• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A multidimensional analysis of chromatin dynamics in living cells by quantitative measurements and reconstruction

Planned Research

Project AreaDynamic chromatin structure and function
Project/Area Number 25116005
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Institute of Technology (2014-2017)
Osaka University (2013)

Principal Investigator

Kimura Hiroshi  東京工業大学, 科学技術創成研究院, 教授 (30241392)

Co-Investigator(Kenkyū-buntansha) 山縣 一夫  近畿大学, 生物理工学部, 准教授 (10361312)
Project Period (FY) 2013-06-28 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥155,870,000 (Direct Cost: ¥119,900,000、Indirect Cost: ¥35,970,000)
Fiscal Year 2017: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2016: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2015: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2014: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2013: ¥53,690,000 (Direct Cost: ¥41,300,000、Indirect Cost: ¥12,390,000)
Keywordsクロマチン / ヒストン修飾 / 遺伝子発現制御 / 転写 / エピジェネティクス / 細胞核 / 遺伝子制御 / 発現制御 / 発生・分化 / ゲノム / 組織・細胞 / バイオテクノロジー / 細胞・組織 / エピジェネティクス制御 / シグナル伝達
Outline of Final Research Achievements

Chromatin dynamics plays an important role in cell regulation through the control of gene expression and genome integrity. This study aimed to reveal the significance of chromatin dynamics by quantitative measurements and reconstruction in living cells. We have developed techniques to monitor histone modification and DNA methylation in living cells, and revealed the function of histone acetylation in gene activation. This study greatly contributed to understand the basic mechanism of gene regulation in living cells.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (152 results)

All 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (13 results) Journal Article (71 results) (of which Int'l Joint Research: 16 results,  Peer Reviewed: 68 results,  Open Access: 53 results,  Acknowledgement Compliant: 28 results) Presentation (47 results) (of which Int'l Joint Research: 11 results,  Invited: 44 results) Book (6 results) Remarks (13 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] ケンブリッジ大学/エジンバラ大学/オックスフォード大学(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] マックスプランク研究所/マックスデルブリュックセンター/ヘルムホルツセンター(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] キュリー研究所/ツールーズ大学(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ロックフェラー大学/コロラド州立大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Max‐Delbruck Centre for Mol. Med./Max Planck Institute-CBG(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Colorado, Aurora/Colorado State University(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Edinburgh/University of Cambridge(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Toulouse(フランス)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Max‐Delbruck Centre for Mol. Med./Max Planck Institute-CBG(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] The Hospital for Sick Children/The University of Toronto/Unviersity of Montreal(カナダ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Colorado State University(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Birmingham/University of Edinbrough(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Toulouse(フランス)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence2018

    • Author(s)
      Parry AJ, Hoare M, Bihary D, Hansel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D'Santos P, Russel IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M.
    • Journal Title

      Nat Commun

      Volume: 9 Issue: 1 Pages: 1840-1840

    • DOI

      10.1038/s41467-018-04283-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry.2018

    • Author(s)
      Ruppert JG, Samejima K, Platani M, Molina O, Kimura H, Jeyaprakash AA, Ohta S, Earnshaw WC.
    • Journal Title

      EMBO J

      Volume: 37 Issue: 6

    • DOI

      10.15252/embj.201797677

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration2018

    • Author(s)
      Harada Akihito、Maehara Kazumitsu、Ono Yusuke、Taguchi Hiroyuki、Yoshioka Kiyoshi、Kitajima Yasuo、Xie Yan、Sato Yuko、Iwasaki Takeshi、Nogami Jumpei、Okada Seiji、Komatsu Tetsuro、Semba Yuichiro、Takemoto Tatsuya、Kimura Hiroshi、Kurumizaka Hitoshi、Ohkawa Yasuyuki
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1400-1400

    • DOI

      10.1038/s41467-018-03845-1

    • NAID

      120006949474

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.2018

    • Author(s)
      Jenness C, Giunta S, Muller MM, Kimura H, Muir TW, Funabiki H.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 115 Issue: 5

    • DOI

      10.1073/pnas.1717509115

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] H3S10ph broadly marks early-replicating domains in interphase ESCs and shows reciprocal antagonism with H3K9me2.2018

    • Author(s)
      Chen CCL, Goyal P, Karimi MM, Abildgaard MH, Kimura H, Lorincz MC.
    • Journal Title

      Genome Res

      Volume: 28 Issue: 1 Pages: 37-51

    • DOI

      10.1101/gr.224717.117

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nucleosome stability measured in situ by automated quantitative imaging2017

    • Author(s)
      Imre L, Simandi Z, Horvath A, Fenyofalvi G, Nanasi P, Niaki EF, Hegedus E, Bacso Z, Weyemi U, Mauser R, Ausio J, Jeltsch A, Bonner W, Nagy L, Kimura H, Szabo G.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 12743-12743

    • DOI

      10.1038/s41598-017-12608-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly2017

    • Author(s)
      Atsuko Shirai, Takayuki Kawaguchi, Hideaki Shimojo, Daisuke Muramatsu, Mayumi Ishida-Yonetani, Yoshifumi Nishimura, Hiroshi Kimura, Jun-ichi Nakayama, Yoichi Shinkai
    • Journal Title

      eLIFE

      Volume: 6

    • DOI

      10.7554/elife.25317

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.2017

    • Author(s)
      Isobe S.Y., Nagao K., Nozaki N., Kimura H., and Obuse C.
    • Journal Title

      Cell Rep.

