| Budget Amount *help |
¥137,020,000 (Direct Cost: ¥105,400,000、Indirect Cost: ¥31,620,000)
Fiscal Year 2016: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
Fiscal Year 2015: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
Fiscal Year 2014: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2013: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
Fiscal Year 2012: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000)
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| Outline of Final Research Achievements |
In this study, we aimed to elucidate the mechanism controlling leukocyte trafficking during adaptive immune responses and to obtain quantitative information on immune cell migration between lymphoid tissues. We have revealed that 1) DOCK8 plays a key role in migration of dendritic cells and macrophages by linking Cdc42 activation to actomyosin dynamics through the association with LRAP35a; and 2) CD4+ T cells from DOCK8-deficient mice produce large amounts of IL-31, a major pruritogen associated with atopic dermatitis, depending on the transcriptional factor EPAS1. In addition, we developed knock-in mice expressing photoconvertible protein KikGR and quantitatively analyzed migration of various subsets of leukocytes under steady and inflammatory conditions.
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