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Elucidation of control mechanisms of transcriptional checkpoint during Pol II elongation, termination, and recycle

Planned Research

Project AreaIntegral understanding of the mechanism of transcription cycle through quantitative, high-resolution approaches
Project/Area Number 24118002
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Institute of Technology

Principal Investigator

YAMAGUCHI Yuki  東京工業大学, 生命理工学院, 教授 (50345360)

Co-Investigator(Kenkyū-buntansha) 田村 智彦  横浜市立大学, 医学(系)研究科(研究院), 教授 (50285144)
高橋 秀尚  北海道大学, 医学(系)研究科(研究院), 講師 (30423544)
川内 潤也  東京医科歯科大学, 難治疾患研究所, 助教 (20544498)
Co-Investigator(Renkei-kenkyūsha) NISHIYAMA Akira  横浜市立大学, 大学院医学研究科, 准教授 (80589664)
NAKABAYASHI Jun  横浜市立大学, 先端医科学研究センター, 准教授 (80322733)
Research Collaborator ISOBE Tomoyasu  
YAMAMOTO Junichi  
KATO Junko  
SUZUKI Hidefumi  
SOU Seifuku  
SHIBATA Hirotaka  
TATENO Shumpei  
HASEGAWA Sakiko  
ARAKAKI Takayuki  
ZUKERAN Ari  
KUROTAKI Daisuke  
BAN Tatsuma  
FUSHIMI Kentaro  
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥224,250,000 (Direct Cost: ¥172,500,000、Indirect Cost: ¥51,750,000)
Fiscal Year 2016: ¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2015: ¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2014: ¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2013: ¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2012: ¥51,870,000 (Direct Cost: ¥39,900,000、Indirect Cost: ¥11,970,000)
Keywords遺伝子 / 発現制御 / 発生・分化 / 生体生命情報学 / 酵素
Outline of Final Research Achievements

Synthesis of full-length RNAs is made possible through multiple interactions of Pol II with DNA, RNA, and proteins (e.g., chromatin factors, transcription initiation factors, elongation factors, termination factors, and RNA processing factors), which together form a large complex that undergoes rapid remodeling during the transcription cycle. However, the detail of this dynamic process remains poorly understood. Here we set out to explore mechanisms for the remodeling of the Pol II-containing complex during the transcription cycle and regulatory checkpoints in it, through identification and characterization of new Pol II-interacting factors and kinetic analyses in living cells.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(202 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (2 results) Journal Article (54 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 50 results,  Open Access: 20 results,  Acknowledgement Compliant: 24 results) Presentation (138 results) (of which Int'l Joint Research: 17 results,  Invited: 18 results) Book (2 results) Remarks (6 results)

  • [Int'l Joint Research] Institute for Systems Biology/Stowers Institute for Medical Research(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] The Universiry of Oxford(英国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Down-regulation of Irf8 by Lyz2-cre/loxP accelerates osteoclast differentiation in vitro2017

    • Author(s)
      Saito E, Suzuki D, Kurotaki D, Mochizuki A, Manome Y, Suzawa T, Toyoshima Y, Ichikawa T, Funatsu T, Inoue T, Takami M, Tamura T, Inagaki K, and Kamijo R
    • Journal Title

      Cytotechnology

      Volume: 印刷中

    • DOI

      10.1007/s10616-016-0013-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biallelic TBCD mutations cause early-onset neurodegenerative encephalopathy2017

    • Author(s)
      Miyake N, Fukai R, Ohba C, ... Shiina M, Ogata K, Okuno-Yuguchi J, Fueki N, Ogiso Y, Suzumura H, Watabe Y, Imataka G, Leong HY, Fattal-Valevski A, Kramer U, Miyatake S, Kato M, Okamoto N, Sato Y, Mitsuhashi S, Nishino I, Kaneko N, Nishiyama A, Tamura T, Mizuguchi T, Nakashima M, Tanaka F, Saitsu H, Matsumoto N
    • Journal Title

      Am J Hum Genet.

      Volume: 99 Pages: 950-961

    • DOI

      10.1016/j.ajhg.2016.08.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 転写反応の生化学2017

    • Author(s)
      山口雄輝
    • Journal Title

      生体の科学

      Volume: 68(3)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.2017

    • Author(s)
      Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M.
    • Journal Title

      Nature communications

      Volume: 7 Pages: 11030-11030

    • DOI

      10.1038/ncomms11030

    • NAID

      130007529314

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of basophil and mast cell development by transcription factors2016

    • Author(s)
      Sasaki H, Kurotaki D, Tamura T
    • Journal Title

      Allergol. Int.

      Volume: 65 Issue: 2 Pages: 127-134

    • DOI

      10.1016/j.alit.2016.01.006

    • NAID

      130005290401

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transcriptional and epigenetic regulation of innate immune cell development by the transcription factor, interferon regulatory factor-82016

    • Author(s)
      Kurotaki D., Tamura T.
    • Journal Title

      Journal of Interferon & Cytokine Research

      Volume: 36 Pages: 433-441

    • DOI

      10.1089/jir.2015.0138

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity.2016

    • Author(s)
      Ban T., Sato G.R., Nishiyama A., Akiyama A., Takasuna M., Umehara M., Suzuki S., Ichino M., Matsunaga S., Kimura A., Kimura Y., Yanai H., Miyashita S., Kuromitsu J., Tsukahara K., Yoshimatsu K., Endo I., Yamamoto T., Hirano H., Ryo A., Taniguchi T., Tamura T.
    • Journal Title

      Immunity

      Volume: 45 Pages: 319-32

    • DOI

      10.1016/j.immuni.2016.07.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex.2016

    • Author(s)
      Anwar D., Takahashi H., Watanabe M., Suzuki M., Fukuda S., Hatakeyama S.
    • Journal Title

      BBA Gene Regulatory Mechanisms

      Volume: 1859 Pages: 975-982

    • NAID

      120006328999

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.2016

    • Author(s)
      Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita Y., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama K.I. and Atsumi T.
    • Journal Title

      Rheumatology

      Volume: 55 Pages: 1117-1126

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM39 negatively regulates the NFkB-mediated signaling pathway through stabilization of cactin.2016

    • Author(s)
      Suzuki M., Watanabe M., Nakamaru Y., Takagi D., Takahashi H., Fukuda S. and Hatakeyama S.
    • Journal Title

      Cell. Mol. Life Sci.

      Volume: 73 Pages: 1085-1101

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2.2016

    • Author(s)
      Hayashi M, Maehara K, Harada A, Semba Y, Kudo K, Takahashi H, Oki S, Meno C, Ichiyanagi K, Akashi K, Ohkawa Y.
    • Journal Title

      J. Cell. Biochem.

      Volume: 117 Pages: 780-792

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes2016

    • Author(s)
      Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama K, Tsutsui H, Hatakeyama S
    • Journal Title

      J. Mol. Cell. Cardiol.

      Volume: 100 Pages: 43-53

    • NAID

      120006360069

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 転写因子によるミエロイド系細胞の分化制御2016

    • Author(s)
      田村 智彦, 西山 晃
    • Journal Title

      日本臨牀

      Volume: 74 Pages: 481-486

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2.2016

    • Author(s)
      Hayashi M, Maehara K, Harada A, Semba Y, Kudo K, Takahashi H, Oki S, Meno C, Ichiyanagi K, Akashi K, Ohkawa Y.
    • Journal Title

      J. Cell. Biochem.

      Volume: 117 Pages: 780-792

    • DOI

      10.1002/jcb.25368

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin2016

    • Author(s)
      Suzuki M, Watanabe M, Nakamaru Y, Takagi D, Takahashi H, Fukuda S, Hatakeyama S.
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 73 Pages: 1085-1101

    • DOI

      10.1007/s00018-015-2040-x

    • NAID

      120005981342

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes2016

    • Author(s)
      Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita Y., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama K.I. and Atsumi T. et al.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 印刷中 Pages: 1117-1126

    • DOI

      10.1093/rheumatology/kew005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Non-overlapping Functions of Rtf1 and the Paf1 Complex.2015

    • Author(s)
      Cao, Q. F., C., Yamamoto, J., Isobe, T., Tateno, S., Murase, Y., Chen, Y., Handa, H. and Yamaguchi, Y.
    • Journal Title

      Mol. Cell Biol.

