|Budget Amount *help
¥149,370,000 (Direct Cost: ¥114,900,000、Indirect Cost: ¥34,470,000)
Fiscal Year 2017: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2016: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2015: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2014: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥56,810,000 (Direct Cost: ¥43,700,000、Indirect Cost: ¥13,110,000)
|Outline of Final Research Achievements
To elucidate operation principle of glial assembly, we have focused on astrocytes and their assembly, their mode and mechanisms of operation were analyzed. We also used a high-throughput assay system of Drosophila. Using stroke model, we have found that astrocytes as an assembly, respond to very slight ischemic stimuli so-called preconditioning, and changed their phenotypes to neuroprotective ones, leading to induction of ischemic tolerance. Furthermore, in the neuropathic pain model, astrocytes in the primary sensory cortex become synaptogenic phenotypes, and then cross the innocuous network with nocuous neuronal networks, leading to induction of mechanical allodynia. As for a high through-put assay, we identified various genes that are essential for function or development of glial assembly.
Taken together, we have found various modes and mechanisms of astrocytic assembly, which greatly affect brain functions both in physiology and pathophysiology of brain functions.