| Budget Amount *help |
¥139,360,000 (Direct Cost: ¥107,200,000、Indirect Cost: ¥32,160,000)
Fiscal Year 2016: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2015: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2014: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2013: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2012: ¥51,480,000 (Direct Cost: ¥39,600,000、Indirect Cost: ¥11,880,000)
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| Outline of Final Research Achievements |
We tried to identify and understand the micro-endopenotypes of psychiatric disorders associated with environmental factors such as PTSD. To do this, we developed mouse model of PTSD that showed enhancement of fear after traumatic memory retrieval. This model showed that fear is enhanced through the activation of gene expression and protein degradation in the hippocampus-amygdala-mPFC circuits after fear memory retrieval. These findings suggest that over-activation of these circuits after fear memory retrieval is a candidate of micro-endopenotypes that causes PTSD. Furthermore, we found that remote fear memory returns to a hippocampus dependent state after long time recall. Using this phenomenon, we showed that following prolonged fear memory retrieval, hippocampal neurogenesis enhancers promote forgetting of remote contextual fear memory. Therefore, we proposed that forgetting of traumatic memory contributes to the development of PTSD treatment.
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