| Budget Amount *help |
¥178,230,000 (Direct Cost: ¥137,100,000、Indirect Cost: ¥41,130,000)
Fiscal Year 2017: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2016: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
Fiscal Year 2015: ¥30,290,000 (Direct Cost: ¥23,300,000、Indirect Cost: ¥6,990,000)
Fiscal Year 2014: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
Fiscal Year 2013: ¥57,980,000 (Direct Cost: ¥44,600,000、Indirect Cost: ¥13,380,000)
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| Outline of Final Research Achievements |
We have investigated molecular machinery of membrane dynamics in autophagy and relationship between autophagy and diseases. In results, we showed that inositol polyphosphate-5-phosphatase E (INPP5E) involved in autophagosome-lysosome fusion process via actin polymerization on lysosomes. INPP5E is one of the genes responsible for Joubert syndrome, a brain abnormality. We demonstrated a possibility that defect in autophagy causes this disease. In addition, we revealed that endothelial cells have a defect in autophagy against invading bacteria in contrast to epithelial cells, which is caused by their intrinsic inability to target bacteria with ubiquitin that acts a tag for autophagosome formation.
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