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Analysis of Chromatin Dynamics In Cell Differentiation

Planned Research

Project AreaDynamic chromatin structure and function
Project/Area Number 25116010
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University

Principal Investigator

Ohkawa Yasuyuki  九州大学, 生体防御医学研究所, 教授 (80448430)

Project Period (FY) 2013-06-28 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥93,990,000 (Direct Cost: ¥72,300,000、Indirect Cost: ¥21,690,000)
Fiscal Year 2017: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2015: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2014: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2013: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Keywordsエピゲノム / クロマチン構造 / ヒストンバリアント / 発現制御 / 遺伝子 / 発生・分化 / クロマチン / ゲノム / 骨格筋分化 / 次世代シークエンサー
Outline of Final Research Achievements

In this project, we analyzed chromatin dynamics upon cellular differentiation. Especially, we have focused on the functions of tissue-specific histone H3 variant genes which we identified in 2015 in this project. A representative study published this year reports that H3mm7, a skeletal muscle satellite dominant histone H3 variant, was required for normal skeletal muscle regeneration upon injury. H3mm7 was shown to be involved in the loosening of chromatin structure by forming “mobile” nucleosomes in which the absence of the interaction between H3.3S57 and H4R40 was observed. This project has led to more than 57 published papers based on the genome-wide study of chromatin dynamics.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (150 results)

All 2018 2017 2016 2015 2014 2013 2010 Other

All Journal Article (74 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 74 results,  Open Access: 64 results,  Acknowledgement Compliant: 27 results) Presentation (63 results) (of which Int'l Joint Research: 9 results,  Invited: 27 results) Book (5 results) Remarks (6 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration2018

    • Author(s)
      Harada Akihito、Maehara Kazumitsu、Ono Yusuke、Taguchi Hiroyuki、Yoshioka Kiyoshi、Kitajima Yasuo、Xie Yan、Sato Yuko、Iwasaki Takeshi、Nogami Jumpei、Okada Seiji、Komatsu Tetsuro、Semba Yuichiro、Takemoto Tatsuya、Kimura Hiroshi、Kurumizaka Hitoshi、Ohkawa Yasuyuki
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1400-1400

    • DOI

      10.1038/s41467-018-03845-1

    • NAID

      120006949474

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence2018

    • Author(s)
      Takizawa Yoshimasa、Tanaka Hiroki、Machida Shinichi、Koyama Masako、Maehara Kazumitsu、Ohkawa Yasuyuki、Wade Paul A.、Wolf Matthias、Kurumizaka Hitoshi
    • Journal Title

      Open Biology

      Volume: 8 Issue: 3 Pages: 170255-170255

    • DOI

      10.1098/rsob.170255

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sensitive detection of fluorescence in western blotting by merging images2018

    • Author(s)
      Kondo Yukari、Higa Shinichiro、Iwasaki Takeshi、Matsumoto Tomoya、Maehara Kazumitsu、Harada Akihito、Baba Yoshihiro、Fujita Masatoshi、Ohkawa Yasuyuki
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 1 Pages: 0191532-0191532

    • DOI

      10.1371/journal.pone.0191532

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of miR-305, a microRNA that promotes aging, and its target mRNAs in Drosophila2018

    • Author(s)
      Ueda Makiko、Sato Tetsuya、Ohkawa Yasuyuki、Inoue Yoshihiro H.
    • Journal Title

      Genes to Cells

      Volume: 23 Issue: 2 Pages: 80-93

    • DOI

      10.1111/gtc.12555

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temporal regulation of chromatin during myoblast differentiation2017

    • Author(s)
      Harada Akihito、Ohkawa Yasuyuki、Imbalzano Anthony N.
    • Journal Title

      Seminars in Cell & Developmental Biology

      Volume: 72 Pages: 77-86

    • DOI

      10.1016/j.semcdb.2017.10.022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of histone H3.5 in human spermatogenesis and spermatogenic disorders2017

    • Author(s)
      Shiraishi K.、Shindo A.、Harada A.、Kurumizaka H.、Kimura H.、Ohkawa Y.、Matsuyama H.
    • Journal Title

      Andrology

      Volume: 6 Issue: 1 Pages: 158-165

    • DOI

      10.1111/andr.12438

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi2017

    • Author(s)
      Kajitani Takuya、Kato Hiroaki、Chikashige Yuji、Tsutsumi Chihiro、Hiraoka Yasushi、Kimura Hiroshi、Ohkawa Yasuyuki、Obuse Chikashi、Hermand Damien、Murakami Yota
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 114 Issue: 52

    • DOI

      10.1073/pnas.1714579115

    • NAID

      120006539374

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone methyltransferase G9a is a key regulator of the starvation-induced behaviors in Drosophila melanogaster.2017

    • Author(s)
      Shimaji, K., Tanaka, R., Maeda, T., Ozaki, M., Yoshida, H., Ohkawa, Y., Sato, T., Suyama, M. and Yamaguchi, M.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 14763-14763

    • DOI

      10.1038/s41598-017-15344-2

    • NAID

      120006368029

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The novel heme-dependent inducible protein, SRRD regulates heme biosynthesis and circadian rhythms.2017

    • Author(s)
      Adachi Y, Umeda M, Kawazoe A, Sato T, Ohkawa Y, Kitajima S, Izawa S, Sagami I, Taketani S.
    • Journal Title

      Arch Biochem Biophys.

