• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Discovery of new molecules involved in learning and memory and study of their mode of action

Planned Research

Project AreaPrinciples of memory dynamism elucidated from a diversity of learning systems
Project/Area Number 25115010
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

IINO YUICHI  東京大学, 大学院理学系研究科(理学部), 教授 (40192471)

Co-Investigator(Kenkyū-buntansha) 饗場 篤  東京大学, 大学院医学系研究科(医学部), 教授 (20271116)
Co-Investigator(Renkei-kenkyūsha) KUNITOMO Hirofumi  東京大学, 大学院理学系研究科, 准教授 (20302812)
TOMIOKA Masahiro  東京大学, 大学院理学系研究科, 助教 (40466800)
TOYOSHIMA Yu  東京大学, 大学院理学系研究科, 助教 (10632341)
OHNO Hayao  東京大学, 大学院理学系研究科, 特任助教 (00747272)
Sato Hirofumi  東京大学, 大学院理学系研究科, 特任研究員 (40779435)
Research Collaborator WANG Lifang  東京大学, 大学院理学系研究科, 大学院生
MORI Keita  東京大学, 大学院理学系研究科, 大学院生
YANAGI Shuichi  東京大学, 大学院理学系研究科, 大学院生
SAKAI Naoko  東京大学, 大学院理学系研究科, 特任研究員
Project Period (FY) 2013-06-28 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥106,990,000 (Direct Cost: ¥82,300,000、Indirect Cost: ¥24,690,000)
Fiscal Year 2017: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2016: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2015: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2014: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2013: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Keywords線虫C.elegans / 化学走性 / インスリン/PI3キナーゼ 経路 / 遺伝子改変マウス / カルシンテニン / 学習 / 長期記憶 / TOR経路 / 線虫 / マウス / ジアシルグリセロール / TOR / インスリン/PI3キナーゼ経路 / 線虫C. elegans / インスリン/PIキナーゼ経路 / インスリン/PI3キナーゼ経路 / ホスホリパーゼC
Outline of Final Research Achievements

By using C. elegans, we tried to reveal molecular dynamics, circuit dynamics and behavioral dynamics for learning and memory. We found multiple molecular-neural mechanisms for short term memory, memory of stimulus strength, inter-cellular transfer of memory signal and single-cell differential memory.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (96 results)

All 2018 2017 2016 2015 2014 2013 Other

All Journal Article (28 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 26 results,  Open Access: 18 results,  Acknowledgement Compliant: 8 results) Presentation (66 results) (of which Int'l Joint Research: 22 results,  Invited: 10 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage2018

    • Author(s)
      Sudo Atsushi、Kanagawa Motoi、Kondo Mai、Ito Chiyomi、Kobayashi Kazuhiro、Endo Mitsuharu、Minami Yasuhiro、Aiba Atsu、Toda Tatsushi
    • Journal Title

      Human molecular genetics

      Volume: 27 Issue: 7 Pages: 1174-1185

    • DOI

      10.1093/hmg/ddy032

    • NAID

      120006459805

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans2017

    • Author(s)
      Sakai Naoko、Ohno Hayao、Tomioka Masahiro、Iino Yuichi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 5 Pages: e0177900-e0177900

    • DOI

      10.1371/journal.pone.0177900

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Luqin-like RYamide peptides regulate food-evoked responses in C. elegans2017

    • Author(s)
      Ohno H, Yoshida M, Sato T, Kato J, Miyazato M, Kojima M, Ida T, Iino Y
    • Journal Title

      Elife

      Volume: 6. pii Pages: 1-23

    • DOI

      10.7554/elife.28877

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamics of Presynaptic Diacylglycerol in a Sensory Neuron Encode Differences Between Past and Current Stimulus Intensity2017

    • Author(s)
      Ohno H, Sakai N, Adachi T, Iino Y.
    • Journal Title

      Cell Reports

      Volume: 20 Issue: 10 Pages: 2294-2303

    • DOI

      10.1016/j.celrep.2017.08.038

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel role of Rac-Mid1 signaling in medial cerebellar development.2017

