| Budget Amount *help |
¥216,970,000 (Direct Cost : ¥166,900,000、Indirect Cost : ¥50,070,000)
Fiscal Year 2017 : ¥40,170,000 (Direct Cost : ¥30,900,000、Indirect Cost : ¥9,270,000)
Fiscal Year 2016 : ¥40,170,000 (Direct Cost : ¥30,900,000、Indirect Cost : ¥9,270,000)
Fiscal Year 2015 : ¥40,170,000 (Direct Cost : ¥30,900,000、Indirect Cost : ¥9,270,000)
Fiscal Year 2014 : ¥33,800,000 (Direct Cost : ¥26,000,000、Indirect Cost : ¥7,800,000)
Fiscal Year 2013 : ¥62,660,000 (Direct Cost : ¥48,200,000、Indirect Cost : ¥14,460,000)
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| Outline of Final Research Achievements |
Continual production of numerous sperm in the testes ensured the continuity of life. Here, spermatogenic stem cells play essential roles through giving rise to both the sperm-producing differentiating cells and the self-renewing stem cells, in a well balance manner. This study has contributed toward the understanding of the nature of spermatogenic stem cells by proposing a novel model for the stem cell dynamics, discovering a crucial change in the status of genome DNA, discovery of novel molecular mechanisms making the selfrenewal and differentiation compatible in uniform tissue environment, as well as investigating the mechanisms underlying the stem cell number regulation and post-transplantation repopulation.
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