      Volume: 631 Pages: 19-29

    • DOI

      10.1016/j.abb.2017.08.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1.2017

    • Author(s)
      Sasaki F, Koga T, Saeki K, Okuno T, Kazuno S, Fujimura T, Ohkawa Y, Yokomizo T
    • Journal Title

      PLoS One

      Volume: 12 Issue: 9 Pages: 0185133-0185133

    • DOI

      10.1371/journal.pone.0185133

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation2017

    • Author(s)
      Kudou Kensuke、Komatsu Tetsuro、Nogami Jumpei、Maehara Kazumitsu、Harada Akihito、Saeki Hiroshi、Oki Eiji、Maehara Yoshihiko、Ohkawa Yasuyuki
    • Journal Title

      Open Biology

      Volume: 7 Issue: 9 Pages: 170119-170119

    • DOI

      10.1098/rsob.170119

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability2017

    • Author(s)
      Fukuda Kei、Inoguchi Yukihiro、Ichiyanagi Kenji、Ichiyanagi Tomoko、Go Yasuhiro、Nagano Masashi、Yanagawa Yojiro、Takaesu Noboru、Ohkawa Yasuyuki、Imai Hiroo、Sasaki Hiroyuki
    • Journal Title

      Human Molecular Genetics

      Volume: 26 Issue: 18 Pages: 3508-3519

    • DOI

      10.1093/hmg/ddx236

    • NAID

      120006367980

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Persistent detection of alternatively spliced BCR-ABL variant results in a failure to achieve deep molecular response2017

    • Author(s)
      Yuda Junichiro、Miyamoto Toshihiro、Odawara Jun、Ohkawa Yasuyuki、Semba Yuichiro、Hayashi Masayasu、Miyamura Koichi、Tanimoto Mitsune、Yamamoto Kazuhito、Taniwaki Masafumi、Akashi Koichi
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 11 Pages: 2204-2212

    • DOI

      10.1111/cas.13353

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin?N-cadherin pathway after spinal cord injury2017

    • Author(s)
      Hara Masamitsu、Kobayakawa Kazu、Ohkawa Yasuyuki、Kumamaru Hiromi、Yokota Kazuya、Saito Takeyuki、Kijima Ken、Yoshizaki Shingo、Harimaya Katsumi、Nakashima Yasuharu、Okada Seiji
    • Journal Title

      Nature Medicine

      Volume: 23 Issue: 7 Pages: 818-828

    • DOI

      10.1038/nm.4354

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells2017

    • Author(s)
      Semba Yuichiro、Harada Akihito、Maehara Kazumitsu、Oki Shinya、Meno Chikara、Ueda Jun、Yamagata Kazuo、Suzuki Atsushi、Onimaru Mitsuho、Nogami Jumpei、Okada Seiji、Akashi Koichi、Ohkawa Yasuyuki
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Issue: 15 Pages: 8758-8772

    • DOI

      10.1093/nar/gkx475

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes2017

    • Author(s)
      Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Ohkawa Y,他39名
    • Journal Title

      Ann Rheum Dis.

      Volume: 76 Issue: 5 Pages: 869

    • DOI

      10.1136/annrheumdis-2016-209632

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.82017

    • Author(s)
      Taguchi H, Xie Y, Horikoshi N, Maehara K, Harada A, Nogami J, Sato K, Arimura Y, Osakabe A, Kujirai T, Iwasaki T, Semba Y, Tachibana T, Kimura H, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Biochemistry

      Volume: 56 Issue: 16 Pages: 2184-2196

    • DOI

      10.1021/acs.biochem.6b01098

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Thymine DNA glycosylase modulates the DNA damage response and gene expression by base excision repair-dependent and -independent mechanisms2017

    • Author(s)
      Tomohumi Nakamura, Kouichi Murakami, Haruto Tada, Yoshihiko Uehara, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Hisato Saitoh, Hideo Nishitani, Tetsuya Ono, Ryotaro Nishi, Masayuki Yokoi, Wataru Sakai, and Kaoru Sugasawa
    • Journal Title

      Genes to Cells

      Volume: 22 Issue: 4 Pages: 392-405

    • DOI

      10.1111/gtc.12481

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Crystal structure of the overlapping dinucleosome composed of hexasome and octasome2017

    • Author(s)
      Daiki Kato, Akihisa Osakabe, Yasuhiro Arimura, Yuka Mizukami, Naoki Horikoshi, Kazumi Saikusa, Satoko Akashi, Yoshifumi Nishimura, Sam-Yong Park, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Atsushi Matsumoto, Hidetoshi Kono, Rintaro Inoue, Masaaki Sugiyama, Hitoshi Kurumizaka
    • Journal Title

      Science

      Volume: 356 Issue: 6334 Pages: 205-208

    • DOI

      10.1126/science.aak9867

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells2017

    • Author(s)
      Li B, BabaT, Miyabayashi K, Sato T, Shima Y, Ichinose T, Miura D, Ohkawa Y, Suyama M, Morohashi KI
    • Journal Title

      Endocrine Journal

      Volume: 64 Issue: 3 Pages: 315-324

    • DOI

      10.1507/endocrj.EJ16-0467

    • NAID

      130005529460

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.2017

    • Author(s)
      Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, Akiyama H, Kimura H, Kanal Y, Ishihara Y, Haraguchi S, Miyazaki A, Rozman D, Yamazaki T, Choi MH, Ohkawa Y, Suyama M, Morohashi KI
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 41912-41912

    • DOI

      10.1038/srep41912

    • NAID

      120006799381

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis2017

    • Author(s)
      Ueda J., Harada A., Urahama T., Machida S., Maehara K., Hada M., Makino Y., Nogami J., Horikoshi N., Osakabe A., Taguchi H., Tanaka H., Tachiwana H., Yao T., Yamada M., Iwamoto T., Isotani A., Ikawa M., Tachibana T., Okada Y., Kimura H., Ohkawa Y., Kurumizaka H., Yamagata K.
    • Journal Title

      Cell Reports

      Volume: 18(3) Issue: 3 Pages: 593-600

    • DOI

      10.1016/j.celrep.2016.12.065

    • NAID

      120006957416

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes/Macrophages after Spinal Cord Injury.2017

    • Author(s)
      Yokota K, Kobayakawa K, Saito T, Hara M, Kijima K, Ohkawa Y, Harada A, Okazaki K, Ishihara K, Yoshida S, Kudo A, Iwamoto Y, Okada S.
    • Journal Title

      Am J Pathol.

