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Host cell competnecy for negative-stranded RNA viruses

Planned Research

Project AreaMolecular basis of host cell competency in virus infection
Project/Area Number 24115002
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionUniversity of Tsukuba

Principal Investigator

NAGATA Kyosuke  筑波大学, 学長 (40180492)

Co-Investigator(Kenkyū-buntansha) 朴 三用  横浜市立大学, 生命医科学研究科, 教授 (20291932)
Research Collaborator Kawaguchi Atsushi  筑波大学, 医学医療系, 助教 (90532060)
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥143,130,000 (Direct Cost: ¥110,100,000、Indirect Cost: ¥33,030,000)
Fiscal Year 2016: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2015: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2014: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2013: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Keywordsインフルエンザウイルス / RNAポリメラーゼ / RNP / エンドソーム / 微小管 / 小胞輸送 / ウイルス / 宿主因子 / ゲノム複製 / 転写 / RNA依存性RNAポリメラーゼ / 構造生物学 / 感染症 / 分子生物学
Outline of Final Research Achievements

This research aimed to identify host factors, which regulate influenza virus genome function, and to analyze the replicational and post-replicational regulation of influenza virus genome.
We identified pp32/APRIL and Prp18 as stimulatory factors of viral RNA polymerase. Further, we found that newly synthesized viral genomes are recruited to the centrosome by YB-1, and the progeny viral genome is transported to the plasma membrane via cholesterol-enriched Rab11a-positive recycling endosomes. Cholesterol is thought to be a trigger for the virus assembly concomitantly with arrival of the virus genome beneath the plasma membrane.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (93 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (2 results) Journal Article (38 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 38 results,  Open Access: 11 results,  Acknowledgement Compliant: 11 results) Presentation (49 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Remarks (4 results)

  • [Int'l Joint Research] ボルドー大学(フランス)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ボルドー大学(フランス)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mitotic phosphorylation of CCCTC-binding factor (CTCF) reduces its DNA binding activity.2017

    • Author(s)
      Sekiya T, Murano K, Kato K, Kawaguchi A, Nagata K.
    • Journal Title

      FEBS Open Bio

      Volume: 7 Issue: 3 Pages: 397-404

    • DOI

      10.1002/2211-5463.12189

    • NAID

      120007129136

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pre-mRNA Processing Factor Prp18 Is a Stimulatory Factor of Influenza Virus RNA Synthesis and Possesses Nucleoprotein Chaperone Activity.2017

    • Author(s)
      Minakuchi M, Sugiyama K, Kato Y, Naito T, Okuwaki M, Kawaguchi A, Nagata K.
    • Journal Title

      Journal of Virology

      Volume: 91 Issue: 3

    • DOI

      10.1128/jvi.01398-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of a Genetically Stable High-Fidelity Influenza Vaccine Strain.2017

    • Author(s)
      Naito T, Mori K, Ushirogawa H, Takizawa N, Nobusawa E, Odagiri T, Tashiro M, Ohniwa RL, Nagata K, Saito M.
    • Journal Title

      Journal of Virology

      Volume: 91

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polycomb repressive complex 2 facilitates the nuclear export of the influenza viral genome through the interaction with M1.2016

    • Author(s)
      Asaka MN, Kawaguchi A, Sakai Y, Mori K, Nagata K.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 33608-33608

    • DOI

      10.1038/srep33608

    • NAID

      120007129419

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional characterization and efficient detection of Nucleophosmin/NPM1 oligomers.2016

    • Author(s)
      Lin J, Hisaoka M, Nagata K, Okuwaki M.
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 480 Pages: 702-708

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1.2016

    • Author(s)
      Lin J, Kato M, Nagata K, Okuwaki M.
    • Journal Title

      Nucleic Acids Research

      Volume: gkw1285 Pages: 3707-3723

    • DOI

      10.1093/nar/gkw1285

    • NAID

      120007129193

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of Nuclear Antiviral Factors against Invading DNA Viruses: The Immediate Fate of Incoming Viral Genomes.2016

    • Author(s)
      Komatsu T, Nagata K, Wodrich H.
    • Journal Title

      Viruses

      Volume: 8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tracking adenovirus genomes identifies morphologically distinct late DNA replication compartments.2016

