Study on selective autophagy on cellular functions

• Project Area: Multidisciplinary research on autophagy: from molecular mechanisms to disease states
• Project/Area Number: 25111006
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Niigata University (2014-2017); Tokyo Metropolitan Institute of Medical Science (2013)
• Principal Investigator: KOMATSU Masaaki 新潟大学, 医歯学系, 教授 (90356254)
• Co-Investigator(Kenkyū-buntansha): 和栗 聡 福島県立医科大学, 医学部, 教授 (30244908)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥213,720,000 (Direct Cost: ¥164,400,000、Indirect Cost: ¥49,320,000); Fiscal Year 2017: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000); Fiscal Year 2016: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000); Fiscal Year 2015: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000); Fiscal Year 2014: ¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000); Fiscal Year 2013: ¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000)
• Keywords: オートファジー / タンパク質分解 / p62 / Nrf2 / 肝細胞がん / リソソーム / 代謝 / 膜輸送 / 蛋白質 / 細胞・組織 / 転写 / 癌

Outline of Final Research Achievements

Autophagy has long been thought of as a bulk degradation system in which cytoplasmic components are sequestered by double-membrane structures called autophagosomes, and the contents are then degraded after autophagosomes fuse with lysosomes. Genetic experiments in yeast identified a set of Autophagy-related (ATG) genes that are essential for autophagy. We have since elucidated many of the molecular underpinnings of autophagy and the physiologic roles of these processes in various systems. Moreover, growing lines of evidence have shed light on indispensable role for autophagy in cellular homeostasis, which is mediated by selective degradation of a specific substrate(s). Such selectivity allows diverse cellular regulation, similar to the ubiquitin proteasome pathway. In this research program, we have addressed the pathophysiological roles of selective autophagy.

Research Products

• [Int'l Joint Research] King Faisal Specialist Hospital(サウジアラビア)
• [Int'l Joint Research] Cambridge Institute for Medical Research(英国)
• [Int'l Joint Research] Necker Enfants Malades Institute(フランス)
• [Int'l Joint Research] Hannam University(韓国)
• [Int'l Joint Research] University of Turku(フィンランド)
• [Int'l Joint Research] Merck KGaA/Goethe University/University of Munster(Germany)
• [Int'l Joint Research] University of Helsinki(Finland)
• [Int'l Joint Research] Yonsei University/Seoul National University/Hannam University(韓国)
• [Int'l Joint Research] ICCNS/Tsinghua University(China)
• [Int'l Joint Research] Columbia University/University of Kansas Medical Center(米国)
• [Int'l Joint Research] Merck KGaA/Goethe University School of Medicine/Goethe University(Germany)
• [Int'l Joint Research] NIID/University of Salento(Italy)
• [Int'l Joint Research] University of Kentucky/University of Arkansas/Friedman Brain Institute(米国)
• [Journal Article] Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development. (2018)
  • Author(s): Michael S Nahorski、... *C Geoffrey Woods, *Masaaki Komatsu, *Fowzan S Alkuraya.
  • Journal Title: Brain Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. (2018)
  • Author(s): M Morita, T Sato, M Nomura, Y Sakamoto, Y Inoue, R Tanaka, S Ito, K Kurosawa, K Yamaguchi, Y Sugiura, H Takizaki, Y Yamashita, R Katakura, I Sato, Y Okada, H Watanabe, G Kondoh, et al.
  • Journal Title: Cancer Cell Volume: 12 Issue: 3 Pages: 355-367
  • DOI: 10.1016/j.ccell.2018.02.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1 (2018)
  • Author(s): Prabakaran Thanes、...Paludan Soren R
  • Journal Title: EMBO J. Volume: - Issue: 8
  • DOI: 10.15252/embj.201797858
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function (2018)
  • Author(s): Yamaguchi Tomokazu et al
  • Journal Title: Science Signaling Volume: 11 Issue: 516 Pages: 3638-3638
  • DOI: 10.1126/scisignal.aan3638
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice. (2018)
  • Author(s): Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N.
  • Journal Title: Sci Rep. Volume: ８ Issue: 1 Pages: 2813-2813
  • DOI: 10.1038/s41598-018-21325-w
  • Peer Reviewed / Open Access
• [Journal Article] Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant. (2018)
  • Author(s): Kageyama Shun、Saito Tetsuya、Obata Miki、Koide Ryouhei、 Ichimura Yoshinobu、Komatsu Masaaki.
