| Budget Amount *help |
¥79,690,000 (Direct Cost: ¥61,300,000、Indirect Cost: ¥18,390,000)
Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2016: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2015: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2014: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2013: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
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| Outline of Final Research Achievements |
During life cycle of multicellular organisms, different cells and tissues acquire different programs of gene expression. For most of cell types in the body, programs for gene expression become fixed once the cells differentiate. However, some cells in the body undergo “reprogramming” of gene expression in normal developmental situation. In particular, the ultimate reprogramming happens after fertilization by which differentiated-cell gametes acquire totipotency as undifferentiated totipotent cells. Epigenome plays a major role in the reprogramming. In this study, we identified regulatory factors for DNA and histone methylation in mouse preimplantation embryos and partly revealed roles of these epigenome in the reprogramming.
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