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Competition between viruses and intracellular antiviral immunity

Planned Research

Project AreaMolecular basis of host cell competency in virus infection
Project/Area Number 24115004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

Fujita Takashi  京都大学, ウイルス・再生医科学研究所, 教授 (10156870)

Co-Investigator(Kenkyū-buntansha) 高折 晃史  京都大学, 医学(系)研究科(研究院), 教授 (20324626)
Co-Investigator(Renkei-kenkyūsha) KATO Hiroki  京都大学, ウイルス・再生医科学研究所, 准教授 (10597173)
SHINDO Keisuke  京都大学, 医学研究科, 助教 (10602344)
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥117,910,000 (Direct Cost: ¥90,700,000、Indirect Cost: ¥27,210,000)
Fiscal Year 2016: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2015: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2014: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2013: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Keywords自然免疫 / インターフェロン / ウイルス / 感染症 / RIG-I / ストレス顆粒 / イメージング / 複製複合体 / ゲノム / 遺伝子 / 免疫学 / APOBEC
Outline of Final Research Achievements

Fujita has elucidated that DHX36 and Pumilio play critical role in recognition of viral RNA in antiviral stress granule (avSG) by RIG-I-Like Receptor (RLR). They discovered that Picornaviruses evade RLR function by cleaving G3BP, an important component of avSG, to evade immune response. They discovered that viral poly A+ RNA is recognized in avSG to enhance host immune responses. IPS-1 is a critical adaptor for RLR signaling. They discovered that aggregation of TRAF binding domain is sufficient for signaling.
Takaori-Kondo has elucidated that the upregulation of intracellular level of HIV-1 Vif by CBF-β is mainly caused by suppressing MDM2-mediated proteasomal degradation and that expression of APOBEC3B is augmented by activation of the classical NF-κB pathways.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (55 results)

All 2017 2016 2015 2014 2013 2012

All Journal Article (34 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 34 results,  Open Access: 10 results,  Acknowledgement Compliant: 7 results) Presentation (21 results) (of which Int'l Joint Research: 6 results,  Invited: 14 results)

  • [Journal Article] Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in COPD Epithelium.2016

    • Author(s)
      Hsu AC, Parsons K, Moheimani F, Knight DA, Hansbro PM, Fujita T, Wark PA
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 55 Issue: 1 Pages: 117-127

    • DOI

      10.1165/rcmb.2015-0306oc

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules.2016

    • Author(s)
      Oh SW, Onomoto K, Wakimoto M, Onoguchi K, Ishidate F, Fujiwara T, Yoneyama M, Kato H, Fujita T.
    • Journal Title

      PLoS Pathogens

      Volume: 12 Issue: 2 Pages: 1-22

    • DOI

      10.1371/journal.ppat.1005444

    • NAID

      120005763384

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functional IRF3 deficiency in a patient with herpes simplex encephalitis.2015

    • Author(s)
      Andersen LL, Mørk N, Reinert LS, Kofod-Olsen E, Narita R, Jørgensen SE, Skipper KA, Höning K, Gad HH, Østergaard L, Ørntoft TF, Hornung V, Paludan SR, Mikkelsen JG, Fujita T, Christiansen M, Hartmann R, Mogensen TH.
    • Journal Title

      J Exp Med

      Volume: 212 Issue: 9 Pages: 1371-1379

    • DOI

      10.1084/jem.20142274

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.2015

    • Author(s)
      Okazaki T., Higuchi M., Takeda K., Iwatsuki-Horimoto K., Kiso M., Miyagishi M., Yanai H., Kato A., Yoneyama M., Fujita T., Taniguchi T., Kawaoka Y., Ichijo H. and Gotoh Y.
    • Journal Title

      Science Signaling

      Volume: 8 Issue: 388 Pages: 1-12

    • DOI

      10.1126/scisignal.aab1883

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of genes suppressing interferon effects in peripheral blood mononuclear cells during triple antiviral therapy for chronic hepatitis C.2015

    • Author(s)
      Iijima S, Matsuura K, Watanabe T, Onomoto K, Fujita T, Ito K, Iio E, Miyaki T, Fujiwara K, Shinkai N, Kusakabe A, Endo M, Nojiri S, Joh T, Tanaka Y.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 2 Pages: 1-9

    • DOI

      10.1371/journal.pone.0118000

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Viral RNA detection by RIG-I-like receptors.2015

    • Author(s)
      Yoneyama M, Onomoto K, Jogi M, Akaboshi T, Fujita T.
    • Journal Title

      Curr. Opin. Immunol.