  • Journal Title: Mol Cell Biol. Volume: 38 Issue: 7
  • DOI: 10.1128/mcb.00642-17
  • Peer Reviewed / Open Access
• [Journal Article] Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways (2018)
  • Author(s): Mizunoe Yuhei、Kobayashi Masaki、Sudo Yuka、Watanabe Shukoh、Yasukawa Hiromine、Natori Daiki、Hoshino Ayana、Negishi Arisa、Okita Naoyuki、Komatsu Masaaki、Higami Yoshikazu
  • Journal Title: Redox Biol. Volume: 15 Pages: 115-124
  • DOI: 10.1016/j.redox.2017.09.007
  • Peer Reviewed / Open Access
• [Journal Article] L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human Niemann-Pick type C disease. (2017)
  • Author(s): Yanagisawa H, Ishii T, Endo K, Kawakami E, Nagao K, Miyashita T, Akiyama K, Watabe K, Komatsu M, Yamamoto D, Eto Y.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 15994-15994
  • DOI: 10.1038/s41598-017-15305-9
  • Peer Reviewed / Open Access
• [Journal Article] Autophagy-monitoring and autophagy-deficient mice. (2017)
  • Author(s): Kuma A, Komatsu M, Mizushima N.
  • Journal Title: Autophagy Volume: 13 Issue: 10 Pages: 1619-1628
  • DOI: 10.1080/15548627.2017.1343770
  • Peer Reviewed / Open Access
• [Journal Article] Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway (2017)
  • Author(s): Kim Tae Sung、Shin Yern-Hyerk、Lee Hye-Mi、Kim Jin Kyung、Choe Jin Ho、Jang Ji-Chan、Um Soohyun、Jin Hyo Sun、Komatsu Masaaki、Cha Guang-Ho、Chae Han-Jung、Oh Dong-Chan、Jo Eun-Kyeong
  • Journal Title: Sci Rep. Volume: 7 Issue: 1
  • DOI: 10.1038/s41598-017-03477-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis. (2017)
  • Author(s): Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
  • Journal Title: Autophagy Volume: 17 Issue: 5 Pages: 1-14
  • DOI: 10.1080/15548627.2017.1314897
  • NAID: 120006881392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7 (2017)
  • Author(s): Koike Masato、Shibata Masahiro、Sunabori Takehiko、Yamaguchi Junji、Sakimura Kenji、Komatsu Masaaki、Tanaka Keiji、Uchiyama Yasuo
  • Journal Title: The American Journal of Pathology Volume: 187 Issue: 7 Pages: 1586-1600
  • DOI: 10.1016/j.ajpath.2017.02.020
  • Peer Reviewed
• [Journal Article] Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation (2017)
  • Author(s): van Wijk Sjoerd J. L.、Fricke Franziska、Herhaus Lina、Gupta Jalaj、H?tte Katharina、Pampaloni Francesco、Grumati Paolo、Kaulich Manuel、Sou Yu-shin、Komatsu Masaaki、Greten Florian R.、Fulda Simone、Heilemann Mike、Dikic Ivan
  • Journal Title: Nat Microbiol. Volume: 2 Issue: 7 Pages: 17066-17066
  • DOI: 10.1038/nmicrobiol.2017.66
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress. (2017)
  • Author(s): Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R.
  • Journal Title: Cell Res. Volume: - Issue: 5 Pages: 657-674
  • DOI: 10.1038/cr.2017.40
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autophagy in the liver: functions in health and disease. (2017)
  • Author(s): Ueno T, Komatsu M
  • Journal Title: Nat Rev Gastroenterol Hepatol. Volume: 14 Issue: 3 Pages: 170-184
  • DOI: 10.1038/nrgastro.2016.185
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A novel approach to assess the ubiquitin-fold modifier 1-system in cells. (2017)
  • Author(s): Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, Komatsu M.
  • Journal Title: FEBS Lett. Volume: 591 Issue: 1 Pages: 196-204
  • DOI: 10.1002/1873-3468.12518
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma. (2016)
  • Author(s): Ye X, Zhou Q, Matsumoto Y, Moriyama M, Kageyama S, Komatsu M, Satoh S, Tsuchida M, Saijo Y.
  • Journal Title: Anticancer Res. Volume: 36 Pages: 6021-6029
• [Journal Article] Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. (2016)
  • Author(s): Lee DH, Han DH, Nam KT, Park JS, Kim SH, Lee M, Kim G, Min BS, Cha BS, Lee YS, Sung SH, Jeong H, Ji HW, Lee MJ, Lee JS, Lee HY, Chun Y, Kim J, Komatsu M, Lee YH, Bae SH.
