| Budget Amount *help |
¥154,570,000 (Direct Cost: ¥118,900,000、Indirect Cost: ¥35,670,000)
Fiscal Year 2016: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2015: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2014: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2013: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2012: ¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
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| Outline of Final Research Achievements |
A hallmark in the human brain development is the formation of a new germinal zone, outer subventricular zone (OSVZ) during neurogenesis, in addition to the common germinal zone (VZ). The OSVZ expands the population of neural progenitors extensively undergoing proliferative and neurogenic divisions to generate a massive amount of neurons. Thus, the formation of the OSVZ, which is absent in rodents, highly contributes to brain expansion in gyrencephalyc mammals such as primates. We have attempted to make double mutants of mouse recessive autosomal primary microcephaly (MCPH) genes and the LGN gene. Its defect randomizes spindle orientations, consequently generating scattered progenitors just like those in the OSVZ . Here we show that a double mutant for a MCPH gene, Aspm, and LGN exhibits a dramatic reduction in the brain size. We will discuss the detailed phenotype of the double mutant.
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