Characteristics and functions of stromal cells in secondary lymphoid tissues

• Project Area: Analysis and synthesis of multi-dimensional immune organ network
• Project/Area Number: 24111005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: MIYASAKA Masayuki 大阪大学, その他部局等, 名誉教授 (50064613)
• Co-Investigator(Kenkyū-buntansha): 片貝 智哉 新潟大学, 医歯学系, 教授 (00324682) ; 梅本 英司 大阪大学, 医学(系)研究科(研究院), 准教授 (90452440) ; 早坂 晴子 近畿大学, 理工学部, 准教授 (70379246)
• Research Collaborator: Takeda Akira Turku大学, 博士研究員 ; Sirpa Jalkanen Turku大学, 教授 ; Malko Salmi Turku大学, 教授
• Project Period (FY): 2012-06-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥171,210,000 (Direct Cost: ¥131,700,000、Indirect Cost: ¥39,510,000); Fiscal Year 2016: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000); Fiscal Year 2015: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000); Fiscal Year 2014: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000); Fiscal Year 2013: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000); Fiscal Year 2012: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
• Keywords: ストローマ細胞 / リゾリン脂質 / ケモカイン / ケモカイン受容体 / リンパ球 / 免疫学 / リンパ節 / 樹状細胞

Outline of Final Research Achievements

In collaboration with Drs. A. Takeda, S. Jalkanen, and M. Salmi of University of Turku, Finland, the principal investigator, M. Miyasaka, and the co-investigator, E. Umemoto, found that a specific stromal subset secretes multiple bioactive molecules that regulate lymphocyte trafficking into and within lymph nodes. They also found that a different stromal subset mediates transport of small-molecular substances from the lymphatic sinus into the lymph node parenchyma. A co-investigator, H. Hayasaka, identified a mechanism whereby a chemokine induces homo- and hetero-oligomerization of chemokine receptors. A co-investigator, T. Katakai, analyzed stromal cells in lymph nodes in detail and identified a novel stromal subset.

Research Products

• [Int'l Joint Research] University of Turku(Finland)
• [Int'l Joint Research] Weizmann Institute of Science(Israel)
• [Int'l Joint Research] University of Texas/University of California San Diego(米国)
• [Int'l Joint Research] University of Birmingham(United Kingdom)
• [Int'l Joint Research] University of Turku(Finland)
• [Int'l Joint Research] University of Pecs(Hungary)
• [Int'l Joint Research] Gachon University(韓国)
• [Int'l Joint Research] Univ of Cincinnati College of Medicine(米国)
• [Journal Article] The molecular cues regulating immune cell trafficking (2017)
  • Author(s): Takeda A, Sasaki N, Miyasaka M.
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 93 Issue: 4 Pages: 183-195
  • DOI: 10.2183/pjab.93.012
  • NAID: 130006770748
  • ISSN: 0386-2208, 1349-2896
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Amine oxidase activity regulates the development of pulmonary fibrosis. (2017)
  • Author(s): Marttila-Ichihara F, Elima K, Auvinen K, Veres TZ, Rantakari P, Weston C, Miyasaka M, Adams D, Jalkanen S, Salmi M.
  • Journal Title: FASEB J Volume: 印刷中 Issue: 6 Pages: 2477-2491
  • DOI: 10.1096/fj.201600935r
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intubation-free in vivo imaging of the tracheal mucosa using two photon microscopy. (2017)
  • Author(s): Veres TZ, Kopcsanyi T, Tirri M, Braun A, Miyasaka M, Germain RN, Jalkanen S, Salmi M.
  • Journal Title: Sci Rep Volume: 印刷中 Issue: 1 Pages: 694-694
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy. (2017)
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  • Journal Title: JCI Insight Volume: 2 Issue: 1
  • DOI: 10.1172/jci.insight.89140
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Allergen-induced CD4+ T-cell cytokine production within airway mucosal DC-T-cell clusters drives the local recruitment of myeloid effector cells. (2017)
  • Author(s): Veres TZ, Kopcsanyi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN.
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• [Journal Article] Thymocytes in Lyve1-CRE/S1pr1f/f mice accumulate in the thymus due to cell-intrinsic loss of sphingosine-1-phosphate receptor expression. (2016)
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  • Journal Title: Front Immunol Volume: 7 Pages: 489-489
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Gene expression profiling of different arms of lymphatic vasculature identifies new candidates for manipulation of cell traffic. (2016)
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  • Journal Title: Proc Natl Acad Sci USA Volume: 113 Issue: 38 Pages: 10643-10648
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of super-resolution microscopies. (2016)
  • Author(s): Jung Y, Riven I, Feigelson SW, Kartvelishvily E, Tohya K, Miyasaka M, Alon R, Haran G.