  • Journal Title: Free Radic Biol Med. Volume: 99 Pages: 520-532
  • DOI: 10.1016/j.freeradbiomed.2016.09.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain. (2016)
  • Author(s): Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A.
  • Journal Title: Elife Volume: 20
  • DOI: 10.7554/elife.14810
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy. (2016)
  • Author(s): Muona M, Ishimura R, Laari A,...... , Komatsu M.
  • Journal Title: Am J Hum Genet. Volume: 99 Issue: 3 Pages: 683-94
  • DOI: 10.1016/j.ajhg.2016.06.020
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming (2016)
  • Author(s): Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T et al.
  • Journal Title: Nature Commun Volume: 7 Issue: 1 Pages: 12030-12030
  • DOI: 10.1038/ncomms12030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice. (2016)
  • Author(s): Yang H, Ni HM, Guo F, Ding Y, Shi YH, Lahiri P, Frohlich LF, Rulicke T, Smole C, Schmidt VC, Zatloukal K, Cui Y, Komatsu M, Fan J, Ding WX.
  • Journal Title: J Biol Chem. Volume: 291 Issue: 36 Pages: 18663-18674
  • DOI: 10.1074/jbc.m116.739821
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation. (2016)
  • Author(s): Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V.
  • Journal Title: J Biol Chem. Volume: - Issue: 17 Pages: 9025-9041
  • DOI: 10.1074/jbc.m116.715474
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease (2016)
  • Author(s): Kuwahara S, Hosojima M, Kaneko R, Aoki H, Nakano D, Sasagawa T, Kabasawa H, Kaseda R, Yasukawa R, Ishikawa T, Suzuki A, Sato H, Kageyama S, Tanaka T, Kitamura N, Narita I, Komatsu M, Nishiyama A, Saito A
  • Journal Title: J Am Soc Nephro Volume: in press Issue: 7 Pages: 1996-2008
  • DOI: 10.1681/asn.2015020190
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells. (2015)
  • Author(s): Atsushi Eino, Shun Kageyama, Takefumi Uemura, Hiromichi Annoh, Tetsuya Saito, Ichiei Narita, Satoshi Waguri, Masaaki Komatsu.
  • Journal Title: Journal of Cell Science Volume: 128 Pages: 4453-4461
  • DOI: 10.1242/jcs.180174
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p62/SQSTM1 functions as a signaling hub and an autophagy adaptor. (2015)
  • Author(s): Katsuragi Y, Ichimura Y, Komatsu M.
  • Journal Title: FEBS J. Volume: 282 Issue: 24 Pages: 4672-4678
  • DOI: 10.1111/febs.13540
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation. (2015)
  • Author(s): Grassi G, Di Caprio G, Santangelo L, Fimia GM, Cozzolino AM, Komatsu M, Ippolito G, Tripodi M, Alonzi T.
  • Journal Title: Cell Death Dis. Volume: 6 Issue: 9 Pages: e1880-e1880
  • DOI: 10.1038/cddis.2015.249
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis. (2015)
  • Author(s): Ouseph MM, Huang Y, Banerjee M, Joshi S, MacDonald L, Zhong Y, Liu H, Li X, Xiang B, Zhang G, Komatsu M, Yue Z, Li Z, Storrie B, Whiteheart SW, Wang QJ.
  • Journal Title: Blood. Volume: 126 Issue: 10 Pages: 1224-33
  • DOI: 10.1182/blood-2014-09-598722
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Autophagy protects against colitis by the maintenance of normal gut microflora and secretion of mucus. (2015)
  • Author(s): Tsuboi K, Nishitani M, Takakura A, Imai Y, Komatsu M and Kawashima H.
  • Journal Title: J. Biol. Chem. Volume: 290 Issue: 33 Pages: 20511-20526
  • DOI: 10.1074/jbc.m114.632257
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. (2015)
  • Author(s): Lim, J., Lachenmayer, ML., Wu, S., Liu, W., Kundu, M., Wang, R., Komatsu, M., Oh, YJ., Zhao, Y., *Yue, Z.
  • Journal Title: PLoS Genet. Volume: 11 Issue: 2 Pages: e1004987-e1004987
  • DOI: 10.1371/journal.pgen.1004987
  • Peer Reviewed / Open Access
• [Journal Article] The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates. (2015)
  • Author(s): Morimoto D,Walinda E, Fukada H, Sou YS, Kageyama S, Hoshino M, Fujii T, Tsuchiya H, Saeki Y, Arita K, Ariyoshi M, Tochio H, Iwai K, Namba K, Komatsu M, Tanaka K, Shirakawa M.