    • Author(s)
      Komatsu T, Robinson DR, Hisaoka M, Ueshima S, Okuwaki M, Nagata K, Wodrich H.
    • Journal Title

      Traffic

      Volume: 17 Issue: 11 Pages: 1168-1180

    • DOI

      10.1111/tra.12429

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regulation of Cellular Dynamics and Chromosomal Binding Site Preference of Linker Histones H1.0 and H1.X.2016

    • Author(s)
      Okuwaki M, Abe M, Hisaoka M, Nagata K.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 36 Pages: 2681-2696

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-κB Signaling Pathway.2016

    • Author(s)
      Saito S, Cigdem S, Okuwaki M, Nagata K.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 36 Issue: 13 Pages: 1820-1835

    • DOI

      10.1128/mcb.00158-16

    • NAID

      120007135298

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion2016

    • Author(s)
      Moriyama, M. et al.
    • Journal Title

      J. Virol.

      Volume: 90 Issue: 8 Pages: 4105-4114

    • DOI

      10.1128/jvi.00120-16

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influenza virus induces cholesterol-enriched endocytic recycling compartments for budozone formation via cell cycle-independent centrosome maturation2015

    • Author(s)
      Kawaguchi A, Hirohama M, Harada Y, Osari S, Nagata K.
    • Journal Title

      PLoS pathogens

      Volume: 11 Issue: 11 Pages: e1005284-e1005284

    • DOI

      10.1371/journal.ppat.1005284

    • NAID

      120007129744

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA2015

    • Author(s)
      Sugiyama K, Kawaguchi A, Okuwaki M, Nagata K.
    • Journal Title

      eLife

      Volume: 4

    • DOI

      10.7554/elife.08939

    • NAID

      120007135522

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Measles virus C protein facilitates transcription by the control of N protein-viral genomic RNA interaction in early phases of infection2015

    • Author(s)
      Nishie T, Nagata K.
    • Journal Title

      BIochem Biophys Res Commune

      Volume: 463 Issue: 4 Pages: 1262-1266

    • DOI

      10.1016/j.bbrc.2015.06.099

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Method for Visualization of Incoming Adenovirus Chromatin Complexes in Fixed and Living Cells2015

    • Author(s)
      Komatsu T, Dacheux D, Kreppel F, Nagata K, Wodrich H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 9 Pages: e0137102-e0137102

    • DOI

      10.1371/journal.pone.0137102

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies2015

    • Author(s)
      Komatsu T, Nagata K, Wodrich H.
    • Journal Title

      Journal of Virology

      Volume: 90 Issue: 3 Pages: 1657-1667

    • DOI

      10.1128/jvi.02545-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Oseltamivir Expands Quasispecies of Influenza Virus through Cell-to-cell Transmission2015

    • Author(s)
      Mori K, Murano K, Ohniwa RL, Kawaguchi A, Nagata K.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 9163-9163

    • DOI

      10.1038/srep09163

    • NAID

      120007130320

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Actin-myosin network is required for proper assembly of influenza virus particles2015

    • Author(s)
      Kumakura M, Kawaguchi A, Nagata K.
    • Journal Title

      Virology

      Volume: 476 Pages: 141-150

    • DOI

      10.1016/j.virol.2014.12.016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Centrosome maturation requires YB-1 to regulate dynamic instability of microtubules for nucleus reassembly.2015

    • Author(s)
      Kawaguchi A, Asaka MN, Matsumoto K, Nagata K.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 8768-8768

    • DOI

      10.1038/srep08768

    • NAID

      120007130347

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Glucocorticoids facilitate the transcription from the human cytomegalovirus major immediate early promoter in glucocorticoid receptor- and nuclear factor-I-like protein-dependent manner.2015

    • Author(s)
      Inoue-Toyoda M, Kato K, Nagata K, Yoshikawa H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 476 Issue: 1 Pages: 9-14

    • DOI

      10.1016/j.bbrc.2015.01.091

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli2014

    • Author(s)
      Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Sekimizu K and Akimitsu N.
    • Journal Title

      Molecular cell

      Volume: 53 Issue: 3 Pages: 393

    • DOI

      10.1016/j.molcel.2014.01.009

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of the N-terminal portion of influenza virus RNA polymerase subunit PB1 in nucleotide recognition.2014

    • Author(s)
      Binh NT, Wakai C, Kawaguchi A, Nagata K.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 443 Issue: 3 Pages: 975-979