  • Journal Title: Proc Natl Acad Sci USA Volume: 113 Issue: 40
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney (2016)
  • Author(s): Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, and Yanagita M.
  • Journal Title: JCI. Insight. Volume: 1 Issue: 11
  • DOI: 10.1172/jci.insight.87680
  • NAID: 120005820865
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Microenvironmental control of high-speed interstitial T cell migration in the lymph node. (2016)
  • Author(s): Katakai T, Kinashi T.
  • Journal Title: Front Immunol Volume: 7 Pages: 194-194
  • DOI: 10.3389/fimmu.2016.00194
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. (2016)
  • Author(s): Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E.
  • Journal Title: Elife Volume: 5
  • DOI: 10.7554/elife.10561
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. (2016)
  • Author(s): Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M
  • Journal Title: Int Immunol. Volume: なし Issue: 6 Pages: 283-292
  • DOI: 10.1093/intimm/dxv072
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Small intestinal eosinophils regulate TH17 cells by producing IL-1 receptor antagonist. (2016)
  • Author(s): Sugawara R, Lee E-J, Jang MS, Jeun E-J, Hong C-P, Kim J-H, Park A, Yun CH, Hong S-W, Kim Y-M, Seoh J-Y, Jung YJ, Surh CD, Miyasaka M, Yang B-G, Jang MH
  • Journal Title: J Exp Med. Volume: 213 Issue: 4 Pages: 555-567
  • DOI: 10.1084/jem.20141388
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Divergence of vascular specification in visceral lymphoid organs - genetic determinants and differentiation checkpoints. (2016)
  • Author(s): Kellermayer Z, Hayasaka H, Kajtar B, Simon D, Robles EF, Martinez-Climent JA, Balogh P.
  • Journal Title: Int Rev Immunol. Volume: In press Issue: 6 Pages: 489-502
  • DOI: 10.3109/08830185.2015.1059427
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] CRTAM determines the CD4+ cytotoxic T lymphocyte lineage. (2016)
  • Author(s): Takeuchi, A., Badr Mel, S., Miyauchi, K., Ishihara, C., Onishi, R., Guo, Z., Sasaki. Y., Ike, H., Takumi, A., Tsuji, NM., Murakami, Y., Katakai, T., Kubo, M. and Saito, T.
  • Journal Title: J. Exp. Med. Volume: 213 Issue: 1 Pages: 123-138
  • DOI: 10.1084/jem.20150519
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-10-producing lung interstitial macrophages prevent neutrophilic asthma. (2016)
  • Author(s): Kawano H, Kayama H, Nakama T, Hashimoto T, Umemoto E, Takeda K.
  • Journal Title: Int Immunol. Volume: in press Issue: 10 Pages: 489-501
  • DOI: 10.1093/intimm/dxw012
  • Peer Reviewed / Open Access
• [Journal Article] Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. (2016)
  • Author(s): Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motoka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawwa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, and Takeda K
  • Journal Title: Nature Volume: 532 Issue: 7597 Pages: 117-121
  • DOI: 10.1038/nature17406
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Lysophosphatidic acid as a regulator of lymphocyte trafficking in the lymph nodes. (2015)
  • Author(s): Takeda A, Umemoto E, Miyasaka M.
  • Journal Title: Translational Cancer Research Volume: 4 Pages: 537-543
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes. (2015)
  • Author(s): Rantakari P, Auvinen K, Jäppinen N, Kapraali M, Valtonen J, Karikoski M, Gerke H, Iftakhar-E-Khuda I, Keuschnigg J, Umemoto E, Tohya K, Miyasaka M, Elima K, Jalkanen S, Salmi M.
  • Journal Title: Nat Immunol. Volume: １６ Issue: 4 Pages: 386-396
  • DOI: 10.1038/ni.3101
  • Peer Reviewed / Open Access
• [Journal Article] Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis. (2015)
  • Author(s): Ishihara S, Nishikimi A, Umemoto E, Miyasaka M, Saegusa M, Katagiri K
  • Journal Title: Nature Communications Volume: 6 Issue: 1 Pages: 8982-8982
  • DOI: 10.1038/ncomms9982
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production (2015)
  • Author(s): Jung Y, Wen T, Mingler MK, Wang YH, Chaplin DD, Lee EH, Jang MH, Woo SY, Seoh JY, Miyasaka M, Rothenberg ME.