  • Journal Title: Nat Commun. Volume: 6 Issue: 1 Pages: 6116-6116
  • DOI: 10.1038/ncomms7116
  • NAID: 120005528125
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin. (2014)
  • Author(s): Donohue, E., Balgi, AD., Komatsu, M., *Roberge, M.
  • Journal Title: PLoS One Volume: 10 Issue: 12 Pages: 9-12
  • DOI: 10.1371/journal.pone.0114964
  • Peer Reviewed / Open Access
• [Journal Article] A treadmill exercise reactivates the signaling of the mammalian target of rapamycin (mTor) in the skeletal muscles of starved mice. (2014)
  • Author(s): Zheng, D.M., Bian, Z., Furuya, N., Oliva Trejo, J.A., Takeda-Ezaki, M., Takahashi, K., Hiraoka, Y., Mineki, R., Taka, H., Ikeda, S., Komatsu, M., Fujimura, T., Ueno, T., Ezaki, J.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 456 Issue: 1 Pages: 519-526
  • DOI: 10.1016/j.bbrc.2014.11.118
  • Peer Reviewed / Open Access
• [Journal Article] The significant role of autophagy in the granular layer in normal skin differentiation and hair growth. (2014)
  • Author(s): Yoshihara, N., Ueno, T., Takagi, A., Trejo, JA., Haruna, K., Suga, Y., Komatsu, M., Tanaka, K., *Ikeda, S.
  • Journal Title: Arch. Dermatol. Res. Volume: 307 Issue: 2 Pages: 159-169
  • DOI: 10.1007/s00403-014-1508-0
  • Peer Reviewed / Open Access
• [Journal Article] Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes. (2014)
  • Author(s): Lim, YM., Lim, H., Hur, KY., Quan, W., Lee, HY., Cheon, H., Ryu, D., Koo, SH., Kim, HL., Kim, J., Komatsu, M., *Lee, MS.
  • Journal Title: Nat. Commun. Volume: 5 Issue: 1 Pages: 4934-4934
  • DOI: 10.1038/ncomms5934
  • Peer Reviewed
• [Journal Article] Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. (2014)
  • Author(s): Yoo, HM., Kang, SH., Kim, JY., Lee, JE., Seong, MW., Lee, SW., Ka, SH., Sou,YS., Komatsu, M., Tanaka, K., Lee, ST., Noh, DY., Baek, SH., Jeon, YJ., *Chung, CH.
  • Journal Title: Mol. Cell Volume: 56 Issue: 2 Pages: 261-274
  • DOI: 10.1016/j.molcel.2014.08.007
  • Peer Reviewed
• [Journal Article] Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway (2014)
  • Author(s): Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, and Komatsu M.
  • Journal Title: J Biol Chem Volume: 289 Issue: 36 Pages: 24944-24955
  • DOI: 10.1074/jbc.m114.580357
  • Peer Reviewed / Open Access
• [Journal Article] Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes. (2014)
  • Author(s): Kim, J., Cheon, H., Jeong, YT., Quan ,W., Kim, KH., Cho, JM., Lim, YM., Oh, SH., Jin, SM., Kim, JH., Lee, MK., Kim, S., Komatsu, M., Kang, SW., *Lee, MS.
  • Journal Title: J. Clin. Invest. Volume: 124 Issue: 8 Pages: 3311-3324
  • DOI: 10.1172/jci69625
  • Peer Reviewed
• [Journal Article] Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression. (2014)
  • Author(s): Liu, Z., Chen, P., Gao, H., Gu, Y., Yang, J., Peng, H., Xu, X., Wang, H., Yang, M., Liu, X., Fan, L., Chen, S., Zhou, J., Sun, Y., Ruan, K., Cheng, S., Komatsu, M., White, E., Li, L., Ji, H., Finley, D., *Hu, R.
  • Journal Title: Cancer Cell Volume: 26 Issue: 1 Pages: 106-120
  • DOI: 10.1016/j.ccr.2014.05.015
  • Peer Reviewed
• [Journal Article] Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. (2014)
  • Author(s): Oliva Trejo JA, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y.