      Volume: 35 Pages: 3459-3470

    • DOI

      10.1128/mcb.00601-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription2015

    • Author(s)
      Laitem, C., Zaborowska, J., Tellier, M., Yamaguchi, Y., Cao. Q.-F., Egloff, S., Handa, H., and Murphy, S.
    • Journal Title

      Transcription

      Volume: 6 Pages: 79-90

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Regulation of myelopoiesis by the transcription factor IRF82015

    • Author(s)
      Tamura T, Kurotaki D, Koizumi S.
    • Journal Title

      Int. J. Hematol.

      Volume: 101 Pages: 342-351

    • DOI

      10.1007/s12185-015-1761-9

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Guest editorial: Transcriptional control in myeloid cell development and related diseases2015

    • Author(s)
      Tamura T.
    • Journal Title

      International Journal of Hematology

      Volume: 101 Pages: 317-318

    • DOI

      10.1007/s12185-015-1770-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 転写因子IRF8による好塩基球とマスト細胞の分化制御2015

    • Author(s)
      佐々木 悠, 黒滝 大翼, 田村 智彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 593-596

    • NAID

      40020505142

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Transcription factors in the development of myeloid cells2015

    • Author(s)
      田村 智彦, 小泉 真一, 黒滝 大翼
    • Journal Title

      Jpn. J. Clin. Hematol.

      Volume: 56 Issue: 10 Pages: 1861-1870

    • DOI

      10.11406/rinketsu.56.1861

    • NAID

      130005103301

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex2015

    • Author(s)
      Takahashi, H., Takigawa, I., Watanabe, M., Anwar, D., Shibata, M., Tomomori-Sato, C., Sato, S., Ranjan, A., Seidel, C.W., Tsukiyama, T., Mizushima, W., Hayashi, M., Ohkawa, Y., Conaway, J.W., Conaway, R.C. and Hatakeyama, S
    • Journal Title

      Nature Communications

      Volume: 5 Pages: 1-15

    • DOI

      10.1038/ncomms6941

    • NAID

      120005621881

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular role of RNF43 in canonical and noncanonical Wnt signaling2015

    • Author(s)
      T. Tsukiyama,et al.
    • Journal Title

      Molecular and Cellular Biology

      Volume: in press Pages: 2007-2023

    • DOI

      10.1128/mcb.00159-15

    • NAID

      120005672365

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ2015

    • Author(s)
      Watanabe, M., Takahashi, H., Saeki, Y., Ozaki, T., Itoh, S., Suzuki, M., Mizushima, W., Tanaka, K., and Hatakeyama, S.
    • Journal Title

      eLIfe

      Volume: 4

    • DOI

      10.7554/elife.05615

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TRIM29 regulates the p63-mediated pathway in cervical cancer cells.2015

    • Author(s)
      Masuda, Y., Takahashi, H. and Hatakeyama, S.
    • Journal Title

      Biochim. Biophys. Acta-Mol. Cell Res.

      Volume: 1853 Pages: 2296-2305

    • DOI

      10.1016/j.bbamcr.2015.05.035

    • NAID

      120005906885

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.2015

    • Author(s)
      Masuda, Y., Takahashi, H., Sato, S., Tomonori-Sato, C., Saraf, A., Washburn, M.P., Florens, L., Conaway, R.C., Conaway, J.W. and Hatakeyama, S.
    • Journal Title

      Nature communications

      Volume: 6 Pages: 7299-7299

    • DOI

      10.1038/ncomms8299

    • NAID

      120005647269

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads in vitro regardless of their sizes and shapes2015

    • Author(s)
      M.-A. Kawano, K. Doi, H. Fukuda, Y. Kita, K. Imai, T. Inoue, T. Enomoto, M. Matsui, M. Hatakeyama, Y. Yamaguchi, H. Handa
    • Journal Title

      Biotechnology Reports

      Volume: 5 Pages: 105-111

    • DOI

      10.1016/j.btre.2014.12.008

    • Related Report
      2014 Annual Research Report
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  • [Journal Article] Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.2015

    • Author(s)
      H. Sasaki, D. Kurotaki, N. Osato, H. Sato, I. Sasaki, S. Koizumi, H. Wang, C. Kaneda, A. Nishiyama, T. Kaisho, H. Aburatani, H. C. Morse III, K. Ozato, T. Tamura.
    • Journal Title

      Blood.

      Volume: 125(2) Pages: 358-369

    • DOI

      10.1182/blood-2014-02-557983

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
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    • Author(s)
      Kurotaki D., Uede T., Tamura T
    • Journal Title

      Functions and development of red pulp macrophages

      Volume: 59 Pages: 55-62

    • DOI

      10.1111/1348-0421.12228

    • NAID

      40020388159

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes2014

    • Author(s)
      J. Yamamoto, Y. Hagiwara, K. Chiba, T. Isobe, T. Narita, H. Handa, Y. Yamaguchi
    • Journal Title

      Nature Communications

      Volume: 5 Pages: 4263-4263

    • DOI

      10.1038/ncomms5263

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
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    • Author(s)
      M. Takemoto, Y. Kawamura, M. Hirohama, Y. Yamaguchi, H. Handa, H. Saitoh, Y. Nakao, M. Kawada, K. Khalid, H. Koshino, K. Kimura, A. Ito, M. Yoshida
    • Journal Title

      J. Antibiot.

      Volume: 67 Pages: 335-338

    • DOI

      10.1038/ja.2013.142

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Magnetically promoted rapid immunoreactions using functionalized fluorescent magnetic beads: a proof of principle2014

    • Author(s)
      S. Sakamoto, K. Omagari, Y. Kita, Y. Mochizuki, Y. Naito, S. Kawata, S. Matsuda, O. Itano, H. Jinno, H. Takeuchi, Y. Yamaguchi, Y. Kitagawa, H. Handa
    • Journal Title

      Clinical Chem.

      Volume: 60 Pages: 610-620

    • DOI

      10.1373/clinchem.2013.211433

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils2014

    • Author(s)
      Kurotaki D., Yamamoto M., Nishiyama A., Uno K., Ban T., Ichino M., Sasaki H., Matsunaga S., Yoshinari M., Ryo A., Nakazawa M., Ozato K., Tamura T.
    • Journal Title

      Nature Communications

      Volume: 5 Pages: 1-15

    • DOI

      10.1038/ncomms5978

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
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    • Author(s)
      小泉真一, 田村智彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 62 Pages: 510-518

    • NAID

      40020265581

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Vesnarinone Suppresses TNF α mRNA Expression by Inhibiting Valosin-containing Protein2013

    • Author(s)
      Hotta K, Nashimoto A, Yasumura E, Suzuki M, Azuma M, Iizumi Y, Shima D, Nabeshima R, Hiramoto M, Okada A, Sakata-Sogawa K, Tokunaga M, Ito T, Ando H, Sakamoto S, Kabe Y, Aizawa S, Imai T, Yamaguchi Y, Watanabe H, Handa H
    • Journal Title

      Mol. Pharmacol.

