| Budget Amount *help |
¥89,180,000 (Direct Cost: ¥68,600,000、Indirect Cost: ¥20,580,000)
Fiscal Year 2017: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2015: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2014: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2013: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
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| Outline of Final Research Achievements |
Electrospray cryogenic ion trap spectrometer was developed, and applied to complexes of partial sequence of receptor proteins and several ligands to reveal their interactions at molecular level. In addition, hydration effects on their structures were clarified by using hydrated clusters in which number of water molecules and their orientation can be rigorously determined. Furthermore, Structures of alkali metal ion complexes of biomolecules were investigated by using isomer-selected infrared spectroscopy, and conformational specificity depending on the alkali metal ions was revealed. Through these results, we successfully demonstrated that precise spectroscopic studies on the interaction centers cut out from biomolecules, i.e., "bottom-up approach" is useful.
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