  • Journal Title: Biochemical and biophysical research communications Volume: 446(4) Issue: 4 Pages: 1190-1196
  • DOI: 10.1016/j.bbrc.2014.03.088
  • Peer Reviewed / Open Access
• [Journal Article] Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures. (2014)
  • Author(s): Lystad, AH., Ichimura, Y., Takagi, K., Yang, Y., Pankiv, S., Kanegae, Y., Kageyama, S., Suzuki, M., Saito, I., Mizushima,T., *Komatsu, M., *Simonsen, A.
  • Journal Title: EMBO Rep. Volume: 15 Issue: 5 Pages: 557-565
  • DOI: 10.1002/embr.201338003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A cluster of thin tubular structures mediates transformation of the endoplasmic reticulum to autophagic isolation membrane (2014)
  • Author(s): Uemura T, Yamamoto M, Kametaka A, Sou YS, Yabashi A, Yamada A, Annoh H, Kametaka S, Komatsu M, Waguri S
  • Journal Title: Molecular and Cellular Biology Volume: 34 Issue: 9 Pages: 1695-1706
  • DOI: 10.1128/mcb.01327-13
  • Peer Reviewed / Open Access
• [Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy. (2014)
  • Author(s): Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y.
  • Journal Title: Biochem Biophys Res Commun. Volume: 446 Issue: 1 Pages: 309-315
  • DOI: 10.1016/j.bbrc.2014.02.093
  • Peer Reviewed
• [Journal Article] Dissection of the role of p62/Sqstml in activation of Nrf2 during xenophagy. (2014)
  • Author(s): Ishimura, R., Tanaka, K., and Komatsu, M.
  • Journal Title: FEBS Lett. Volume: 588 Issue: 5 Pages: 822-828
  • DOI: 10.1016/j.febslet.2014.01.045
  • Peer Reviewed
• [Journal Article] PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. (2014)
  • Author(s): Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Ueno T.
  • Journal Title: Autophagy Volume: 10 Issue: 4 Pages: 631-41
  • DOI: 10.4161/auto.27785
  • Peer Reviewed
• [Journal Article] Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria. (2013)
  • Author(s): Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
  • Journal Title: Mol Cell Volume: 52 Pages: 794-804
  • Peer Reviewed
• [Journal Article] Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. (2013)
  • Author(s): Torisu T, Torisu K, Lee IH, Liu J, Malide D, Combs CA, Wu XS, Rovira II, Fergusson MM, Weigert R, Connelly PS, Daniels MP, Komatsu M, Cao L, Finkel T.
  • Journal Title: Nat Med. Volume: 19 Issue: 10 Pages: 1281-1287
  • DOI: 10.1038/nm.3288
  • Peer Reviewed
• [Journal Article] Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. (2013)
  • Author(s): Bonilla DL, Bhattacharya A, Sha Y, Xu Y, Xiang Q, Kan A, Jagannath C, Komatsu M, Eissa NT.
  • Journal Title: Immunity Volume: 39 Pages: 534-547
  • Peer Reviewed
• [Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013)
  • Author(s): Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M.
  • Journal Title: Mol Cell Volume: 51 Pages: 618-631
  • Peer Reviewed
• [Presentation] オートファジー欠損マウスからわかったこと (2018)
  • Author(s): 小松雅明
  • Organizer: 第5回JCVP学術集会
  • Invited
• [Presentation] 選択的オートファジーによる転写制御：ストレス応答と脂肪酸酸化 (2018)
  • Author(s): 小松雅明
  • Organizer: 第1回オルガネラゾーン研究会
  • Invited
• [Presentation] 選択的オートファジー、その異常と疾患 (2018)
  • Author(s): 小松雅明
  • Organizer: ユビキチン研究会
  • Invited
• [Presentation] オートファジー欠損マウスからわかったこと (2017)
  • Author(s): 小松雅明
  • Organizer: 疾患細胞生物研究会
  • Place of Presentation: 徳島大学（徳島県徳島市）
  • Year and Date: 2017-03-23
  • Invited
• [Presentation] オートファジー欠損マウスからわかったこと (2017)
  • Author(s): 小松雅明
  • Organizer: 第33回高峰カンファレンス
  • Place of Presentation: 如水会館（東京都千代田区）
  • Year and Date: 2017-03-13
  • Invited
