| Budget Amount *help |
¥311,350,000 (Direct Cost: ¥239,500,000、Indirect Cost: ¥71,850,000)
Fiscal Year 2017: ¥59,670,000 (Direct Cost: ¥45,900,000、Indirect Cost: ¥13,770,000)
Fiscal Year 2016: ¥59,670,000 (Direct Cost: ¥45,900,000、Indirect Cost: ¥13,770,000)
Fiscal Year 2015: ¥58,630,000 (Direct Cost: ¥45,100,000、Indirect Cost: ¥13,530,000)
Fiscal Year 2014: ¥58,760,000 (Direct Cost: ¥45,200,000、Indirect Cost: ¥13,560,000)
Fiscal Year 2013: ¥74,620,000 (Direct Cost: ¥57,400,000、Indirect Cost: ¥17,220,000)
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| Outline of Final Research Achievements |
Autophagy is a lysosome-mediated degradation system for cytoplasmic materials and it has become clear that autophagy is related to various biological phenomena. Under this Project, we elucidated the molecular mechanisms underlying autophagosome formation, autophagosome-lysosome fusion, and autophagosomal membrane degradation, as well as novel physiological roles for autophagy in mice. Furthermore, a novel reporter to monitor autophagic activity was established, and autophagy-modulating drugs were aslo identified.
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