  • Journal Title: Mucosal Immunol. Volume: なし Issue: 4 Pages: 930-942
  • DOI: 10.1038/mi.2014.123
  • Peer Reviewed / Open Access
• [Journal Article] The HIV-1 gp120/CXCR4 axis promotes CCR7 ligand-dependent CD4 T cell migration: CCR7 homo- and CCR7/CXCR4 hetero-oligomer formation as a possible mechanism for up-regulation of functional CCR7. (2015)
  • Author(s): Hayasaka H, Kobayashi D, Yoshimura H, Nakayama EE, Shioda T, Miyasaka M.
  • Journal Title: PLoS ONE. Volume: 10 Issue: 2 Pages: 1371-1371
  • DOI: 10.1371/journal.pone.0117454
  • Peer Reviewed / Open Access
• [Journal Article] Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells (2015)
  • Author(s): Sugimoto K, Hayakawa F, Shimada S, Morishita T, Shimada K, Katakai T, Tomita A, Kiyoi H, Naoe T
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 13054-13054
  • DOI: 10.1038/srep13054
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. (2015)
  • Author(s): Tsai, S-H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada, Y., Takeda, A., Yoshikawa, S., Obata-Ninomiya, K., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H. and Takeda, K.
  • Journal Title: Immunity Volume: 42(2) Issue: 2 Pages: 279-293
  • DOI: 10.1016/j.immuni.2015.01.015
  • Peer Reviewed / Open Access
• [Journal Article] Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated infammatory monocyte migration (2014)
  • Author(s): Naoya T otsuka, Yun-Gi Kim, Kazumasa Kanemaru, Kouta Niizuma, Eiji Umemoto, Kei Nagai, Satoko T ahara-Hanaoka, Chigusa Nakahasi-Oda, Shin-ichiro Honda, Masayuki Miyasaka, Kazuko Shibuya & Akira Shibuya
  • Journal Title: Nature Communications Volume: 5:4710 Issue: 1 Pages: 4710-4710
  • DOI: 10.1038/ncomms5710
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid - lysophosphatidic acid receptor 1 cascade. (2014)
  • Author(s): Miyabe Y, Miyabe C, Iwai Y, Yokoyama W, Sekine C, Sugimoto K, Harigai M, Miyasaka M, Miyasaka N, Nanki T.
  • Journal Title: Arthritis Res Ther. Volume: 16 Issue: 5 Pages: 461-461
  • DOI: 10.1186/s13075-014-0461-9
  • Peer Reviewed / Open Access
• [Journal Article] Autotaxin Produced by Stromal Cells Promotes LFA-1－Independent and Rho-Dependent Interstitial T Cell Motility (2014)
  • Author(s): Katakai T., Kondo N., Ueda Y., and Kinashi T
  • Journal Title: J Immunol Volume: 193 Issue: 2 Pages: 617-626
  • DOI: 10.4049/jimmunol.1400565
  • Peer Reviewed
• [Journal Article] Generation of colonic IgA-secreting cells in the cecal patch (2014)
  • Author(s): Masahata, K., Umemoto, E., Kayama, H., Kotani, M., Nakamura, S., Kurakawa, T., Kikuta, J., Gotoh, K., Motooka, D., Sato, S., Higuchi, T., Baba, Y., Kurosaki, T., Kinoshita, M., Shimada, Y., Kimura, T., Okumura, R., Takeda, A., Tajima, M., Yoshie, O., Fukuzawa, M., Kiyono, H., Fagarasan, S., Iida, T., Ishii, M., Takeda, K
  • Journal Title: Nature Comm Volume: 5 Issue: 1 Pages: 3704-3704
  • DOI: 10.1038/ncomms4704
  • Peer Reviewed / Open Access
• [Journal Article] Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions. (2013)
  • Author(s): Umemoto, E, Takeda, A., Jin, S., Luo, Z., Nakahogi, N., Hayasaka, H., Lee, C.M., Tanaka, T. & Miyasaka, M.
  • Journal Title: PLoS One Volume: 8 Issue: 12 Pages: 1-12
  • DOI: 10.1371/journal.pone.0083681
  • Peer Reviewed
• [Journal Article] Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis (2013)
  • Author(s): Bai Z
  • Journal Title: J. Immunology Volume: 190 Issue: 5 Pages: 2036-2048
  • DOI: 10.4049/jimmunol.1202025
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• [Journal Article] Four-dimensional spatial nanometry of single particles in living cells using polarized quantum rods. (2013)
  • Author(s): Watanabe, T.M., Fujii, F., Jin, T., Umemoto, E., Miyasaka, M., Fujita, H. & Yanagida, T.