    • Author(s)
      Nakamura T, Ueyama T, Ninoyu Y, Sakaguchi H, Choijookhuu N, Hishikawa Y, Kiyonari H, Kohta M, Sakahara M, de Curtis I, Kohmura E, Hisa Y, Aiba A, Saito N.
    • Journal Title

      Development

      Volume: 144 Issue: 10 Pages: 1863-1875

    • DOI

      10.1242/dev.147900

    • NAID

      120006363303

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF12017

    • Author(s)
      Kanayama Mayuko、Hayano Toshiya、Koebis Michinori、Maeda Tatsuya、Tabe Yoko、Horie Shigeo、Aiba Atsu
    • Journal Title

      Prostate

      Volume: 77 Issue: 15 Pages: 1489-1498

    • DOI

      10.1002/pros.23425

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Gustatory Neural Circuit of Caenorhabditis elegans Generates Memory-Dependent Behaviors in Na(+) Chemotaxis.2017

    • Author(s)
      Lifang Wang, Hirofumi Sato, Yohsuke Satoh, Masahiro Tomioka, Hirofumi Kunitomo and Yuichi Iino
    • Journal Title

      J Neurosci

      Volume: 37 Issue: 8 Pages: 2097-2111

    • DOI

      10.1523/jneurosci.1774-16.2017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Accurate Automatic Detection of Densely Distributed Cell Nuclei in 3D Space.2016

    • Author(s)
      Toyoshima Y, Tokunaga T, Hirose O, Kanamori M, Teramoto T, Jang MS, Kuge S, Ishihara T, Yoshida R, Iino Y.
    • Journal Title

      PLoS Comput Biol.

      Volume: 12 Issue: 6 Pages: 1-20

    • DOI

      10.1371/journal.pcbi.1004970

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor.2016

    • Author(s)
      Masahiro Tomioka, Yasuki Naito, Hidehito KUROYANAGI, and Yuichi Iino.
    • Journal Title

      Nature Communications

      Volume: - Issue: 1 Pages: 11645-11645

    • DOI

      10.1038/ncomms11645

    • NAID

      120006348540

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth2016

    • Author(s)
      Endo, M., Hattori,M., Toriyabe, H., Ohno, H., Kamiguchi, H., Iino, Y. and Ozawa, T.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 23976-23976

    • DOI

      10.1038/srep23976

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus2016

    • Author(s)
      Madoka Narushima, Motokazu Uchigashima, Yuki Yagasaki, Takeshi Harada, Yasuyuki Nagumo, Naofumi Uesaka, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata and Masanobu Kano
    • Journal Title

      Neuron

      Volume: 91 Issue: 5 Pages: 1097

    • DOI

      10.1016/j.neuron.2016.07.035

    • URL

      https://pure.teikyo.jp/en/publications/bf67227c-49b3-4c38-ae2c-6d003084e0f6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways.2016

    • Author(s)
      Kikuchi I, Takahashi-Kanemitsu A, Sakiyama N, Tang C, Tang PJ, Noda S, Nakao K, Kassai H, Sato T, Aiba A, and Hatakeyama M.
    • Journal Title

      Nat Commun

      Volume: 7 Issue: 1 Pages: 12887-12887

    • DOI

      10.1038/ncomms12887

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comprehensive behavioral phenotyping of a new semaphorin 3 F mutant mouse.2016

    • Author(s)
      Matsuda I, Shoji H, Yamasaki N, Miyakawa T, Aiba A.
    • Journal Title

      Mol Brain.

