| Co-Investigator(Kenkyū-buntansha) |
江島 亜樹 東京大学, 農学生命科学研究科, 特任講師 (00548571)
山崎 大介 東京大学, 定量生命科学研究所, 助教 (80588377)
廣井 誠 東京大学, 定量生命科学研究所, 助教 (80597831)
阿部 崇志 東京大学, 定量生命科学研究所, 助教 (70756824)
村上 智史 東京大学, 分子細胞生物学研究所, 助教 (10463902)
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| Budget Amount *help |
¥115,830,000 (Direct Cost: ¥89,100,000、Indirect Cost: ¥26,730,000)
Fiscal Year 2017: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
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| Outline of Final Research Achievements |
During olfactory associative learning in Drosophila, odors activate specific subsets of intrinsic mushroom body (MB) neurons. We identify two classes of intrinsic MB γ neurons, γCRE-p and γCRE-n, which encode aversive and appetitive valences and act antagonistically. The mushroom body output neurons, MBON-γ5β’2a/β’2mp and MBON-γ2α’1, mediate the actions of γCRE-p and γCRE-n neurons.
We found that a single pair of GABAergic neurons (MBON-γ1pedc) inhibits the effects of dopaminergic neurons, resulting in the suppression of aversive memory acquisition during the odor presentation in the absence of electric shocks, but not during the odor presentation when shocked and thereby prevents an insignificant stimulus from becoming an aversive unconditioned stimulus. We also found RGK1, the RGK small GTPase is accumulated at the synaptic site in the MBs and enhances memory retention by suppressing Rac-dependent memory decay.
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