  • Journal Title: Biophysical Journal Volume: 105 Pages: 555-564
  • Peer Reviewed
• [Journal Article] Necessity of Lysophosphatidic Acid Receptor 1 for Development of Arthritis (2013)
  • Author(s): Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T
  • Journal Title: Arthritis Rheum Volume: 65 Issue: 8 Pages: 2037-2047
  • DOI: 10.1002/art.37991
  • Peer Reviewed
• [Journal Article] GATA-1 regulates the generation and function of basophils (2013)
  • Author(s): Nei Y, Obata-Ninomiya K, Tsutsui H, Ishiwata K, Miyasaka M, Matsumoto K, Nakae S, Kanuka H, Inase N, Karasuyama H
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Issue: 46 Pages: 18620-5
  • DOI: 10.1073/pnas.1311668110
  • Peer Reviewed
• [Journal Article] Dendritic Cells Regulate High-Speed Interstitial T Cell Migration in the Lymph Node via LFA-1/ICAM-1. (2013)
  • Author(s): Katakai T, Habiro K, Kinashi T.
  • Journal Title: J Immunol Volume: 191(3) Issue: 3 Pages: 1188-99
  • DOI: 10.4049/jimmunol.1300739
  • Peer Reviewed
• [Journal Article] Constitutive Plasmacytoid Dendritic Cell Migration to the Splenic White Pulp Is Cooperatively Regulated by CCR7- and CXCR4-Mediated Signaling. (2012)
  • Author(s): Umemoto, E.
  • Journal Title: J. Immunol. Volume: 189 Issue: 1 Pages: 191-199
  • DOI: 10.4049/jimmunol.1200802
  • Peer Reviewed
• [Presentation] Thymocytes in Lyve1-CRE/S1pr1f/f mice accumulate in the thymus due to cell-intrinsic loss of sphingosine-1-phosphate receptor expression. (2017)
  • Author(s): Takeda A, Miyasaka M.
  • Organizer: 7th International Workshop of Kyoto T Cell Conference (KTCC2017)
  • Place of Presentation: Shiran Kaikan, Kyoto University (Kyoto)
  • Year and Date: 2017-03-13
  • Int'l Joint Research
• [Presentation] Opening Remarks. (2017)
  • Author(s): Miyasaka M.
  • Organizer: The 19th Takeda Science Foundation Symposium on Bioscience “Chronic Inflammation - Initiation, Progression, and Resolution”
  • Place of Presentation: Center for Learning and Innovation, Takeda Pharmaceutical Company, Ltd. (Suita, Osaka)
  • Year and Date: 2017-01-20
  • Int'l Joint Research
• [Presentation] Visualization of adenine nucleotides in lymph nodes. (2016)
  • Author(s): Sasaki N, Takeda A, Umemoto E, Miyasaka M.
  • Organizer: The 45th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Okinawa Convention Center (Ginowan, Okinawa)
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] CCR7 homo-oligomerization plays an important role in CCR7-dependent signaling. (2016)
  • Author(s): Kobayashi D, Miyasaka M, Hayasaka H.
  • Organizer: The 45th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Okinawa Convention Center (Ginowan, Okinawa)
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] Implications of Spns2-deficiency on S1P-driven lymphocytes egress, HEV-integrity and immunity. (2016)
  • Author(s): Simmons S, Sasaki N, Umemoto E, Yoshizumi N, Kitazawa Y, Okudaira M, Inoue A, Tohya K, Aoki J, Matsuno K, Takeda K, Miyasaka M, Ishii M.
  • Organizer: The 45th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Okinawa Convention Center (Ginowan, Okinawa)
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] 免疫細胞の動態を規定する微小環境 (2016)
  • Author(s): 宮坂昌之
  • Organizer: 第４０回日本リンパ学会総会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター（東京都文京区）
  • Year and Date: 2016-06-24
• [Presentation] Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. (2016)
  • Author(s): Takeda A, Umemoto E, Jalkanen S, Miyasaka M.
  • Organizer: Keystone Symposia Conference: Stromal Cells in Immunity (Q4)
  • Place of Presentation: Keystone, Colorado, USA
  • Year and Date: 2016-02-07
  • Int'l Joint Research
• [Presentation] The endothelial protein PLVAP in lymphatics controls the entry of antigens into the lymph nodes. (2016)
  • Author(s): Auvinen K, Rantakari P, Jappinen N, Miyasaka M, Jalkanen S, Salmi M.
