| Budget Amount *help |
¥78,130,000 (Direct Cost: ¥60,100,000、Indirect Cost: ¥18,030,000)
Fiscal Year 2016: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2015: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2014: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2012: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
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| Outline of Final Research Achievements |
Drug discovery in psychiatry has been limited to chemical modifications of compounds originally discovered serendipitously. Therefore, more mechanism-oriented strategies of drug discovery for mental disorders are awaited, and the dendritic spine is one of the strong candidate of the pathophysiology of schizophrenia. Thus, we performed the longitudinal in vivo spine imaging of schizophrenia model mice and found out that the marked reduction in the spine density in the model mice. We also developed a novel synaptic optoprobe that specifically manipulates the spine and demonstrated the higher brain functions such as the learning and memory is dependent on the spine. Taken together, our results warranted the importance of the spine as the microendophenotype of schizophrenia.
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