      Volume: Vol.83 Pages: 11-15

    • DOI

      10.1124/mol.112.081935

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral protein-coating of magnetic nanoparticles using simian virus 40 VP12013

    • Author(s)
      T. Enomoto, M.-A. Kawano, H. Fukuda, W. Sawada, T. Inoue, K. C. Haw, Y. Kita, S. Sakamoto, Y. Yamaguchi, T. Imai, M. Hatakeyama, S. Saito, A. Sandhu, M. Matsui, I. Aoki, H. Handa
    • Journal Title

      J Biotechnol.

      Volume: 167 Pages: 8-15

    • DOI

      10.1016/j.jbiotec.2013.06.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression2013

    • Author(s)
      Isobe, T., Song, S.-N. J., Tiwari, P., Ito, H., Yamaguchi, Y., and Yoshizaki, K.
    • Journal Title

      FEBS Letters

      Volume: 587 Pages: 2487-2492

    • DOI

      10.1016/j.febslet.2013.06.028

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity2013

    • Author(s)
      V. Gupta, S. Liu, H. Ando, R. Ishii, S. Tateno, Y. Kaneko, M. Yugami, S. Sakamoto, Y. Yamaguchi, O. Nureki, H. Handa
    • Journal Title

      Mol. Pharmacol.

      Volume: 84 Pages: 824-833

    • DOI

      10.1124/mol.113.087940

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The transcription factor IRF8 counteracts BCR-ABL to rescue dendritic cell development in chronic myelogenous leukemia.2013

    • Author(s)
      Watanabe T, Hotta C, Koizumi S, Miyashita K, Nakabayashi J, Kurotaki D, Sato GR, Yamamoto M, Nakazawa M, Fujita H, Sakai R, Fujisawa S, Nishiyama A, Ikezawa Z, Aihara M, Ishigatsubo Y, Tamura T.
    • Journal Title

      Cancer Res

      Volume: 73(22) Pages: 6642-53

    • DOI

      10.1158/0008-5472.can-13-0802

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition in activated genes.2013

    • Author(s)
      Sarai N., Nimura K., Tamura T., Kanno T., Patel M.C., Heightman T. D., Ura K. and Ozata K.
    • Journal Title

      EMBO Journal

      Volume: 32 Pages: 2392-2406

    • DOI

      10.1038/emboj.2013.176

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BRD4 coordinates recruitment of pause-release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon stimulated genes2013

    • Author(s)
      Patel MC, Tamura T(他7人)
    • Journal Title

      Molecular and Cellular Biology

      Volume: 33 Pages: 2497-2507

    • DOI

      10.1128/mcb.01180-12

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells2013

    • Author(s)
      Iwasaki, Y.
    • Journal Title

      Eur J Immunol.

      Volume: undefined Pages: 1063-1073

    • DOI

      10.1002/eji.201242942

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional properties of Mammalian elongin A and its role in stress response.2013

    • Author(s)
      Kawauchi J, Inoue M, Fukuda M, Uchida Y, Yasukawa T, Conaway RC, Conaway JW, Aso T,
    • Journal Title

      J. Biol. Chem.

      Volume: 288(34) Pages: 24302-20315

    • DOI

      10.1074/jbc.m113.496703

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis.2013

    • Author(s)
      Karasawa S, Azuma M, Kasama T, Sakamoto S, Kabe Y, Imai T, Yamaguchi Y, Miyazawa K, Handa H
    • Journal Title

      Mol. Pharmacol.

      Volume: 83 Pages: 613-620

    • DOI

      10.1124/mol.112.082602

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.2013

    • Author(s)
      Daisuke Kurotaki et al.
    • Journal Title

      Blood.

      Volume: 121 Pages: 1839-1849

    • DOI

      10.1182/blood-2012-06-437863

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence.2012

    • Author(s)
      Kershaw J, Leuze C, Aoki I, Obata I, Kanno I, Ito H, Yamaguchi Y, Handa H.
    • Journal Title

      Neuroimage

      Volume: 70 Pages: 10-20

    • DOI

      10.1016/j.neuroimage.2012.12.036

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of Bisphenol A.2012

    • Author(s)
      Ito, Y., Ito, T., Karasawa, S., Enomoto, T., Nashimoto, A., Hase, Y., Sakamoto, S., Ito, T., Mimori, T., Matsumoto, Y., Yamaguchi, Y., Handa, H.
    • Journal Title

      Plos ONE

      Volume: 7(12)

    • DOI

      10.1371/journal.pone.0050481

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DSIF restricts NF-kappa B signaling by coordinating elongation with mRNA Processing of negative feedback genes2012

    • Author(s)
      Diamant, G.
    • Journal Title

      Cell Reports

      Volume: 2 Pages: 722-731

    • DOI

      10.1016/j.celrep.2012.08.041

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond2012

    • Author(s)
      Yamaguchi, Y.
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1829 Pages: 98-104

    • DOI

      10.1016/j.bbagrm.2012.11.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype.2012

    • Author(s)
      T. Masuda*, M. Tsuda*, R. Yoshinaga, H.Tozaki-Saitoh, K. Ozato, T. Tamura, K. Inoue.
    • Journal Title

      Cell Reports

      Volume: 1(4) Pages: 334-340

    • DOI

      10.1016/j.celrep.2012.02.014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress.2012

    • Author(s)
      Akira Nishiyama et al.
    • Journal Title

      PLoS ONE

      Volume: 7

    • DOI

      10.1371/journal.pone.0034719

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells.2012

    • Author(s)
      Taketani K, Kawauchi J, Tanaka-Okamoto M, Ishizaki H, Tanaka Y, Sakai T, Miyoshi J, Maehara Y, Kitajima S.
    • Journal Title

      Oncogene

      Volume: 31(17) Pages: 2210-21

    • DOI

      10.1038/onc.2011.397

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.2012

    • Author(s)
      Yasukawa T, Bhatt S, Takeuchi T, Kawauchi J, Takahashi H, Tsutsui A, Muraoka T, Inoue M, Tsuda M, Kitajima S, Conaway RC, Conaway JW, Trainor PA, Aso T.
    • Journal Title

      J. Biol. Chem.

      Volume: 2(5) Pages: 1129-1136

    • DOI

      10.1016/j.celrep.2012.09.031

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗炎症薬サリチル酸が示す生体内作用メカニズムの解析2017

    • Author(s)
      坂本 聡、Gupta Vipul、劉 舒捷、安藤秀樹、舘野峻平、金子裕生、湯上真人、石井亮平、濡木 理、山口雄輝、半田 宏
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 単一細胞RNA-seqによる早期樹状細胞前駆細胞の同定2017

    • Author(s)
      黒滝 大翼, 中林 潤, Herbert C. Morse III, Keiko Ozato, 鈴木 穣, 田村 智彦
    • Organizer
      第21回造血器腫瘍研究会
    • Place of Presentation
      熊本大学山崎記念館(熊本県熊本市)
    • Year and Date
      2017-02-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] IRF Transcription Factors in the Development and Function of Mononuclear Phagocytes2017

    • Author(s)
      Tamura T.
    • Organizer
      The 2017 Japan-NIH Joint Symposium
    • Place of Presentation
      東北大学星陵オーディトリアム(宮城県仙台市)
    • Year and Date
      2017-02-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] BCR-ABL inactivates the enhancer of the Irf8 gene and represses its expression2017

    • Author(s)
      Sasaki H., Nishiyama A., Koizumi S., Nakabayashi J., Kaneko N., Tamura T.
    • Organizer
      The 2017 Japan-NIH Joint Symposium
    • Place of Presentation
      東北大学星陵オーディトリアム(宮城県仙台市)
    • Year and Date
      2017-02-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stepwise and mutual activation between distal enhancer and proximal promoter in the induction of cell differentiation-related genes2017

