| Project Area | Generative design to unlock the potential of protein function |
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| Project/Area Number |
24H02260
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| Research Category |
Grant-in-Aid for Transformative Research Areas (A)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (II)
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| Research Institution | Nagoya University |
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Principal Investigator |
TAMA FLORENCE 名古屋大学, 理学研究科, 教授 (20648191)
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| Co-Investigator(Kenkyū-buntansha) |
宮下 治 国立研究開発法人理化学研究所, 計算科学研究センター, 上級研究員 (10620528)
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| Project Period (FY) |
2024-04-01 – 2029-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥106,730,000 (Direct Cost: ¥82,100,000、Indirect Cost: ¥24,630,000)
Fiscal Year 2025: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2024: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
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| Keywords | protein dynamics / intrinsically disordered / integrative modeling / MD simulations |
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| Outline of Research at the Start |
Biomolecules are essential for cellular processes, and disruptions in their function can lead to severe diseases. Engineering biomolecules with specific functions offers tremendous promise for society. Because biomolecules are intrinsically flexible, experimental investigation to elucidate their function is challenging. We will work on the integration of experimental data with simulation, Data Integration Simulation, to provide approaches for elucidating biomolecular function and apply them to specific proteins, such as the Cryptochrome proteins involved in the circadian rhythm.
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