      Volume: 9(1) Issue: 1 Pages: 15-15

    • DOI

      10.1186/s13041-016-0196-4

    • NAID

      120005758427

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A possible aid in targeted insertion of large DNA elements by CRISPR/Cas in mouse zygotes.2016

    • Author(s)
      Nakao, H.;Harada, T.;Nakao, K.;Kiyonari, H.;Inoue, K.;Furuta, Y.;Aiba, A.
    • Journal Title

      Genesis

      Volume: 54 Issue: 2 Pages: 65-77

    • DOI

      10.1002/dvg.22914

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Territories of heterologous inputs onto purkinje cell dendrites are segregated by mglur1-dependent parallel fiber synapse elimination2016

    • Author(s)
      Ichikawa R, Hashimoto K, Miyazaki T, Uchigashima M, Yamasaki M, Aiba A, Kano M, Watanabe M
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 113 Issue: 8 Pages: 2282

    • DOI

      10.1073/pnas.1511513113

    • NAID

      120005828473

    • URL

      https://pure.teikyo.jp/en/publications/ef6116f6-3235-46cc-b619-656ef2bb4818

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of different behavioral components by neuropeptide and dopamine signalings in non-associative odor learning of Caenorhabditis elegans.2015

    • Author(s)
      Yamazoe-Umemoto, A.;Fujita, K.;Iino, Y.;Iwasaki, Y.;Kimura, K. D.
    • Journal Title

      Neurosci Res

      Volume: 99 Pages: 22-33

    • DOI

      10.1016/j.neures.2015.05.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for Na+ transport mechanism by a light-driven Na+ pump2015

    • Author(s)
      H. E. Kato, K. Inoue, R. Abe-Yoshizumi, Y. Kato, H. Ono, M. Konno, S. Hososhima, T. Ishizuka, M. R. Hoque, H. Kunitomo, J. Ito, S. Yoshizawa, K. Yamashita, M. Takemoto, T. Nishizawa, R. Taniguchi, K. Kogure, A. D. Maturana, Y. Iino, H. Yawo, R. Ishitani, H. Kandori*, O. Nureki*
    • Journal Title

      Nature

      Volume: 未定 Issue: 7550 Pages: 48-53

    • DOI

      10.1038/nature14322

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi2015

    • Author(s)
      Hamakawa M, Uozumi T, Ueda N, Iino Y & Hirotsu T
    • Journal Title

      BMC Biology

      Volume: 13 Issue: 1 Pages: 6-6

    • DOI

      10.1186/s12915-015-0114-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] シナプスにおけるインスリン/PI3K経路と記憶学習-インスリン経路が線虫の味覚学習を制御する仕組み-2015

    • Author(s)
      富岡征大・飯野雄一
    • Journal Title

      糖尿病学

      Volume: xxxx

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Cdc42 is critical for cartilage development during endochondral ossification.2015

    • Author(s)
      Suzuki W, Yamada A, Aizawa R, Suzuki D, Kassai H, Harada T, Nakayama M, Nagahama R, Maki K, Takeda S, Yamamoto M, Aiba A, Baba K, Kamijo R
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 1 Pages: 314-322

    • DOI

      10.1210/en.2014-1032

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Generation of cloned mice from adult neurons by direct nuclear transfer.2015

    • Author(s)
      Mizutani E, Oikawa M, Kassai H, Inoue K, Shiura H, Hirasawa R, Kamimura S, Matoba S, Ogonuki N, Nagatomo H, Abe K, Wakayama T, Aiba A, Ogura A
    • Journal Title

      Biology of Reproduction

      Volume: 92 Issue: 3 Pages: 1-11

    • DOI

      10.1095/biolreprod.114.123455

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans2014

    • Author(s)
      Ohno H, Kato S, Naito Y, Kunitomo H, Tomioka M, Iino Y.
    • Journal Title

      Science

      Volume: 345 Issue: 6194 Pages: 313-7

    • DOI

      10.1126/science.1250709

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Experience-Dependent Bidirectional Chemotaxis by a Neural Circuit Switch in Caenorhabditis elegans2014

    • Author(s)
      Yohsuke Satoh, Hirofumi Sato, Hirofumi Kunitomo, Xianfeng Fei, Koichi Hashimoto, Yuichi Iino
    • Journal Title

      The Journal of Neuroscience

      Volume: 34 Issue: 47 Pages: 15631-15637

    • DOI

      10.1523/jneurosci.1757-14.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カルシンテニンに依存したシナプス領域のインスリン/PI3K経路の活性化が線虫の学習を制御する2014

    • Author(s)
      大野速雄・富岡征大・飯野雄一
    • Journal Title

      実験医学

      Volume: 32 Pages: 3094-7

    • Related Report
      2014 Annual Research Report
  • [Journal Article] The glutamate receptor GluN2 subunit regulates synaptic trafficking of AMPA receptors in the neonatal mouse brain2014

    • Author(s)
      Hamada, S., Ogawa, I., Yamasaki, M., Kiyama, Y., Watabe, A. M., Kassai, H., Nakano, K., Aiba, A., Watanabe, M. and Manabe, T.
    • Journal Title

      European Journal of Neuroscience

      Volume: 40 Issue: 8 Pages: 3136-3146

    • DOI

      10.1111/ejn.12682

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain2014

    • Author(s)
      Uesaka N, Uchigashima,M, Mikuni T, Nakazawa T, Nakao H, Hirai K, Aiba A, Watanabe M, Kano M
    • Journal Title

      Science

      Volume: 344 Issue: 6187 Pages: 1020-1023

    • DOI

      10.1126/science.1252514

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Selective Activation of mTORC1 Signaling Recapitulates Microcephaly, Tuberous Sclerosis, and Neurodegenerative Diseases2014

    • Author(s)
      Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A
    • Journal Title

      Cell Reports

      Volume: 7 Issue: 5 Pages: 1626

    • DOI

      10.1016/j.celrep.2014.04.048

    • URL

      https://pure.teikyo.jp/en/publications/d714d3c6-814c-403f-81f6-3d5a4a38414b

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle.2014

    • Author(s)
      Takenaka N, Yasuda N, Nihata Y, Hosooka T, Noguchi T, Aiba A, Satoh T.
    • Journal Title

      Cell Signal.

      Volume: 26 Issue: 11 Pages: 2460-2469

    • DOI

      10.1016/j.cellsig.2014.07.002

    • NAID

      120006895710

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Generation and characterization of calsyntenin triple knockout mice2018

    • Author(s)
      Keita Mori, Michinori Koebisu, Shizuka Kobayashi, Yuji Kiyama, Toshiya Manabe, Atsu Aiba, Yuichi Iino
    • Organizer
      "Principles of memory dynamism elucidated from a diversity of learning systems"2018 Workshop & Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] Roles of the CLC chloride channel CLH-1 in salt chemotaxis learning of Caenorhabditis elegans2018

    • Author(s)
      Park ChanHyun(パク チャンヒョン)、櫻井裕樹、飯野雄一、國友博文
    • Organizer
      新学術領域研究「多様性から明らかにする記憶ダイナミズムの共通原理」2018 Workshop & Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] The DAF-16/FOXO transcription factor controls associative learning in C. elegans2018

    • Author(s)
      Takashi Nagashima, Masahiro Tomioka, Yuichi Iino
    • Organizer
      新学術領域研究「多様性から明らかにする記憶ダイナミズムの共通原理」2018 Workshop & Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] E3 ubiquitin ligases regulate taste avoidance learning in C. elegans2018

    • Author(s)
      Yasuaki Ike, Tao Jiang, Masahiro Tomioka, Yuichi Iino.
    • Organizer
      新学術領域研究「多様性から明らかにする記憶ダイナミズムの共通原理」2018 Workshop & Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of behavioral plasticity by insulin-like signaling in C. elegans2018

    • Author(s)
      Masahiro TOMIOKA and Yuichi IINO
    • Organizer
      新学術領域研究「多様性から明らかにする記憶ダイナミズムの共通原理」2018 Workshop & Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] Roles of the ClC chloride channel clh-1 in salt chemotaxis learning of Caenorhabditis elegans.2017

    • Author(s)
      ChanHyun Park, Yuki Sakurai, Yuichi Iino, Hirofumi Kunitomo
    • Organizer
      第17回東京大学生命科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Long-lasting memory of salt chemotaxis learning in C. elegans2017

    • Author(s)
      Shuichi Yanagi, Mai Uemura, Yuichi Iino, Hirofumi Kunitomo
    • Organizer
      37th Blankenese Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular and neural circuit mechanisms for experience-dependent behavioral switching in C. elegans2017

    • Author(s)
      YUICHI IINO
    • Organizer
      37th Blankenese Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiple isoforms of the DAF-16/FOXO transcription factor regulate taste avoidance learning2017

    • Author(s)
      Takashi NAGASHIMA, Masahiro TOMIOKA, Yuichi IINO
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of the CLC chloride channel clh-1 in food-associated salt chemotaxis learning of Caenorhabditis elegans.2017

    • Author(s)
      ChanHyun Park, Yuki Sakurai, Yuichi Iino, Hirofumi Kunitomo
    • Organizer
      21st International C. elegans conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of neurons and analysis of the neural circuit involved in the learned salt-avoidance behavior in C. elegans.2017

    • Author(s)
      M.S. Jang, Y. Toyoshima, H. Kunitomo, Y. Iino
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A versatile insulin-like signaling regulates taste avoidance learning2017

    • Author(s)
      Masahiro Tomioka and Yuichi Iino
    • Organizer
      21st International C. elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diacylglycerol encodes differences between past and current stimulus intensity2017

    • Author(s)
      Hayao Ohno, Naoko Sakai, Takeshi Adachi, and Yuichi Iino
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple isoforms of a DAF-16/FOXO transcription factor are involved in learning and memory in C. elegans2017

    • Author(s)
      Takashi NAGASHIMA, Masahiro TOMIOKA, Yuichi IINO
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A versatile role of insulin-like signaling in learning behavior in C. elegans2017

    • Author(s)
      Masahiro Tomioka, Takashi Nagashima, Mai Goyashiki, Yuichi Iino
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Generation and characterization of calsyntenin triple knockout mice2017

    • Author(s)
      森 啓太、古戎 道典、大野 速雄 、小林静香、真鍋俊也、饗場 篤、飯野 雄一
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多彩なインスリン様シグナル伝達により制御されるC. elegansの学習記憶2017

    • Author(s)
      富岡 征大、永嶋 宇、後屋敷 舞、飯野 雄一
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 哺乳類におけるカルシンテニンの機能:トリプルノックアウト マウスを用いた解析2017

    • Author(s)
      森 啓太、古戎 道典、小林 静香、城山 優冶、真鍋 俊也、饗場 篤、飯野 雄一
    • Organizer
      ConBio2017(第40回日本分子生物学会年会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫 C. エレガンスの塩濃度の記憶と走化性の分子・神経機構2017

    • Author(s)
      國友博文、佐藤博文、飯野雄一
    • Organizer
      次世代脳プロジェクト・冬のシンポジウム4領域合同若手シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] The role of insulin-like signaling in learning behavior in C. elegans2017

    • Author(s)
      Masahiro Tomioka
    • Organizer
      JSPS Core-to-Core Project International Seminar
    • Place of Presentation
      東京大学(東京都・文京区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of the insulin-like signaling pathway in learning in C. elegans2017

    • Author(s)
      Masahiro Tomioka, Takashi Nagashima, Yuichi Iino
    • Organizer
      Gordon Research Conferences IGF & Insulin System in Physiology & Disease
    • Place of Presentation
      Ventura Beach Marriott ( CA, U.S.A.)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Generation and characterization of calsyntenin triple knockout mice2017

    • Author(s)
      Keita Mori, Michinori Koebis, Hayao Ohno, Shizuka Kobayashi, Toshiya Manabe, Atsu Aiba, Yuichi Iino
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 線虫C. エレガンスの摂食状態に依存した行動変化を司る分子機構2016

    • Author(s)
      大野速雄、井田隆徳、加藤紳也、内藤泰樹、國友博文、富岡征大、飯野雄一
    • Organizer
      第30回日本糖尿病・肥満動物学会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A neural circuit for memory-dependent Na+ chemotaxis dissected in Caenorhabditis elegans2016

    • Author(s)
      Lifang WANG, Hirofumi Sato, Yohsuke Sato, Masahiro Tomioka, Hirofumi Kunitomo, Yuichi Iino
    • Organizer
      17th International Symposium on Olfaction and Taste (ISOT2016)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線虫C. elegansのClC型クロライドチャネルclh-1の塩走性学習における機能の解明2016

    • Author(s)
      Park ChanHyun、櫻井祐樹、飯野 雄一、國友博文
    • Organizer
      第46回日本神経精神薬理学会年会
    • Place of Presentation
      COEX(韓国・ソウル)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Diacylglycerol encodes differences between past and current stimulus intensity2016

    • Author(s)
      Hayao Ohno and Yuichi Iino
    • Organizer
      CeNeuro2016 (C. elegans Topic Meeting: NEURONAL DEVELOPMENT, SYNAPTIC FUNCTION & BEHAVIOR)
    • Place of Presentation
      名古屋大学豊田講堂(愛知県・名古屋市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The ClC chloride channel CLH-1 is required for salt chemotaxis learning of Caenorhabditis elegans2016

    • Author(s)
      ChanHyunPark, Yuki Sakurai, Hirofumi Kunitomo, Yuichi Iino
    • Organizer
      CeNeuro2016 (C. elegans Topic Meeting: NEURONAL DEVELOPMENT, SYNAPTIC FUNCTION & BEHAVIOR)
    • Place of Presentation
      名古屋大学豊田講堂(愛知県・名古屋市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of DAF-16/FOXO, a transcription factor that is involved in learning and memory in C. elegans2016

    • Author(s)
      Takashi Nagashima, Masahiro Tomioka, Yuichi Iino
    • Organizer
      CeNeuro2016 (C. elegans Topic Meeting: NEURONAL DEVELOPMENT, SYNAPTIC FUNCTION & BEHAVIOR)
    • Place of Presentation
      名古屋大学豊田講堂(愛知県・名古屋市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecules and the neural circuit for switching the chemosensory behavior in C. elegans2016

    • Author(s)
      Yuichi Iino
    • Organizer
      NSF-AMED Workshop: Comparative Principles of Brain Architecture and Functions
    • Place of Presentation
      Marriott Marquis San Diego Marina, San Diego, U.S.A.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 線虫C. elegansのClC型クロライドチャネルclh-1の塩濃度走性における機能の解明 (Roles of the ClC chloride channel clh-1 in salt chemotaxis learning of Caenorhabditis elegans)2016

    • Author(s)
      ChanHyun Park, Yuki Sakurai, Hirofumi Kunitomo, Yuichi Iino
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 線虫C. elegansの学習・記憶におけるDAF-16/FOXO転写因子の役割2016

    • Author(s)
      永嶋宇、富岡征大、飯野雄一
    • Organizer
      第39回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 線虫C. elegansのインスリン/PI3K経路による飢餓学習の制御機構の解析2016

    • Author(s)
      池 泰明、姜 涛、富岡 征大、飯野 雄一
    • Organizer
      第39回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Roles of FOXO transcription factor in taste avoidance learning in C. elegans2016

    • Author(s)
      Takashi NAGASHIMA, Masahiro TOMIOKA, Yuichi IINO
    • Organizer
      The 15th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      九州大学(福岡県・福岡市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of a regulatory mechanism of taste avoidance learning in C. elegans2016

    • Author(s)
      Yasuaki Ike, Tao Jiang, Masahiro Tomioka, Yuichi Iino
    • Organizer
      The 15th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP)
    • Place of Presentation
      九州大学(福岡県・福岡市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線虫C.エレガンスの塩濃度の記憶と走化性の分子・神経機構2015

    • Author(s)
      國友博文、飯野雄一
    • Organizer
      包括脳冬のシンポジウム
    • Place of Presentation
      一橋大学一橋講堂学術総合センター(東京都千代田区)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 線虫の化学走性における定位行動の神経機構2015

    • Author(s)
      佐藤陽介、佐藤博文、國友博文、飯野雄一
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第82回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 線虫C. elegansの記憶学習に関わるDAF-16/FOXO転写因子の解析2015

    • Author(s)
      永嶋宇、富岡征大、飯野雄一
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第80回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Roles of a ClC chloride channel CLH-1, which is required for salt chemotaxis of Caenorhabditis elegans.2015

    • Author(s)
      桜井裕樹、朴燦賢、飯野雄一、國友博文
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第82回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 線虫C. elegansの飢餓学習において餌情報を伝達するインスリン様ペプチドの探索2015

    • Author(s)
      後屋敷舞、富岡征大、飯野雄一
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第82回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 線虫C. elegansの糖濃度走性を制御する神経機構の解析2015

    • Author(s)
      片江 圭太、富岡 征大、上岡 雄太郎、飯野 雄一
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第82回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 線虫C. elegansのインスリン/PI3キナーゼ経路による塩濃度学習の制御機構の解析2015

    • Author(s)
      池 泰明、姜 涛、富岡 征大、飯野 雄一
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第82回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dissecting the roles of primary interneurons that regulate memory-dependent salt concentration chemotaxis.2015

    • Author(s)
      Hirofumi Kunitomo, Hirofumi Sato, Yohsuke Satoh, and Yuichi Iino
    • Organizer
      20th International C. elegans Meeting
    • Place of Presentation
      Los Angeles, U.S.A.
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo imaging of diacylglycerol signaling in a taste receptor neuron involved in salt-concentration memory2015

    • Author(s)
      H. Ohno, Y. Iino
    • Organizer
      20th International C. elegans Meeting
    • Place of Presentation
      Los Angeles, U.S.A.
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A gustatory neural circuit for experience-dependent salt chemotaxis in C. elegans2015

    • Author(s)
      Hirofumi Sato, Hirofumi Kunitomo, Xianfeng Fei, Koichi Hashimoto, Yuichi Iino
    • Organizer
      20th International C. elegans Meeting
    • Place of Presentation
      Los Angeles, U.S.A.
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TOR signaling pathway is involved in regulation of salt chemotaxis learning.2015

    • Author(s)
      Naoko Sakai, Masahiro Tomioka, Hayao Ohno, Hirofumi Kunitomo, Yuichi Iino.
    • Organizer
      20th International C. elegans Meeting
    • Place of Presentation
      Los Angeles, U.S.A.
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Neural Circuit of Caenorhabditis elegans for Memory-Dependent Na+ Chemotaxis2015

    • Author(s)
      L. WANG, M. TOMIOKA, H. KUNITOMO, Y. IINO
    • Organizer
      20th International C. elegans Meeting
    • Place of Presentation
      Los Angeles, U.S.A.
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular and Neural Circuit Mechanisms for Experience-Dependent Modulation of Chemotaxis2015

    • Author(s)
      Yuichi Iino
    • Organizer
      Gordon Research Conference "Modulation of Neural Circuits & Behavior"
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2015-06-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Memory formation by axonal transport of an insulin receptor isoform in Caenorhabditis elegans2015

    • Author(s)
      Yuichi Iino
    • Organizer
      AND Mini Conference
    • Place of Presentation
      KKR熱海(熱海市)
    • Year and Date
      2015-01-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 線虫の経験塩濃度依存的な行動を制御する神経回路の解明2014

    • Author(s)
      佐藤 博文
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線虫C. elegans の記憶学習に関わるジアシルグリセロールのin vivoイメージング2014

    • Author(s)
      大野 速雄
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線虫C. elegans の塩濃度学習におけるモノアミン神経伝達物質の働き2014

    • Author(s)
      川崎 瑞己
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線虫C. elegans の糖濃度連合学習に関わる遺伝子の探索2014

    • Author(s)
      内山 千紘
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線虫C. elegans の糖濃度走性に潜む行動戦略の解析2014

    • Author(s)
      片江 圭太
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線虫C. elegans を用いた塩走性学習の長期記憶形成2014

    • Author(s)
      植村 舞
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] CRISPR/Cas9システムを用いたノックインマウスの作製2014