      Volume: 187 Issue: 3 Pages: 639-653

    • DOI

      10.1016/j.ajpath.2016.11.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development.2016

    • Author(s)
      Miyabayashi K, Shima Y, Inoue M, Sato T, Baba T, Ohkawa Y, Suyama M, Morohashi KI.
    • Journal Title

      Sex Dev.

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A One-Step Immunostaining Method to Visualize Rodent Muscle Fiber Type within a Single Specimen.2016

    • Author(s)
      Sawano S, Komiya Y, Ichitsubo R, Ohkawa Y, Nakamura M, Tatsumi R, Ikeuchi Y, Mizunoya W.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 11 Pages: e0166080-e0166080

    • DOI

      10.1371/journal.pone.0166080

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of Immunoglobulin Gene Sequences from a Small Read Number of mRNA-Seq Using Hybridomas.2016

    • Author(s)
      Kuniyoshi Y, Maehara K, Iwasaki T, Hayashi M, Semba Y, Fujita M, Sato Y, Kimura H, Harada A, Ohkawa Y.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: e0165473-e0165473

    • DOI

      10.1371/journal.pone.0165473

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CHD8 haploinsufficiency results in autistic-like phenotypes in mice2016

    • Author(s)
      Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T., Nakayama, K. I.
    • Journal Title

      Nature

      Volume: 537 Issue: 7622 Pages: 675-679

    • DOI

      10.1038/nature19357

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MRG15 is required for pre-mRNA splicing and spermatogenesis.2016

    • Author(s)
      Iwamori N, Tominaga K, Sato T, Riehle K, Iwamori T, Ohkawa Y, Coarfa C, Ono E, Matzuk MM.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113 Issue: 37

    • DOI

      10.1073/pnas.1611995113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] LATS2 Positively Regulates Polycomb Repressive Complex 2.2016

    • Author(s)
      Torigata K, Daisuke O, Mukai S, Hatanaka A, Ohka F, Motooka D, Nakamura S,Ohkawa Y, Yabuta N, Kondo Y, Nojima H.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 7 Pages: e0158562-e0158562

    • DOI

      10.1371/journal.pone.0158562

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin.2016

    • Author(s)
      Yabe-Wada T, Matsuba S, Takeda K, Sato T, Suyama M, Ohkawa Y, Takai T, Shi H, Philpott CC, Nakamura A.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 26566-26566

    • DOI

      10.1038/srep26566

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The feasibility of in vivo imaging of infiltrating blood cells for predicting the functional prognosis after spinal cord injury.2016

    • Author(s)
      Yokota K, Saito T, Kobayakawa K, Kubota K, Hara M, Murata M, Ohkawa Y, Iwamoto Y, Okada S.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 25673-25673

    • DOI

      10.1038/srep25673

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histone H4 lysine 20 acetylation is associated with gene repression in human cells.2016

    • Author(s)
      Kaimori, J. Y., Maehara, K., Hayashi-Takanaka, Y., Harada, A., Fukuda, M., Yamamoto, S., Ichimaru, N., Umehara, T., Yokoyama, S., Matsuda, R., Ikura, T., Nagao, K., Obuse, C., Nozaki, N., Takahara, S., Takao, T., Ohkawa, Y., Kimura, H., and Isaka, Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 24318-24318

    • DOI

      10.1038/srep24318

    • NAID

      120005770760

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing2016

    • Author(s)
      Kobayashi W., Takaku M., Machida S., Tachiwana H., Maehara K., Ohkawa Y. and Kurumizaka H
    • Journal Title

      Scientific reports

      Volume: 6 Issue: 1 Pages: 24428-24428

    • DOI

      10.1038/srep24228

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Exploration of nucleosome positioning patterns in transcription factor function.2016

    • Author(s)
      Maehara K, Ohkawa Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 19620-19620

    • DOI

      10.1038/srep19620

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis.2016

    • Author(s)
      Urahama T, Harada A, Maehara K, Horikoshi N, Sato K, Sato Y, Shiraishi K, Sugino N, Osakabe A, Tachiwana H, Kagawa W, Kimura H, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Epigenetics Chromatin

      Volume: 9 Issue: 1 Pages: 1-16

    • DOI

      10.1186/s13072-016-0051-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes.2016

    • Author(s)
      Oka M, Mura S, Yamada K, Sangel P, Hirata S, Maehara K, Kawakami K, Tachibana T, Ohkawa Y, Kimura H, Yoneda Y
    • Journal Title

      eLIFE

      Volume: 5

    • DOI

      10.7554/elife.09540

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] solation and characterization of mouse fetal Leydig progenitor cells2016

    • Author(s)
      Miki Inoue, Yuichi Shima, Kanako Miyabayashi, Tetsuya Sato, Takashi Baba, Yasuyuki Ohkawa, Haruhiko Akiyama, Mikita Suyama, Ken-ichirou Morohashi
    • Journal Title

      Endocrinology

      Volume: 157 Issue: 3 Pages: 1222-1233

    • DOI

      10.1210/en.2015-1773

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2.2015

    • Author(s)
      Hayashi M, Maehara K, Harada A, Semba Y, Kudo K, Takahashi H, Oki S, Meno C, Ichiyanagi K, Akashi K, Ohkawa Y.
    • Journal Title