    • Author(s)
      Nishiyama A., Nakabayashi J., Fushimi K., Tamura T.
    • Organizer
      The 2017 Japan-NIH Joint Symposium
    • Place of Presentation
      東北大学星陵オーディトリアム(宮城県仙台市)
    • Year and Date
      2017-02-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isolation and characterization of the earliest dendritic cell-primed progenitors2017

    • Author(s)
      Kurotaki D., Kawase W., Nakabayashi J., Morse H.C., Ozato K., Suzuki Y., Tamura T.
    • Organizer
      The 2017 Japan-NIH Joint Symposium
    • Place of Presentation
      東北大学星陵オーディトリアム(宮城県仙台市)
    • Year and Date
      2017-02-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RNAポリメラーゼⅡ転写産物の長さを決める3’末端プロセシングの制御メカニズムの解明2017

    • Author(s)
      瑞慶覧 安里、舘野 峻平、山本 淳一、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウスES細胞における2細胞期特異的な遺伝子の発現制御メカニズムの解析2017

    • Author(s)
      鈴木 翔子、柴田 紘孝、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] E3ユビキチンリガーゼCRBNの細胞内局在が免疫調整薬IMiDsの薬効に及ぼす影響2017

    • Author(s)
      徳山 遥香、片山 美樹、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ターゲット因子の解析を基盤とする生物活性物質が示す作用機構の解明2017

    • Author(s)
      坂本 聡、山口 雄輝、半田 宏
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] DNA損傷時に誘導される転写制御の生理的意義とTLPの役割2017

    • Author(s)
      鈴木 秀文、前田 亮、木村 宏、浦 聖恵、山口 雄輝、田村 隆明
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多発性骨髄腫における Pomalidomide 標的因子の網羅的探索2017

    • Author(s)
      舘野 峻平 、飯田 緑 、藤井 聡 、佐倉 絵里、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 樹状細胞へ運命決定された早期前駆細胞の発見2017

    • Author(s)
      川瀬 航, 黒滝 大翼, 中林 潤, Herbert C.Morse III, Keiko Ozato, 鈴木 穣, 田村 智彦
    • Organizer
      冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞分化特異的な遺伝子発現を導く遠位エンハンサーと近位プロモーター領域間での相互活性化2017

    • Author(s)
      西山 晃, 中林 潤, 伏見 健太郎, 田村 智彦
    • Organizer
      冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞分化特異的な遺伝子発現を導く遠位エンハンサーと近位プロモーター領域間での相互活性化2017

    • Author(s)
      西山 晃, 中林 潤, 伏見 健太郎, 田村 智彦
    • Organizer
      第34回染色体ワークショップ・第15回核ダイナミクス研究会
    • Place of Presentation
      かずさアカデミアホール(千葉県木更津市)
    • Year and Date
      2017-01-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Single cell RNA-seq reveals the earliest dendritic cell-primed hematopoietic progenitors2017

    • Author(s)
      Kurotaki D., Kawase W., Nakabayashi J., Morse H.C., Ozato K., Suzuki Y., Tamura T.
    • Organizer
      新学術領域「先進ゲノム支援」国際シンポジウム「The Start of New Genomics」
    • Place of Presentation
      東京大学伊藤謝恩ホール(東京都文京区)
    • Year and Date
      2017-01-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lyn suppresses IRF5 by preventing the stepwise IRF5 post-translational modifications2016

    • Author(s)
      Sato G.R., Ban T., Nishiyama A., Ichino M., Yanai H., Ryo A., Taniguchi T., Tamura T.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] BCR-ABL promotes the generation of basophils expressing high levels of the immune checkpoint related protein PD-L1 in a murine CML model2016

    • Author(s)
      Kaneko N., Nishiyama A., Sasaki H., Koizumi S., Tamura T.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Soluble factors derived from BCR-ABL-expressing hematopoietic cells inhibit the development of dendritic cells in mice2016

    • Author(s)
      Harada I., Ichino M., Nishiyama A., Tamura T.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Single-cell RNA-seq reveals a novel dendritic cell-primed early progenitor population2016

    • Author(s)
      Kurotaki D., Kawase W., Nakabayashi J., Morse H.C., Ozato K., Tamura T.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] IRF5 hyperactivation caused by Lyn deficiency is linked to the development of SLE-like disease2016

    • Author(s)
      Ban T., Sato G.R., Nishiyama A., Ichino M., Yanai H., Ryo A., Taniguchi T., Tamura T.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Transcription factor IRF8 governs enhancer landscape dynamics in the development of mononuclear phagocytes2016

    • Author(s)
      Tamura T.
    • Organizer
      The International Conference on Transcription Cycle 2016
    • Place of Presentation
      東京大学小柴ホール(東京都文京区)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 単核貪食細胞分化におけるエンハンサーランドスケープ動態と転写因子IRF82016

    • Author(s)
      田村 智彦
    • Organizer
      第41回神戸ラボ全体研究会議
    • Place of Presentation
      神戸バイオテクノロジー研究・人材育成センター(兵庫県神戸市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 細胞分化特異的な遺伝子発現を導く遠位エンハンサーとプロモーターの相互活性化2016

    • Author(s)
      西山 晃, 中林 潤, 伏見 健太郎,田村 智彦
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] How Pol II termination and 3' processing sites are precisely determined in higher eukaryotes.高等真核生物においてPol IIの転写終結と3'プロセシングの部位はいかにして正確に決定されるのか2016

    • Author(s)
      Ari Zukeran, Junichi Yamamoto, and Yuki Yamaguchi
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] NELFを中心としたポリ(A)付加部位選択のメカニズム2016

    • Author(s)
      瑞慶覧 安里、山本 淳一、山口 雄輝
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Regulation of transcription termination by Human Mediator complex2016

    • Author(s)
      高橋秀尚, 畠山鎮次
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] BCR-ABL induces the formation of activate enhancers for immunosuppressive genes2016

    • Author(s)
      Nishiyama A., Koizumi S., Sasaki H., Kaneko N., Harada I., Tamura T.
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] C/EBPβ mediates the repression of Irf8 expression and dendritic cell development by BCR-ABL2016

    • Author(s)
      Sasaki H., Nishiyama A., Koizumi S., Kaneko N., Yokota A., Hirai H., Nakabayashi J., Tamura T.
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 単一細胞RNA-seqによる早期樹状細胞前駆細胞の同定2016

    • Author(s)
      黒滝 大翼, 中林 潤, Herbert C. Morse III, Keiko Ozato, 鈴木 穣, 田村 智彦
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] The transcription factor IRF8 and enhancer landscape dynamics in the development of mononuclear phagocytes2016

    • Author(s)
      Tamura T.
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] メディエーター複合体による転写制御機構2016

    • Author(s)
      高橋秀尚, 畠山鎮次
    • Organizer
      日本生化学会
    • Place of Presentation
      東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高等真核生物においてPOL Ⅱの転写終結と3'プロセシングの部位はいかにして正確に決定されるのか2016

    • Author(s)
      瑞慶覧 安里、長谷川 冴妃子、館野 峻平、山本 淳一、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」班会議2016
    • Place of Presentation
      松島一の坊(宮城県宮城郡)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] TBP類似因子TLPによるDNA損傷応答時の転写抑制と細胞死誘導機構の解析2016

    • Author(s)
      鈴木 秀文、前田 亮、浦 聖恵、木村 宏、山口 雄輝、田村 隆明
    • Organizer
      新学術領域研究「転写サイクル」班会議2016
    • Place of Presentation
      松島一の坊(宮城県宮城郡)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] NELFを中心としたポリ(A)付加部位選択のメカニズム2016