    • DOI

      10.1016/j.bbrc.2013.12.071

    • NAID

      120007130532

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upstream binding factor-dependent and pre-rRNA transcription-independent association of pre-rRNA processing factors with rRNA gene.2014

    • Author(s)
      Ueshima, S., Nagata, K., and Okuwaki, M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 443 Issue: 1 Pages: 22-27

    • DOI

      10.1016/j.bbrc.2013.11.039

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsically disordered regions of nucleophosmin/B23 regulate its RNA binding activity through their inter- and intra-molecular association.2014

    • Author(s)
      Hisaoka, M., Nagata, K., and Okuwaki, M.
    • Journal Title

      Nucleic Acids Res.

      Volume: 42 Issue: 2 Pages: 1180-1195

    • DOI

      10.1093/nar/gkt897

    • NAID

      120007130533

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The N-terminal region of influenza virus polymerase PB1 adjacent to the PA binding site is involved in replication but not transcription of the viral genome.2013

    • Author(s)
      Binh NT, Wakai C, Kawaguchi A, Nagata K.
    • Journal Title

      Frontiers in Microbiology

      Volume: 4 Pages: 398-398

    • NAID

      120007130538

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions.2013

    • Author(s)
      Komatsu T, Sekiya T, Nagata K.
    • Journal Title

      Scientific Report

      Volume: 3 Issue: 1 Pages: 2187-2187

    • DOI

      10.1038/srep02187

    • NAID

      120007136881

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-influenza virus activity of Ginkgo biloba leaf extracts.2013

    • Author(s)
      Haruyama T, Nagata K.
    • Journal Title

      Journal of Natural Medicine

      Volume: 67(3) Issue: 3 Pages: 636-642

    • DOI

      10.1007/s11418-012-0725-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel and unique transcription factor in the intraerythrocytic stage of Plasmodium falciparum.2013

    • Author(s)
      Komaki-Yasuda, K., Okuwaki, M., Nagata, K., Kawazu, S., and Kano, S.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 9 Pages: e74701-e74701

    • DOI

      10.1371/journal.pone.0074701

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies.2013

    • Author(s)
      Oaks JJ, Santhanam R, Walker CJ, Roof S, Harb JG, Ferenchak G, Eisfeld AK, Van Brocklyn JR, Briesewitz R, Saddoughi SA, Nagata K, Bittman R, Caligiuri MA, Abdel-Wahab O, Levine R, Arlinghaus RB, Quintas-Cardama A, Goldman JM, Apperley J, Reid A, Milojkovic D, Ziolo MT, Marcucci G, Ogretmen B, Neviani P, Perrotti D.
    • Journal Title

      Blood

      Volume: 122(11) Issue: 11 Pages: 1923-1934

    • DOI

      10.1182/blood-2013-03-492181

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary crystallographic analysis of an Escherichia coli-selected mutant of the nuclease domain of the metallonuclease colicin E7.2013

    • Author(s)
      10) Czene A, Tóth E, Gyurcsik B, Otten H, Poulsen JC, Lo Leggio L, Larsen S, Christensen HE, Nagata K.
    • Journal Title

      Acta Crystallography Section F Structural Biology and Crystalization Communications

      Volume: 69 Issue: 5 Pages: 551-554

    • DOI

      10.1107/s1744309113008233

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the N-terminal loop in the function of the colicin E7 nuclease domain2013

    • Author(s)
      Czene A, Németh E, Zóka IG, Jakab-Simon NI, Körtvélyesi T, Nagata K, Christensen HE, Gyurcsik B
    • Journal Title

      J. Biol. Inorg. Chem

      Volume: 18 Issue: 3 Pages: 309-321

    • DOI

      10.1007/s00775-013-0975-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YB-1, Y-box binding protein-1, is a porter to lead influenza virus ribonucleoprotein complexes to microtubules.2012

    • Author(s)
      Kawaguchi, A., Matsumoto, K., and Nagata, K.
    • Journal Title

      Journal of Virology

      Volume: 86 Issue: 20 Pages: 11086-11095

    • DOI

      10.1128/jvi.00453-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication-uncoupled histone deposition during adenovirus DNA replication.2012

    • Author(s)
      Komatsu T.
    • Journal Title

      Journal of Virology

      Volume: 86(12) Issue: 12 Pages: 6701-6711

    • DOI

      10.1128/jvi.00380-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity2012

    • Author(s)
      Onomoto K, Jogi M, Yoo J-S, Narita R, Morimoto S, Takemura A, Sambhara S, Kawaguchi A, Osari S, Nagata K, Matsumiya T, Namiki H, Yoneyama M, Fujita T
    • Journal Title

      PLoS One

      Volume: 7 Issue: 8 Pages: 1-15

    • DOI

      10.1371/journal.pone.0043031

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B23/Nucleophosmin is involved in regulation of adenovirus chromatin structure at late infection stages, but not in its replication and transcription2012

    • Author(s)
      Abdus MD.Samad, et al
    • Journal Title

      Journal of General Virology

      Volume: (In press) Issue: 6 Pages: 1328-1338

    • DOI

      10.1099/vir.0.036665-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell tropism and pathogenesis of measles virus in monkeys2012

    • Author(s)
      Kato SI., et al.
    • Journal Title

      Front.Microbiol.

      Volume: (in press) Pages: 14-14

    • DOI

      10.3389/fmicb.2012.00014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functions of homo- and hetero-oligomers of human Nucleoplasmin/Nucleophosmin family proteins NPM1, NPM2, and NPM3 during sperm chromatin remodeling2012

    • Author(s)
      Okuwaki M, Sumi A, Hisaoka M, Saotome-Nakamura A, Akashi S, Nishimura Y, Nagata K
    • Journal Title

      Nucleic Acids Res

      Volume: 40 Issue: 11 Pages: 4861-4878

    • DOI

      10.1093/nar/gks162

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New sandwich-type enzyme-linked immunosorbent assay for human MxA protein in a whole blood using monoclonal antibodies against GTP-binding domain for recognition of viral infection.2012

    • Author(s)
      Kawamura M.
    • Journal Title

      Journal of Clinical Laboratory Analysis

      Volume: 26 Issue: 3 Pages: 174-183

    • DOI

      10.1002/jcla.21507

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Viral budozone formation in concert with influenza virus genome transport using recycling endosomes.2016

    • Author(s)
      Kuroki T, Nagata K, Kawaguchi A.
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター・北海道・札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] In situ detection of M1-NS2 complex formation essential for nuclear export of the influenza virus genome.2016

    • Author(s)
      Yamashita S, Asaka MN, Nagata K, Kawaguchi A.
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター・北海道・札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Influenza A virus infection induces Caspase-1-dependent cell death with pro-inflammatory cytokines in human lung epithelial cells.2016

    • Author(s)
      Lee SJ, Nagata K, Kawaguchi A.
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター・北海道・札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Intracellular trafficking of influenza virus genome via centrosome maturation.2015

    • Author(s)
      Kawaguchi A.
    • Organizer
      The 38th Annual meeting of the Molecular Biology Society for Japan
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Influenza virus induces cholesterol-enriched endocytic recycling compartments for budozone formation through centrosome maturation.2015

    • Author(s)
      Kawaguchi A, Hirohama M, Nagata K.
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RNA replicon as proper noun2015

    • Author(s)
      Nagata K.
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel host factor-dependent influenza A virus vRNA synthesis from its cRNA.2015

    • Author(s)
      Sugiyama K, Kawaguchi A, Okuwaki M, Nagata K.
    • Organizer
      The 14th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intracellular trafficking of influenza virus genome mediated by endocytic recycling compartments located at the centrosome.2015

    • Author(s)
      Kawaguchi A, Hirohama M, Nagata K.
    • Organizer
      The 16th International Negative Strand Virus Meeting
    • Place of Presentation
      シエナ大学(シエナ)
    • Year and Date
      2015-06-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中心体の機能制御を介したインフルエンザウイルスゲノムの細胞内輸送機構2014

    • Author(s)
      川口敦史、広浜美香子、永田恭介
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Host factor-dependent influenza virus genome replication2014

    • Author(s)
      Nagata K.
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルスポリメラーゼサブユニット間の適合性2014

    • Author(s)
      原田芳美、永田恭介、川口敦史
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] インフルエンザウイルス粒子形成におけるアクトミオシンネットワークの機能2014

    • Author(s)
      熊倉充子、川口敦史、永田恭介
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] インフルエンザウイルスcell-to-cell感染によるウイルスゲノムの多様化2014

    • Author(s)
      森幸太郎、川口敦史、村野健作、永田恭介
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] YB-1 is a porter to lead influenza virus ribonucleoprotein complexes to microtubules for the virus production.2013

    • Author(s)
      Kawaguchi A.
    • Organizer
      The 2nd Meeting on RNA and Biofunctions-Asis Study "RNA Biofunctions and Viruses"
    • Place of Presentation
      Fukuoka
    • Year and Date
      2013-01-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] Host factor-dependent RNA replication of the influenza virus genome.2013

    • Author(s)
      永田恭介
    • Organizer
      The 12th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      淡路
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルスゲノムの機能発現機構と創薬展開2013

    • Author(s)
      永田恭介
    • Organizer
      第66回日本細菌学会九州支部総会・第50回日本ウイルス学会九州支部総会
    • Place of Presentation
      長崎
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Tamiflu resistant cell-to-cell transmission of cell associated influenza virus2013

    • Author(s)
      森幸太郎、春山貴弘、永田恭介
    • Organizer
      The 12th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      淡路
    • Related Report
      2013 Annual Research Report
  • [Presentation] インフルエンザポリメラーゼ遺伝子間の適合性2013

    • Author(s)
      原田芳美、川口敦史、永田恭介
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] インフルエンザウイルスゲノムの細胞内輸送機構におけるNS1の新規機能2013

    • Author(s)
      長利卓、川口敦史、永田恭介
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] インフルエンザウイルス増殖にかかわる細胞骨格関連因子2013

    • Author(s)
      熊倉充子、永田恭介
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] インフルエンザウイルスにおけるNA非依存的cell-to-cell感染機構2013

    • Author(s)
      森幸太郎、春山貴弘、永田恭介
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] インフルエンザウイルス感染に応答した宿主因子YB-1による中心体の機能制御2013

    • Author(s)
      川口敦史、永田恭介
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] rRNA遺伝子の種特異的転写機構の解析2013

    • Author(s)
      村野健作、永田恭介
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポリコーム複合体因子であるEZH2はインフルエンザウイルスタンパク質M1およびインフルエンザウイルスゲノムの核外輸送を制御する2013

    • Author(s)
      浅賀正充、川口敦史、永田恭介
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] M期リン酸化によるCTCFのDNA結合活性制御の解析2013

    • Author(s)
      関屋健史、村野健作、永田恭介
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 薬剤耐性ウイルスが出現しない抗インフルエンザウイルス薬開発に向けた宿主因子依存性ウイルスRNAゲノムの複製転写機構.2012

    • Author(s)
      永田恭介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] RNA依存性RNAポリメラーゼを用いた新規レポーターシステムによるrRNA遺伝子の種特異的転写機構の解析.2012

    • Author(s)
      村野健作
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞がん化に関わる核膜孔タンパク質の発現異常.2012

    • Author(s)
      齋藤祥子
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規宿主因子YB-1によるインフルエンザウイルスRNP複合体の微小管への輸送機構解析.2012

    • Author(s)
      川口敦史
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] VprBP, a Substrate Receptor Subunit of Cullin4-DDB1 E3 Ubiquitin Ligase Complex, is Involved Ubiquitination of Histone H1.2012

    • Author(s)
      加藤広介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] EZH2はインフルエンザゲノムの核外輸送を制御する.2012

    • Author(s)
      浅賀正充
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト化マウスを用いた麻疹ウイルス感染モデルマウスの作製.2012

    • Author(s)
      木村英樹
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] インフルエンザウイルスRNAポリメラーゼの伸長活性に及ぼすキャップ構造の意義.2012

    • Author(s)
      若井ちとせ
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞骨格関連因子によるインフルエンザウイルス増殖制御.2012

    • Author(s)
      熊倉充子
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規宿主因子YB-1によるインフルエンザウイルスゲノムの細胞内輸送制御.2012

    • Author(s)
      川口敦史
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] YB-1 is a porter to lead influenza virus ribonucleoprotein complexes to microtubules.2012

    • Author(s)
      Kawaguchi A.
    • Organizer
      The 3rd Leading Graduate Schools International Conference (Tsukuba Global Science Week)
    • Place of Presentation
      Tsukuba
    • Year and Date
      2012-11-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] esign of a novel artificial metallonuclease for targeting the breakpoint in Duchenne Muscular Dystrophy.2012

    • Author(s)
      Gyurcsik B.
    • Organizer
      The 3rd Leading Graduate Schools International Conference (Tsukuba Global Science Week)
    • Place of Presentation
      Tsukuba
    • Year and Date
      2012-11-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Species-specific transcription mechanism of rRNA gene revealed by a novel monitoring system-using RNA-dependent RNA polymerase.2012

    • Author(s)
      Murano K.
    • Organizer
      The 7th Tsukuba Medical Science Research Meeting (Tsukuba Global Science Week)
    • Place of Presentation
      Tsukuba
    • Year and Date
      2012-11-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] The promoter binding sites in the influenza virus polymerase PB1.2012

    • Author(s)
      Binh N.T.
    • Organizer
      The 7th Tsukuba Medical Science Research Meeting (Tsukuba Global Science Week)
    • Place of Presentation
      Tsukuba
    • Year and Date
      2012-11-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Function of IREF-2, a newly identified for replication of the influenza virus RNA genome.2012

    • Author(s)
      Sugiyama K.
    • Organizer
      The 7th Tsukuba Medical Science Research Meeting (Tsukuba Global Science Week)
    • Place of Presentation
      Tsukuba
    • Year and Date
      2012-11-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] A novel function of NS1 viral protein in intracellular of the influenza virus genome.2012

    • Author(s)
      Osari S.
    • Organizer
      The 7th Tsukuba Medical Science Research Meeting (Tsukuba Global Science Week)
    • Place of Presentation
      Tsukuba
    • Year and Date
      2012-11-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Assembly and maintenance of the nucleolar structure by RNA and RNA binding protein.2012

    • Author(s)
      Okuwaki M.
    • Organizer
      Human Biology Symposium-Biology and Regenerative Medicine
    • Place of Presentation
      Tsukuba
    • Year and Date
      2012-10-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒストンH1シャペロンTAF-Iによるクロマチン動態制御機構の解析.2012

    • Author(s)
      加藤広介
    • Organizer
      生殖サイクル若手勉強会2012
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウイルス研究が育んだ現代生命科学.2012

    • Author(s)
      永田恭介
    • Organizer
      第9回ウイルス学キャンプin湯河原
    • Place of Presentation
      熱海
    • Year and Date
      2012-07-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] インフルエンザウイルスゲノムの細胞内輸送機構の解析.2012

    • Author(s)
      川口敦史
    • Organizer
      第9回ウイルス学キャンプin湯河原
    • Place of Presentation
      熱海
    • Year and Date
      2012-07-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] インフルエンザウイルスゲノムの輸送にかかわる細胞骨格関連因子の解析.2012

    • Author(s)
      熊倉充子
    • Organizer
      第9回ウイルス学キャンプin湯河原
    • Place of Presentation
      熱海
    • Year and Date
      2012-07-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] NS1によるインフルエンザウイルスゲノムの細胞内局在決定機構の解析.2012

    • Author(s)
      長利卓
    • Organizer
      第9回ウイルス学キャンプin湯河原
    • Place of Presentation
      熱海
    • Year and Date
      2012-07-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウイルスポリメラーゼによって規定されるトリインフルエンザウイルスの哺乳類細胞への適応機構

    • Author(s)
      原田芳美、 川口敦史、 永田恭介
    • Organizer
      日本生化学会関東支部例会
    • Place of Presentation
      甲府
    • Related Report
      2013 Annual Research Report
  • [Presentation] インフルエンザウイルスゲノムの複製機構に基盤をおいた創薬

    • Author(s)
      永田恭介
    • Organizer
      第42回ヒューマンサイエンス総合研究セミナー
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Remarks] 筑波大学医学医療系分子ウイルス学

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/infectionbiology/virology/

    • Related Report
      2016 Annual Research Report
  • [Remarks] ウイルス感染現象における宿主細胞コンピテンシーの分子基盤

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/infcompetence/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 筑波大学 分子ウイルス学分野

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/infectionbiology/virology/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 筑波大学 感染生物学分子ウイルス学分野

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/infectionbiology/virology/

    • Related Report
      2012 Annual Research Report

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Published: 2012-11-27   Modified: 2023-03-16  

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