      Volume: 32 Pages: 48-53

    • DOI

      10.1016/j.coi.2014.12.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] RIG-I-like receptors and autoimmune diseases.2015

    • Author(s)
      Kato H, Fujita T
    • Journal Title

      Curr Opin Immunol

      Volume: 37 Pages: 40-45

    • DOI

      10.1016/j.coi.2015.10.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction.2015

    • Author(s)
      Miyakawa K, Matsunaga S, Kanou K, Matsuzawa A, Morishita R, Kudoh A, Shindo K, Yokoyama M, Sato H, Kimura H, Tamura T, Yamamoto N, Ichijo H, Takaori-Kondo A, Ryo A.
    • Journal Title

      Nature Communications

      Volume: 6:6945 Issue: 1 Pages: 6945-6945

    • DOI

      10.1038/ncomms7945

    • NAID

      120005745628

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] T memory stem cells are the hierarchical apex of adult T-cell leukemia2015

    • Author(s)
      Nagai Y, Kawahara M, Hishizawa M, Shimazu Y, Sugino N, Fujii S, Kadowaki N, Takaori-Kondo A
    • Journal Title

      Blood

      Volume: 125 Issue: 23 Pages: 3527-3535

    • DOI

      10.1182/blood-2014-10-607465

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemia.2015

    • Author(s)
      Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A.
    • Journal Title

      Science Advances

      Volume: 1 Issue: 3 Pages: 1-9

    • DOI

      10.1126/sciadv.1400203

    • NAID

      120005601014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aicardi-Goutières syndrome is caused by IFIH1 mutations.2014

    • Author(s)
      Oda, H., Nakagawa, K., Abe, J., Awaya, T., Funabiki, M., Hijikata, A., Nishikomori, R., Funatsuka, M., Ohshima, Y., Sugawara, Y., Yasumi, T., Kato, H., Shirai, T., Ohara, O., Fujita, T., Heike, T.
    • Journal Title

      America Journal of Human Genetics

      Volume: 95 Issue: 1 Pages: 121-125

    • DOI

      10.1016/j.ajhg.2014.06.007

    • NAID

      120005460706

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.2014

    • Author(s)
      Narita R, Takahasi K, Murakami E, Hirano E, Yamamoto SP, Yoneyama M, Kato H, Fujita T.
    • Journal Title

      PLoS Pathog.

      Volume: 10 Issue: 10 Pages: 1-11

    • DOI

      10.1371/journal.ppat.1004417

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensing viral invasion by RIG-I like receptors2014

    • Author(s)
      Yoo JS, Kato H, Fujita T
    • Journal Title

      Current Opinion in Microbiology

      Volume: 20 Pages: 131-138

    • DOI

      10.1016/j.mib.2014.05.012

    • NAID

      120005458276

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Antiviral innate immunity and stress granule responses.2014

    • Author(s)
      Onomoto K, Yoneyama M, Fung G, Kato H, Fujita T.
    • Journal Title

      Trends Immunol.

      Volume: 35 Issue: 9 Pages: 420-428

    • DOI

      10.1016/j.it.2014.07.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmunity caused by constitutive activation of cytoplasmic viral RNA sensors2014

    • Author(s)
      Kato H, Fujita T
    • Journal Title

      Cytokine & Growth Factor Reviews

      Volume: 25 Issue: 6 Pages: 739-747

    • DOI

      10.1016/j.cytogfr.2014.08.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of Association between Intact/Deletion Polymorphisms of the APOBEC3B Gene and HIV-1 Risk.2014

    • Author(s)
      Imahashi M, Izumi T, Watanabe D, Imamura J, Matsuoka K, Ode H, Masaoka T, Sato K, Kaneko N, Ichikawa S, Koyanagi Y, Takaori-Kondo A, Utsumi M, Yokomaku Y, Shirasaka T, Sugiura W, Iwatani Y, Naoe T.
    • Journal Title