• [Presentation] 肝特異的オートファジー欠損マウスからわかったこと：オートファジーの異常とがん (2017)
  • Author(s): 小松雅明
  • Organizer: 第１３回酸化ストレスと肝研究会
  • Place of Presentation: ホテルレオパレス博多(福岡県福岡市）
  • Year and Date: 2017-02-02
  • Invited
• [Presentation] オートファジー関連タンパク質修飾システム：その異常と病態 (2017)
  • Author(s): 小松雅明
  • Organizer: 国際高等研究所プロジェクト「生命活動を生体高分子への修飾から俯瞰する」
  • Place of Presentation: 国際高等研究所（京都府木津川市）
  • Year and Date: 2017-01-23
  • Invited
• [Presentation] オートファジーとがん代謝解析：メタボローム解析からわかったこと (2017)
  • Author(s): 小松雅明
  • Organizer: 第33回Wakoワークショップ
  • Invited
• [Presentation] Regulation of transcription factors through selective autophagy (2017)
  • Author(s): Masaaki Komatsu
  • Organizer: The First International Conference on Autophagy and Liver Diseases
  • Int'l Joint Research / Invited
• [Presentation] オートファジー欠損マウスからわかったこと (2017)
  • Author(s): 小松雅明
  • Organizer: 第57回日本臨床化学会年次学術集会
  • Invited
• [Presentation] p62/Sqstm1, friend or foe? (2017)
  • Author(s): Masaaki Komatsu
  • Organizer: EMBO Conference"Autophagy: From molecular principles to human diseases"
  • Int'l Joint Research / Invited
• [Presentation] 肝特異的オートファジー欠損マウスからわかったこと (2017)
  • Author(s): 小松雅明
  • Organizer: 第17回肝疾患フォーラム
  • Invited
• [Presentation] オートファジー欠損マウスから分かったこと (2017)
  • Author(s): 小松雅明
  • Organizer: 第17回Niigata Bone Research Conference
  • Invited
• [Presentation] オートファジー欠損マウスから分かったこと (2017)
  • Author(s): 小松雅明
  • Organizer: 日本外科代謝栄養学会第54回学術集会
  • Invited
• [Presentation] Autophagy-specific substrates, p62 and NBR1 serve as driver gene products on hepatocellular carcinoma (2017)
  • Author(s): Masaaki Komatsu
  • Organizer: The 8th International Symposium on Autophagy
  • Int'l Joint Research / Invited
• [Presentation] オートファジー選択的基質p62/SQSTM1によるがん代謝再編成 (2016)
  • Author(s): 小松雅明
  • Organizer: 日本生化学会 シンポジウム オートファジーのマシナリーと機能
  • Place of Presentation: 仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
  • Year and Date: 2016-09-24
  • Invited
• [Presentation] 肝特異的オートファジー欠損マウスからわかったこと (2016)
  • Author(s): 小松雅明
  • Organizer: 第25回日本肝臓医生物学研究会
  • Place of Presentation: NASPAニューオータニ（新潟県湯沢町）
  • Year and Date: 2016-09-17
  • Invited
• [Presentation] Pathophysiological roles of autophagy in mice (2016)
  • Author(s): Komatsu M.
  • Organizer: International Symposium of the Center for Animal Disease Models 2016
  • Place of Presentation: 東京ガーデンパレス（東京都文京区）
  • Year and Date: 2016-07-16
  • Invited
• [Presentation] オートファジーの異常と疾患 (2016)
  • Author(s): 小松雅明
  • Organizer: 第35回分子病理研究会
  • Place of Presentation: 慶應義塾大学（神奈川県横浜市）
  • Year and Date: 2016-07-15
  • Invited
• [Presentation] p62/Sqstm1 regulates glucose and glutamine metabolisms through a transcription-factor NRF2 (2016)
  • Author(s): 小松雅明
  • Organizer: 第4回がんと代謝研究会
  • Place of Presentation: かごしま県民交流センター（鹿児島県鹿児島市）
  • Year and Date: 2016-07-07
  • Invited
• [Presentation] p62/Sqstm1 regulates glucose and glutamine metabolisms through a transcription-factor NRF2 (2016)
  • Author(s): Komatsu M.
  • Organizer: Keystone Symposium on Autophagy: Molecular and Physiological Mechanism
  • Place of Presentation: ウイスラー（カナダ）
  • Year and Date: 2016-06-05
  • Int'l Joint Research / Invited
• [Presentation] Autophagy defect and tumor development in mouse livers (2016)
  • Author(s): Komatsu M.
  • Organizer: Cold Spring Harbor Asia Ubiquitin Family Autophagy and Diseases
  • Place of Presentation: 蘇州（中国）
  • Year and Date: 2016-04-18
  • Int'l Joint Research / Invited
• [Presentation] Metabolic reprogramming in human hepatocellular carcinoma by p62/SQSTM1 (2016)
  • Author(s): Komatsu M.