      J Cell Biochem

      Volume: 117 Issue: 3 Pages: 780-792

    • DOI

      10.1002/jcb.25368

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Guéren.2015

    • Author(s)
      2)Ozeki Y, Igarashi M, Doe M, Tamaru A, Kinoshita N, Ogura Y, Iwamoto T, Sawa R, Umekita M, Enany S, Nishiuchi Y, Osada-Oka M, Hayashi T, Niki M, Tateishi Y, Hatano M, Matsumoto S.
    • Journal Title

      PLoS One

      Volume: 10 Pages: 214-221

    • DOI

      10.1016/j.jprot.2016.01.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposon.2015

    • Author(s)
      Hatanaka Y, Inoue K, Oikawa M, Kamimura S, Ogonuki N, Kodam E, Ohkawa Y, Tsukada Y, Ogura A.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 112 Issue: 47 Pages: 14641-14646

    • DOI

      10.1073/pnas.1512775112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA.2015

    • Author(s)
      Osakabe A, Adachi F, Arimura Y, Maehara K, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Open Biol.

      Volume: 5 Issue: 10 Pages: 150128-150128

    • DOI

      10.1098/rsob.150128

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tissue-specific expression of histone H3 variants diversified after species separation.2015

    • Author(s)
      Maehara K, Harada A, Sato Y, Matsumoto M, Nakayama KI, Kimura H, Ohkawa Y.
    • Journal Title

      Epigenetics Chromatin

      Volume: 8 Issue: 1 Pages: 1-17

    • DOI

      10.1186/s13072-015-0027-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies.2015

    • Author(s)
      Hayashi-Takanaka Y., Maehara K., Harada A., Umehara T., Yokoyama S., Obuse C., Ohkawa Y., Nozaki N., Kimura H.
    • Journal Title

      Chromosome Res.

      Volume: 23 Issue: 4 Pages: 753-766

    • DOI

      10.1007/s10577-015-9486-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis2015

    • Author(s)
      Shimaji K, Konishi T, Tanaka S, Yoshida H, Kato Y, Ohkawa Y, Sato T, Suyama M, Kimura H, Yamaguchi M.
    • Journal Title

      Genes to Cells

      Volume: 20 Issue: 11 Pages: 902-914

    • DOI

      10.1111/gtc.12281

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury.2015

    • Author(s)
      Yokota K, Kobayakawa K, Kubota K, Miyawaki A, Okano H, Ohkawa Y, Iwamoto Y, Okada S.
    • Journal Title

      Stem Cell Reports.

      Volume: 5 Issue: 2 Pages: 264-277

    • DOI

      10.1016/j.stemcr.2015.06.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka.2015

    • Author(s)
      Nishimura T, Sato T, Yamamoto Y, Watakabe I, Ohkawa Y, Suyama M, Kobayashi S, Tanaka M.
    • Journal Title

      Science

      Volume: 349 Issue: 6245 Pages: 328-331

    • DOI

      10.1126/science.aaa2657

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme.2015

    • Author(s)
      Nasipakb B, Padilla-Benavides T, Green K, Leszyk J, Mao W, Konda S, Sif S, Shaffer S, Ohkawa Y, Imbalzano AN.
    • Journal Title

      Nat Commun.

      Volume: 6 Issue: 1 Pages: 7441-7441

    • DOI

      10.1038/ncomms8441

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] agplus: a rapid and flexible tool for aggregation plots.2015

    • Author(s)
      Maehara K, Ohkawa Y.
    • Journal Title

      Bioinformatics.

      Volume: 18 Issue: 18 Pages: 3046-3047

    • DOI

      10.1093/bioinformatics/btv322

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture.2015

    • Author(s)
      Sugimoto N, Maehara K, Yoshida K, Yasukouchi S, Osano S, Watanabe S, Aizawa M, Yugawa T, et al.
    • Journal Title

      Nucleic Acids Res.

      Volume: 43 Issue: 12 Pages: 5898-5911

    • DOI

      10.1093/nar/gkv509

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens.2015

    • Author(s)
      Ohnishi YH, Ohnishi YN, Nakamura T, Ohno M, Kennedy PJ, Yasuyuki O, Nishi A, Neve R, Tsuzuki T, Nestler EJ.
    • Journal Title

      PLoS One

      Volume: 10(5) Issue: 5 Pages: e0126710-e0126710

    • DOI

      10.1371/journal.pone.0126710

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A cluster of non-coding RNAs activates the ESR1 locus during breast cancer adaptation to hormone deprivation2015

    • Author(s)
      S. Tomita, M.O. Abdalla, S. Fujiwara, H. Matsumori, K. Maehara, Y. Ohkawa, H. Iwase, N. Saitoh, and M. Nakao.
    • Journal Title

      Nat. Commun.

      Volume: 6 Issue: 1 Pages: 6966-6966

    • DOI

      10.1038/ncomms7966

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies.2015

    • Author(s)
      Kawaguchi T, Tanigawa A, Naganuma T, Ohkawa Y, Souquere S, Pierron G, Hirose T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 112 Issue: 14 Pages: 4304-4309

    • DOI

      10.1073/pnas.1423819112

    • NAID

      120005661435

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatial re-organization of myogenic regulatory sequences temporally controls gene expression2015

    • Author(s)
      Harada A, Mallappa C, Okada S, Butler JT, Baker SP, Lawrence JB, Ohkawa Y, Imbalzano AN.
    • Journal Title

      Nucleic Acids Research

      Volume: 43 Issue: 4 Pages: 2008-2021

    • DOI

      10.1093/nar/gkv046

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex2015

    • Author(s)
      Takahashi, H., Takigawa, I., Watanabe, M., Anwar, D., Shibata, M., Tomomori-Sato, C., Sato, S., Ranjan, A., Seidel, C.W., Tsukiyama, T., Mizushima, W., Hayashi, M., Ohkawa, Y., Conaway, J.W., Conaway, R.C. and Hatakeyama, S
    • Journal Title

      Nature Commun.