    • Author(s)
      瑞慶覧 安里、館野 峻平、山本 淳一、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」班会議2016
    • Place of Presentation
      松島一の坊(宮城県宮城郡)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Hierarchical regulation of enhancer establishment and gene expression by transcription factors during mononuclear phagocyte development2016

    • Author(s)
      Kurotaki D., Nakabayashi J., Nishiyama A., Sasaki H., Kaneko N., Ozato K., Suzuki Y., Tamura T.
    • Organizer
      International Congress of Immunology
    • Place of Presentation
      メルボルン市(オーストラリア)
    • Year and Date
      2016-08-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 転写因子IRF8によるミエロイド系細胞分化のエピジェネティック制御2016

    • Author(s)
      黒滝 大翼
    • Organizer
      第22回血液科学セミナー
    • Place of Presentation
      ヤクルトホール(東京都港区)
    • Year and Date
      2016-07-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] CRBNに対するサリドマイド光学異性体の結合基盤解析2016

    • Author(s)
      坂本 聡、伊藤 拓水、森 智行、安藤 秀樹、山口 雄輝、箱嶋 敏雄、半田 宏
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] リガンド依存的ユビキチンリガーゼCRBNの制御機構2016

    • Author(s)
      伊藤 拓水、朝妻 知子、山本 淳一 安藤 秀樹、佐藤 智美、山口 雄輝、半田 宏
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Epigenetic regulation of monocyte and dendritic cell development by the transcription factor IRF82016

    • Author(s)
      Tamura T.
    • Organizer
      The 24th International Symposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都千代田区)
    • Year and Date
      2016-06-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A critical link between Lyn-mediated suppression of the TLR-MyD88-IRF5 pathway and the development of SLE-like disease2016

    • Author(s)
      Ban T., Sato G.R., Nishiyama A., Akiyama A., Takasuna M., Umehara M., Suzuki S., Ichino M., Matsunaga S., Kimura A., Kimura Y., Yanai H., Miyashita S., Kuromitsu J., Tsukahara K., Yoshimatsu K., Endo I., Yamamoto T., Hirano H., Ryo A., Taniguchi T., Tamura T.
    • Organizer
      The Annual Meeting of the American Association of Immunologists
    • Place of Presentation
      シアトル市(アメリカ合衆国)
    • Year and Date
      2016-05-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 単球・樹状細胞分化におけるエンハンサー動態の解析と転写因子IRF8の役割2016

    • Author(s)
      黒滝 大翼, 中林 潤, 西山 晃, 佐々木 悠, 金子 尚史, 小泉 真一, Keiko Ozato, 鈴木 穣, 田村 智彦
    • Organizer
      第20回造血器腫瘍研究会
    • Place of Presentation
      かずさアーク(千葉県木更津市)
    • Year and Date
      2016-02-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多発性骨髄腫におけるPomalidomide標的因子の網羅的探索2016

    • Author(s)
      舘野 峻平、飯田 緑、藤井 聡、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規抗がん剤の作用機構の解明2016

    • Author(s)
      佐倉 絵里、舘野 峻平、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] PolⅡ複合体をモデルとしたタンパク質間相互作用の実験系の評価2016

    • Author(s)
      新垣 貴之、徳山 遥香、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] NELFを中心としたRNAの品質管理のメカニズム2016

    • Author(s)
      瑞慶覧 安里、山本 淳一、磯部 智康、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] サリドマイド標的タンパク質CRBNの相互作用因子の探索2016

    • Author(s)
      徳山 遥香、新垣 貴之、山口雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウスES細胞における2細胞期特異的な遺伝子の発現制御メカニズムの解析2016

    • Author(s)
      鈴木 翔子、柴田 紘孝、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] サリドマイドの多様な薬理作用の分子メカニズム2016

    • Author(s)
      山口 雄輝、伊藤 巧水、山本 淳一、半田 宏
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] snRNA3'末端プロセシング因子インテグレーターの構造・機能解析2016

    • Author(s)
      外山 黛、荻原 裕里、Thiengtrong, Benjarat、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 単球及び樹状細胞の前駆細胞における遺伝子発現とエンハンサー形成の階層的制御2016

    • Author(s)
      黒滝 大翼, 中林 潤, 西山 晃, 佐々木 悠, 金子 尚史, 小泉 真一, Keiko Ozato, 鈴木 穣, 田村 智彦
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      山中湖畔荘ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 単球分化でのKlf4遺伝子発現にて見いだされた、遠位エンハンサーと遺伝子間の多段階、かつ双方向性の活性化機構の解析2016

    • Author(s)
      西山 晃, 中林 潤, 黒滝 大翼, 田村 智彦
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      山中湖畔荘ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 単球分化を促す転写因子IRF8により活性化されるKlf4遠位エンハンサーを起点としたクロマチンネットワークの解析2016

    • Author(s)
      西山 晃, 中林 潤, 田村 智彦
    • Organizer
      第33回染色体ワークショップ、第14回核ダイナミクス研究会
    • Place of Presentation
      松島一の坊(宮城県宮城郡)
    • Year and Date
      2016-01-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Elucidation of the molecular mechanisms of action of bioactive natural products using high performance affinity beads2015

    • Author(s)
      Satoshi Sakamoto, Yuki Yamaguchi, Takumi Ito, Hiroshi Handa
    • Organizer
      PACIFCHEM2015
    • Place of Presentation
      ホノルル(アメリカ)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biochemical analyses of CRBN, the target protein for immunomodulatory drugs (IMiDs)2015

    • Author(s)
      Satoshi Sakamoto, ,Takumi Ito, Yuki Yamaguchi, Hideki Ando, Hiroshi Handa
    • Organizer
      PACIFCHEM2015
    • Place of Presentation
      ホノルル(アメリカ)
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhancer landscape dynamics and the role of Irf8 in mononuclear phagocyte development2015

    • Author(s)
      Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kaneko N, Koizumi S, Ozato K, Suzuki Y, Tamura T
    • Organizer
      57th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      オーランド(アメリカ)
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多発性骨髄腫に対するポマリドマイドの標的因子の網羅的探索2015

    • Author(s)
      館野 俊平、飯田 緑、藤井 聡、山口 雄輝
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 単球分化を促す転写因子IRF8により活性化されるKlf4遠位エンハンサーを起点とした染色体間クロマチンネットワークの解析2015

    • Author(s)
      西山 晃, 中林 潤, 岡部 篤史, 堤 修一, 油谷 浩幸, 田村 智彦
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Transcription factor IRF8 governs the enhancer landscape dynamics during monocyte and dendritic cell development2015

    • Author(s)
      Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kaneko N, Koizumi S, Ozato K, Suzuki Y, Tamura T
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Role of Human Mediator Subunit Med26 in Transcription Elongation2015

    • Author(s)
      Hidehisa Takahashi, Joan W. Conaway, Ronald C. Conaway, Shigetsugu Hatakeyama
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Transcription factor IRF8 governs the enhancer landscape dynamics in mononuclear phagocyte development2015

    • Author(s)
      Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kaneko N, Koizumi S, Ozato K, Tamura T
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] PolⅡの転写伸長と運命決定制御のメカニズム2015

    • Author(s)
      山口雄輝
    • Organizer
      第2回北陸エピジェネティクス研究会
    • Place of Presentation
      富山大学(富山県富山市)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ミエロイド系細胞の分化と転写因子2015

    • Author(s)
      田村 智彦
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      ホテル金沢(石川県金沢市)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] BCR-ABLは樹状細胞前駆細胞におけるPU.1結合や活性化エンハンサーの分布を変化させる2015

    • Author(s)
      小泉 真一, 西山 晃, 中林 潤, 佐々木 悠, 宮下 和甫, 黒滝 大翼, 田村 智彦
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      ANAクラウンプラザホテル金沢(石川県金沢市)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 単球-樹状細胞系譜分化におけるエンハンサーランドスケープの解読2015