  • Organizer: 2016 Minisymposium on Autophagy
  • Place of Presentation: 台北（台湾）
  • Year and Date: 2016-04-15
  • Invited
• [Presentation] Autophagy defect and tumor development in mouse livers (2016)
  • Author(s): Komatsu M.
  • Organizer: APASL STC 2016
  • Place of Presentation: プサン（韓国）
  • Year and Date: 2016-04-09
  • Int'l Joint Research / Invited
• [Presentation] オートファジー：その異常と疾患 (2016)
  • Author(s): 小松雅明
  • Organizer: 第11回レドックス・ライフイノベーションシンポジウム
  • Place of Presentation: お茶の水女子大学（東京都文京区）
  • Year and Date: 2016-03-17
  • Invited
• [Presentation] Metabolic reprogramming in human hepatocellular carcinoma by p62/SQSTM1 (2015)
  • Author(s): 小松雅明
  • Organizer: BMB2015 シンポジウム
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-11-30
  • Invited
• [Presentation] Metabolic reprogramming in human hepatocellular carcinoma by p62/SQSTM1 (2015)
  • Author(s): Masaaki Komatsu
  • Organizer: American Association for the study of Liver Diseases (AALD) Basic Science Symposium: Autophagy in the Liver
  • Place of Presentation: サンフランシスコ（アメリカ）
  • Year and Date: 2015-11-14
  • Int'l Joint Research / Invited
• [Presentation] Metabolic reprogramming in human hepatocellular carcinoma by p62/SQSTM1 (2015)
  • Author(s): Masaaki Komatsu
  • Organizer: Joint Korea-Japan Symposium on Autophagy (A3)
  • Place of Presentation: ソウル（韓国）
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] オートファジーその異常とがん代謝 (2015)
  • Author(s): 小松雅明
  • Organizer: 第39回日本鉄バイオサイエンス学会 特別講演
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市）
  • Year and Date: 2015-08-29
  • Invited
• [Presentation] p62/SQSTM1はNRF2依存的な代謝適応を介して肝細胞がんの悪性化を促進する (2015)
  • Author(s): 小松雅明
  • Organizer: 第3回がんと代謝研究会
  • Place of Presentation: 石川県立音楽堂交流ホール（石川県金沢市）
  • Year and Date: 2015-07-16
• [Presentation] Metabolic reprogramming in autophagy-deficient tumors and HCC (2015)
  • Author(s): Masaaki Komatsu
  • Organizer: 3rd International Symposium on RCCH
  • Place of Presentation: ソウル（韓国）
  • Year and Date: 2015-06-19
  • Invited
• [Presentation] オートファジー欠損マウスから見えてきたがん代謝 (2015)
  • Author(s): 小松雅明
  • Organizer: 日本肝臓学会 サテライト 第51回肝形態学研究会
  • Place of Presentation: ホテル日航熊本（熊本県熊本市）
  • Year and Date: 2015-05-19
  • Invited
• [Presentation] Metabolic reprogramming in human hepatocellular carcinoma by p62/SQSTM1 (2015)
  • Author(s): Masaaki Komatsu
  • Organizer: The 7th International Symposium on Autophagy 2015
  • Place of Presentation: Smoky Willow, Huangshan, China
  • Year and Date: 2015-03-19 – 2015-03-23
  • Invited
• [Presentation] オートファジーによる生体防御 (2014)
  • Author(s): 小松雅明
  • Organizer: 第33回日本認知症学会学術集会（シンポジウム）
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-29 – 2014-12-01
  • Invited
• [Presentation] オートファジーの異常と代謝変動 (2014)
  • Author(s): 小松雅明
  • Organizer: 第37回日本分子生物学会年（ワークショップ）
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] オートファジーの異常と代謝変動 (2014)
  • Author(s): 小松雅明
  • Organizer: 第87回日本生化学会大会 （シンポジウム）
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-10-15 – 2014-10-18
  • Invited
• [Presentation] Persistent activation of Nrf2 through autophagy-specific substrate p62 in HCC (2014)
  • Author(s): Masaaki Komatsu
  • Organizer: 第73回日本癌学会学術総会（シンポジウム）
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] オートファジーが司る転写因子群による代謝制御機構 (2014)
