A multidimensional analysis of chromatin dynamics in living cells by quantitative measurements and reconstruction

• Project Area: Dynamic chromatin structure and function
• Project/Area Number: 25116005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Institute of Technology (2014-2017); Osaka University (2013)
• Principal Investigator: Kimura Hiroshi 東京工業大学, 科学技術創成研究院, 教授 (30241392)
• Co-Investigator(Kenkyū-buntansha): 山縣 一夫 近畿大学, 生物理工学部, 准教授 (10361312)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥155,870,000 (Direct Cost: ¥119,900,000、Indirect Cost: ¥35,970,000); Fiscal Year 2017: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000); Fiscal Year 2016: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000); Fiscal Year 2015: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000); Fiscal Year 2014: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000); Fiscal Year 2013: ¥53,690,000 (Direct Cost: ¥41,300,000、Indirect Cost: ¥12,390,000)
• Keywords: クロマチン / ヒストン修飾 / 遺伝子発現制御 / 転写 / エピジェネティクス / 細胞核 / 遺伝子制御 / 発現制御 / 発生・分化 / ゲノム / 組織・細胞 / バイオテクノロジー / 細胞・組織 / エピジェネティクス制御 / シグナル伝達

Outline of Final Research Achievements

Chromatin dynamics plays an important role in cell regulation through the control of gene expression and genome integrity. This study aimed to reveal the significance of chromatin dynamics by quantitative measurements and reconstruction in living cells. We have developed techniques to monitor histone modification and DNA methylation in living cells, and revealed the function of histone acetylation in gene activation. This study greatly contributed to understand the basic mechanism of gene regulation in living cells.

Research Products

• [Int'l Joint Research] ケンブリッジ大学/エジンバラ大学/オックスフォード大学(英国)
• [Int'l Joint Research] マックスプランク研究所/マックスデルブリュックセンター/ヘルムホルツセンター(ドイツ)
• [Int'l Joint Research] キュリー研究所/ツールーズ大学(フランス)
• [Int'l Joint Research] ロックフェラー大学/コロラド州立大学(米国)
• [Int'l Joint Research] Max‐Delbruck Centre for Mol. Med./Max Planck Institute-CBG(ドイツ)
• [Int'l Joint Research] University of Colorado, Aurora/Colorado State University(米国)
• [Int'l Joint Research] University of Edinburgh/University of Cambridge(英国)
• [Int'l Joint Research] University of Toulouse(フランス)
• [Int'l Joint Research] Max‐Delbruck Centre for Mol. Med./Max Planck Institute-CBG(ドイツ)
• [Int'l Joint Research] The Hospital for Sick Children/The University of Toronto/Unviersity of Montreal(カナダ)
• [Int'l Joint Research] Colorado State University(米国)
• [Int'l Joint Research] University of Birmingham/University of Edinbrough(英国)
• [Int'l Joint Research] University of Toulouse(フランス)
• [Journal Article] NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence (2018)
  • Author(s): Parry AJ, Hoare M, Bihary D, Hansel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D'Santos P, Russel IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M.
  • Journal Title: Nat Commun Volume: 9 Issue: 1 Pages: 1840-1840
  • DOI: 10.1038/s41467-018-04283-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry. (2018)
  • Author(s): Ruppert JG, Samejima K, Platani M, Molina O, Kimura H, Jeyaprakash AA, Ohta S, Earnshaw WC.
  • Journal Title: EMBO J Volume: 37 Issue: 6
  • DOI: 10.15252/embj.201797677
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration (2018)
  • Author(s): Harada Akihito、Maehara Kazumitsu、Ono Yusuke、Taguchi Hiroyuki、Yoshioka Kiyoshi、Kitajima Yasuo、Xie Yan、Sato Yuko、Iwasaki Takeshi、Nogami Jumpei、Okada Seiji、Komatsu Tetsuro、Semba Yuichiro、Takemoto Tatsuya、Kimura Hiroshi、Kurumizaka Hitoshi、Ohkawa Yasuyuki
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 1400-1400
  • DOI: 10.1038/s41467-018-03845-1
  • NAID: 120006949474
  • Peer Reviewed / Open Access
• [Journal Article] HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. (2018)
  • Author(s): Jenness C, Giunta S, Muller MM, Kimura H, Muir TW, Funabiki H.
  • Journal Title: Proc Natl Acad Sci USA Volume: 115 Issue: 5
  • DOI: 10.1073/pnas.1717509115
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] H3S10ph broadly marks early-replicating domains in interphase ESCs and shows reciprocal antagonism with H3K9me2. (2018)
  • Author(s): Chen CCL, Goyal P, Karimi MM, Abildgaard MH, Kimura H, Lorincz MC.
  • Journal Title: Genome Res Volume: 28 Issue: 1 Pages: 37-51
  • DOI: 10.1101/gr.224717.117
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nucleosome stability measured in situ by automated quantitative imaging (2017)
  • Author(s): Imre L, Simandi Z, Horvath A, Fenyofalvi G, Nanasi P, Niaki EF, Hegedus E, Bacso Z, Weyemi U, Mauser R, Ausio J, Jeltsch A, Bonner W, Nagy L, Kimura H, Szabo G.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 12743-12743
  • DOI: 10.1038/s41598-017-12608-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly (2017)
  • Author(s): Atsuko Shirai, Takayuki Kawaguchi, Hideaki Shimojo, Daisuke Muramatsu, Mayumi Ishida-Yonetani, Yoshifumi Nishimura, Hiroshi Kimura, Jun-ichi Nakayama, Yoichi Shinkai
  • Journal Title: eLIFE Volume: 6
  • DOI: 10.7554/elife.25317
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair. (2017)
  • Author(s): Isobe S.Y., Nagao K., Nozaki N., Kimura H., and Obuse C.
  • Journal Title: Cell Rep. Volume: 2 Issue: 2 Pages: 297-307
  • DOI: 10.1016/j.celrep.2017.06.056
  • Peer Reviewed / Open Access
• [Journal Article] Reduction in chromosome mobility accompanies nuclear organization during early embryogenesis in Caenorhabditis elegans (2017)
  • Author(s): Arai Ritsuko、Sugawara Takeshi、Sato Yuko、Minakuchi Yohei、Toyoda Atsushi、Nabeshima Kentaro、Kimura Hiroshi、Kimura Akatsuki
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 3631-3631
  • DOI: 10.1038/s41598-017-03483-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 (2017)
  • Author(s): Taguchi H, Xie Y, Horikoshi N, Maehara K, Harada A, Nogami J, Sato K, Arimura Y, Osakabe A, Kujirai T, Iwasaki T, Semba Y, Tachibana T, Kimura H, Ohkawa Y, Kurumizaka H.
  • Journal Title: Biochemistry Volume: 56 Issue: 16 Pages: 2184-2196
  • DOI: 10.1021/acs.biochem.6b01098
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Semi-quantitative Analysis of H4K20mel Levels in Living Cells Using Mintbody (2017)
  • Author(s): Sato Y, Kimura H
  • Journal Title: Bio-protocol Volume: 7 Issue: 10
  • DOI: 10.21769/bioprotoc.2276
  • Peer Reviewed / Open Access
• [Journal Article] Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase (2017)
  • Author(s): Yamazaki Taiga、Hatano Yu、Handa Tetsuya、Kato Sakiko、Hoida Kensuke、Yamamura Rui、Fukuyama Takashi、Uematsu Takayuki、Kobayashi Noritada、Kimura Hiroshi、Yamagata Kazuo
  • Journal Title: PLoS ONE Volume: 12 Issue: 5 Pages: 1-18
  • DOI: 10.1371/journal.pone.0177764
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 3. Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array (2017)
  • Author(s): Partolina M, Thoms HC, MacLeod KG, Rodriguez-Blanco G, Clarke MN, Venkatasubramani AV, Beesoo R, Larionov V, Neergheen-Bhujun VS, Serrels B, Kimura H, Carragher NO, Kagansky A.
  • Journal Title: Cell Death Discov Volume: 3 Issue: 1 Pages: 16077-16077
  • DOI: 10.1038/cddiscovery.2016.77
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3. (2017)
  • Author(s): Kakumu E
  • Journal Title: Genes Cells. Volume: 3 Issue: 3 Pages: 310-327
  • DOI: 10.1111/gtc.12479
  • Peer Reviewed / Open Access
• [Journal Article] Reduction in chromosome mobility accompanies nuclear organization during early embryogenesis in Caenorhabditis elegans (2017)
  • Author(s): Arai R, Sugawara T, Sato Y, Minakuchi Y, Toyoda A, Nabeshima K, Kimura H, Kimura A.
  • Journal Title: Sci Rep Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis (2017)
  • Author(s): Ueda J., Harada A., Urahama T., Machida S., Maehara K., Hada M., Makino Y., Nogami J., Horikoshi N., Osakabe A., Taguchi H., Tanaka H., Tachiwana H., Yao T., Yamada M., Iwamoto T., Isotani A., Ikawa M., Tachibana T., Okada Y., Kimura H., Ohkawa Y., Kurumizaka H., Yamagata K.
  • Journal Title: Cell Reports Volume: 18(3) Issue: 3 Pages: 593-600
  • DOI: 10.1016/j.celrep.2016.12.065
  • NAID: 120006957416
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A genetically encoded probe for live-cell imaging of H4K20 monomethylation (2016)
  • Author(s): Sato Y., Kujirai T., Arai R., Asakawa H., Ohtsuki C., Horikoshi N., Yamagata K., Ueda J., Nagase T., Haraguchi T., Hiraoka Y., Kimura A., Kurumizaka H., Kimura, H.
  • Journal Title: J. Mol. Biol. Volume: 428 Issue: 20 Pages: 3885-3902
  • DOI: 10.1016/j.jmb.2016.08.010
  • Peer Reviewed / Open Access
• [Journal Article] Histone H4 lysine 20 acetylation is associated with gene repression in human cells. (2016)
  • Author(s): Kaimori, J. Y., Maehara, K., Hayashi-Takanaka, Y., Harada, A., Fukuda, M., Yamamoto, S., Ichimaru, N., Umehara, T., Yokoyama, S., Matsuda, R., Ikura, T., Nagao, K., Obuse, C., Nozaki, N., Takahara, S., Takao, T., Ohkawa, Y., Kimura, H., and Isaka, Y.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 24318-24318
  • DOI: 10.1038/srep24318
  • NAID: 120005770760
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structure and function of human histone H3.Y nucleosome. (2016)
  • Author(s): Kujirai, T., Horikoshi, N., Sato, K., Maehara, K., Machida, S., Osakabe, A., Kimura, H., Ohkawa, Y. and Kurumizaka, H.
  • Journal Title: Nucleic Acids Research Volume: 1 Issue: 13 Pages: 1-15
  • DOI: 10.1093/nar/gkw202
  • Peer Reviewed / Open Access
• [Journal Article] Tracking dynamics of histone H3 lysine 9 acetylation in Xenopus laevis tail regeneration (2016)
  • Author(s): Suzuki M, Takagi C, Miura S, Sakane Y, Sakuma T, Sakamoto N, Endo T, Kamei Y, Kimura H, Yamamoto T, Ueno N, Suzuki K
  • Journal Title: Genes to Cells Volume: Vol.21 (4) Issue: 4 Pages: 358-369
  • DOI: 10.1111/gtc.12349
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Histone H3K36 trimethylation is essential for multiple silencing mechanism in fission yeast. (2016)
  • Author(s): Shota Suzuki, Hiroaki Kato, Yutaka Suzuki, Yuji Chikashige, Yasushi Hiraoka, Hiroshi Kimura, Koji Nagao, Chikashi Obuse, Shinya Takahata and Yota Murakami
  • Journal Title: Nucleic Acids Research Volume: 44 (9) Issue: 9 Pages: 4147-4162
  • DOI: 10.1093/nar/gkw008
  • NAID: 120005819302
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis. (2016)
  • Author(s): Urahama T, Harada A, Maehara K, Horikoshi N, Sato K, Sato Y, Shiraishi K, Sugino N, Osakabe A, Tachiwana H, Kagawa W, Kimura H, Ohkawa Y, Kurumizaka H.
  • Journal Title: Epigenetics Chromatin Volume: 9 Issue: 1 Pages: 1-16
  • DOI: 10.1186/s13072-016-0051-y
  • Peer Reviewed / Open Access
• [Journal Article] ヌクレオーム解析時代の幕開け (2016)
  • Author(s): 田代 聡、木村 宏
  • Journal Title: 細胞工学 Volume: 35 Pages: 66-69
• [Journal Article] Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes. (2016)
  • Author(s): Oka M, Mura S, Yamada K, Sangel P, Hirata S, Maehara K, Kawakami K, Tachibana T, Ohkawa Y, Kimura H, Yoneda Y
  • Journal Title: eLIFE Volume: 5
  • DOI: 10.7554/elife.09540
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3. (2016)
  • Author(s): Martins NMC, Bergmann JH, Shono N, Kimura H, Larionov V, Masumoto H and Earnshaw WC.
  • Journal Title: Mol Biol Cell Volume: 27 Issue: 1 Pages: 177-196
  • DOI: 10.1091/mbc.e15-08-0605
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Behavior of Mouse Spermatozoa in the Female Reproductive Tract from Soon after Mating to the Beginning of Fertilization. (2016)
  • Author(s): Muro Y, Hasuwa H, Isotani A, Miyata H, Yamagata K, Ikawa M, Yanagimachi R, Okabe M
  • Journal Title: Biol Reprod Volume: 印刷中 Issue: 4 Pages: 80-80
  • DOI: 10.1095/biolreprod.115.135368
  • Peer Reviewed / Open Access
• [Journal Article] Generation of Hprt-disrupted rat through mouse←rat ES chimeras. (2016)
  • Author(s): Isotani A, Yamagata K, Okabe M, Ikawa M
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 24215-24215
  • DOI: 10.1038/srep24215
  • NAID: 120006957423
  • Peer Reviewed / Open Access
• [Journal Article] Micronucleus formation causes perpetual unilateral chromosome inheritance in mouse embryos. (2016)
  • Author(s): Vazquez-Diez C, Yamagata K, Trivedi S, Haverfield J, FitzHarris G
  • Journal Title: Proc Natl Acad Sci U S A Volume: 113 Issue: 3 Pages: 626-631
  • DOI: 10.1073/pnas.1517628112
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells. (2015)
  • Author(s): Dias JD, Rito T, Torlai Triglia E, Kukalev A, Ferrai C, Chotalia M, Brookes E, Kimura H, Pombo A
  • Journal Title: eLIFE Volume: 4
  • DOI: 10.7554/elife.11215
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly. (2015)
  • Author(s): Shono N, Ohzeki J, Otake K, Martins NMC, Nagase T, Kimura H, Larionov V, Earnshaw WC, Masumoto H.
  • Journal Title: J Cell Sci. Volume: 128 Issue: 24 Pages: 4572-4587
  • DOI: 10.1242/jcs.180786
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The histone chaperone DAXX maintains the structural organization of heterochromatin domains. (2015)
  • Author(s): Rapkin LM, Ahmed K, Dulev S, Li R, Kimura H, Ishov AM, Bazett-Jones DP
  • Journal Title: Epigenetics Chromatin Volume: 8 Issue: 1 Pages: 44-44
  • DOI: 10.1186/s13072-015-0036-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tissue-specific expression of histone H3 variants diversified after species separation. (2015)
  • Author(s): Maehara K, Harada A, Sato Y, Matsumoto M, Nakayama KI, Kimura H, Ohkawa Y.
  • Journal Title: Epigenetics Chromatin Volume: 8 Issue: 1 Pages: 1-17
  • DOI: 10.1186/s13072-015-0027-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies. (2015)
  • Author(s): Hayashi-Takanaka Y., Maehara K., Harada A., Umehara T., Yokoyama S., Obuse C., Ohkawa Y., Nozaki N., Kimura H.
  • Journal Title: Chromosome Res. Volume: 23 Issue: 4 Pages: 753-766
  • DOI: 10.1007/s10577-015-9486-4
  • Peer Reviewed / Open Access
• [Journal Article] Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis (2015)
  • Author(s): Shimaji K, Konishi T, Tanaka S, Yoshida H, Kato Y, Ohkawa Y, Sato T, Suyama M, Kimura H, Yamaguchi M.
  • Journal Title: Genes to Cells Volume: 20 Issue: 11 Pages: 902-914
  • DOI: 10.1111/gtc.12281
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nucleosome compaction facilitates HP1γ binding to methylated H3K9. (2015)
  • Author(s): Mishima Y, Jayasinghe CD, Lu K, Otani J, Shirakawa M, Kawakami T, Kimura H, Hojo H, Carlton P, Tajima S, Suetake I
  • Journal Title: Nucleic Acids Res Volume: 43 Pages: 10200-10212
  • DOI: 10.1093/nar/gkv841
  • Peer Reviewed / Open Access
• [Journal Article] Histone H4 acetylation required for chromatin decompaction during DNA replication (2015)
  • Author(s): Ruan K, Yamamoto TG, Asakawa H, Chikashige Y, Kimura H, Masukata H, Haraguchi T, Hiraoka Y.
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 1-10
  • DOI: 10.1038/srep12720
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast. (2015)
  • Author(s): Matsuda A, Chikashige Y, Ding DQ, Ohtsuki C, Mori C, Asakawa H, Kimura H, Haraguchi T, Hiraoka Y.
  • Journal Title: Nature Communication Volume: 6 Issue: 1 Pages: 1-12
  • DOI: 10.1038/ncomms8753
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus. (2015)
  • Author(s): Wagatsuma K, Tani-Ichi S, Liang B, Shitara S, Ishihara K, Abe M, Miyachi H, Kitano S, Hara T, Nanno M, Ishikawa H, Sakimura K, Nakao M, Kimura H, Ikuta K.
  • Journal Title: J Immunol. Volume: 195 Issue: 4 Pages: 1804-14
  • DOI: 10.4049/jimmunol.1302456
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Visualizing posttranslational and epigenetic modifications of endogenous proteins in vivo. (2015)
  • Author(s): Kimura H, Hayashi-Takanaka Y, Stasevich TJ, Sato Y
  • Journal Title: Histochem Cell Biol Volume: 144 Issue: 2 Pages: 101-109
  • DOI: 10.1007/s00418-015-1344-0
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Early Development of Cloned Bovine Embryos Produced from Oocytes Enucleated by Fluorescence Metaphase II Imaging Using a Conventional Halogen-Lamp Microscope. (2015)
  • Author(s): .Iwamoto D, Yamagata K, Kishi M, Hayashi-Takanaka Y, Kimura H, Wakayama T, Saeki K.
  • Journal Title: Cell Reprogram Volume: 17 Issue: 2 Pages: 106-114
  • DOI: 10.1089/cell.2014.0086
  • Peer Reviewed
• [Journal Article] 転写 (2015)
  • Author(s): 木村 宏
  • Journal Title: 生体の科学 Volume: 6 Pages: 468-469
• [Journal Article] Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53. (2015)
  • Author(s): Kirschner K, Samarajiwa SA, Cairns JM, Menon S, Pérez-Mancera PA, Tomimatsu K, Bermejo-Rodriguez C, Ito Y, Chandra T, Narita M, Lyons SK, Lynch AG, Kimura H, Ohbayashi T, Tavaré S, Narita M.
  • Journal Title: PLoS Genet Volume: 11 Issue: 3 Pages: e1005053-e1005053
  • DOI: 10.1371/journal.pgen.1005053
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation. (2015)
  • Author(s): Nakatani T, Yamagata K, Kimura T, Oda M, Nakashima H, Hori M, Sekita Y, Arakawa T, Nakamura T, Nakano T.
  • Journal Title: EMBO Rep Volume: 17
• [Journal Article] H3K36 Trimethylation-Mediated Epigenetic Regulation is Activated by Bam and Promotes Germ Cell Differentiation During Early Oogenesis in Drosophila (2015)
  • Author(s): Masanori Mukai, Seiji Hira, Katsuhiro Nakamura, Shoichi Nakamura, Hiroshi Kimura, Masanao Sato and Satoru Kobayashi
  • Journal Title: Biology Open Volume: 4 Issue: 2 Pages: 119-124
  • DOI: 10.1242/bio.201410850
  • Peer Reviewed / Open Access
• [Journal Article] Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle (2015)
  • Author(s): Harada A, Maehara K, Sato Y, Konno D, Tachibana T, Kimura H, Ohkawa Y.
  • Journal Title: Nucleic Acids Research Volume: 43 Issue: 2 Pages: 775-786
  • DOI: 10.1093/nar/gku1346
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Coordinated expression of H3K9 histone methyltransferases during tooth development in mice (2015)
  • Author(s): Kamiunten T, Ideno H, Shimada A, Nakamura Y, Kimura H, Nakashima K, Nifuji A.
  • Journal Title: Histochem Cell Biol. Volume: 143 Issue: 3 Pages: 259-266
  • DOI: 10.1007/s00418-014-1284-0
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of RNA polymerase II activation by histone acetylation in single living cells (2014)
  • Author(s): Stasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H
  • Journal Title: Nature Volume: 516 Issue: 7530 Pages: 272-275
  • DOI: 10.1038/nature13714
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evaluation of chemical fluorescent dyes as a protein conjugation partner for live cell imaging. (2014)
  • Author(s): Hayashi-Takanaka Y, Stasevich TJ, Kurumizaka H, Nozaki N, Kimura H
  • Journal Title: PLoS One Volume: 9 Issue: 9 Pages: e106271-e106271
  • DOI: 10.1371/journal.pone.0106271
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution. (2014)
  • Author(s): Song C, Feodorova Y, Guy J, Peichl L, Jost KL, Kimura H, Cardoso MC, Bird A, Leonhardt H, Joffe B, Solovei I.
  • Journal Title: Epigenetics Chromatin Volume: 7 Issue: 1 Pages: 17-17
  • DOI: 10.1186/1756-8935-7-17
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Quantifying histone and RNA polymerase II post-translational modification dynamics in mother and daughter cells. (2014)
  • Author(s): Stasevich TJ, Sato Y, Nozaki N, Kimura H.
  • Journal Title: Methods Volume: 70 Issue: 2-3 Pages: 77-88
  • DOI: 10.1016/j.ymeth.2014.08.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Adhesion of suspension cells on a coverslip in serum-free conditions. (2014)
  • Author(s): Nakayama T, Mihara K, Kawata J, Kimura H, Saitoh H.
  • Journal Title: Anal Biochem Volume: 466 Pages: 1-3
  • DOI: 10.1016/j.ab.2014.07.023
  • Peer Reviewed / Open Access
• [Journal Article] Hierarchical molecular events driven by oocyte-specific factors lead to rapid and extensive reprogramming. (2014)
  • Author(s): Jullien J, Miyamoto K, Pasque V, Allen GE, Bradshaw CR, Garrett NJ, Halley-Stott RP, Kimura H, Ohsumi K, Gurdon JB.
  • Journal Title: Mol Cell. Volume: 55 Issue: 4 Pages: 524-536
  • DOI: 10.1016/j.molcel.2014.06.024
  • Peer Reviewed / Open Access
• [Journal Article] Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain. (2014)
  • Author(s): Onoda A, Hosoya O, Sano K, Kiyama K, Kimura H, Kawano S, Furuta R, Miyaji M, Tsutsui K, Tsutsui KM.
  • Journal Title: Nucleic Acids Res Volume: 42 Issue: 14 Pages: 9005-9020
  • DOI: 10.1093/nar/gku640
  • Peer Reviewed / Open Access
• [Journal Article] Improved and robust detection of cell nuclei from four dimensional fluorescence images. (2014)
  • Author(s): Bashar MK, Yamagata K, Kobayashi TJ.
  • Journal Title: PLoS One Volume: 9 Issue: 7 Pages: e101891-e101891
  • DOI: 10.1371/journal.pone.0101891
  • Peer Reviewed / Open Access
• [Journal Article] Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly. (2014)
  • Author(s): Hori, T., Shang, W.H., Toyoda, A., Misu, S., Monma, N., Ikeo, K., Molina, O., Vargiu, G., Fujiyama, A., Kimura, H., Earnshaw, W.C., Fukagawa, T.
  • Journal Title: Dev Cell Volume: 29 Issue: 6 Pages: 740-749
  • DOI: 10.1016/j.devcel.2014.05.001
  • Peer Reviewed / Open Access
• [Journal Article] Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity. (2014)
  • Author(s): Yokoyama Y, Matsumoto A, Hieda M*, Shinchi Y, Ogihara E, Hamada M, Nishioka Y, Kimura H, Yoshidome K, Tsujimoto M, Matsuura N.
  • Journal Title: Breast Cancer Res. Volume: 16 Issue: 3
  • DOI: 10.1186/bcr3681
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion. (2014)
  • Author(s): Zierhut C, Jenness C, Kimura H, Funabiki H.
  • Journal Title: Nat Struct Mol Biol Volume: 21 Issue: 7 Pages: 617-625
  • DOI: 10.1038/nsmb.2845
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Heterochromatin dynamics during the differentiation process revealed by the DNA methylation reporter mouse, MethylRO. (2014)
  • Author(s): Ueda J, Maehara K, Mashiko D, Ichinose T, Yao T, Hori M, Sato Y, Kimura H, Ohkawa Y, Yamagata K.
  • Journal Title: Stem Cell Reports Volume: 2 Issue: 6 Pages: 910-924
  • DOI: 10.1016/j.stemcr.2014.05.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells. (2014)
  • Author(s): Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I,
  • Journal Title: PLoS One. Volume: 9 Issue: 5 Pages: e96005-e96005
  • DOI: 10.1371/journal.pone.0096005
  • Peer Reviewed / Open Access
• [Journal Article] Glycolytic gene as the targets of nuclear receptor Ad4BP/SF-1 (2014)
  • Author(s): Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon, Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung, Ken-ichirou Morohashi
  • Journal Title: Nature Commun Volume: 5 Issue: 1 Pages: 3634-3634
  • DOI: 10.1038/ncomms4634
  • Peer Reviewed / Open Access
• [Journal Article] NEAT1 long noncoding RNA regulates transcription via protein sequestration within (2014)
  • Author(s): Hirose T, Virnicchi G, Tanigawa A, Naganuma T, Li R, Kimura H, Yokoi T, Nakagawa S, Bénard M, Fox AH, Pierron G.
  • Journal Title: Mol Biol Cell. Volume: 25 Issue: 1 Pages: 169-183
  • DOI: 10.1091/mbc.e13-09-0558
  • Peer Reviewed
• [Journal Article] Structural basis of a nucleosome containing histone H2A. B/H2A. Bbd that transiently associates with reorganized chromatin. (2013)
  • Author(s): Arimura Y., Kimura H., Oda T., Sato K., Osakabe A., Tachiwana H., Sato Y., Kinugasa Y., Ikura T., Sugiyama M., Sato M., Kurumizaka H.
  • Journal Title: Sci Rep. Volume: 3 Issue: 1 Pages: 3510-3510
  • DOI: 10.1038/srep03510
  • Peer Reviewed / Open Access
• [Journal Article] Structural polymorphism in the L1 loop regions of human H2A. Z. 1 and H2A. Z. 2. (2013)
  • Author(s): Naoki Horikoshi, Koichi Sato, Keisuke Shimada, Yasuhiro Arimura, Akihisa Osakabe, Hiroaki Tachiwana, Yoko Hayashi-Takanaka, Wakana Iwasaki, Wataru Kagawa, Masahiko Harata, Hiroshi Kimura and Hitoshi Kurumizaka.
  • Journal Title: Acta Crystallographica Section D Volume: 69 Issue: 12 Pages: 2431-2439
  • DOI: 10.1107/s090744491302252x
  • Peer Reviewed
• [Journal Article] Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations (2013)
  • Author(s): Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T.
  • Journal Title: J Clin Invest Volume: 123 Pages: 4627-4640
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Latrunculin A treatment prevents abnormal chromosome segregation for successful development of cloned embryos (2013)
  • Author(s): Terashita Y, Yamagata K, Tokoro M, Wakayama S, Li C, Sato E, Tanemura K, Wakayama T.
  • Journal Title: Plos One Volume: 8 Issue: 10 Pages: 1-10
  • DOI: 10.1371/journal.pone.0078380
  • Peer Reviewed / Open Access
• [Journal Article] JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice. (2013)
  • Author(s): Kuroki S, Akiyoshi M, Tokura M, Miyachi H, Nakai Y, Kimura H, Shinkai Y, Tachibana M.
  • Journal Title: Biol Reprod Volume: 89 Issue: 4 Pages: 93-93
  • DOI: 10.1095/biolreprod.113.108597
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Epigenetics of eu- and heterochromatin in inverted and conventional nuclei. (2013)
  • Author(s): Eberhart A, Feodorava Y, Song C, Wanner G, Kiseleva E, Hake S, Furukawa T, Kimura H, Schotta G, Leonhardt H, Joffe B & Solovei I
  • Journal Title: Chromosome Res. Volume: 20 Issue: 5 Pages: 535-554
  • DOI: 10.1007/s10577-013-9375-7
  • Peer Reviewed
• [Journal Article] Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage. (2013)
  • Author(s): Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB, Vermeulen W, Marteijn JA.
  • Journal Title: Mol Cell Volume: 51 Issue: 4 Pages: 469-479
  • DOI: 10.1016/j.molcel.2013.08.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. (2013)
  • Author(s): Sadaie M, Salama R, Carroll T, Tomimatsu K, Chandra T, Young AR, Narita M, Pérez-Mancera PA, Bennett DC, Chong H, Kimura H, Narita M.
  • Journal Title: Genes Dev Volume: 27 Pages: 1800-1808
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In aggressive variants of non-Hodgkin lymphomas, Ezh2 is strongly expressed and polycomb repressive complex PRC1.4 dominates over PRC1.2. (2013)
  • Author(s): Abd Al Kader L, Oka T, Takata K, Sun X, Sato H, Murakami I, Toji T, Manabe A, Kimura H, Yoshino T.
  • Journal Title: Virchows Arch. Volume: 463 Issue: 5 Pages: 697-711
  • DOI: 10.1007/s00428-013-1428-y
  • NAID: 120005359111
  • Peer Reviewed
• [Journal Article] Genetically encoded system to track histone modification in vivo. (2013)
  • Author(s): Yuko Sato, Masanori Mukai, Jun Ueda, Michiko Muraki, Timothy J. Stasevich, Naoki Horikoshi, Tomoya Kujirai, Hiroaki Kita, Taisuke Kimura, Seiji Hira, Yasushi Okada, Yoko Hayashi-Takanaka, Chikashi Obuse, Hitoshi Kurumizaka, Atsuo Kawahara, Kazuo Yamagata, Naohito Nozaki and Hiroshi Kimura
  • Journal Title: Scientific Reports Volume: 3 Issue: 1 Pages: 2436-2436
  • DOI: 10.1038/srep02436
  • Peer Reviewed / Open Access
• [Presentation] Chromatin modification dynamics during gene activation in living cells (2017)
  • Author(s): 木村宏
  • Organizer: 4D Nucleome : The Cell Nucleus in Space and Time
  • Int'l Joint Research / Invited
• [Presentation] Chromatin modification dynamics during gene activation in living cells (2017)
  • Author(s): 木村宏
  • Organizer: 10th Berlin Summer Meeting
  • Int'l Joint Research / Invited
• [Presentation] Chromatin modification dynamics during cell differentiation (2017)
  • Author(s): 木村宏
  • Organizer: Gordon Research Conference “Genome Architecture in Cell Fate & Disease”
  • Int'l Joint Research / Invited
• [Presentation] Chromatin modification dynamics during cell differentiation (2017)
  • Author(s): 木村宏
  • Organizer: HMGU-Japan Epigenetics and Chromatin Meeting
  • Int'l Joint Research / Invited
• [Presentation] Chromatin Integration Labeling Technology (2017)
  • Author(s): 木村宏
  • Organizer: 平成29年度遺伝研研究会『エピジェネティクスの基盤となるクロマチン・細胞核の動的構造変換』
  • Invited
• [Presentation] クロマチン修飾ダイナミクスと転写制御 (2017)
  • Author(s): 木村宏
  • Organizer: 第40回日本分子生物学会年会
  • Invited
• [Presentation] Tracking chromatin modification dynamics during gene activation in vivo (2017)
  • Author(s): Hiroshi Kimura
  • Organizer: Swiss-Japan Symposium “Chromatin Structure and Dynamics”
  • Place of Presentation: Basel, Switzerland
  • Int'l Joint Research / Invited
• [Presentation] Visualizing the dynamics of histone H4K20 methylation in living cells (2016)
  • Author(s): Yuko Sato and Hiroshi Kimura
  • Organizer: 3R Meeting
  • Place of Presentation: 松江市
  • Year and Date: 2016-11-13
  • Int'l Joint Research
• [Presentation] Tracking post-translational modifications in living cells (2016)
  • Author(s): Hiroshi Kimura
  • Organizer: UK-Japan Symposium “From single molecules to cells and tissues”
  • Place of Presentation: Leicester, UK
  • Year and Date: 2016-07-04
  • Int'l Joint Research / Invited
• [Presentation] 転写とクロマチン修飾の生細胞ダイナミクス (2016)
  • Author(s): 木村 宏
  • Organizer: ATRXシンポジウム
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2016-04-01
  • Invited
• [Presentation] 初期胚ライブセルイメージングを始めるには～タイムラプスを用いた知見を含めて～ (2016)
  • Author(s): 山縣一夫
  • Organizer: 第１１回日本生殖再生医学会学術集会
  • Place of Presentation: シェーンバッハ・サボー（東京都千代田区）
  • Year and Date: 2016-03-06
  • Invited
• [Presentation] Histone modification dynamics in living cells (2016)
  • Author(s): Hiroshi Kimura
  • Organizer: Colorado Chromatin Meeting 2016
  • Place of Presentation: Fort Collins, Colorado, USA
  • Int'l Joint Research / Invited
• [Presentation] 転写誘導におけるヒストンアセチル化の役割 (2015)
  • Author(s): 木村 宏
  • Organizer: BMB2015
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] Mouse testis specific histone H3 variant, H3t is essential for spermatogenesis (2015)
  • Author(s): 山縣一夫
  • Organizer: BMB2015
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] 初期胚ライブセルイメージングを始めよう (2015)
  • Author(s): 山縣一夫
  • Organizer: 東京ビックサイト
  • Place of Presentation: 東京ビックサイト
  • Year and Date: 2015-11-26
  • Invited
• [Presentation] Live-cell imaging of chromatin and DNA-methylation dynamics using MethylRO mouse (2015)
  • Author(s): Kazuo Yamagata
  • Organizer: 6th Hiroshima Conference on Education and Science in Dentistry
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2015-10-24
  • Int'l Joint Research / Invited
• [Presentation] クロマチン修飾と転写活性化のin vivoダイナミクス (2015)
  • Author(s): 木村 宏
  • Organizer: 第53回日本生物物理学会年会
  • Place of Presentation: 金沢大学 角間キャンパス
  • Year and Date: 2015-09-13
  • Invited
• [Presentation] ライブセルイメージングを用いた着床前初期胚の質の評価 (2015)
  • Author(s): 山縣一夫
  • Organizer: 関西実験動物研究会第１２７回研究会
  • Place of Presentation: 大阪大学銀杏会館
  • Year and Date: 2015-09-12
  • Invited
• [Presentation] Kinetics of Histone and RNA polymerase II Modifications during Transcriptional Activation (2015)
  • Author(s): Hiroshi Kimura
  • Organizer: International Symposium on Chromatin Structure, Dyanamics, and Function
  • Place of Presentation: 淡路夢舞台
  • Year and Date: 2015-08-24
  • Int'l Joint Research / Invited
• [Presentation] Tracking posttranslational and epigenetic modifications of endogenous proteins in vivo (2015)
  • Author(s): Hiroshi Kimura
  • Organizer: 24th Wilhelm Bernhard Workshop on the Cell Nucleus/57th Symposium of the Society for Histochemistry
  • Place of Presentation: Schloss Wilhelminenberg, Vienna, Austria
  • Year and Date: 2015-08-20
  • Int'l Joint Research / Invited
• [Presentation] 生細胞・生体内のヒストン修飾イメージング (2015)
  • Author(s): 木村 宏
  • Organizer: 第67回日本細胞生物学会大会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-07-02
  • Invited
• [Presentation] エピゲノム修飾の生細胞・生体内ダイナミクス (2015)
  • Author(s): 木村 宏
  • Organizer: 第9回日本エピジェネティクス研究会年会
  • Place of Presentation: 学術総合センター
  • Year and Date: 2015-05-25
  • Invited
• [Presentation] Visualization of Dynamics of Methylated DNA in living cell and animal. (2015)
  • Author(s): Kazuo Yamagata
  • Organizer: International Symposium on Bio-imaging and Gene Targeting Sciences in Okayama
  • Place of Presentation: 岡山
  • Year and Date: 2015-02-15
  • Invited
• [Presentation] メチローマウスで動くメチル化DNAを追う (2015)
  • Author(s): 山縣一夫
  • Organizer: "平成26年度基礎生物学研究所重点共同利用研究
  • Place of Presentation: 岡崎
  • Year and Date: 2015-01-19
  • Invited
• [Presentation] Tracking functional chromatin components in living cells and organisms (2014)
  • Author(s): Hiroshi Kimura
  • Organizer: 4D Nucleome meeting
  • Place of Presentation: 広島
  • Year and Date: 2014-12-17 – 2014-12-19
  • Invited
• [Presentation] Tracking epigenetic modifications and transcription activity in living cells and organisms (2014)
  • Author(s): Hiroshi Kimura
  • Organizer: 8th International Symposium on Nanomedicine
  • Place of Presentation: 松山
  • Year and Date: 2014-12-04 – 2014-12-06
  • Invited
• [Presentation] 初期胚の高精細イメージングで見えてくるもの (2014)
  • Author(s): 山縣一夫
  • Organizer: 第59回本生殖医学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-12-03 – 2014-12-05
  • Invited
• [Presentation] 発生過程や刺激に応答した転写活性化とヒストン修飾の動態 (2014)
  • Author(s): 木村 宏、スタセビッチ ティモシー、佐藤優子
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-25 – 2014-11-27
  • Invited
• [Presentation] Regulation of Transcription Cycle by Histone Modifications in Living Cells (2014)
  • Author(s): Hiroshi Kimura
  • Organizer: The International Symposium on Transcription Cycle 2014
  • Place of Presentation: 東京
  • Year and Date: 2014-11-24
  • Invited
• [Presentation] Histone modification and transcription dynamics in living cells and organisms (2014)
  • Author(s): Hiroshi Kimura
  • Organizer: The 9th 3R Symposium
  • Place of Presentation: 御殿場
  • Year and Date: 2014-11-17 – 2014-11-21
  • Invited
• [Presentation] メチローで 動くメチル化ＤＮＡを追う (2014)
  • Author(s): 山縣一夫
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
  • Invited
• [Presentation] ヒストンとＲＮＡポリメラーゼの翻訳後修飾の生細胞・生体内計測 (2014)
  • Author(s): 木村 宏
  • Organizer: 第52回日本生物物理学会年会
  • Place of Presentation: 札幌
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] 発生・分化に伴うヒストン修飾のダイナミクス (2014)
  • Author(s): 木村 宏
  • Organizer: 第56回歯科基礎医学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] ヒストン修飾翻訳後修飾と転写の生細胞動態 (2014)
  • Author(s): 木村 宏
  • Organizer: 第14回蛋白質科学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-06-25 – 2014-06-27
  • Invited
• [Presentation] ライブセルイメージングで「卵子の質」を定量化する (2014)
  • Author(s): 山縣一夫
  • Organizer: 第66回日本細胞生物学会大会
  • Place of Presentation: 奈良
  • Year and Date: 2014-06-11 – 2014-06-13
  • Invited
• [Presentation] Quantification of embryo quality by live-cell imaging (2014)
  • Author(s): Kazuo Yamagata
  • Organizer: 47th Annual Meeting of the Japanese Society of Developmental Biologists
  • Place of Presentation: 名古屋
  • Year and Date: 2014-05-27 – 2014-05-30
  • Invited
• [Presentation] ライブセルイメージングで「卵子の質」を評価する (2014)
  • Author(s): 山縣一夫
  • Organizer: 第55回日本卵子学会
  • Place of Presentation: 神戸
  • Year and Date: 2014-05-17 – 2014-05-18
  • Invited
• [Presentation] ライブセルイメージングで「卵子の質」を評価する (2014)
  • Author(s): 山縣一夫
  • Organizer: 日本受精着床学会 第10回ART生涯研修コース
  • Place of Presentation: 東京
  • Year and Date: 2014-03-02
  • Invited
• [Presentation] 生細胞におけるヒストンH3アセチル化による転写活性化の二段階制御 (2013)
  • Author(s): 木村 宏
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-03 – 2013-12-06
  • Invited
• [Presentation] 初期胚の「質」を定量化することで不妊を知る (2013)
  • Author(s): 山縣一夫
  • Organizer: 日本動物学会 第84回 岡山大会
  • Place of Presentation: 岡山
  • Year and Date: 2013-09-26 – 2013-09-28
  • Invited
• [Presentation] 生細胞解析により明らかとなったヒストン修飾による転写活性化の二段階制御 (2013)
  • Author(s): 木村 宏
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 横浜
  • Year and Date: 2013-09-19 – 2013-09-21
  • Invited
• [Presentation] Imaging global epigenetic dynamics during mouse pre-implantation development (2013)
  • Author(s): 山縣一夫
  • Organizer: 日本遺伝学会 第85回大会
  • Place of Presentation: 横浜
  • Year and Date: 2013-09-19 – 2013-09-20
  • Invited
• [Presentation] ストレス応答とクロマチン修飾動態の生細胞解析 (2013)
  • Author(s): 木村 宏
  • Organizer: 第86回生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2013-09-11 – 2013-09-13
  • Invited
• [Presentation] 働き者と怠け者をどう見分けるか？ (2013)
  • Author(s): 木村 宏
  • Organizer: 2013年イメージング若手の会
  • Place of Presentation: 千葉県野田市
  • Year and Date: 2013-09-07 – 2013-09-08
• [Presentation] Bimodal regulation of RNA polymerase II transcription kinetics by histone acetylation in single living cells (2013)
  • Author(s): Hiroshi Kimura and Timothy J. Stasevich
  • Organizer: 23th Wilhelm Bernhard Workshop on the cell nucleus
  • Place of Presentation: Debrecen, Hungary
  • Year and Date: 2013-08-19 – 2013-08-23
  • Invited
• [Presentation] ライブセルイメージングで「卵子の質」を評価する (2013)
  • Author(s): 山縣一夫
  • Organizer: 第31回日本受精着床学会総会・学術講演会
  • Place of Presentation: 別府
  • Year and Date: 2013-08-08 – 2013-08-09
  • Invited
• [Presentation] Abnormal Chromosome Segregation at Early Cleavage is a Major Cause of the Full-term Developmental Failure of Mouse Clones (2013)
  • Author(s): 山縣一夫
  • Organizer: The 61st NIBB Conference "Cellular Community in Mammalian Embryogenesis"細胞コミュニティ国際会議
  • Place of Presentation: 岡崎
  • Year and Date: 2013-07-10 – 2013-07-12
• [Book] 新・生細胞蛍光イメージング (2015)
  • Author(s): 原口徳子、木村 宏、平岡 泰
  • Total Pages: 340
  • Publisher: 共立出版
• [Book] DNA Replication, Recombination, and Repair Molecular Mechanisms and Pathology (Eds F. Hanaoka, K. Sugasawa) (2015)
  • Author(s): Hiroshi Kimura, Yuko Sato
  • Total Pages: 555
  • Publisher: Springer
• [Book] エピジェネティクス―基礎研究から産業応用への展望―（畑田出穂、久保田健夫／編） (2014)
  • Author(s): 佐藤優子、木村宏
  • Total Pages: 393
  • Publisher: シーエムシー出版
• [Book] 遺伝子医学MOOK「エピジェネティクスと病気」（佐々木裕之／監、中尾光善・中島欣一／編） (2013)
  • Author(s): 木村 宏、佐藤優子
  • Total Pages: 280
  • Publisher: メディカル・ドゥ
• [Book] エピジェネティクスキーワード事典（牛島俊和・眞貝洋一／編） (2013)
  • Author(s): 木村 宏
  • Total Pages: 315
  • Publisher: 羊土社
• [Book] 染色体と細胞核のダイナミクス（平岡 泰・原口徳子／編） (2013)
  • Author(s): 木村 宏、胡桃坂仁志
  • Total Pages: 224
  • Publisher: 化学同人
• [Remarks] 東工大 木村宏研究室
  • URL: http://kimura-lab.bio.titech.ac.jp/
• [Remarks] 東工大 木村宏研究者情報
  • URL: http://t2r2.star.titech.ac.jp/cgi-bin/researcherinfo.cgi?q_researcher_content_number=CTT100673940
• [Remarks] 東工大 科学技術創成研究院 細胞制御工学研究センター
  • URL: http://www.rcb.iir.titech.ac.jp/
• [Remarks] 東京工業大学 木村研究室
  • URL: http://kimura-lab.bio.titech.ac.jp/
• [Remarks] 東京工業大学 科学技術創成研究院 細胞制御工学研究センター
  • URL: https://cell-biology.jimdo.com/
• [Remarks] 東京工業大学 リサーチデポジトリ 木村 宏
  • URL: http://t2r2.star.titech.ac.jp/cgi-bin/researcherinfo.cgi?q_researcher_content_number=CTT100673940
• [Remarks] 新学術領域「クロマチン動構造」
  • URL: http://nucleosome.kyushu-u.ac.jp/
• [Remarks] 東京工業大学 木村宏研究室
  • URL: http://kimura-lab.bio.titech.ac.jp/
• [Remarks] 東京工業大学 科学技術創成研究院 細胞制御工学ユニット
  • URL: http://cell-biology.jimdo.com/
• [Remarks] 東京工業大学 リサーチリポジトリ 木村宏
  • URL: http://t2r2.star.titech.ac.jp/cgi-bin/researcherinfo.cgi?q_researcher_content_number=CTT100673940
• [Remarks] 東京工業大学大学院生命理工学研究科 木村宏研究室
  • URL: http://kimura-lab.bio.titech.ac.jp/
• [Remarks] 東京工業大学大学院生命理工学研究科 木村宏研究室
  • URL: http://www.bio.titech.ac.jp/laboratory/kimura-kajikawa/kimura/index.html
• [Remarks] 東京工業大学 生命理工学研究科 木村宏研究室
  • URL: http://www.bio.titech.ac.jp/laboratory/kimura-kajikawa/kimura/index.html
• [Patent(Industrial Property Rights)] ヒストンH3トリメチル化リシン特異的モノクローナル抗体又はその抗原結合性断片 (2017)
  • Inventor(s): 木村 宏、佐藤優子、大井彰人、胡桃坂仁志、鯨井智也、他
  • Industrial Property Rights Holder: 東京工業大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-111580
  • Filing Date: 2017
• [Patent(Industrial Property Rights)] ＤＮＡ結合タンパク質の結合領域の近傍に所望のＤＮＡ断片を挿入する方法 (2016)
  • Inventor(s): 大川恭行、原田、哲仁、胡桃坂仁志、木村宏、等
  • Industrial Property Rights Holder: 国立大学法人九州大学、国立大学法人東京工業大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-167967
  • Filing Date: 2016-08-30