      Volume: 5 Issue: 1 Pages: 5941-5941

    • DOI

      10.1038/ncomms6941

    • NAID

      120005621881

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle2015

    • Author(s)
      Harada A, Maehara K, Sato Y, Konno D, Tachibana T, Kimura H, Ohkawa Y.
    • Journal Title

      Nucleic Acids Research

      Volume: 43 Issue: 2 Pages: 775-786

    • DOI

      10.1093/nar/gku1346

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Genome-Wide Analysis Identifies a Notch-RBP-Jκ-IL-7Rα Axis That Controls IL-17-Producing γδ T Cell Homeostasis in Mice.2015

    • Author(s)
      Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, Ikuta K, Yoshikai Y.
    • Journal Title

      J Immunol.

      Volume: 194 Pages: 243-251

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation.2014

    • Author(s)
      Matsumoto M, Baba A, Yokota T, Nishikawa H, Ohkawa Y, Kayama H, Kallies A, Nutt SL, Sakaguchi S, Takeda K, Kurosaki T, Baba Y.
    • Journal Title

      Immunity.

      Volume: 41 Pages: 1040-1051

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SraTailor: Graphical user interface software for processing and visualizing ChIP-seq data.2014

    • Author(s)
      Oki S, Maehara K, Ohkawa Y, Meno C.
    • Journal Title

      Genes Cells.

      Volume: 19 Pages: 919-926

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans2014

    • Author(s)
      Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S
    • Journal Title

      Science Translational Medicine

      Volume: 6 Issue: 256 Pages: 256-256

    • DOI

      10.1126/scitranslmed.3009430

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of RNA polymerase II activation by histone acetylation in single living cells2014

    • Author(s)
      Stasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H
    • Journal Title

      Nature

      Volume: 516 Issue: 7530 Pages: 272-275

    • DOI

      10.1038/nature13714

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2.2014

    • Author(s)
      Tanaka M, Yamaguchi M, Shiota M, Kawamoto Y, Takahashi K, Inagaki A, Osada-Oka M, Harada A, Wanibuchi H, Izumi Y, Miura K, Iwao H, Ohkawa Y.
    • Journal Title

      Monoclon Antib Immunodiagn Immunother.

      Volume: 33 Pages: 261-269

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide analysis of histone modifications in human endometrial stromal cells.2014

    • Author(s)
      Tamura I, Ohkawa Y, Sato T, Suyama M, Jozaki K, Okada M, Lee L, Maekawa R, Asada H, Sato S, Yamagata Y, Tamura H, Sugino N.
    • Journal Title

      Mol Endocrinol.

      Volume: 28 Pages: 1656-1669

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterochromatin dynamics during differentiation process revealed by the DNA methylation reporter mouse, MethylRO.2014

    • Author(s)
      Ueda J, Maehara K, Mashiko D, Ichinose T, Yao T, Hori M, Sato Y, Kimura K, Ohkawa Y, Yamagata K.
    • Journal Title

      Stem Cell Reports.

      Volume: 2 Pages: 910-924

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glycolytic gene as the targets of nuclear receptor Ad4BP/SF-12014

    • Author(s)
      Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon, Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung, Ken-ichirou Morohashi
    • Journal Title

      Nature Commun

      Volume: 5 Issue: 1 Pages: 3634-3634

    • DOI

      10.1038/ncomms4634

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of a Monoclonal Antibody for INI1/hSNF5/BAF47.2014

    • Author(s)
      Harada A, Hayashi M, Kuniyoshi Y, Semba Y, Sugahara S, Tachibana T, Ohkawa Y, Fujita M.
    • Journal Title

      Monoclonal Antibodies Immunodiagnosis and Immunotherapy

      Volume: 33 Issue: 1 Pages: 49-51

    • DOI

      10.1089/mab.2013.0065

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of a Monoclonal Antibody for C/EBPB : The Subnuclear Localization of C/EBPB in Mouse L929 Cells.2014

    • Author(s)
      Harada A, Okazaki E, Okada S, Tachibana T, Ohkawa Y.
    • Journal Title

      Monoclonal Antibodies Immunodiagnosis and Immunotherapy

      Volume: 33 Issue: 1 Pages: 34-37

    • DOI

      10.1089/mab.2013.0069

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The PPARγ locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner2014

    • Author(s)
      LeBlanc SE, Wu Q, Barutcu AR, Xiao H, Ohkawa Y, Imbalzano AN
    • Journal Title

      PLoS One

      Volume: 9(1) Issue: 1 Pages: e86140-e86140

    • DOI

      10.1371/journal.pone.0086140

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt signaling regulates left-right axis formation in the node of mouse embryos2013

    • Author(s)
      Kitajima, Oki, Ohkawa, Sumi, Meno
    • Journal Title

      Dev Biol

      Volume: 380 Issue: 2 Pages: 222-32

    • DOI

      10.1016/j.ydbio.2013.05.011

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I2013

    • Author(s)
      Katahira J, Okuzaki D, Inoue H, Yoneda Y, Maehara K, Ohkawa Y
    • Journal Title

      Nucleic Acids Res

      Volume: 41(14) Issue: 14 Pages: 7060-72

    • DOI

      10.1093/nar/gkt414

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury.2013

    • Author(s)
      Saiwai H, Kumamaru H, Ohkawa Y, Kubota K, Kobayakawa K, Yamada H, Yokomizo T, Iwamoto Y, Okada S.
    • Journal Title

      J Neurochem.

