| Budget Amount *help |
¥289,250,000 (Direct Cost: ¥222,500,000、Indirect Cost: ¥66,750,000)
Fiscal Year 2017: ¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2016: ¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2015: ¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2014: ¥64,870,000 (Direct Cost: ¥49,900,000、Indirect Cost: ¥14,970,000)
Fiscal Year 2013: ¥92,950,000 (Direct Cost: ¥71,500,000、Indirect Cost: ¥21,450,000)
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| Outline of Final Research Achievements |
It has been proposed that differentiation of primordial germ cells (PGCs) into eggs and sperm requires repression of somatic genes in PGCs, activation of germline genes in PGCs, and determination of PGCs sexual identity. In this study, we aim to clarify the mechanisms by which PGCs with such characteristics are formed in Drosophila. Here, we revealed the molecular mechanisms of how somatic gene expression is suppressed by maternal Nanos protein, and germline gene is activated by maternal Ovo and Mamo in PGCs. We further searched the genes working upstream and downstream of Sxl, which is required for feminization of PGCs.
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