      PLoS ONE

      Volume: 9 Pages: 1-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Small molecules that inhibit Vif-induced degradation of APOBEC3G.2014

    • Author(s)
      2.Matsui M, Shindo K, Izumi T, Io K, Shinohara M, Komano J, Kobayashi M, Kadowaki N, Harris RS, Takaori-Kondo A
    • Journal Title

      Virology Journal

      Volume: 11 Issue: 1 Pages: 122-129

    • DOI

      10.1186/1743-422x-11-122

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm22014

    • Author(s)
      T Mikawa, T Maruyama, K Okamoto, H Nakagama, ME LLeonart, T Tsusaka, K Hori, I Murakami, T Izumi, A T-Kondo, M Yokode, G Peters, D Beach, & H Kondoh
    • Journal Title

      Journal of Cell Biology

      Volume: 204 Issue: 5 Pages: 729

    • DOI

      10.1083/jcb.201306149

    • NAID

      120005385888

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model.2014

    • Author(s)
      4.Sato K, Takeuchi JS, Misawa N, Izumi T, Kobayashi T, Kimura Y, Iwami S, Takaori-Kondo A, Hu WS, Aihara K, Ito M, An DS, Pathak VK, Koyanagi Y
    • Journal Title

      PLoS Pathogens

      Volume: 10 Pages: 1-15

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA52014

    • Author(s)
      Funabiki M, Kato H, Miyachi M, Toki H, Motegi H, Inoue M, Minowa O, Yoshida A, Deguchi K, Sato H, Ito S, Shiroishi T, Takeyasu K, Noda T and Fujita T
    • Journal Title

      Immunity

      Volume: 40 Pages: 199-212

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation2014

    • Author(s)
      Yoo, J-S., Takahasi, K., Ng, CS., Ouda, R., Onomoto, K., Yoneyama, M., Lai, J-C., Lattmann, S., Nagamine, Y., Matsui, T., Iwabuchi, K., Kato, H. Fujita, T.
    • Journal Title

      PLoS Pathog

      Volume: 10(3) Issue: 3 Pages: 1-18

    • DOI

      10.1371/journal.ppat.1004012

    • NAID

      120005466661

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis.2014

    • Author(s)
      Matsui Y, Shindo K, Nagata K, Io K, Tada K, Iwai F, Kobayashi M, Kadowaki N, Harris R, Takaori-Kondo A
    • Journal Title

      Virology

      Volume: 449 Pages: 82-87

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CKIP-1 Is an Intrinsic Negative Regulator of T-Cell Activation through an Interaction with CARMA1.2014

    • Author(s)
      Sakamoto T, Kobayashi M, Tada K, Shinohara M, Io K, Nagata K, Iwai F, Takiuchi Y, Arai Y, Yamashita K, Shindo K, Kadowaki N, Koyanagi Y, Takaori-Kondo A
    • Journal Title

      PLoS One

      Volume: 9 Issue: 1 Pages: 1-11

    • DOI

      10.1371/journal.pone.0085762

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Analysis of Location- and Sequence-Dependent Deamination by APOBEC3G Using Real-Time NMR Spectroscopy.2014

    • Author(s)
      Furukawa A, Sugase K, Morishita R, Nagata T, Kodaki T, Takaori-Kondo A, Ryo A, Katahira M.
    • Journal Title

      Angew Chem Int Ed Engl.

      Volume: 53 Pages: 2349-2352

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium2013

    • Author(s)
      Hayashi Y, Onomoto K, Narita R, Yoneyama, M, Kato H, Nakagawa T, Ito J, Taura A, Fujita T
    • Journal Title

      Microbes and Infection

      Volume: 15 Pages: 592-598

    • NAID

      120005312147

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses2013

    • Author(s)
      Ng C-S, Jogi M, Yoo J-S, Onomoto K, Koike S, Iwasaki T, Yoneyama M, Kato H, Fujita T
    • Journal Title

      Journal of Virology

      Volume: 87 Pages: 9511-9522

    • NAID

      120005327032

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human CD1c+ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D3.2013