    • Author(s)
      黒滝 大翼, 中林 潤, 西山 晃, 佐々木 悠, 金子 尚史, 小泉 真一, Keiko Ozato, 鈴木 穣, 田村 智彦
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      ホテル金沢(石川県金沢市)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写因子IRF8によるマスト細胞の分化制御2015

    • Author(s)
      佐々木 悠, 黒滝 大翼, 田村 智彦
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      ホテル金沢(石川県金沢市)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] A role of the transcription factor IRF8 in basophil and mast cell development2015

    • Author(s)
      Sasaki H, Kurotaki D, Osato N, Sato H, Sasaki I, Koizumi S, Wang H, Kaneda C, Nishiyama A, Kaisho T, Aburatani H, Morse HC III, Ozato K, Tamura T
    • Organizer
      International Society for Experimental Hematology 44th Annual Scientific Meeting
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IRF8 inhibits the activity of C/EBPα to restrain mononuclear phagocyte progenitors from differentiating into neutrophils2015

    • Author(s)
      Kurotaki D, Yamamoto M, Nishiyama A, Uno K, Ban T, Ichino M, Sasaki H, Matsunaga S, Yoshinari M, Ryo A, Nakazawa M, Ozato K, Tamura T
    • Organizer
      International Society for Experimental Hematology 44th Annual Scientific Meeting
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhancer landscape dynamics during monocyte and dendritic cell development and the role of the transcription factor IRF82015

    • Author(s)
      Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kaneko N, Koizumi S, Ozato K, Suzuki Y, Tamura T
    • Organizer
      International Society for Experimental Hematology 44th Annual Scientific Meeting
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulatory Mechanisms for Pol II Termination Sites and 3' Processing Pathways in Higher Eukaryotes2015

    • Author(s)
      Yuki Yamaguchi and Junichi Yamamoto
    • Organizer
      MECHANISM OF EUKARYOTIC TRANSCRIPTION
    • Place of Presentation
      Cold Spring Harbor(アメリカ)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 単核貪食細胞系の分化における遺伝子発現制御機構の包括的解明2015

    • Author(s)
      黒滝大翼, 佐々木悠, 金子尚史, 田村智彦
    • Organizer
      新学術領域「ゲノム支援」2015年度 拡大班会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 単核貪食細胞群の分化機構に関する研究2015

    • Author(s)
      黒滝大翼, 中林 潤, 西山 晃, 鈴木 穣, 田村智彦
    • Organizer
      新学術領域「ゲノム支援」2015年度 拡大班会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex2015

    • Author(s)
      Hidehisa Takahashi, Ichigaku Takigawa, Masashi Watanabe, Delnur Anwar, Mio Shibata, Chieri Tomomori-Sato, Shigeo Sato, Amol Ranjan, Chris W. Seidel, Tadasuke Tsukiyama, Wataru Mizushima, Joan W. Conaway, Ronald C. Conaway, Shigetsugu Hatakeyama
    • Organizer
      Mechanism of Eukaryotic Transcription
    • Place of Presentation
      Cold spring harbor(アメリカ)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 転写伸張因子DSIFのCTRを介した転写制御機構の解析2015

    • Author(s)
      磯部 智康、山口 雄輝
    • Organizer
      転写サイクル班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] NELFを中心としたmRNAの品質管理のメカニズム2015

    • Author(s)
      瑞慶覧 安里、山本 淳一、磯部 智康、山口 雄輝
    • Organizer
      転写サイクル班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写伸長段階の制御メカニズム:新たな制御因子の探索2015

    • Author(s)
      山口 雄輝、磯部 智康、曹 青福、山本 淳一
    • Organizer
      転写サイクル班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写因子IRF8による造血前駆細胞におけるエンハンサー形成及び活性化制御機構の解明2015

    • Author(s)
      田村智彦
    • Organizer
      新学術領域「転写サイクル」班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 単球分化を促す転写因子IRF8により活性化されるKlf4遠位エンハンサーを起点とした染色体間クロマチンネットワークの解析2015

    • Author(s)
      西山 晃, 中林 潤, 岡部篤史, 堤 修一, 油谷浩幸, 田村智彦
    • Organizer
      新学術領域「転写サイクル」班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写因子IRF8は単球や樹状細胞の前駆細胞においてエンハンサーランドスケープのダイナミクスを制御する2015

    • Author(s)
      黒滝大翼, 中林 潤, 西山 晃, 佐々木悠, 金子尚史, 小泉真一, Keiko Ozato, 鈴木 穣, 田村智彦
    • Organizer
      新学術領域「転写サイクル」班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Med26はLittle elongation complexをリクルートすることでsmall nuclear RNA遺伝子の発現を制御する2015

    • Author(s)
      高橋秀尚, 畠山鎮次
    • Organizer
      第17回日本RNA学会年会
    • Place of Presentation
      ホテルライフォート札幌(北海道札幌市)
    • Year and Date
      2015-07-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 転写因子IRF8による好塩基球分化制御機構の解明2015

    • Author(s)
      黒滝 大翼, 佐々木 悠, 大里 直樹, 佐藤 英明, 佐々木 泉, 小泉 真一, Hongsheng Wang, 金田 智香, 西山 晃, 改正 恒康, 油谷 浩幸, Herbert C. Morse III, Keiko Ozato, 田村 智彦
    • Organizer
      第26回生体防御学会学術総会
    • Place of Presentation
      生涯学習センター(東京都台東区)
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] IMiDs標的タンパク質CRBNの生化学的解析2015

    • Author(s)
      坂本 聡、伊藤拓水、安藤秀樹、山口雄輝、半田 宏
    • Organizer
      日本ケミカルバイオロジー学会第10回年会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] アフィニティビーズを利用した生物活性物質標的タンパク質の単離・同定・評価2015

    • Author(s)
      坂本 聡、山口雄輝、半田 宏
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes2015

    • Author(s)
      山本 淳一、半田 宏、山口 雄輝
    • Organizer
      冬の若手ワークショップ2015
    • Place of Presentation
      ホテル松本楼(群馬県渋川市)
    • Year and Date
      2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写伸長因子DSIFのリン酸化の転写伸長反応への寄与の解析2015

    • Author(s)
      磯部 智康、千葉 国俊、山口 雄輝
    • Organizer
      冬の若手ワークショップ2015
    • Place of Presentation
      ホテル松本楼(群馬県渋川市)
    • Year and Date
      2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 単球分化における転写因子IRF8によるKlf4遺伝子誘導をモデルとした、遠位エンハンサーと遺伝子間の段階的で双方向性の活性化についての解析2015

    • Author(s)
      西山 晃, 藩 龍馬, 中林 潤, 田村智彦
    • Organizer
      冬の若手ワークショップ2015
    • Place of Presentation
      ホテル松本楼(群馬県渋川市)
    • Year and Date
      2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写因子IRF8によるC/EBPαの機能阻害が単核貪食細胞前駆細胞において好中球分化能の喪失をもたらす2015

    • Author(s)
      黒滝大翼, 山本道雄, 西山 晃, 宇野和宏, 藩 龍馬, 市野素英, 佐々木 悠, 松永智子, 吉成正裕, 梁 明秀, 中澤正年, Keiko Ozato, 田村智彦
    • Organizer
      第19回造血器腫瘍研究会
    • Place of Presentation
      グランデはがくれ(佐賀県佐賀市)
    • Year and Date
      2015-01-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of the transcription factor IRF8 in the developmental pathways of mast cells2014

    • Author(s)
      Sasaki H., Kurotaki D., Tamura T.
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] p53非存在下でのATF3の機能2014

