| Budget Amount *help |
¥138,450,000 (Direct Cost: ¥106,500,000、Indirect Cost: ¥31,950,000)
Fiscal Year 2016: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2015: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2014: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2013: ¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
Fiscal Year 2012: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
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| Outline of Final Research Achievements |
Virus infection is based on a balance between virus-host battle. To prevent virus infection, it is very important to understand its molecular mechanism. As an example of a virus-host battle, we analyzed the influenza virus mediated inhibitory mechanism of TNF-α-mediated immune response and the mechanism of miRNA (miR-199a-3p / -5p) mdeiated inhibition of HSV-1 virus replication. We succeeded in elucidating the molecular mechanism of each battles and clarifying a part of the survival strategy of virus and host. In addition, we have succeeded in identifying novel HSV-1 viral proteins related to neurotoxicity exhibited by HSV-1 virus by proteomic analysis.
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