  • Organizer: Keystone Symposia Conference: Stromal Cells in Immunity (Q4)
  • Place of Presentation: Keystone, Colorado, USA
  • Year and Date: 2016-02-07
  • Int'l Joint Research
• [Presentation] Emerging Approaches in Leukocyte Trafficking. (2016)
  • Author(s): Miyasaka M.
  • Organizer: The Scandinavian Society for Immunology 2016 Summer School “Recent breakthroughs in immunology - emerging new concepts, approaches and methods”
  • Place of Presentation: Turku, Finland
  • Int'l Joint Research / Invited
• [Presentation] Regulation of adhesion cascades of naive and effector T cells by Rap1 is critical for mucosal homeostasis. (2016)
  • Author(s): Ishihara S, Nishikimi A, Umemoto E, Miyasaka M, Katagiri K.
  • Organizer: The 45th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Okinawa Convention Center (Ginowan, Okinawa)
  • Int'l Joint Research
• [Presentation] カバーレター・レスポンスレターの重要性など (2016)
  • Author(s): 宮坂昌之
  • Organizer: 第４５回日本免疫学会学術集会（International Immunology ランチョンセミナー）
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県宜野湾市）
  • Int'l Joint Research
• [Presentation] CCR7 homo-oligomerization regulates CCR7 ligand dependent cell migration. (2015)
  • Author(s): Kobayashi D, Ochi H, Muroka K, Miyasaka M, Hayasaka H.
  • Organizer: The 38th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Kobe Portopia Hotel, etc (Kobe, Hyogo)
  • Year and Date: 2015-12-01
  • Int'l Joint Research
• [Presentation] Trans-lymphatic endothelial passage of antigens and cells from the subcapsular sinus into the parenchyma in lymph nodes. (2015)
  • Author(s): Miyasaka M, Sasaki N, Takeda A, Umemoto E.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Sapporo Convention Center (Sapporo, Hokkaido)
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] The role of the transcription factor Dach1 in the high endothelial venule development. (2015)
  • Author(s): Hayasaka H, Balogh P, Miyasaka M.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Sapporo Convention Center (Sapporo, Hokkaido)
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] Spinster-homologue-2 (Spns2) controls S1P-driven lymphocyte egress from lymphoid organs. The 44th Annual Meeting of the Japanese Society for Immunology. (2015)
  • Author(s): Szandor S, Umemoto E, Fukuhara S, Kitazawa Y, Okudaira M, Inoue A, Motooka D, Nakamura S, Mochizuki N, Matsuno K, Takeda K, Miyasaka M, Ishii M.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Sapporo Convention Center (Sapporo, Hokkaido)
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] Live imaging of allogeneic T cell rejection in the host lymph nodes. (2015)
  • Author(s): Kanda Y, Kinashi T, Matsuno K, Katakai T.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Sapporo Convention Center (Sapporo, Hokkaido)
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] Lypd8 maintains gut homeostasis through separation of flagellated bacteria and colonic epithelia. (2015)
  • Author(s): Okumura R, Umemoto E, Kayama H, Takeda K.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Sapporo Convention Center (Sapporo, Hokkaido)
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] Rheumatoid arthritis patients-derived microbiota induce Th17-mediated arthritis in SKG mice. (2015)
  • Author(s): Maeda Y, Umemoto E, Matsushita M, Saeki Y, Ito Y, Hirota K, Sakaguchi N, Kumanogoh A, Sakaguchi S, Takeda K.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Sapporo Convention Center (Sapporo, Hokkaido)
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] リンパ節での恒常的リンパ球血管外移動はリゾリン脂質シグナリングにより調節される (2015)
  • Author(s): 宮坂昌之
  • Organizer: 第22回国立国際医療研究センター研究所セミナー
  • Place of Presentation: 国立国際医療研究センター研究所（東京都新宿区）
  • Year and Date: 2015-10-19
  • Invited
• [Presentation] A role of SIRPα/CD172a on eosinophil stability in secondary lymphoid tissues. (2015)
  • Author(s): Verjan Garcia N, Miyasaka M.
  • Organizer: Immunocolombia 2015
  • Place of Presentation: Medellin, Colombia
  • Year and Date: 2015-10-13
  • Int'l Joint Research
• [Presentation] Locally produced lysophospholipids direct lymphocyte extravasation. (2015)
  • Author(s): Miyasaka M.