    • Author(s)
      Sato T, Kitawaki T, Fujita H, Iwata M, Iyoda T, Inaba K, Ohteki T, Hasegawa S, Kawada K, Sakai Y, Ikeuchi H, Nakase H, Niwa A, Takaori-Kondo A, Kadowaki N
    • Journal Title

      Journal Immunology

      Volume: 191 Pages: 3152-3160

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of a Dominant-Negative Fragment Due to G3BP1 Cleavage Contributes to the Disruption of Mitochondria-Associated Protective Stress Granules during CVB3 Infection2013

    • Author(s)
      Fung G, Ng C-S, Zhang J, Shi J, Wong J, Piesik P, Han L, Chu F, Jagdeo J, Jan E, Fujita T, Luo H
    • Journal Title

      PLoS ONE

      Volume: 8(11) Issue: 11 Pages: 1-15

    • DOI

      10.1371/journal.pone.0079546

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional characterization of domains of IPS-1 using an inducible oligomerization system2013

    • Author(s)
      Takamatsu S,Onoguchi K, Onomoto K, Narita R, Takahasi K, Ishidate F, Fujiwara TK, Yoneyama M, Kato H, Fujita T
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: 1-9

    • DOI

      10.1371/journal.pone.0053578

    • NAID

      120005241348

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors2013

    • Author(s)
      Takaori-Kondo A
    • Journal Title

      Frontier in Microbiology

      Volume: 4 Pages: 1-5

    • DOI

      10.3389/fmicb.2013.00034

    • NAID

      120005244663

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity2012

    • Author(s)
      Onomoto K, Jogi M, Yoo J-S, Narita R, Morimoto S, Takemura A, Sambhara S, Kawaguchi A, Osari S, Nagata K, Matsumiya T, Namiki H, Yoneyama M, Fujita T
    • Journal Title

      PLoS One

      Volume: 7 Issue: 8 Pages: 1-15

    • DOI

      10.1371/journal.pone.0043031

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells.2012

    • Author(s)
      Shinohara M
    • Journal Title

      Sci Rep

      Volume: 2 Issue: 1 Pages: 806-806

    • DOI

      10.1038/srep00806

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR study of xenotropic murine leukemia virus-related virus protease in a complex with amprenavir2012

    • Author(s)
      Ayako Furukawa, Hideyasu Okamura, Ryo Morishita, Satoko Matsunaga, Naohiro Kobayashi, Takahisa Ikegami, Tsutomu Kodaki, Akifumi Takaori-Kondo, Ryo Akihide, Takashi Nagata, Masato Katahira
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 24巻 Issue: 2 Pages: 284-289

    • DOI

      10.1016/j.bbrc.2012.07.083

    • NAID

      120004873605

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and enzymatic characterization of XMRV protease by a cell-free proteolytic analysis.2012

    • Author(s)
      Matsunaga S
    • Journal Title

      J Proteomics

      Volume: 75 Issue: 15 Pages: 4863-4873

    • DOI

      10.1016/j.jprot.2012.05.047

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Leader-containing uncapped viral transcript activates RIG-I in antiviral stress granules2017

    • Author(s)
      Seong-Wook Oh, Hiroki Kato, Takashi Fujita
    • Organizer
      Keystone Symposia, Viral Immunity
    • Place of Presentation
      Santa Fe, NM, USA
    • Year and Date
      2017-02-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of innate immune responses in SFTSV infection2016

    • Author(s)
      Shintaro Yamada, Masayuki Shimojima, Ryo Narita, Hiroki Kato,Masayuki Saijo, Takashi Fujita
    • Organizer
      The 15th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules2016

    • Author(s)
      Seong-Wook Oh, Koji Onomoto, Mai Wakimoto, Kazuhide Onoguchi, Fumiyoshi Ishidate, Takahiro Fujiwara, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita
    • Organizer
      The 15th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The function of antiviral signal molecule IPS-1 via mitochondria2016

    • Author(s)
      Mai Wakimoto, Fumiyoshi Ishidate, Takahiro Fujiwara, Hiroki Kato, Takashi Fujita
    • Organizer
      The 15th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Leader-containing uncapped viral transcript activates RIG-I in antiviral stress granules2015