      Volume: 125 Issue: 1 Pages: 74-88

    • DOI

      10.1111/jnc.12135

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord2013

    • Author(s)
      Kumamaru H, Kobayakawa K, Saiwai H, Kubota K, Yokota K, Ohkawa Y, Shiba K, Iwamoto Y, Okada S
    • Journal Title

      Stem Cells

      Volume: 31(8) Issue: 8 Pages: 1535-47

    • DOI

      10.1002/stem.1404

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A panel of specific monoclonal antibodies directed against various phosphorylated histones H3.2013

    • Author(s)
      Yoshimi T, Ohkawa Y, Azuma M, Tachibana T.
    • Journal Title

      Monoclon Antib Immunodiagn Immunother.

      Volume: 32 Issue: 2 Pages: 119-124

    • DOI

      10.1089/mab.2012.0105

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation2013

    • Author(s)
      Villacorte M, Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama T, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N, Yamada G
    • Journal Title

      Oncogene

      Volume: 32 Issue: 29 Pages: 3477-3482

    • DOI

      10.1038/onc.2012.376

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV12010

    • Author(s)
      Hara K, Hashimoto H, Murakumo Y, Kobayashi S, Kogame T, Unzai S, Akashi S, Takeda S, Shimizu T, Sato M
    • Journal Title

      J Biol Chem

      Volume: 285 Issue: 40 Pages: 12299-12307

    • DOI

      10.1074/jbc.

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ChILT- an Epigenomic Profiling for Single Cell Analysis2018

    • Author(s)
      大川恭行
    • Organizer
      CDBシンポジウム2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒストンH3の選択による細胞分化制御機構 ~トランスクリプトミクスによるアプローチ~2018

    • Author(s)
      大川恭行
    • Organizer
      よこはまNMR研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒストンH3の選択による細胞分化制御機構~トランスクリプトミクスによるアプローチ~2018

    • Author(s)
      大川恭行
    • Organizer
      群馬大学生調研セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 骨格筋再生を制御するゲノムワイドな遺伝子制御機構~ヒストンの組成変化が拓く新たなエピゲノム制御~2018

    • Author(s)
      大川恭行
    • Organizer
      PROS学術シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 1細胞エピゲノム解析技術の開発2018

    • Author(s)
      大川恭行
    • Organizer
      日本がん分子標的治療学会TRワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ゲノムから遺伝子が選ばれる仕組み2018

    • Author(s)
      大川恭行
    • Organizer
      クロマチン一般公開シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒストンH3バリアントの選択による転写基底レベル調節機構2017

    • Author(s)
      大川恭行
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2017-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨格筋分化のエピゲノム制御を捉える2017

    • Author(s)
      大川恭行
    • Organizer
      第5回骨格筋生物学研究会
    • Place of Presentation
      東京大学駒場キャンパス
    • Year and Date
      2017-03-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] The baselines of transcription levels are determined by selective incorporation of histone H3 variants2017

    • Author(s)
      大川恭行
    • Organizer
      Transcriptional and Epigenetic Control in Stem Cells (J1)
    • Place of Presentation
      Resort at Squaw Creek,California, USA
    • Year and Date
      2017-01-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒストンバリアントによる細胞運命決定機構2017

    • Author(s)
      大川恭行
    • Organizer
      京都大学 学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒストンH3バリアントで制御される組織特異的構造2017

    • Author(s)
      大川恭行
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ChILT - an immunoprecipitation-free epigenome profiling technology2017

    • Author(s)
      大川恭行
    • Organizer
      第12回研究所ネットワーク国際シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Tissue-specific Chromatin Structures According to Histone H3 Variants2017

    • Author(s)
      大川恭行
    • Organizer
      研究セミナー
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒストンバリアントによる組織特異的クロマチン構造の形成2017

    • Author(s)
      大川恭行
    • Organizer
      日本遺伝学会第89回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Myogenic chromatin structure is formed with the novel histone H3 variant.2017

    • Author(s)
      大川恭行
    • Organizer
      EMBO Workshop Histone Vriants
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ChILT - an Immunoprecipitation-free Epigenome Profiling Technology.2017

    • Author(s)
      大川恭行
    • Organizer
      1st Munchen-Japan Mini Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 骨格筋再生の核内プログラム~トランスクリプトミクス解析の新たな展開~2017

    • Author(s)
      大川恭行
    • Organizer
      運動器科学研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Tissue‐specific Chromatin Structures According Histone H3 Variants2017

    • Author(s)
      大川恭行
    • Organizer
      第12回国際ゲノム会議
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Myogenic Chromatin Structure Is Formed with the Histone H3 Variant H3mm72017

    • Author(s)
      大川恭行
    • Organizer
      Gordon Research Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ChiLT-an Immunoprecipitation-free Epigenome Profiling Technology2017

    • Author(s)
      大川恭行
    • Organizer
      Single Cell Omics (E3)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒストンH3バリアントによる骨格筋特異的クロマチン構造制御2017

    • Author(s)
      大川恭行
    • Organizer
      第11回日本エピジェネティクス研究会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Histone variants and cell differentiation2016

    • Author(s)
      大川恭行
    • Organizer
      Colorado Chromatin Meeting 2016
    • Place of Presentation
      Colorado, USA
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] トランスクリプトミクスで解析する骨格筋形成2016

    • Author(s)
      大川恭行
    • Organizer
      第2回日本筋学会学術集会
    • Place of Presentation
      国立研究開発法人国立精神・神経医療研究センター
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] N6-methyladenosine is required for the processing of MyoD pre-mRNA for maintaining skeletal muscle differentiation potential.2016

    • Author(s)
      大川 恭行
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Whistler Conference Centre
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 次世代スパースタープログラムの4年間2016