  • Organizer: MIKRO Seminars of Infection Biology and Infectious Diseases
  • Place of Presentation: Turku, Finland
  • Year and Date: 2015-09-30
  • Int'l Joint Research / Invited
• [Presentation] A locally generated motogenic lysophospholipid, LPA, regulates trans-HEV and also interstitial migration of lymphocytes in lymph nodes. (2015)
  • Author(s): Miyasaka M.
  • Organizer: Ringberg Symposium, Molecular Mechanisms in Leukocyte Traffic
  • Place of Presentation: Tegernsee, Germany
  • Year and Date: 2015-09-13
  • Int'l Joint Research / Invited
• [Presentation] The endothelial protein PLVAP in lymphatics controls the entry of leukocytes into lymph nodes. (2015)
  • Author(s): Rantakari P, Jappinen N, Auvinen K, Kapraali M, Miyasaka M, Jalkanen S Salmi M.
  • Organizer: The 4th European Congress of Immunology
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-09-06
  • Int'l Joint Research
• [Presentation] からだを守る免疫のしくみ、そして老化とは？－健康食品の有効性？ (2015)
  • Author(s): 宮坂昌之
  • Organizer: 第９９回信濃木崎夏期大学
  • Place of Presentation: 木崎湖畔 信濃木崎夏期大学（長野県大町市）
  • Year and Date: 2015-08-09
  • Invited
• [Presentation] リゾリン脂質シグナリングを介した免疫細胞動態の制御 (2015)
  • Author(s): 宮坂昌之
  • Organizer: Research PlaNet 2015
  • Place of Presentation: 梅田スカイビルタワーウェスト（大阪府大阪市）
  • Year and Date: 2015-06-20
  • Invited
• [Presentation] 生体イメージングでのぞく免疫応答のダイナミクス (2015)
  • Author(s): 片貝智哉
  • Organizer: 平成27年度 日本生化学会関東支部例会
  • Place of Presentation: 新潟日報メディアシップ（新潟県新潟市）
  • Year and Date: 2015-06-20
  • Invited
• [Presentation] リンパ節内のリンパ球動態と組織微小環境 (2015)
  • Author(s): 片貝智哉
  • Organizer: 第17回新潟血液研究会
  • Place of Presentation: ANAクラウンプラザホテル（新潟県新潟市）
  • Year and Date: 2015-06-05
  • Invited
• [Presentation] 免疫臓器の組織微小環境と免疫細胞動態 (2015)
  • Author(s): 片貝智哉
  • Organizer: 第１２回 Niigata Bone Research Conference
  • Place of Presentation: 新潟
  • Year and Date: 2015-03-03
  • Invited
• [Presentation] Lysophospholipid signaling regulates lymphocyte extravasation in lymph nodes. (2014)
  • Author(s): Miyasaka, M.
  • Organizer: Minisymposium on Leukocyte Trafficking and Immune Responses
  • Place of Presentation: Turku, Finland
  • Year and Date: 2014-12-18
  • Invited
• [Presentation] Functional analysis of the subcapsular sinus floor that allows leukocyte migration from the sinus to the lymph node parenchyma. (2014)
  • Author(s): Sasaki, N., Hata, E., Umemoto, E., Hayasaka, H. & Miyasaka, M.
  • Organizer: The 43rd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
  • Year and Date: 2014-12-10 – 2014-12-14
• [Presentation] The role of LPA4/6 receptors in lymphocyte trafficking across high endothelial venules of lymph nodes. (2014)
  • Author(s): Hata, E., Sasaki, N., Takeda, A., Umemoto, E., Hayasaka, H. & Miyasaka, M.
  • Organizer: The 43rd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
  • Year and Date: 2014-12-10 – 2014-12-14
• [Presentation] GATA-1 controls the generation and function of basophils. (2014)
  • Author(s): Obata-Ninomiya, K., Nei, Y., Tsutsui, H., Ishiwata, K., Miyasaka, M., Matsumoto, K., Nakae, S., Kanuka, H., Inase, N., Nakayama, T. & Karasuyama, H.
  • Organizer: The 43rd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
  • Year and Date: 2014-12-10 – 2014-12-14
• [Presentation] Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration. (2014)
  • Author(s): Totsuka, N., Kim, Y., Kanemaru, K., Niizuma, K., Umemoto, E., Nagai, K., Tahara-Hanaoka, S., Oda-Nakahashi, C., Honda, S., Miyasaka, M., Shibuya, K. & Shibuya, A.
