| Project Area | Generative design to unlock the potential of protein function |
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| Project/Area Number |
24H02267
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| Research Category |
Grant-in-Aid for Transformative Research Areas (A)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (II)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
キャンベル ロバート.アール 東京大学, 大学院理学系研究科(理学部), 教授 (40831318)
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| Co-Investigator(Kenkyū-buntansha) |
寺井 琢也 東京大学, 大学院理学系研究科(理学部), 准教授 (00508145)
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| Project Period (FY) |
2024-04-01 – 2029-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥91,910,000 (Direct Cost: ¥70,700,000、Indirect Cost: ¥21,210,000)
Fiscal Year 2025: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2024: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
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| Keywords | Generative Design / Protein Engineering / Fluorescence / Biosensor / Directed Evolution |
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| Outline of Research at the Start |
This research has two major aims. Major Aim (1) is to establish the principles of fluorescent protein-based biosensor function using spectroscopic, computational, and structural techniques. Major Aim (2) is to explore the use of Generative Protein Design, informed with insights obtained under the first aim, to guide the development of improved fluorescent protein-based biosensors. Taking advantage of the power of directed evolution, we will deliver a set of improved far-red and near-infrared biosensors for investigation of the roles of central metabolites in biology and disease models.
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