  • Author(s): 小松雅明
  • Organizer: 第19回日本病態プロテアーゼ学会学術集会（ワークショップ）
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 2014-08-08 – 2014-08-09
  • Invited
• [Presentation] Coupling of the Keap1-Nrf2 System to Autophagy (2014)
  • Author(s): Masaaki Komatsu
  • Organizer: Cold Spring Harbor Asia Conferences Protein Modification & Homeostasis (Symposium)
  • Place of Presentation: Suzhou Dushu Lake Conference Center, Suzhou, China
  • Year and Date: 2014-06-16 – 2014-06-20
  • Invited
• [Presentation] p62のリン酸化によるオートファジーとKeap1-Nrf2システムの連動機構 (2014)
  • Author(s): 小松雅明
  • Organizer: 第66回日本細胞生物学会大会
  • Place of Presentation: 奈良県新公会堂
  • Year and Date: 2014-06-11 – 2014-06-13
• [Presentation] オートファジーとKeap1－Nrf2システムの連動機構 (2014)
  • Author(s): 小松雅明
  • Organizer: 第14回日本抗加齢医学会総会（シンポジウム）
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-06-06 – 2014-06-08
  • Invited
• [Presentation] Coupling of the Keap1-Nrf2 System to Autophagy (2014)
  • Author(s): Masaaki Komatsu
  • Organizer: 2014 Korean Society for Biochemistry and Molecular Biology (Symposium)
  • Place of Presentation: Coex, Seoul, Korea
  • Year and Date: 2014-05-14 – 2014-05-16
  • Invited
• [Presentation] Coupling of the Keap1-Nrf2 system to autophagy (2014)
  • Author(s): Masaaki Komatsu
  • Organizer: The Environmental Response 2014
  • Place of Presentation: Sendai, Japan
  • Invited
• [Presentation] Coupling of the Keap1-Nrf2 system to autophagy (2014)
  • Author(s): Masaaki Komatsu
  • Organizer: Asian Pacific Association for The Study of the Liver
  • Place of Presentation: Brisbane, Australia
  • Invited
• [Presentation] Coupling of the Keap1-Nrf2 system to autophagy (2014)
  • Author(s): Masaaki Komatsu
  • Organizer: 17th Biennial Meeting of Society for Free Radical Research International
  • Place of Presentation: Kyoto, Japan
  • Invited
• [Presentation] オートファジーとKeap1-Nrf2システムの接点：その異常と主要増殖 (2013)
  • Author(s): 小松雅明
  • Organizer: 第22回日本Cell Death学会学術集会
  • Place of Presentation: 京都大学芝蘭会館
  • Invited
• [Presentation] オートファジーとKeap1-Nrf2制御系の接点：がん増殖におけるその意義 (2013)
  • Author(s): 田中啓二、小松雅明
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] オートファジーによる腫瘍抑制効果 (2013)
  • Author(s): 小松雅明
  • Organizer: 第1回がん代謝研究会
  • Place of Presentation: 慶應義塾大学先端生命科学研究所
  • Invited
• [Presentation] プロテアソーム機能不全に起因するユビキチン凝集体形成とその生理的意義 (2013)
  • Author(s): 小松雅明
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Invited
• [Remarks] 新潟大学大学院医歯学総合研究科分子生物学
  • URL: http://www.med.niigata-u.ac.jp/bc1/index.html
• [Remarks] 新学術領域研究（研究領域提案型）オートファジーの集学的研究 分子基盤から疾患まで
  • URL: http://www.proteolysis.jp/autophagy/index.html
• [Remarks] 「肝臓オートファジーの役割とその異常と肝疾患」に関する包括的な総説を発表しました
  • URL: http://www.niigata-u.ac.jp/news/2017/27691/
• [Remarks] てんかんや小頭症を伴う遺伝性重度発達障害の原因解明
  • URL: http://www.niigata-u.ac.jp/news/2016/22709/
• [Remarks] 肝臓がんを抑制する新規化合物を同定しました
  • URL: http://www.niigata-u.ac.jp/news/2016/20330/
• [Remarks] 医歯学系の小松雅明教授がトムソン・ロイターのHCRのCertificateを授与されました
  • URL: http://www.niigata-u.ac.jp/news/2016/16536/
• [Remarks] 新潟大学大学院医歯学総合研究科小松研究室
  • URL: http://www.med.niigata-u.ac.jp/bc1/welcome.html
• [Remarks]
  • URL: http://www.med.niigata-u.ac.jp/bc1/welcome.html
• [Remarks] 新潟大学大学院医歯学総合研究科 分子遺伝学講座
  • URL: http://www.med.niigata-u.ac.jp/bc1/welcome.html