    • Author(s)
      内田 洋平, 川内 潤也, 福本 悟史, Paul Sheridan, 山口 類, 井元 清哉, 宮野 悟, 北嶋 繁孝
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] E3ユビキチンリガーゼの基質認識レセプター CRBNとポマリドマイド依存的な基質Aiolosの生化学的解析2014

    • Author(s)
      片山 美樹,伊藤 拓水,安藤 秀樹,山口 雄輝,半田 宏
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Stepwise and bidirectional activation of the Klf4 distal enhancer and the Klf4 gene by the transcription factor IRF8 during monocyte differentiation2014

    • Author(s)
      Nishiyama A., Ban T., Tamura T.
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pol II脱リン酸化酵素FCP1のp53を介した細胞増殖における役割2014

    • Author(s)
      福本 悟史, 川内 潤也, 北嶋 繁孝
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト大腸がんにおけるWnt標的遺伝子ATF3の遊走、浸潤、転移抑制機能2014

    • Author(s)
      新井 菜月, 井上 允, 藤沢 晃久, 川内 潤也, 関根 茂樹, 北嶋 繁孝
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト大腸がん細胞株におけるWnt/b-catenin経路依存的ATF3発現制御2014

    • Author(s)
      藤沢 晃久, 井上 允, 新井 菜月, 川内 潤也, 関根 茂樹, 北嶋 繁孝
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regulatory Mechanisms for Pol II Termination Sites and 3' Processing Pathways in Higher Eukaryotes2014

    • Author(s)
      山口雄輝、山本淳一
    • Organizer
      転写サイクル国際シンポジウム2014
    • Place of Presentation
      東工大蔵前会館(東京都目黒区)
    • Year and Date
      2014-11-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] BCR-ABL inactivates the distal enhancer of the Irf8 gene and represses its expression2014

    • Author(s)
      Tamura T., Miyashita K., Koizumi S., Yamamoto M., Kurotaki D., Nakabayashi J., Ishigatsubo Y., Nishiyama A.
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-11-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 転写因子IRF8は 好塩基球分化に必要である2014

    • Author(s)
      佐々木悠, 黒滝大翼, 大里直樹, 佐藤英明, 佐々木泉, Wang Hongsheng, 金田智香, 西山 晃, 改正恒康, 油谷浩幸, Herbert C. Morse III, Keiko Ozato, 田村智彦
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 単球分化において転写因子IRF8がKlf4遠位エンハンサーとプロモーターの段階的活性化を誘導する2014

    • Author(s)
      西山 晃, 黒滝大翼, 田村智彦
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 樹状細胞と単球はその分化に異なるIRF8発現量を要する2014

    • Author(s)
      佐藤英明, 黒滝大翼, 佐々木悠, 佐藤 豪, Keiko Ozato, 田村智彦
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 感覚神経系の発生・分化におけるElongin Aの標的遺伝子の同定2014

    • Author(s)
      安川 孝史, 村岡 拓也, 筒井 文, 佐藤 チエリ, 佐藤 滋生, 川内 潤也, 井上 允, 北嶋 繁孝, Conaway Ronald C, Conaway Joan W, 麻生 悌二郎
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] ストレス応答におけるmammalian Elongin Aの特徴と役割2014

    • Author(s)
      井上 允, 川内 潤也, 安川 孝史, Conaway Ronald C., Conaway Joan W., 麻生 悌二郎, 北嶋 繁孝
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写伸長因子DSIFにリン酸化依存的に相互作用する因子の機能解析2014

    • Author(s)
      磯部 智康、千葉 国俊、山口 雄輝
    • Organizer
      転写サイクル班会議2014
    • Place of Presentation
      慶山(山梨県笛吹市)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes2014

    • Author(s)
      山本 淳一、半田 宏、山口 雄輝
    • Organizer
      転写サイクル班会議2014
    • Place of Presentation
      慶山(山梨県笛吹市)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写伸長因子DSIFおよびNELFがES細胞の多分化能維持に果たす役割2014

    • Author(s)
      柴田 紘孝、半田 宏、山口 雄輝
    • Organizer
      転写サイクル班会議2014
    • Place of Presentation
      慶山(山梨県笛吹市)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規転写伸長因子ヒトRtf1が関与する転写制御の分子機構2014

    • Author(s)
      曹 青福、陳 業熹、半田 宏、山口 雄輝
    • Organizer
      転写サイクル班会議2014
    • Place of Presentation
      慶山(山梨県笛吹市)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒトRNA ポリメラーゼII 転写産物のプロセシング経路の選択機構2014

    • Author(s)
      山口雄輝、山本淳一、半田宏
    • Organizer
      転写サイクル班会議2014
    • Place of Presentation
      慶山(山梨県笛吹市)
    • Year and Date
      2014-08-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 単球分化に必須のIRF8-KLF4転写因子カスケードの発見2014

    • Author(s)
      黒滝大翼, 大里直樹, 西山 晃, 山本道雄, 田村智彦
    • Organizer
      第10回麒麟塾
    • Place of Presentation
      コクヨホール(東京都港区)
    • Year and Date
      2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗炎症薬サリチル酸の生体内作用機構の解析2014

    • Author(s)
      坂本 聡、Vipul Gupta、劉 舒捷、安藤 秀樹、舘野 峻平、金子 裕生、湯上 真人、石井 亮平、濡木 理、山口 雄輝、半田 宏
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪大学(大阪市豊中市)
    • Year and Date
      2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写因子IRF8はCMLにおいてBCR-ABLによる樹状細胞分化不全を救済する2014

    • Author(s)
      Tamura T
    • Organizer
      造血器腫瘍研究会
    • Place of Presentation
      がん研究会がん研究所吉田富三記念講堂(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The mechanism of action of thalidomide, a drug with two faces2013

    • Author(s)
      Yamaguchi, Y.
    • Organizer
      International Marine Biotechnology Symposium 2013
    • Place of Presentation
      沖縄産業支援センター(沖縄)
    • Year and Date
      2013-03-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] DSIF and NELF interact with Integrator and participate in 3’ processing of snRNA genes: A possible mechanism controlling the fate of Pol II2013

    • Author(s)
      Yamaguchi, Y., Yamamoto, J., and Handa, H.
    • Organizer
      CSHL Meeting on Mechanisms of Eukaryotic Transcription
    • Place of Presentation
      Cold Spring Harbor Laboratory(米国ニューヨーク州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The diverse pharmacological effects of thalidomide2013

    • Author(s)
      Yamaguchi, Y.
    • Organizer
      BioJapan 2013 World Business Forum
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The IRF8-KLF4 transcription factor cascade critically regulates the development of inflammatory monocytes2013

    • Author(s)
      Kurotaki D., Osato N., Nishiyama A., Yamamoto M., Ban T., Sato H., Nakabayashi J., Umehara M., Nakazawa M., Miyake N., Matsumoto N., Ozato K., Tamura T.
    • Organizer
      The Joint International Meeting of the Japanese Society for Interferon and Cytokine Research and Macrophage Molecular and Cellular Biology 2013
    • Place of Presentation
      都市センターホテル(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The transcription factor IRF8 is required for the development of basophils2013

    • Author(s)
      Sasaki H., Kurotaki D., Sato H., Morse H.C. III, Ozato K., Tamura T.
    • Organizer
      The Joint International Meeting of the Japanese Society for Interferon and Cytokine Research and Macrophage Molecular and Cellular Biology 2013
    • Place of Presentation
      都市センターホテル(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 転写因子IRF8は単球-樹状細胞前駆細胞においてC/EBPαの機能を阻害し、好中球分化能の喪失をもたらす2013