  • Organizer: The 43rd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
  • Year and Date: 2014-12-10 – 2014-12-14
• [Presentation] Lymphocytes caught before the act - how Spinster-homologue-2 (Spns2) controls S1P-driven lymphocyte egress from lymphoid organs. (2014)
  • Author(s): Simmons, S., Umemoto, E., Fukuhara, S., Kitazawa, Y., Okudaira, M., Inoue, A., Nakamura, S., Iida, T., Aoki, J., Matsuno, K., Miyasaka, M., Takeda, K. & Ishii, M.
  • Organizer: The 43rd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
  • Year and Date: 2014-12-10 – 2014-12-14
• [Presentation] The cecal patch is a major site for generation of colonic IgA-secreting cells. (2014)
  • Author(s): Umemoto, E., Kayama, H., Kikuta, J., Okumura, R., Takeda, A., Ishii, M. & Takeda, K.
  • Organizer: The 43rd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
  • Year and Date: 2014-12-10 – 2014-12-14
• [Presentation] The autotaxn/LPA axis is a novel regulator of lymphocyte extravasation at high endothelial venules. (2014)
  • Author(s): Miyasaka, M.
  • Organizer: Biomedicum Helsinki Lecture
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 2014-10-29
  • Invited
• [Presentation] リンパ節における恒常的なリンパ球の血管外移動はautotaxin/lysophosphatidic acidにより調節を受ける (2014)
  • Author(s): 宮坂昌之、梅本英司、竹田彰、秦枝里奈、佐々木尚子
  • Organizer: 第８７回日本生化学会大会 シンポジウム「脂質免疫学」
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
  • Invited
• [Presentation] The autotaxin/lysophospholipid axis regulates constitutive lymphocyte transmigration across high endothelial venules in lymph nodes. (2014)
  • Author(s): Miyasaka, M.
  • Organizer: Invited seminar at Karolinska Institute
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2014-09-08
  • Invited
• [Presentation] からだを守る免疫のしくみ、そして老化とは (2014)
  • Author(s): 宮坂昌之
  • Organizer: 第９８回信濃木崎夏期大学
  • Place of Presentation: 安曇野
  • Year and Date: 2014-08-02
  • Invited
• [Presentation] 免疫細胞は自分の行き先をどのようにして知るのか？- In Vivo Veritas. (2014)
  • Author(s): 宮坂昌之
  • Organizer: 第１６回免疫サマースクール レギュラーコース講演
  • Place of Presentation: 小豆島
  • Year and Date: 2014-07-28 – 2014-07-31
• [Presentation] 脾臓におけるケモカインの発現と白血球動態. (2014)
  • Author(s): 梅本英司、宮坂昌之
  • Organizer: 第119回日本解剖学会総会・全国学術集会
  • Place of Presentation: 東京
  • Invited
• [Presentation] オートタシキン/リゾホスファチジン酸によるリンパ球トラフィキングの制御機構 (2014)
  • Author(s): 梅本英司、竹田彰、宮坂昌之
  • Organizer: 第１回先進イメージング医学研究会・学術集会（第７回生体イメージング研究会）
  • Place of Presentation: 神戸
• [Presentation] The autotaxin/lysophosphatidic acid axis regulates lymphocyte extravasation at lymph node high endothelial venules. (2013)
  • Author(s): Miyasaka, M.
  • Organizer: 2013 FASEB Science Research Conference: Lysophospholipid and Other Related Mediators - From Bench to Clinic.
  • Place of Presentation: Niseko
  • Invited
• [Presentation] Autotaxin/lysophosphatidic acid はリンパ球の血管外移動の新しい調節因子である. (2013)
  • Author(s): 宮坂昌之、梅本英司、竹田彰、秦枝里奈、佐々木尚子
  • Organizer: 第５５回日本脂質生化学会
  • Place of Presentation: 宮城県松島
  • Invited
• [Presentation] 免疫細胞の動態制御とストローマ細胞. (Regulation of immune cell trafficking by stromal cells.) . (2013)
  • Author(s): 宮坂昌之
  • Organizer: 第３７回日本リンパ学会総会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] からだを守る免疫のしくみ. (2013)
  • Author(s): 宮坂昌之
  • Organizer: 第９７回・信濃木崎夏期大学
  • Place of Presentation: 安曇野
  • Invited
• [Presentation] The autotaxin/lysophosphatidic acid is a regulator of lymphocyte extravasation at the high endothelial venules of lymph nodes. (2013)
  • Author(s): Miyasaka, M., Umemoto, E., Takeda, A., Bai, Z., Cai, L., Hata, E., Tohya, K., Veeraveedu, P. & Sugiura, Y.
