| Budget Amount *help |
¥94,380,000 (Direct Cost: ¥72,600,000、Indirect Cost: ¥21,780,000)
Fiscal Year 2017: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2015: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2014: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2013: ¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000)
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| Outline of Final Research Achievements |
In this study, we identified a molecular assembly, consists of shootin1, cortactin and L1-CAM, which is involved in neuronal axon outgrowth and guidance. This molecular assembly senses shallow gradients of extracellular netrin-1 concentration and decides the direction of axon outgrowth through its spatially regulated assembly and disassembly. This assembly is also involved in a new type of axon guidance mechanism which utilizes mechanical slippage between L1-CAM and adhesive substrates. This mechanism is disrupted in a human patient of L1-CAM/CRASH syndrome, suffering corpus callosum agenesis and corticospinal tract hypoplasia. Furthermore, the molecular assembly, consists of shootin1, cortactin and L1-CAM, mediates cell migration and a new type of intracellular molecular transport mechanism.
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