| Budget Amount *help |
¥125,320,000 (Direct Cost: ¥96,400,000、Indirect Cost: ¥28,920,000)
Fiscal Year 2017: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2016: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2015: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2014: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2013: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
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| Outline of Final Research Achievements |
Autophagy is a major degradation system within cells, which plays a wide range of physiological roles and is linked to a number of human diseases. However, fundamental issues still remain to be addressed in the molecular mechanisms of autophagy, which is required to develop therapeutic methods for related diseases. In this study, we used yeast as an excellent model organism for the study of molecular mechanisms of basic biological phenomena and cell-free systems composed of purified proteins and artificial membranes which allow us to analyze the functions of related molecules. Finally, we obtained many important results about molecular mechanisms underlying the biogenesis of the autophagosome, a central event in autophagy, and degradation targets and regulatory mechanisms of selective types of autophagy, which specifically degrade certain components of cells.
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