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] 免疫細胞は自分の行き先をどのようにして知るのか？ - In Vivo Veritas. (2013)
  • Author(s): 宮坂昌之
  • Organizer: 第１５回免疫サマースクール（レギュラーコース講義）
  • Place of Presentation: 福岡
• [Presentation] Environmental control of high-speed T cell migration in the lymph node (2013)
  • Author(s): Katakai, T.
  • Organizer: The 42nd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Chiba
• [Presentation] リンパ節における高速T細胞遊走と組織環境 (2013)
  • Author(s): 片貝智哉
  • Organizer: 第３７回日本リンパ学会総会
  • Place of Presentation: 福岡
• [Presentation] リンパ節微小環境によるT細胞高速遊走の制御 (2013)
  • Author(s): 片貝智哉
  • Organizer: 日本顕微鏡学会 第６９回学術講演会
  • Place of Presentation: 大阪
• [Presentation] オートタキシン/リゾホスファチジン酸は、リンパ節高内皮細静脈の基底膜におけるリンパ球の通過を制御する. (2013)
  • Author(s): 梅本英司、白忠彬、蔡林君、竹田彰、東家一雄、駒井豊、Punniyakoti T. Veeraveedu、秦枝里奈、杉浦悠毅、末松誠、奥平真一、青木淳賢、宮坂昌之
  • Organizer: 第３７回日本リンパ学会総会
  • Place of Presentation: 福岡
• [Presentation] The role of LPA receptors on endothelial cells in lymphocyte trafficking across high endothelial venules of lymph nodes. (2013)
  • Author(s): Hata, E., Sasaki, N., Takeda, A., Umemoto, E., Hayasaka, H. & Miyasaka, M.
  • Organizer: The 42nd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Chiba
• [Presentation] The role of LPA receptors on lymphocytes in lymphocyte trafficking across high endothelial venules of lymph nodes. (2013)
  • Author(s): Takeda, A., Umemoto, E., Hata, E., Sasaki, N. & Miyasaka, M.
  • Organizer: The 42nd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Chiba
• [Presentation] Migration behavior of naive T cells and activated T cells via afferent lymphatics. (2012)
  • Author(s): Hata, E.
  • Organizer: The 41st Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2012-12-05
• [Presentation] Autotaxin-derived lysophosphatidic acid acts on high endothelial venule endothelial cells to promote lymphocyte-endothelial cell interactions. (2012)
  • Author(s): Takeda, A.
  • Organizer: The 41st Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2012-12-05
• [Presentation] Constitutive Plasmacytoid Dendritic Cell Migration to the Splenic White Pulp is Cooperatively Regulated by CCR7- and CXCR4-Mediated Signaling. (2012)
  • Author(s): Umemoto, E.
  • Organizer: Towards Comprehensive Understanding of Immune Dynamism (TCUID 2012)
  • Place of Presentation: Osaka
  • Year and Date: 2012-10-30
• [Presentation] 免疫細胞は自分の行き先をどのようにして知るのか？ (2012)
  • Author(s): 宮坂昌之
  • Organizer: 第14回免疫サマースクール2012. レギュラーコース講義.
  • Place of Presentation: 那須
  • Year and Date: 2012-07-24
  • Invited
• [Presentation] 免疫細胞の動態と機能を規定する「形・構造」. (2012)
  • Author(s): 宮坂昌之
  • Organizer: 第14回免疫サマースクール2012. イントロダクトリーコース講義.
  • Place of Presentation: 那須
  • Year and Date: 2012-07-23
  • Invited
• [Presentation] 定常状態における形質細胞様樹状細胞の脾白脾髄への移動はCCR7およびCXCR4の協調作用により制御される. (2012)
  • Author(s): 梅本英司
  • Organizer: 第３６回日本リンパ学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-06-29
• [Book] Chronic Inflammation: Mechanisms and Regulation (2016)
  • Author(s): Miyasaka M, Takeda A, Hata E, Sasaki N, Umemoto E, Jalkanen S.
  • Total Pages: 702
  • Publisher: Springer Japan
• [Book] Encyclopedia of Immunobiology (2016)
  • Author(s): Miyasaka M, Hata E, Tohya K, Hayasaka H.
  • Total Pages: 3126
  • Publisher: Elsevier
• [Book] Encyclopedia of Immunobiology (2016)
  • Author(s): Miyasaka M, Takeda A, Hata E, Sasaki N, Umemoto E.
  • Total Pages: 3126
  • Publisher: Elsevier
• [Remarks] 世界初！リンパ球が狭いリンパ節（砦）でスムーズに動くしくみを解明
  • URL: http://www.sankei.com/west/news/160130/wst1601300008-n1.html