| Budget Amount *help |
¥95,940,000 (Direct Cost: ¥73,800,000、Indirect Cost: ¥22,140,000)
Fiscal Year 2016: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
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| Outline of Final Research Achievements |
The animals that had been exposed to cytokines as neonates later develop the abnormal behaviors relevant to schizophrenia. In the present investigation, we explored the cytokine animal model for schizophrenia, focusing on the monoaminergic pathways. Among various cytokines, epidermal growth factor (EGF) produced the most remarkable impact on animal behaviors. In the EGF model, dopaminergic neurons exhibited abnormal pallidal innervations and a postpubertal firing increase as well as their antipsychotic sensitivity. There were no significant influences on the other monoaminergic neurons in the EGF model. In addition, the EGF model in rats displayed the remarkable deficits particularly in the auditory system. These observations suggest that prenatal or perinatal cytokine exposure results in dopaminergic mal-development and deficits in auditory cognition.
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