| Budget Amount *help |
¥78,130,000 (Direct Cost: ¥60,100,000、Indirect Cost: ¥18,030,000)
Fiscal Year 2016: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2015: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2014: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2012: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
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| Outline of Final Research Achievements |
In this project, we performed genomic and epigenomic analyses of neuronal cells derived from patients with psychiatric disorders. We revealed cytosine modification status from a small amount of brain neuronal DNA, and identified genomic region showing altered cytosine modification status in patients. We also found the increased LINE-1 copy number in neurons of patients with schizophrenia. We performed ultra-deep sequencing in brain genomic DNA and developed efficient method for detecting somatic mutations. Finally, by applying the developed method, we successfully identified the somatic mutations in monozygotic twins discordant for schizophrenia-related disorder.
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