone marrow microenvio- nment primed for hematopoietic rege- neration2012

    • Author(s)
      Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasa- wa T, Suda T, Kubota Y
    • Journal Title

      Blood

      Volume: 119 Issue: 23 Pages: 5429-5437

    • DOI

      10.1182/blood-2011-11-393645

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow niches for hematopoietic stem cells and immune cells.2012

    • Author(s)
      Sugiyama, T.
    • Journal Title

      Inflamm. Allergy Drug Targets

      Volume: 11 Issue: 3 Pages: 201-206

    • DOI

      10.2174/187152812800392689

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] The microenvironmental niches for hematopoietic stem and progenitor cells in the bone marrow2016

    • Author(s)
      Nagasawa, T.
    • Organizer
      International Society for Stem Cell Research (ISSCR) 2016 Annual Meeting.
    • Place of Presentation
      San Francisco California, USA.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 造血幹細胞、免疫担当細胞を維持する骨髄の微小環境(ニッチ)2016

    • Author(s)
      長澤 丘司
    • Organizer
      第64回日本輸血細胞治療学会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 造血幹細胞、免疫担当細胞を維持する骨髄の微小環境(ニッチ)2016

    • Author(s)
      長澤 丘司
    • Organizer
      第68回日本細胞生物学会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 骨髄の造血幹細胞ニッチを構成する脂肪・骨芽細胞前駆細胞2016

    • Author(s)
      長澤 丘司
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪府立国際会議場(大阪府大阪市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Lympho-hematopoiesis2016

    • Author(s)
      長澤 丘司
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      ラグナガーデンホテル(沖縄県宜野湾市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow.2015

    • Author(s)
      Nagasawa, T.
    • Organizer
      The 77th Annual meeting of the Japan society of Hematology.
    • Place of Presentation
      金沢市アートホール(石川県金沢市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow.2015

    • Author(s)
      Nagasawa, T.
    • Organizer
      44th Annual Scientific Meeting of the ISEH-International Society for Experimental Hematology.
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 造血幹細胞・前駆細胞を維持する骨髄の微小環境(ニッチ)2015

    • Author(s)
      長澤 丘司
    • Organizer
      ERATO高柳オステオネットワークプロジェクト成果発表会 特別講演
    • Place of Presentation
      東京大学医学部講堂(東京)
    • Year and Date
      2015-03-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow2014

    • Author(s)
      Nagasawa, T.
    • Organizer
      第43回日本免疫学会学術集会 シンポジウム microenvironments for stem and immune cells.
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 造血幹細胞と血液・免疫細胞の産生を調節する微小環境(ニッチ)の解明2014

    • Author(s)
      長澤 丘司
    • Organizer
      2014年度 武田科学振興財団研究助成金・奨励金贈呈 記念講演
    • Place of Presentation
      シェラトン都ホテル東京(東京)
    • Year and Date
      2014-11-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow2014

    • Author(s)
      Nagasawa, T.
    • Organizer
      The 24th Hot Spring Harbor International Symposium
    • Place of Presentation
      九州大学(福岡)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow2014

    • Author(s)
      Nagasawa, T.
    • Organizer
      Stowers Institute for Medical Research, Wednesday Lectures.
    • Place of Presentation
      Stowers Institute for Medical Research Kansas, USA
    • Year and Date
      2014-09-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow2014

    • Author(s)
      Nagasawa, T., Omatsu,Y., Sugiyama,T.
    • Organizer
      Cold Spring Harbor Conferences Asia; Frontiers of Immunology in Health and Diseases.
    • Place of Presentation
      Cold Spring Harbor Conferences Asia, Suzhou, China
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow2014

    • Author(s)
      Nagasawa, T.
    • Organizer
      第35回 日本炎症・再生医学会 JSIR-JCO Joint Symposium
    • Place of Presentation
      万国津梁館(沖縄)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 骨髄の造血幹細胞ニッシェと脂肪・骨前駆細胞CAR細胞2013

    • Author(s)
      長澤 丘司
    • Organizer
      第118回日本解剖学会総会・全国学術集会  シンポジウム 骨髄幹細胞ニッチと神経―免疫―内分泌クロストーク
    • Place of Presentation
      サンポートホール高松・かがわ国際会議場・高松
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The adipo-osteogenic progenitors with long processes function as niches for hematopoietic stem and progenitor cells2012