    • Author(s)
      大川恭行
    • Organizer
      新学術領域「動的クロマチン構造と機能」の若手の会シンポジウム
    • Place of Presentation
      早稲田大学 西早稲田キャンパス
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] トランスクリプトミクスで解析する骨格筋形成2016

    • Author(s)
      大川恭行
    • Organizer
      第4回若手による骨格筋細胞研究会
    • Place of Presentation
      ウィンクあいち
    • Related Report
      2016 Annual Research Report
  • [Presentation] トランスオミクス研究の新展開―全ての遺伝子をみるー2016

    • Author(s)
      大川恭行
    • Organizer
      藤田保健衛生大学 医学会
    • Place of Presentation
      藤田学園フジタホール
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 遺伝子のすがたを全部見る2016

    • Author(s)
      大川恭行
    • Organizer
      新学術領域クロマチン動構造主催の一般公開シンポジウム
    • Place of Presentation
      早稲田大学 国際会議場 井深大記念ホール
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cell fate decision on chromatin by MyoD2015

    • Author(s)
      大川 恭行
    • Organizer
      BMB2010(第38回日本分子生物学会年会・第88回日本生化学会大会合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Diversity of Mouse Histone H3 Variants2015

    • Author(s)
      大川 恭行
    • Organizer
      International Symposium on Chromatin Structure,
    • Place of Presentation
      Awaji Yumebutai International Conference Center
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 筋分化および形成破綻におけるエピゲノム制御2015

    • Author(s)
      大川 恭行
    • Organizer
      第1回日本筋学会学術集会
    • Place of Presentation
      国立精神・神経医療研究センター 研修棟ユニバーサルホール
    • Year and Date
      2015-08-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] クロマチンコード解読への挑戦 -NGS解析の展開-2015

    • Author(s)
      大川 恭行
    • Organizer
      第33回内分泌代謝学サマーセミナー
    • Place of Presentation
      柳川藩主立花邸 御花
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] クロマチン構造にプログラムされた骨格筋分化能~エピゲノム解析で解読するヒストンバーコード~2015

    • Author(s)
      大川 恭行
    • Organizer
      千葉大学医学研究院開催セミナー
    • Place of Presentation
      千葉大学 医学部
    • Year and Date
      2015-04-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The diversity of mouse histone H3 variants.2015

    • Author(s)
      Yasuyuki Ohkawa
    • Organizer
      Epigenomics (Z2)
    • Place of Presentation
      Keystone ResortUSA
    • Year and Date
      2015-03-29 – 2015-04-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Incorporation of Histone H3 Variants Dictates the Lineage Potential of Skeletal Muscle.2015

    • Author(s)
      Yasuyuki Ohkawa
    • Organizer
      Transcriptional and Epigenetic Influences on Stem Cell States (C9)
    • Place of Presentation
      Sheraton Steamboat Resort USA
    • Year and Date
      2015-03-23 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒストンバリアントが制御する骨格筋分化能2015

    • Author(s)
      大川 恭行
    • Organizer
      クロマチン・デコーディング研究会
    • Place of Presentation
      国際高等研究所
    • Year and Date
      2015-03-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒストンH3バリアントの多様性2015

    • Author(s)
      大川 恭行
    • Organizer
      ヒストンバリアント研究会
    • Place of Presentation
      東京工業大学 すずかけ台キャンパス
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] High order chromatin remodeling in skeletal muscle differentiation2015

    • Author(s)
      大川 恭行
    • Organizer
      エピジェネティクス全体会議
    • Place of Presentation
      理化学研究所 多細胞システム形成研究センター
    • Year and Date
      2015-02-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 次世代シークエンサーによるエピゲノム解析 ~大規模情報処理パイプラインへの取り組み~2015

    • Author(s)
      大川 恭行
    • Organizer
      京都大学学術情報メディアセンターセミナー
    • Place of Presentation
      京都大学学術情報メディアセンター 南館 201マルチメディア講義室
    • Year and Date
      2015-01-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 骨格筋分化における空間クロマチン制御へのアプローチ2015

    • Author(s)
      大川 恭行
    • Organizer
      定量生物学の会
    • Place of Presentation
      九州大学 筑紫キャンパス
    • Year and Date
      2015-01-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒストンH3バリアントの多様性2014

    • Author(s)
      大川恭行
    • Organizer
      第37回日本分子生物学年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロマチン構造制御による骨格筋分化運命機構の解明2014

    • Author(s)
      大川恭行
    • Organizer
      骨格筋研究会
    • Place of Presentation
      コープイン京都
    • Year and Date
      2014-11-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨格筋分化におけるヒストンバリアントによるエピゲノム制御2014

    • Author(s)
      大川恭行
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒストンバリアントによる遺伝子選択 ~ヒストンバーコード解析の新たな展開~2014

    • Author(s)
      大川恭行
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒストンバリアントが制御する骨格筋分化能~ヒストンバーコード説の新たな展開~2014

    • Author(s)
      大川恭行
    • Organizer
      招聘セミナー講演
    • Place of Presentation
      基礎生物学研究所
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Incorporation of Histone H3 Variants Dictates the Lineage Potential of Skeletal Muscle.2014

    • Author(s)
      Akihito Harada, Kazumitsu Maehara, Yuko Sato, Hiroshi Kimura and Yasuyuki Ohkawa
    • Organizer
      FASEB;Science Research Conferences
    • Place of Presentation
      The Steamboat Grand Resort
    • Year and Date
      2014-07-20 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Diversity of histone H3 variants on mouse genome2014

    • Author(s)
      Yasuyuki Ohkawa
    • Organizer
      ENBO Workshop Histone varisnts
    • Place of Presentation
      IGBMC in Strasbourg
    • Year and Date
      2014-06-02 – 2014-06-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨格筋分化運命を決定するゲノムマーキング機構2014

