| Budget Amount *help |
¥192,920,000 (Direct Cost: ¥148,400,000、Indirect Cost: ¥44,520,000)
Fiscal Year 2016: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2015: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2014: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2013: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2012: ¥61,750,000 (Direct Cost: ¥47,500,000、Indirect Cost: ¥14,250,000)
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| Outline of Final Research Achievements |
In this study, we show that ubiquitin-proteasome system controls the assembly and disassembly of primary cilia: CRL3-KCTD17 ubiquitin E3 ligase leads to poly-ubiquitination and degradation of trichoplein, a suppressor of ciliogenesis, thereby inducing ciliogenesis in response to serum starvation. In proliferating cells, trichoplein is destabilized by USP8 deubiquitinase. Importantly, we reveal that epidermal growth factor receptor (EGFR) kinase directly phosphorylates and activates USP8. These data indicate that the ubiquitin-proteasome-mediated control of trichoplein level is critical for ciliogenesis.
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