      Volume: 2 Issue: 2 Pages: 297-307

    • DOI

      10.1016/j.celrep.2017.06.056

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduction in chromosome mobility accompanies nuclear organization during early embryogenesis in Caenorhabditis elegans2017

    • Author(s)
      Arai Ritsuko、Sugawara Takeshi、Sato Yuko、Minakuchi Yohei、Toyoda Atsushi、Nabeshima Kentaro、Kimura Hiroshi、Kimura Akatsuki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 3631-3631

    • DOI

      10.1038/s41598-017-03483-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.82017

    • Author(s)
      Taguchi H, Xie Y, Horikoshi N, Maehara K, Harada A, Nogami J, Sato K, Arimura Y, Osakabe A, Kujirai T, Iwasaki T, Semba Y, Tachibana T, Kimura H, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Biochemistry

      Volume: 56 Issue: 16 Pages: 2184-2196

    • DOI

      10.1021/acs.biochem.6b01098

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Semi-quantitative Analysis of H4K20mel Levels in Living Cells Using Mintbody2017

    • Author(s)
      Sato Y, Kimura H
    • Journal Title

      Bio-protocol

      Volume: 7 Issue: 10

    • DOI

      10.21769/bioprotoc.2276

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase2017

    • Author(s)
      Yamazaki Taiga、Hatano Yu、Handa Tetsuya、Kato Sakiko、Hoida Kensuke、Yamamura Rui、Fukuyama Takashi、Uematsu Takayuki、Kobayashi Noritada、Kimura Hiroshi、Yamagata Kazuo
    • Journal Title

      PLoS ONE

      Volume: 12 Issue: 5 Pages: 1-18

    • DOI

      10.1371/journal.pone.0177764

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 3. Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array2017

    • Author(s)
      Partolina M, Thoms HC, MacLeod KG, Rodriguez-Blanco G, Clarke MN, Venkatasubramani AV, Beesoo R, Larionov V, Neergheen-Bhujun VS, Serrels B, Kimura H, Carragher NO, Kagansky A.
    • Journal Title

      Cell Death Discov

      Volume: 3 Issue: 1 Pages: 16077-16077

    • DOI

      10.1038/cddiscovery.2016.77

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3.2017

    • Author(s)
      Kakumu E
    • Journal Title

      Genes Cells.

      Volume: 3 Issue: 3 Pages: 310-327

    • DOI

      10.1111/gtc.12479

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduction in chromosome mobility accompanies nuclear organization during early embryogenesis in Caenorhabditis elegans2017

    • Author(s)
      Arai R, Sugawara T, Sato Y, Minakuchi Y, Toyoda A, Nabeshima K, Kimura H, Kimura A.
    • Journal Title

      Sci Rep

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis2017

    • Author(s)
      Ueda J., Harada A., Urahama T., Machida S., Maehara K., Hada M., Makino Y., Nogami J., Horikoshi N., Osakabe A., Taguchi H., Tanaka H., Tachiwana H., Yao T., Yamada M., Iwamoto T., Isotani A., Ikawa M., Tachibana T., Okada Y., Kimura H., Ohkawa Y., Kurumizaka H., Yamagata K.
    • Journal Title

      Cell Reports

      Volume: 18(3) Issue: 3 Pages: 593-600

    • DOI

      10.1016/j.celrep.2016.12.065

    • NAID

      120006957416

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A genetically encoded probe for live-cell imaging of H4K20 monomethylation2016

    • Author(s)
      Sato Y., Kujirai T., Arai R., Asakawa H., Ohtsuki C., Horikoshi N., Yamagata K., Ueda J., Nagase T., Haraguchi T., Hiraoka Y., Kimura A., Kurumizaka H., Kimura, H.
    • Journal Title

      J. Mol. Biol.

      Volume: 428 Issue: 20 Pages: 3885-3902

    • DOI

      10.1016/j.jmb.2016.08.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone H4 lysine 20 acetylation is associated with gene repression in human cells.2016

    • Author(s)
      Kaimori, J. Y., Maehara, K., Hayashi-Takanaka, Y., Harada, A., Fukuda, M., Yamamoto, S., Ichimaru, N., Umehara, T., Yokoyama, S., Matsuda, R., Ikura, T., Nagao, K., Obuse, C., Nozaki, N., Takahara, S., Takao, T., Ohkawa, Y., Kimura, H., and Isaka, Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 24318-24318

    • DOI

      10.1038/srep24318

    • NAID

      120005770760

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structure and function of human histone H3.Y nucleosome.2016

    • Author(s)
      Kujirai, T., Horikoshi, N., Sato, K., Maehara, K., Machida, S., Osakabe, A., Kimura, H., Ohkawa, Y. and Kurumizaka, H.
    • Journal Title

      Nucleic Acids Research

      Volume: 1 Issue: 13 Pages: 1-15

    • DOI

      10.1093/nar/gkw202

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tracking dynamics of histone H3 lysine 9 acetylation in Xenopus laevis tail regeneration2016

    • Author(s)
      Suzuki M, Takagi C, Miura S, Sakane Y, Sakuma T, Sakamoto N, Endo T, Kamei Y, Kimura H, Yamamoto T, Ueno N, Suzuki K
    • Journal Title

      Genes to Cells

      Volume: Vol.21 (4) Issue: 4 Pages: 358-369

    • DOI

      10.1111/gtc.12349

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histone H3K36 trimethylation is essential for multiple silencing mechanism in fission yeast.2016

    • Author(s)
      Shota Suzuki, Hiroaki Kato, Yutaka Suzuki, Yuji Chikashige, Yasushi Hiraoka, Hiroshi Kimura, Koji Nagao, Chikashi Obuse, Shinya Takahata and Yota Murakami
    • Journal Title

      Nucleic Acids Research

      Volume: 44 (9) Issue: 9 Pages: 4147-4162

    • DOI

      10.1093/nar/gkw008

    • NAID

      120005819302

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis.2016

    • Author(s)
      Urahama T, Harada A, Maehara K, Horikoshi N, Sato K, Sato Y, Shiraishi K, Sugino N, Osakabe A, Tachiwana H, Kagawa W, Kimura H, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Epigenetics Chromatin

      Volume: 9 Issue: 1 Pages: 1-16

    • DOI

      10.1186/s13072-016-0051-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ヌクレオーム解析時代の幕開け2016

    • Author(s)
      田代 聡、木村 宏
    • Journal Title

      細胞工学

      Volume: 35 Pages: 66-69

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes.2016

    • Author(s)
      Oka M, Mura S, Yamada K, Sangel P, Hirata S, Maehara K, Kawakami K, Tachibana T, Ohkawa Y, Kimura H, Yoneda Y
    • Journal Title

      eLIFE

      Volume: 5

    • DOI

      10.7554/elife.09540

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3.2016

    • Author(s)
      Martins NMC, Bergmann JH, Shono N, Kimura H, Larionov V, Masumoto H and Earnshaw WC.
    • Journal Title

      Mol Biol Cell

      Volume: 27 Issue: 1 Pages: 177-196

    • DOI

      10.1091/mbc.e15-08-0605

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Behavior of Mouse Spermatozoa in the Female Reproductive Tract from Soon after Mating to the Beginning of Fertilization.2016

    • Author(s)
      Muro Y, Hasuwa H, Isotani A, Miyata H, Yamagata K, Ikawa M, Yanagimachi R, Okabe M
    • Journal Title

      Biol Reprod

      Volume: 印刷中 Issue: 4 Pages: 80-80

    • DOI

      10.1095/biolreprod.115.135368

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of Hprt-disrupted rat through mouse←rat ES chimeras.2016

    • Author(s)
      Isotani A, Yamagata K, Okabe M, Ikawa M
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 24215-24215

    • DOI

      10.1038/srep24215

    • NAID

      120006957423

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Micronucleus formation causes perpetual unilateral chromosome inheritance in mouse embryos.2016

    • Author(s)
      Vazquez-Diez C, Yamagata K, Trivedi S, Haverfield J, FitzHarris G
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 113 Issue: 3 Pages: 626-631

    • DOI

      10.1073/pnas.1517628112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells.2015

    • Author(s)
      Dias JD, Rito T, Torlai Triglia E, Kukalev A, Ferrai C, Chotalia M, Brookes E, Kimura H, Pombo A
    • Journal Title

      eLIFE

      Volume: 4

    • DOI

      10.7554/elife.11215

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.2015

    • Author(s)
      Shono N, Ohzeki J, Otake K, Martins NMC, Nagase T, Kimura H, Larionov V, Earnshaw WC, Masumoto H.
    • Journal Title

      J Cell Sci.

      Volume: 128 Issue: 24 Pages: 4572-4587

    • DOI

      10.1242/jcs.180786

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The histone chaperone DAXX maintains the structural organization of heterochromatin domains.2015

    • Author(s)
      Rapkin LM, Ahmed K, Dulev S, Li R, Kimura H, Ishov AM, Bazett-Jones DP
    • Journal Title

      Epigenetics Chromatin

      Volume: 8 Issue: 1 Pages: 44-44

    • DOI

      10.1186/s13072-015-0036-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tissue-specific expression of histone H3 variants diversified after species separation.2015

    • Author(s)
      Maehara K, Harada A, Sato Y, Matsumoto M, Nakayama KI, Kimura H, Ohkawa Y.
    • Journal Title

      Epigenetics Chromatin

      Volume: 8 Issue: 1 Pages: 1-17

    • DOI

      10.1186/s13072-015-0027-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies.2015

    • Author(s)
      Hayashi-Takanaka Y., Maehara K., Harada A., Umehara T., Yokoyama S., Obuse C., Ohkawa Y., Nozaki N., Kimura H.
    • Journal Title

      Chromosome Res.

      Volume: 23 Issue: 4 Pages: 753-766

    • DOI

      10.1007/s10577-015-9486-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis2015

    • Author(s)
      Shimaji K, Konishi T, Tanaka S, Yoshida H, Kato Y, Ohkawa Y, Sato T, Suyama M, Kimura H, Yamaguchi M.
    • Journal Title

      Genes to Cells

      Volume: 20 Issue: 11 Pages: 902-914

    • DOI

      10.1111/gtc.12281

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nucleosome compaction facilitates HP1γ binding to methylated H3K9.2015

    • Author(s)
      Mishima Y, Jayasinghe CD, Lu K, Otani J, Shirakawa M, Kawakami T, Kimura H, Hojo H, Carlton P, Tajima S, Suetake I
    • Journal Title

      Nucleic Acids Res

      Volume: 43 Pages: 10200-10212

    • DOI

      10.1093/nar/gkv841

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone H4 acetylation required for chromatin decompaction during DNA replication2015

    • Author(s)
      Ruan K, Yamamoto TG, Asakawa H, Chikashige Y, Kimura H, Masukata H, Haraguchi T, Hiraoka Y.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 1-10

    • DOI

      10.1038/srep12720

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast.2015

    • Author(s)
      Matsuda A, Chikashige Y, Ding DQ, Ohtsuki C, Mori C, Asakawa H, Kimura H, Haraguchi T, Hiraoka Y.
    • Journal Title

      Nature Communication

      Volume: 6 Issue: 1 Pages: 1-12

    • DOI

      10.1038/ncomms8753

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.2015

    • Author(s)
      Wagatsuma K, Tani-Ichi S, Liang B, Shitara S, Ishihara K, Abe M, Miyachi H, Kitano S, Hara T, Nanno M, Ishikawa H, Sakimura K, Nakao M, Kimura H, Ikuta K.
    • Journal Title

      J Immunol.

      Volume: 195 Issue: 4 Pages: 1804-14

    • DOI

      10.4049/jimmunol.1302456

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Visualizing posttranslational and epigenetic modifications of endogenous proteins in vivo.2015

    • Author(s)
      Kimura H, Hayashi-Takanaka Y, Stasevich TJ, Sato Y
    • Journal Title

      Histochem Cell Biol

      Volume: 144 Issue: 2 Pages: 101-109

    • DOI

      10.1007/s00418-015-1344-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Early Development of Cloned Bovine Embryos Produced from Oocytes Enucleated by Fluorescence Metaphase II Imaging Using a Conventional Halogen-Lamp Microscope.2015

    • Author(s)
      .Iwamoto D, Yamagata K, Kishi M, Hayashi-Takanaka Y, Kimura H, Wakayama T, Saeki K.
    • Journal Title

      Cell Reprogram

      Volume: 17 Issue: 2 Pages: 106-114

    • DOI

      10.1089/cell.2014.0086

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 転写2015

    • Author(s)
      木村 宏
    • Journal Title

      生体の科学

      Volume: 6 Pages: 468-469

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53.2015

    • Author(s)
      Kirschner K, Samarajiwa SA, Cairns JM, Menon S, Pérez-Mancera PA, Tomimatsu K, Bermejo-Rodriguez C, Ito Y, Chandra T, Narita M, Lyons SK, Lynch AG, Kimura H, Ohbayashi T, Tavaré S, Narita M.
    • Journal Title

      PLoS Genet

      Volume: 11 Issue: 3 Pages: e1005053-e1005053

    • DOI

      10.1371/journal.pgen.1005053

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation.2015

    • Author(s)
      Nakatani T, Yamagata K, Kimura T, Oda M, Nakashima H, Hori M, Sekita Y, Arakawa T, Nakamura T, Nakano T.
    • Journal Title

      EMBO Rep

      Volume: 17

    • Related Report
      2014 Annual Research Report
  • [Journal Article] H3K36 Trimethylation-Mediated Epigenetic Regulation is Activated by Bam and Promotes Germ Cell Differentiation During Early Oogenesis in Drosophila2015

    • Author(s)
      Masanori Mukai, Seiji Hira, Katsuhiro Nakamura, Shoichi Nakamura, Hiroshi Kimura, Masanao Sato and Satoru Kobayashi
    • Journal Title

      Biology Open

      Volume: 4 Issue: 2 Pages: 119-124

    • DOI

      10.1242/bio.201410850

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle2015

    • Author(s)
      Harada A, Maehara K, Sato Y, Konno D, Tachibana T, Kimura H, Ohkawa Y.
    • Journal Title

      Nucleic Acids Research

      Volume: 43 Issue: 2 Pages: 775-786

    • DOI

      10.1093/nar/gku1346

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Coordinated expression of H3K9 histone methyltransferases during tooth development in mice2015

    • Author(s)
      Kamiunten T, Ideno H, Shimada A, Nakamura Y, Kimura H, Nakashima K, Nifuji A.
    • Journal Title

      Histochem Cell Biol.

      Volume: 143 Issue: 3 Pages: 259-266

    • DOI

      10.1007/s00418-014-1284-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of RNA polymerase II activation by histone acetylation in single living cells2014

    • Author(s)
      Stasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H
    • Journal Title

      Nature

      Volume: 516 Issue: 7530 Pages: 272-275

    • DOI

      10.1038/nature13714

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of chemical fluorescent dyes as a protein conjugation partner for live cell imaging.2014

    • Author(s)
      Hayashi-Takanaka Y, Stasevich TJ, Kurumizaka H, Nozaki N, Kimura H
    • Journal Title

      PLoS One

      Volume: 9 Issue: 9 Pages: e106271-e106271

    • DOI

      10.1371/journal.pone.0106271

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution.2014

    • Author(s)
      Song C, Feodorova Y, Guy J, Peichl L, Jost KL, Kimura H, Cardoso MC, Bird A, Leonhardt H, Joffe B, Solovei I.
    • Journal Title

      Epigenetics Chromatin

      Volume: 7 Issue: 1 Pages: 17-17

    • DOI

      10.1186/1756-8935-7-17

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantifying histone and RNA polymerase II post-translational modification dynamics in mother and daughter cells.2014

    • Author(s)
      Stasevich TJ, Sato Y, Nozaki N, Kimura H.
    • Journal Title

      Methods

      Volume: 70 Issue: 2-3 Pages: 77-88

    • DOI

      10.1016/j.ymeth.2014.08.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Adhesion of suspension cells on a coverslip in serum-free conditions.2014

    • Author(s)
      Nakayama T, Mihara K, Kawata J, Kimura H, Saitoh H.
    • Journal Title

      Anal Biochem

      Volume: 466 Pages: 1-3

    • DOI

      10.1016/j.ab.2014.07.023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hierarchical molecular events driven by oocyte-specific factors lead to rapid and extensive reprogramming.2014

    • Author(s)
      Jullien J, Miyamoto K, Pasque V, Allen GE, Bradshaw CR, Garrett NJ, Halley-Stott RP, Kimura H, Ohsumi K, Gurdon JB.
    • Journal Title

      Mol Cell.

      Volume: 55 Issue: 4 Pages: 524-536

    • DOI

      10.1016/j.molcel.2014.06.024

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain.2014

    • Author(s)
      Onoda A, Hosoya O, Sano K, Kiyama K, Kimura H, Kawano S, Furuta R, Miyaji M, Tsutsui K, Tsutsui KM.
    • Journal Title

      Nucleic Acids Res

      Volume: 42 Issue: 14 Pages: 9005-9020

    • DOI

      10.1093/nar/gku640

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improved and robust detection of cell nuclei from four dimensional fluorescence images.2014

    • Author(s)
      Bashar MK, Yamagata K, Kobayashi TJ.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 7 Pages: e101891-e101891

    • DOI

      10.1371/journal.pone.0101891

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly.2014

    • Author(s)
      Hori, T., Shang, W.H., Toyoda, A., Misu, S., Monma, N., Ikeo, K., Molina, O., Vargiu, G., Fujiyama, A., Kimura, H., Earnshaw, W.C., Fukagawa, T.
    • Journal Title

      Dev Cell

      Volume: 29 Issue: 6 Pages: 740-749

    • DOI

      10.1016/j.devcel.2014.05.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity.2014

    • Author(s)
      Yokoyama Y, Matsumoto A, Hieda M*, Shinchi Y, Ogihara E, Hamada M, Nishioka Y, Kimura H, Yoshidome K, Tsujimoto M, Matsuura N.
    • Journal Title

      Breast Cancer Res.

      Volume: 16 Issue: 3

    • DOI

      10.1186/bcr3681

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion.2014

    • Author(s)
      Zierhut C, Jenness C, Kimura H, Funabiki H.
    • Journal Title

      Nat Struct Mol Biol

      Volume: 21 Issue: 7 Pages: 617-625

    • DOI

      10.1038/nsmb.2845

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Heterochromatin dynamics during the differentiation process revealed by the DNA methylation reporter mouse, MethylRO.2014

    • Author(s)
      Ueda J, Maehara K, Mashiko D, Ichinose T, Yao T, Hori M, Sato Y, Kimura H, Ohkawa Y, Yamagata K.
    • Journal Title

      Stem Cell Reports

      Volume: 2 Issue: 6 Pages: 910-924

    • DOI

      10.1016/j.stemcr.2014.05.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells.2014

    • Author(s)
      Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I,
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 5 Pages: e96005-e96005

    • DOI

      10.1371/journal.pone.0096005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glycolytic gene as the targets of nuclear receptor Ad4BP/SF-12014

    • Author(s)
      Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon, Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung, Ken-ichirou Morohashi
    • Journal Title

      Nature Commun

      Volume: 5 Issue: 1 Pages: 3634-3634

    • DOI

      10.1038/ncomms4634

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NEAT1 long noncoding RNA regulates transcription via protein sequestration within2014

    • Author(s)
      Hirose T, Virnicchi G, Tanigawa A, Naganuma T, Li R, Kimura H, Yokoi T, Nakagawa S, Bénard M, Fox AH, Pierron G.
    • Journal Title

      Mol Biol Cell.

      Volume: 25 Issue: 1 Pages: 169-183

    • DOI

      10.1091/mbc.e13-09-0558

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis of a nucleosome containing histone H2A. B/H2A. Bbd that transiently associates with reorganized chromatin.2013

    • Author(s)
      Arimura Y., Kimura H., Oda T., Sato K., Osakabe A., Tachiwana H., Sato Y., Kinugasa Y., Ikura T., Sugiyama M., Sato M., Kurumizaka H.
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 3510-3510

    • DOI

      10.1038/srep03510

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural polymorphism in the L1 loop regions of human H2A. Z. 1 and H2A. Z. 2.2013

    • Author(s)
      Naoki Horikoshi, Koichi Sato, Keisuke Shimada, Yasuhiro Arimura, Akihisa Osakabe, Hiroaki Tachiwana, Yoko Hayashi-Takanaka, Wakana Iwasaki, Wataru Kagawa, Masahiko Harata, Hiroshi Kimura and Hitoshi Kurumizaka.
    • Journal Title

      Acta Crystallographica Section D

      Volume: 69 Issue: 12 Pages: 2431-2439

    • DOI

      10.1107/s090744491302252x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations2013

    • Author(s)
      Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T.
    • Journal Title

      J Clin Invest

      Volume: 123 Pages: 4627-4640

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Latrunculin A treatment prevents abnormal chromosome segregation for successful development of cloned embryos2013

    • Author(s)
      Terashita Y, Yamagata K, Tokoro M, Wakayama S, Li C, Sato E, Tanemura K, Wakayama T.
    • Journal Title

      Plos One

      Volume: 8 Issue: 10 Pages: 1-10

    • DOI

      10.1371/journal.pone.0078380

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice.2013

    • Author(s)
      Kuroki S, Akiyoshi M, Tokura M, Miyachi H, Nakai Y, Kimura H, Shinkai Y, Tachibana M.
    • Journal Title

      Biol Reprod

      Volume: 89 Issue: 4 Pages: 93-93

    • DOI

      10.1095/biolreprod.113.108597

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Epigenetics of eu- and heterochromatin in inverted and conventional nuclei.2013

    • Author(s)
      Eberhart A, Feodorava Y, Song C, Wanner G, Kiseleva E, Hake S, Furukawa T, Kimura H, Schotta G, Leonhardt H, Joffe B & Solovei I
    • Journal Title

      Chromosome Res.

      Volume: 20 Issue: 5 Pages: 535-554

    • DOI

      10.1007/s10577-013-9375-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage.2013

    • Author(s)
      Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB, Vermeulen W, Marteijn JA.
    • Journal Title

      Mol Cell

      Volume: 51 Issue: 4 Pages: 469-479

    • DOI

      10.1016/j.molcel.2013.08.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence.2013

    • Author(s)
      Sadaie M, Salama R, Carroll T, Tomimatsu K, Chandra T, Young AR, Narita M, Pérez-Mancera PA, Bennett DC, Chong H, Kimura H, Narita M.
    • Journal Title

      Genes Dev

      Volume: 27 Pages: 1800-1808

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In aggressive variants of non-Hodgkin lymphomas, Ezh2 is strongly expressed and polycomb repressive complex PRC1.4 dominates over PRC1.2.2013

    • Author(s)
      Abd Al Kader L, Oka T, Takata K, Sun X, Sato H, Murakami I, Toji T, Manabe A, Kimura H, Yoshino T.
    • Journal Title

      Virchows Arch.

      Volume: 463 Issue: 5 Pages: 697-711

    • DOI

      10.1007/s00428-013-1428-y

    • NAID

      120005359111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetically encoded system to track histone modification in vivo.2013

    • Author(s)
      Yuko Sato, Masanori Mukai, Jun Ueda, Michiko Muraki, Timothy J. Stasevich, Naoki Horikoshi, Tomoya Kujirai, Hiroaki Kita, Taisuke Kimura, Seiji Hira, Yasushi Okada, Yoko Hayashi-Takanaka, Chikashi Obuse, Hitoshi Kurumizaka, Atsuo Kawahara, Kazuo Yamagata, Naohito Nozaki and Hiroshi Kimura
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 2436-2436

    • DOI

      10.1038/srep02436

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Chromatin modification dynamics during gene activation in living cells2017

    • Author(s)
      木村宏
    • Organizer
      4D Nucleome : The Cell Nucleus in Space and Time
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromatin modification dynamics during gene activation in living cells2017

    • Author(s)
      木村宏
    • Organizer
      10th Berlin Summer Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromatin modification dynamics during cell differentiation2017

    • Author(s)
      木村宏
    • Organizer
      Gordon Research Conference “Genome Architecture in Cell Fate & Disease”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromatin modification dynamics during cell differentiation2017

    • Author(s)
      木村宏
    • Organizer
      HMGU-Japan Epigenetics and Chromatin Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromatin Integration Labeling Technology2017

    • Author(s)
      木村宏
    • Organizer
      平成29年度遺伝研研究会『エピジェネティクスの基盤となるクロマチン・細胞核の動的構造変換』
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] クロマチン修飾ダイナミクスと転写制御2017

    • Author(s)
      木村宏
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Tracking chromatin modification dynamics during gene activation in vivo2017

    • Author(s)
      Hiroshi Kimura
    • Organizer
      Swiss-Japan Symposium “Chromatin Structure and Dynamics”
    • Place of Presentation
      Basel, Switzerland
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Visualizing the dynamics of histone H4K20 methylation in living cells2016

    • Author(s)
      Yuko Sato and Hiroshi Kimura
    • Organizer
      3R Meeting
    • Place of Presentation
      松江市
    • Year and Date
      2016-11-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tracking post-translational modifications in living cells2016

    • Author(s)
      Hiroshi Kimura
    • Organizer
      UK-Japan Symposium “From single molecules to cells and tissues”
    • Place of Presentation
      Leicester, UK
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 転写とクロマチン修飾の生細胞ダイナミクス2016

    • Author(s)
      木村 宏
    • Organizer
      ATRXシンポジウム
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2016-04-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 初期胚ライブセルイメージングを始めるには~タイムラプスを用いた知見を含めて~2016

    • Author(s)
      山縣一夫
    • Organizer
      第11回日本生殖再生医学会学術集会
    • Place of Presentation
      シェーンバッハ・サボー(東京都千代田区)
    • Year and Date
      2016-03-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Histone modification dynamics in living cells2016

    • Author(s)
      Hiroshi Kimura
    • Organizer
      Colorado Chromatin Meeting 2016
    • Place of Presentation
      Fort Collins, Colorado, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 転写誘導におけるヒストンアセチル化の役割2015

    • Author(s)
      木村 宏
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Mouse testis specific histone H3 variant, H3t is essential for spermatogenesis2015

    • Author(s)
      山縣一夫
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 初期胚ライブセルイメージングを始めよう2015

    • Author(s)
      山縣一夫
    • Organizer
      東京ビックサイト
    • Place of Presentation
      東京ビックサイト
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Live-cell imaging of chromatin and DNA-methylation dynamics using MethylRO mouse2015

    • Author(s)
      Kazuo Yamagata
    • Organizer
      6th Hiroshima Conference on Education and Science in Dentistry
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] クロマチン修飾と転写活性化のin vivoダイナミクス2015

    • Author(s)
      木村 宏
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学 角間キャンパス
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ライブセルイメージングを用いた着床前初期胚の質の評価2015

    • Author(s)
      山縣一夫
    • Organizer
      関西実験動物研究会第127回研究会
    • Place of Presentation
      大阪大学銀杏会館
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Kinetics of Histone and RNA polymerase II Modifications during Transcriptional Activation2015

    • Author(s)
      Hiroshi Kimura
    • Organizer
      International Symposium on Chromatin Structure, Dyanamics, and Function
    • Place of Presentation
      淡路夢舞台
    • Year and Date
      2015-08-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Tracking posttranslational and epigenetic modifications of endogenous proteins in vivo2015

    • Author(s)
      Hiroshi Kimura
    • Organizer
      24th Wilhelm Bernhard Workshop on the Cell Nucleus/57th Symposium of the Society for Histochemistry
    • Place of Presentation
      Schloss Wilhelminenberg, Vienna, Austria
    • Year and Date
      2015-08-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生細胞・生体内のヒストン修飾イメージング2015

    • Author(s)
      木村 宏
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] エピゲノム修飾の生細胞・生体内ダイナミクス2015

    • Author(s)
      木村 宏
    • Organizer
      第9回日本エピジェネティクス研究会年会
    • Place of Presentation
      学術総合センター
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Visualization of Dynamics of Methylated DNA in living cell and animal.2015

    • Author(s)
      Kazuo Yamagata
    • Organizer
      International Symposium on Bio-imaging and Gene Targeting Sciences in Okayama
    • Place of Presentation
      岡山
    • Year and Date
      2015-02-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] メチローマウスで動くメチル化DNAを追う2015

    • Author(s)
      山縣一夫
    • Organizer
      "平成26年度基礎生物学研究所重点共同利用研究
    • Place of Presentation
      岡崎
    • Year and Date
      2015-01-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Tracking functional chromatin components in living cells and organisms2014

    • Author(s)
      Hiroshi Kimura
    • Organizer
      4D Nucleome meeting
    • Place of Presentation
      広島
    • Year and Date
      2014-12-17 – 2014-12-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Tracking epigenetic modifications and transcription activity in living cells and organisms2014

    • Author(s)
      Hiroshi Kimura
    • Organizer
      8th International Symposium on Nanomedicine
    • Place of Presentation
      松山
    • Year and Date
      2014-12-04 – 2014-12-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 初期胚の高精細イメージングで見えてくるもの2014

    • Author(s)
      山縣一夫
    • Organizer
      第59回本生殖医学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 発生過程や刺激に応答した転写活性化とヒストン修飾の動態2014

    • Author(s)
      木村 宏、スタセビッチ ティモシー、佐藤優子
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulation of Transcription Cycle by Histone Modifications in Living Cells2014

    • Author(s)
      Hiroshi Kimura
    • Organizer
      The International Symposium on Transcription Cycle 2014
    • Place of Presentation
      東京
    • Year and Date
      2014-11-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Histone modification and transcription dynamics in living cells and organisms2014

    • Author(s)
      Hiroshi Kimura
    • Organizer
      The 9th 3R Symposium
    • Place of Presentation
      御殿場
    • Year and Date
      2014-11-17 – 2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] メチローで 動くメチル化DNAを追う2014

    • Author(s)
      山縣一夫
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒストンとRNAポリメラーゼの翻訳後修飾の生細胞・生体内計測2014

    • Author(s)
      木村 宏
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 発生・分化に伴うヒストン修飾のダイナミクス2014

    • Author(s)
      木村 宏
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒストン修飾翻訳後修飾と転写の生細胞動態2014

    • Author(s)
      木村 宏
    • Organizer
      第14回蛋白質科学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ライブセルイメージングで「卵子の質」を定量化する2014

    • Author(s)
      山縣一夫
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Quantification of embryo quality by live-cell imaging2014

    • Author(s)
      Kazuo Yamagata
    • Organizer
      47th Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ライブセルイメージングで「卵子の質」を評価する2014

    • Author(s)
      山縣一夫
    • Organizer
      第55回日本卵子学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-05-17 – 2014-05-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ライブセルイメージングで「卵子の質」を評価する2014

    • Author(s)
      山縣一夫
    • Organizer
      日本受精着床学会 第10回ART生涯研修コース
    • Place of Presentation
      東京
    • Year and Date
      2014-03-02
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生細胞におけるヒストンH3アセチル化による転写活性化の二段階制御2013

    • Author(s)
      木村 宏
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-03 – 2013-12-06
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 初期胚の「質」を定量化することで不妊を知る2013

    • Author(s)
      山縣一夫
    • Organizer
      日本動物学会 第84回 岡山大会
    • Place of Presentation
      岡山
    • Year and Date
      2013-09-26 – 2013-09-28
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生細胞解析により明らかとなったヒストン修飾による転写活性化の二段階制御2013

    • Author(s)
      木村 宏
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-19 – 2013-09-21
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Imaging global epigenetic dynamics during mouse pre-implantation development2013

    • Author(s)
      山縣一夫
    • Organizer
      日本遺伝学会 第85回大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-19 – 2013-09-20
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ストレス応答とクロマチン修飾動態の生細胞解析2013

    • Author(s)
      木村 宏
    • Organizer
      第86回生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11 – 2013-09-13
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 働き者と怠け者をどう見分けるか?2013

    • Author(s)
      木村 宏
    • Organizer
      2013年イメージング若手の会
    • Place of Presentation
      千葉県野田市
    • Year and Date
      2013-09-07 – 2013-09-08
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bimodal regulation of RNA polymerase II transcription kinetics by histone acetylation in single living cells2013

    • Author(s)
      Hiroshi Kimura and Timothy J. Stasevich
    • Organizer
      23th Wilhelm Bernhard Workshop on the cell nucleus
    • Place of Presentation
      Debrecen, Hungary
    • Year and Date
      2013-08-19 – 2013-08-23
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ライブセルイメージングで「卵子の質」を評価する2013

    • Author(s)
      山縣一夫
    • Organizer
      第31回日本受精着床学会総会・学術講演会
    • Place of Presentation
      別府
    • Year and Date
      2013-08-08 – 2013-08-09
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Abnormal Chromosome Segregation at Early Cleavage is a Major Cause of the Full-term Developmental Failure of Mouse Clones2013

    • Author(s)
      山縣一夫
    • Organizer
      The 61st NIBB Conference "Cellular Community in Mammalian Embryogenesis"細胞コミュニティ国際会議
    • Place of Presentation
      岡崎
    • Year and Date
      2013-07-10 – 2013-07-12
    • Related Report
      2013 Annual Research Report
  • [Book] 新・生細胞蛍光イメージング2015

    • Author(s)
      原口徳子、木村 宏、平岡 泰
    • Total Pages
      340
    • Publisher
      共立出版
    • Related Report
      2015 Annual Research Report
  • [Book] DNA Replication, Recombination, and Repair Molecular Mechanisms and Pathology (Eds F. Hanaoka, K. Sugasawa)2015

    • Author(s)
      Hiroshi Kimura, Yuko Sato
    • Total Pages
      555
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] エピジェネティクス―基礎研究から産業応用への展望―(畑田出穂、久保田健夫/編)2014

    • Author(s)
      佐藤優子、木村宏
    • Total Pages
      393
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Annual Research Report
  • [Book] 遺伝子医学MOOK「エピジェネティクスと病気」(佐々木裕之/監、中尾光善・中島欣一/編)2013

    • Author(s)
      木村 宏、佐藤優子
    • Total Pages
      280
    • Publisher
      メディカル・ドゥ
    • Related Report
      2013 Annual Research Report
  • [Book] エピジェネティクスキーワード事典(牛島俊和・眞貝洋一/編)2013

    • Author(s)
      木村 宏
    • Total Pages
      315
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 染色体と細胞核のダイナミクス(平岡 泰・原口徳子/編)2013

    • Author(s)
      木村 宏、胡桃坂仁志
    • Total Pages
      224
    • Publisher
      化学同人
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東工大 木村宏研究室

    • URL

      http://kimura-lab.bio.titech.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東工大 木村宏研究者情報

    • URL

      http://t2r2.star.titech.ac.jp/cgi-bin/researcherinfo.cgi?q_researcher_content_number=CTT100673940

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東工大 科学技術創成研究院 細胞制御工学研究センター

    • URL

      http://www.rcb.iir.titech.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京工業大学 木村研究室

    • URL

      http://kimura-lab.bio.titech.ac.jp/

    • Related Report
      2016 Annual Research Report 2013 Annual Research Report
  • [Remarks] 東京工業大学 科学技術創成研究院 細胞制御工学研究センター

    • URL

      https://cell-biology.jimdo.com/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京工業大学 リサーチデポジトリ 木村 宏

    • URL

      http://t2r2.star.titech.ac.jp/cgi-bin/researcherinfo.cgi?q_researcher_content_number=CTT100673940

    • Related Report
      2016 Annual Research Report
  • [Remarks] 新学術領域「クロマチン動構造」

    • URL

      http://nucleosome.kyushu-u.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京工業大学 木村宏研究室

    • URL

      http://kimura-lab.bio.titech.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京工業大学 科学技術創成研究院 細胞制御工学ユニット

    • URL

      http://cell-biology.jimdo.com/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京工業大学 リサーチリポジトリ 木村宏

    • URL

      http://t2r2.star.titech.ac.jp/cgi-bin/researcherinfo.cgi?q_researcher_content_number=CTT100673940

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京工業大学大学院生命理工学研究科 木村宏研究室

    • URL

      http://kimura-lab.bio.titech.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京工業大学大学院生命理工学研究科 木村宏研究室

    • URL

      http://www.bio.titech.ac.jp/laboratory/kimura-kajikawa/kimura/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京工業大学 生命理工学研究科 木村宏研究室

    • URL

      http://www.bio.titech.ac.jp/laboratory/kimura-kajikawa/kimura/index.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] ヒストンH3トリメチル化リシン特異的モノクローナル抗体又はその抗原結合性断片2017

    • Inventor(s)
      木村 宏、佐藤優子、大井彰人、胡桃坂仁志、鯨井智也、他
    • Industrial Property Rights Holder
      東京工業大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-111580
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] DNA結合タンパク質の結合領域の近傍に所望のDNA断片を挿入する方法2016

    • Inventor(s)
      大川恭行、原田、哲仁、胡桃坂仁志、木村宏、等
    • Industrial Property Rights Holder
      国立大学法人九州大学、国立大学法人東京工業大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-167967
    • Filing Date
      2016-08-30
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2013-07-10   Modified: 2022-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi