| Budget Amount *help |
¥89,700,000 (Direct Cost: ¥69,000,000、Indirect Cost: ¥20,700,000)
Fiscal Year 2017: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2016: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2014: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2013: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
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| Outline of Final Research Achievements |
In order to elucidate the mechanism of brain aging, we conducted a study using Alzheimer's disease model mice and a study for healthy elderly people. We found that the inflammatory response in brain tissue greatly contributes to the decline in brain function due to aging. When an inflammatory reaction occurs in the brain, production of inflammatory cytokines is enhanced in glial cells (astrocytes and microglia), and the function of the cerebrovascular barrier is reduced in cerebral blood vessels. It was found that such changes reduce synaptic function in each neuron, modulate the neural network, and reduce memory function and cognitive function during aging. In order to investigate the decline mechanism of learning and memory function, we performed operant learning task fMRI study to visualize brain circuit activity of mouse, such as Alzheimer's Disease model mice.
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