| Budget Amount *help |
¥93,990,000 (Direct Cost: ¥72,300,000、Indirect Cost: ¥21,690,000)
Fiscal Year 2017: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2015: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2014: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2013: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
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| Outline of Final Research Achievements |
In this project, we analyzed chromatin dynamics upon cellular differentiation. Especially, we have focused on the functions of tissue-specific histone H3 variant genes which we identified in 2015 in this project. A representative study published this year reports that H3mm7, a skeletal muscle satellite dominant histone H3 variant, was required for normal skeletal muscle regeneration upon injury. H3mm7 was shown to be involved in the loosening of chromatin structure by forming “mobile” nucleosomes in which the absence of the interaction between H3.3S57 and H4R40 was observed. This project has led to more than 57 published papers based on the genome-wide study of chromatin dynamics.
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