    • Author(s)
      T. Nagasawa
    • Organizer
      第41回日本免疫学会学術集会 シンポジウム
    • Place of Presentation
      神戸国際会議場・神戸
    • Year and Date
      2012-12-05
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 免疫担当細胞の産生と造血幹細胞・前駆細胞ニッシェ2012

    • Author(s)
      長澤 丘司
    • Organizer
      第41回日本免疫学会学術集会  レビュートーク
    • Place of Presentation
      神戸国際会議場・神戸
    • Year and Date
      2012-12-05
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Adipo-osteogenic progenitors function as niches for hematopoietic stem and progenitor cells in the marrow2012

    • Author(s)
      T. Nagasawa
    • Organizer
      The 9th Nikko International Symposium 2012, Understanding complex network systems in disease biology.
    • Place of Presentation
      Jich Medical University, Shimotsuke, Tochigi
    • Year and Date
      2012-10-12
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 骨髄の脂肪・骨前駆細胞 CAR細胞と造血幹細胞ニッシェ2012

    • Author(s)
      長澤 丘司
    • Organizer
      第30回 日本骨代謝学会学術集会 カレント コンセプト1 骨髄とがん細胞
    • Place of Presentation
      京王プラザホテル・東京
    • Year and Date
      2012-07-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 骨髄の造血幹細胞・造血ニッシェ2012

    • Author(s)
      長澤 丘司
    • Organizer
      第33回 日本炎症・再生医学会 シンポジウム 炎症と骨・骨髄
    • Place of Presentation
      ホテル日航福岡・福岡
    • Year and Date
      2012-07-05
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] “Microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow-The adipo-osteogenic progenitors, CXCL12-abundant reticular (CAR) cells-”

    • Author(s)
      T. Nagasawa
    • Organizer
      YM-Kyoto Symposia
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] “The adipo-osteogenic progenitors function as niches for hematopoietic stem and progenitor cells in the marrow”

    • Author(s)
      T. Nagasawa
    • Organizer
      The 6th International workshop of Kyoto T cell conference
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] “骨髄の造血幹細胞・前駆細胞ニッシェ”

    • Author(s)
      長澤 丘司
    • Organizer
      第23回日本サイトメトリー学会 学術集会 シンポジウム4
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] “The Adipo-osteogenic progenitor  CXCL12-abundant reticular (CAR) cells function as niches for hematopoietic stem and progenitor cells in bone marrow”

    • Author(s)
      T. Nagasawa
    • Organizer
      International Conference of the Korean Society for Molecular and Cellular Biology, Symposium:Stem cell niche and cell therapy.
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] “Microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow”

    • Author(s)
      T. Nagasawa
    • Organizer
      Swiss-Kyoto Symposium
    • Place of Presentation
      Zurich, Switzerland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] “The microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow”

    • Author(s)
      T. Nagasawa, Omatsu,Y., Sugiyama,T.
    • Organizer
      第42回日本免疫学会学術集会 シンポジウム Osteoimmunology
    • Place of Presentation
      Chiba, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] “ケモカインと造血幹細胞ニッチ”

    • Author(s)
      長澤 丘司
    • Organizer
      第13回 日本再生医療学会総会 特別講演
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 造血幹細胞を維持する骨髄のニッチ2014

    • Author(s)
      長澤 丘司、尾松 芳樹、杉山 立樹
    • Publisher
      実験医学vol. 32, No. 16
    • Related Report
      2014 Annual Research Report
  • [Book] 組織幹細胞のニッチとは2014

    • Author(s)
      長澤 丘司
    • Publisher
      実験医学vol. 32, No. 16
    • Related Report
      2014 Annual Research Report
  • [Book] 医学のあゆみ「骨免疫学」(別冊)2013

    • Author(s)
      長澤 丘司
    • Total Pages
      7
    • Publisher
      医歯薬出版
    • Related Report
      2013 Annual Research Report
  • [Book] 血液フロンティアvol.232013

    • Author(s)
      長澤 丘司
    • Total Pages
      9
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Annual Research Report
  • [Book] 癌と骨 松本 俊夫、米田 俊之編2013

    • Author(s)
      長澤 丘司
    • Total Pages
      9
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Annual Research Report
  • [Book] The Bone, vol. 272013

    • Author(s)
      長澤 丘司
    • Total Pages
      7
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Annual Research Report
  • [Book] 腎と透析, vol.752013

    • Author(s)
      長澤 丘司
    • Total Pages
      9
    • Publisher
      東京医学社
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2019-07-29  

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