    • Author(s)
      中尾 晴美, 中尾 和貴, 原田 武志, 清成 寛, 古田 泰秀, 沼野 利佳, 饗場 篤
    • Organizer
      第37回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Axonal transport of insulin receptor in the salt-sensing neuron mediates taste avoidance learning in C. elegans2014

    • Author(s)
      Yuichi Iino
    • Organizer
      The 12th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2014-11-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 遺伝子操作による精神疾患モデル動物の作製2014

    • Author(s)
      饗場 篤
    • Organizer
      第33回 躁うつ病薬理生化学的懇話会
    • Place of Presentation
      大丸別荘(福岡県筑紫野市)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function2014

    • Author(s)
      A. Aiba
    • Organizer
      8th International Meeting on Metabotropic Glutamate Receptors
    • Place of Presentation
      Sicily, ITALY
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dissecting the roles of primary interneurons that regulate memory-dependent navigation behavior in C. elegans2014

    • Author(s)
      Hirofumi Kunitomo
    • Organizer
      2014 Cold Spring Harbor Asia Conference, Neurobiology: Diverse Species & Conserved Principles
    • Place of Presentation
      Suzhou/China
    • Year and Date
      2014-09-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combinatorial expression of evolutionally conserved RNA binding proteins determines neuron-type specific alternative splicing of the daf-2 insulin/IGF receptor in C. elegans2014

    • Author(s)
      Masahiro Tomioka
    • Organizer
      2014 C. elegans Development, Cell Biology & Gene Expression Meeting in association with The 6th Asia-Pacific C. elegans Meeting
    • Place of Presentation
      Nara Prefectural New Public Hall, Nara
    • Year and Date
      2014-07-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of ASE Left Gustatory Sensory Neuron in worms’ behavior of NaCl Chemotaxis2014

    • Author(s)
      Lifang WANG
    • Organizer
      2014 C. elegans Development, Cell Biology & Gene Expression Meeting in association with The 6th Asia-Pacific C. elegans Meeting
    • Place of Presentation
      Nara Prefectural New Public Hall, Nara
    • Year and Date
      2014-07-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neural basis of plasticity and bidirectionality of klinotaxis2014

    • Author(s)
      Yohsuke Satoh
    • Organizer
      2014 C. elegans Development, Cell Biology & Gene Expression Meeting in association with The 6th Asia-Pacific C. elegans Meeting
    • Place of Presentation
      Nara Prefectural New Public Hall, Nara
    • Year and Date
      2014-07-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identification of molecules downstream of the insulin/PI3K pathway involved in the regulation of salt chemotaxis learning2014

    • Author(s)
      Naoko Sakai
    • Organizer
      2014 C. elegans topic meeting: Neuronal Development, Synaptic Function and behavior
    • Place of Presentation
      University of Wisconsin-Madison, Wisconsin, USA
    • Year and Date
      2014-07-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neural basis of plasticity and bidirectionality of klinotaxis2014

    • Author(s)
      Yohsuke Satoh
    • Organizer
      2014 C. elegans topic meeting: Neuronal Development, Synaptic Function and behavior
    • Place of Presentation
      University of Wisconsin-Madison, Wisconsin, USA
    • Year and Date
      2014-07-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線虫の化学走性の可塑性の分子神経機構2013

    • Author(s)
      飯野雄一、大野速雄、佐藤博文、佐藤陽介、富岡征大、國友博文
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山大学(岡山市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Where to go? - Neural Circuit Mechanisms for Migration behaviours in C. elegans2013

    • Author(s)
      Yuichi Iino
    • Organizer
      UTokyo Forum 2013
    • Place of Presentation
      チリ大学(サンティアゴ、チリ)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 糖尿病学2015(6章シナプスにおけるインスリン/PI3K経路と記憶学習)2015

    • Author(s)
      富岡征大、飯野雄一
    • Total Pages
      168
    • Publisher
      診断と治療社
    • Related Report
      2015 Annual Research Report
  • [Remarks] いい思いをたどって濃い味に― 線虫の味覚記憶の発見とその神経回路の解明 ―

    • URL

      http://www.s.u-tokyo.ac.jp/ja/press/2017/5236/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2013-07-10   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi