| Budget Amount *help |
¥111,150,000 (Direct Cost: ¥85,500,000、Indirect Cost: ¥25,650,000)
Fiscal Year 2017: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2016: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2015: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2014: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2013: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
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| Outline of Final Research Achievements |
This study aims to understand the nuclear envelope structure that guarantees chromatin functions. Toward this end, we used the beads-induced experimental system, fluorescence live-cell imaging, and molecular genetics. The results showed that the BAF-dependent nuclear envelope formation around the DNA-beads functioned to protect the DNAs from degradation by autophagy. Additionally, the conserved nuclear envelope protein LEM2 functioned to augment heterochromatin formation in the centromeres in fission yeast. Nup132 was required for the centromere functions during meiosis in fission yeast.
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