    • Author(s)
      Oh, S-W., Onomoto, K., Wakimoto, M., Onoguchi, K., Yoneyama, M., Kato, H. and Fujita, T.
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      Fukuoka International Congress Center
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Autoimmunity due to constitutive activation of cytoplasmic viral RNA sensors.2015

    • Author(s)
      Fujita T.
    • Organizer
      Cytokine “Symphonies in Health and Disease”
    • Place of Presentation
      Bamberg
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dysregulation of RIG-I-Like Receptor-dependent signaling causes autoimmune disorder2015

    • Author(s)
      Fujita T.
    • Organizer
      The 14th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路島 夢舞台
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ウイルスセンサー、RIG-I Like Receptorの機能異常による自己免疫疾患2015

    • Author(s)
      藤田 尚志
    • Organizer
      第80回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      東京 東工大
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Innate immune responses against Hepatitis B Virus in ES22014

    • Author(s)
      Wan-Ling Yao, Yuuki Kaname, Sotaro Ikeda, Hiroki Kato, Takashi Fujita
    • Organizer
      The 11th JSH Single Topic Conference
    • Place of Presentation
      Hiroshima
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Antiviral innate immunity in health and disease2014

    • Author(s)
      Fujita T
    • Organizer
      NIH-Japan-JSPS Symposium-Highlights from the frontier of biomedical science from NIH and Japan
    • Place of Presentation
      Bethesda
    • Year and Date
      2014-10-23 – 2014-10-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dysregulation of MDA5-dependent signaling causes autoimmune disorder2014

    • Author(s)
      Fujita T
    • Organizer
      2014 International Conference on Infectious Disease and Cancer
    • Place of Presentation
      Kaohsiung
    • Year and Date
      2014-10-18 – 2014-10-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dysregulation of MDA5-dependent signaling causes autoimmune disorder2014

    • Author(s)
      Fujita T
    • Organizer
      NHRI/IBMS Joint International Conference on Inflammation & Disease
    • Place of Presentation
      Taipei
    • Year and Date
      2014-10-17 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulation of antiviral innate immunity by RIG-I-Like Receptors2014

    • Author(s)
      Fujita, T
    • Organizer
      EMBO Workshop Human RNA Viruses
    • Place of Presentation
      Istanbul
    • Year and Date
      2014-10-06 – 2014-10-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of Viral Infection2014

    • Author(s)
      Narita, R., Takahasi, K., Yoneyama, M. and Fujita, T
    • Organizer
      The 13th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Nara
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Innate Immune Responses Against Hepatitis B Virus in ES22014

    • Author(s)
      Yao, W-L., Kaname, Y., Ikeda, S., Kato, H. and Fujita, T.
    • Organizer
      International Meeting on Molecular Mechanism of Hepatitis B Viruses
    • Place of Presentation
      UCLA
    • Year and Date
      2014-09-03 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Blocking innate immune responses enhanced HBV replication2014

    • Author(s)
      Fujita T
    • Organizer
      2014 TASL-Japan Hepatitis B Workshop 2014
    • Place of Presentation
      Taipei
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulation of antiviral innate immunity by RIG-I-like receptors2014

    • Author(s)
      Fujita T
    • Organizer
      The NF-kB system in health and disease, Keystone Symposia
    • Place of Presentation
      Keystone USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Size-dependent sensing of viral RNA during antiviral responses2013

    • Author(s)
      Fujita T
    • Organizer
      Positive strand RNA Viruses Keystone Symposia
    • Place of Presentation
      Boston USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ウイルス感染によるストレス応答と抗ウイルス自然免疫応答の活性化2013

    • Author(s)
      藤田尚志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Detection of cytoplasmic non-self RNA and activation of antiviral innate immunity2012

    • Author(s)
      Fujita T
    • Organizer
      International Endotoxin and Innate Immunity Society Meeting 2012
    • Place of Presentation
      Tokyo Japan
    • Year and Date
      2012-10-23
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Cytoplasmic sensing of viral RNA by RIG-I-like receptors2012

    • Author(s)
      Fujita T
    • Organizer
      Non-self RNA sensing in virus infected cells and activation of antiviral immunity
    • Place of Presentation
      Le Treilles, France
    • Year and Date
      2012-08-27
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2012-11-27   Modified: 2023-03-16  

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