    • Author(s)
      黒滝大翼,山本道雄,宇野和宏,西山 晃,中林 潤,中澤正年,Herbert C. Morse III,Keiko Ozato,田村智彦
    • Organizer
      第24回日本生体防御学会学術総会
    • Place of Presentation
      くまもと森都心プラザ(熊本県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A dynamic and long-range chromatin control of Klf4 transcription by IRF8 in monocyte differentiation2013

    • Author(s)
      Nishiyama A, Kurotaki D, Tamura T
    • Organizer
      12th Human Proteome Organization World Congress
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] M期での転写メモリーとストレス応答におけるBRD4の役割2013

    • Author(s)
      西山 晃,田村智彦,Keiko Ozato
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The transcription factor IRF8 overrides BCR-ABL to rescue dendritic cell development in chronic myeloid leukemia2013

    • Author(s)
      Watanabe T., Hotta C., Koizumi S., Miyashita K., Nakabayashi J., Kurotaki D., Sato R. G., Yamamoto M., Nishiyama A., Aihara M., Ishigatsubo Y., Tamura T.
    • Organizer
      2013 Inaugural Meeting of the International Cytokine and Interferon Society
    • Place of Presentation
      Hyatt Regency San Francisco(米国カリフォルニア州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The IRF8-KLF4 transcription factor cascade is essential for the development of monocytes2013

    • Author(s)
      Kurotaki D., Osato N., Nishiyama A., Yamamoto M., Ban T., Sato H., Nakabayashi J., Umehara M., Nakazawa M., Miyake N., Matsumoto N., Ozato K., Tamura T.
    • Organizer
      2013 Inaugural Meeting of the International Cytokine and Interferon Society
    • Place of Presentation
      Hyatt Regency San Francisco(米国カリフォルニア州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The transcription factor IRF8 is required for the development of basophils2013

    • Author(s)
      Sasaki H., Kurotaki D., Sato H., Morse HC III., Ozato K., Tamura T.
    • Organizer
      2013 Inaugural Meeting of the International Cytokine and Interferon Society
    • Place of Presentation
      Hyatt Regency San Francisco(米国カリフォルニア州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] IRF8 inhibits the activity of C/EBPs to restrain neutrophil development in monocyte-DC progenitors2013

    • Author(s)
      Kurotaki D., Yamamoto M., Uno K., Nishiyama A., Nakabayashi J., Morse H.C. 3rd., Ozato K., Tamura T.
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 単球分化において転写因子IRF8がKlf4プロモーターと遠位エンハンサーの長距離間の相互活性化を誘導する2013

    • Author(s)
      西山 晃,黒滝大翼,田村智彦
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] IRF8 inhibits the activity of C/EBPalpha to restrain the neutrophil differentiation program in monocyte-dendritic cell progenitors2013

    • Author(s)
      Kurotaki D., Yamamoto M., Nishiyama A., Uno K., Ichino M., Sasaki H., Ban T., Yoshinari M., Nakazawa M., Ozato K., Tamura T.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] IRF8 restrains monocyte-dendritic cell progenitors from differentiating into neutrophils by inhibiting C/EBPalpha activity2013

    • Author(s)
      Kurotaki D., Yamamoto M., Nishiyama A., Uno K., Sasaki H., Ozato K., Tamura T.
    • Organizer
      55th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Ernest N. Morial Convention Center(米国ルイジアナ州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The transcription factor IRF8 is a key transcription factor for basophil development2013

    • Author(s)
      Kurotaki D., Sasaki H., Osato N., Sasaki I., Kaneda C., Sato H., Nishiyama A., Kaisho T., Aburatani H., Morse H.C. 3rd., Ozato K., Tamura T.
    • Organizer
      55th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Ernest N. Morial Convention Center(米国ルイジアナ州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The transcription factor IRF8 is required for basophil development2013

    • Author(s)
      Sasaki H., Kurotaki D., Osato N., Sasaki I., Kaneda C., Nishiyama A., Kaisho T., Morse H.C. III., Ozato K., Tamura T.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] IRF8 Inhibits the Activity of C/EBPalpha to Restrain Monocyte-Dendritic Cell Progenitors from Differentiating into Neutrophils2013

    • Author(s)
      Yamamoto M., Kurotaki D., Nishiyama A., Uno K., Ichino M., Nakazawa M., Ozato K., Tamura T.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A dynamic and long-range chromatin control of Klf4 transcription by IRF8 in monocyte differentiation2013

    • Author(s)
      Nishiyama A., Kurotaki D., Tamura T.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pol II CTD 脱リン酸化酵素FCP1のDNA Damage Response における役割2013

    • Author(s)
      福本 悟史,高屋 俊輔,小高 愛未,川内 潤也,北嶋 繁孝
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] p53非存在下でのATF3の機能2013

    • Author(s)
      井上 允,藤沢 晃久,枝川 真,川内 潤也,関根 茂樹,北嶋 繁孝
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ストレス反応におけるmammalian Elongin Aの特徴と役割2012

    • Author(s)
      井上 允
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] 感覚神経系の発生・分化における転写伸長因子Elongin Aの役割2012

    • Author(s)
      安川 孝史
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゲノム規模解析による単球分化に重要なIRF8-KLF4転写因子カスケードの発見2012

    • Author(s)
      黒滝 大翼
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] Impaired dendritic cell development in chronic myelogenous leukemia can be rescued by restoring expression of the transcription factor IRF82012

    • Author(s)
      Watanabe, T.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-12-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genome-wide analyses revealed the IRF8-KLF4 transcription factor cascade during monocyte differentiation2012

    • Author(s)
      Kurotaki, D.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県
    • Year and Date
      2012-12-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゲノム規模解析による転写因子IRF8を核とした単球分化制御プログラムの理解2012

    • Author(s)
      田村 智彦
    • Organizer
      文部科学省イノベーションシステム整備事業 先端融合領域イノベーション創出拠点形成プログラム「翻訳後修飾プロテオミクス医療研究拠点の形成」第4回公開シンポジウム
    • Place of Presentation
      横浜情報文化センター(神奈川県)
    • Year and Date
      2012-10-01
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The transcription factor IRF8 in the pathogenesis and therapy of chronic myelogenous leukemia2012

    • Author(s)
      Tamura, T.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Chromatin exchange in interferon induced transcription2012

    • Author(s)
      Ozato, K.
    • Organizer
      10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research
    • Place of Presentation
      Centre International de Conferences Geneve(スイス)
    • Year and Date
      2012-09-11
    • Related Report
      2012 Annual Research Report
  • [Book] 遺伝子発現制御機構 クロマチン,転写制御,エピジェネティクス2017

    • Author(s)
      田村隆明、浦清恵、山口雄輝ほか
    • Total Pages
      264
    • Publisher
      東京化学同人
    • Related Report
      2016 Annual Research Report
  • [Book] 基礎からしっかり学ぶ生化学2014

    • Author(s)
      山口雄輝、成田央
    • Total Pages
      245
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Remarks] 新学術領域研究「転写サイクル」ウェブサイト

    • URL

      http://transcriptioncycle.org

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京工業大学 生命理工学院 山口研究室

    • URL

      http://yamaguchi.bio.titech.ac.jp

    • Related Report
      2016 Annual Research Report
  • [Remarks] 横浜市立大学大学院医学研究科 免疫学教室

    • URL

      http://www-user.yokohama-cu.ac.jp/~immunol/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 新学術領域研究「転写サイクル」

    • URL

      http://transcriptioncycle.org/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 新学術領域「転写サイクル」

    • URL

      http://transcriptioncycle.org

    • Related Report
      2013 Annual Research Report
  • [Remarks] 新学術領域「転写サイクル」

    • URL

      http://transcriptioncycle.org

    • Related Report
      2012 Annual Research Report

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Published: 2012-11-27   Modified: 2022-02-07  

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