    • Author(s)
      大川 恭行
    • Organizer
      IGER seminar
    • Place of Presentation
      名古屋大学理学E館 131号室(愛知)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The formation of nucleosome positioning patterns flanked by transcription factor binding site2014

    • Author(s)
      Kazumitsu Maehara, Yasuyuki Ohkawa
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Santa Fe Community Convention Center(USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The balance of histone H3 variants around transcription start sites dictates cell differential potential2014

    • Author(s)
      Akihito Harada, Kazumitsu Maehara, Yasuyuki Ohkawa
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Santa Fe Community Convention Center(USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞分化における高次クロマチン構造制御機構2013

    • Author(s)
      大川 恭行
    • Organizer
      千里ライフサイエンスセミナー「エピジェネティクス制御からの生命活動の理解とその展望」
    • Place of Presentation
      千里ライフサイエンスセンタービル(大阪)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 細胞分化にともなうクロマチン変動メカニズムの解明2013

    • Author(s)
      大川 恭行
    • Organizer
      新学術領域研究「動的クロマチン構造と機能」第1回班会議
    • Place of Presentation
      大阪大学コンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生命を形作る道の暗号を解読する2013

    • Author(s)
      大川 恭行
    • Organizer
      一般公開シンポジウム「DNAをあやつる生物のしくみ」
    • Place of Presentation
      千里ライフサイエンスセンタービル(大阪)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Histone bariants determine the lineage potential of skeletal muscle2013

    • Author(s)
      大川 恭行
    • Organizer
      Fukuoka Internasional Symposium on Genomics & Epigenomics 2013
    • Place of Presentation
      九州大学 総合研究棟(福岡)
    • Related Report
      2013 Annual Research Report
  • [Presentation] High order chromatin regulation in skeletal muscle differentiation2013

    • Author(s)
      Yasuyuki Ohkawa, Hitoshi Kurumizaka, Hiroshi Kimura
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒストンバリアントによる細胞運命制御2013

    • Author(s)
      大川 恭行
    • Organizer
      セミナー
    • Place of Presentation
      (独)国立成育研究医療センター(東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Epigenomic approach unveils cell fate decision2013

    • Author(s)
      大川 恭行
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      慶応大学 日吉キャンパス(神奈川)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 骨格筋分化運命決定のメカニズムを追う~クロマチン構造からみる筋形成~2013

    • Author(s)
      大川 恭行
    • Organizer
      第一回若手による骨格筋研究会
    • Place of Presentation
      京都大学 iPS細胞研究所
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 単一のChIP-Seqデータを使った細胞分化におけるヌクレオソーム配置と転写因子結合の一体的解析2013

    • Author(s)
      前原 一満, 大川 恭行
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] RNA polymerase IIのC末端ドメイン構造の非リン酸化修飾の網羅的解読2013

    • Author(s)
      小田原 淳, 前原 一満, 成相 直樹,原田 哲仁,林 正康,植野 和子,吉見 智彦,立花 太郎, 長崎 正朗, 赤司 浩一,大川 恭行
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス胚性幹細胞においてChromodomain Helicase DNA binding protein (Chd5)はOct3/4と共役して未分化性の維持に寄与する2013

    • Author(s)
      林 正康, 小田原 淳,原田 哲仁,前原 一満, 吉見 智彦,立花 太郎,赤司 浩一,大川 恭行
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒストンH3バリアントは骨格筋分化能を決定する2013

    • Author(s)
      大川 恭行,原田 哲仁, 前原 一満
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒストンH3バリアントの選択的取り込みは骨格筋分化能を支配する2013

    • Author(s)
      原田 哲仁,前原 一満,佐藤 優子,今野 大治郎,立花 太郎,木村 宏,大川 恭行
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2013 Annual Research Report
  • [Book] Surgery Frontier2015

    • Author(s)
      大川 恭行
    • Total Pages
      3
    • Publisher
      ㈱メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] 実験医学2015

    • Author(s)
      上田潤,前原一満,大川恭行,山縣一夫
    • Total Pages
      9
    • Publisher
      羊土社
    • Related Report
      2015 Annual Research Report
  • [Book] 実験医学2015

    • Author(s)
      上田 潤,前原一満,大川恭行,山縣一夫
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] 実験医学2014

    • Author(s)
      大川恭行、原田哲仁
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] 実験医学2013

    • Author(s)
      大川 恭行, 原田 哲仁
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Remarks] Ohkawa lab

    • URL

      http://tx.bioreg.kyushu-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] クロマチン動構造

    • URL

      http://nucleosome.kyushu-u.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://tx.bioreg.kyushu-u.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] クロマチン動構造HP

    • URL

      http://nucleosome.kyushu-u.ac.jp/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] エピジェネティクス分野 / 大川研究室 (九州大学 医学研究院 先端医療医学部門)

    • URL

      http://chromatin.med.kyushu-u.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 平成25年~29年度 新学術領域研究 「動的クロマチン構造と機能」

    • URL

      http://nucleosome.kyushu-u.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] DNA結合タンパク質の結合領域の近傍に所望のDNA断片を挿入する方法2017

    • Inventor(s)
      大川恭行,,原田哲仁,胡桃坂仁志,木村宏,半田哲也,他2名
    • Industrial Property Rights Holder
      大川恭行,,原田哲仁,胡桃坂仁志,木村宏,半田哲也,他2名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] DNA結合タンパク質の結合領域の近傍に所望のDNA断片を挿入する方法2016

    • Inventor(s)
      大川恭行,原田哲仁,胡桃坂仁志,木村宏,半田哲也,他2名
    • Industrial Property Rights Holder
      国立大学法人九州大学,国立大学法人東京工業大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-08-30
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2013-07-10   Modified: 2023-03-16  

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