neuroanatomical analysis of neuron-glia correlation in neuronal circuit maturation

• Project Area: Glial assembly: a new regulatory machinery of brain function and disorders
• Project/Area Number: 25117008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: Fukuyama Hidenao 京都大学, 健康長寿社会の総合医療開発ユニット, 特任教授 (90181297)
• Co-Investigator(Kenkyū-buntansha): 植木 孝俊 名古屋市立大学, 大学院医学研究科, 教授 (60317328) ; 岡戸 晴生 公益財団法人東京都医学総合研究所, その他部局等, その他 (60221842) ; 植木 美乃 名古屋市立大学, 医学(系)研究科(研究院), 講師 (40467478)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥127,660,000 (Direct Cost: ¥98,200,000、Indirect Cost: ¥29,460,000); Fiscal Year 2017: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000); Fiscal Year 2016: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000); Fiscal Year 2015: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000); Fiscal Year 2014: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000); Fiscal Year 2013: ¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
• Keywords: neuroimaging / MRI / PET / molecular imaging / microglia / connectome / 電磁気刺激 / MRIプローブ / プロテアーゼ / 統合失調症 / うつ病 / 神経科学 / トランスレーショナルリサーチ / グリアアセンブリ / 脳発達障害 / 精神神経疾患 / 脳機能イメージング / 蛍光イメージング / ミクログリア / 脳・神経 / 脳神経疾患

Outline of Final Research Achievements

We found a lot of results on Schizophrenia, ADHD, Depression in human brain.
Using molecular imaging, we also revealed microglial function in the brain to regulate reward system, as well as astrocyte interactions.Animal model for Schizophrenia showed the microglial malfunction by ADAM10 activation, and those protease functions related Schizophrenia was visualized by tracers of microglia for animal MRI.

Research Products

• [Journal Article] Asymmetric Functional Connectivity of the Contra- and Ipsilateral Secondary Somatosensory Cortex during Tactile Object Recognition (2018)
  • Author(s): Yu Yinghua、Yang Jiajia、Ejima Yoshimichi、Fukuyama Hidenao、Wu Jinglong
  • Journal Title: Frontiers in Human Neuroscience Volume: 11 Pages: 662-662
  • DOI: 10.3389/fnhum.2017.00662
  • Peer Reviewed / Open Access
• [Journal Article] Lateralization of intrinsic frontoparietal network connectivity and symptoms in schizophrenia. (2017)
  • Author(s): on S, Miyata J, Mori Y, Isobe M, Urayama SI, Aso T, Fukuyama H, Murai T, Takahashi H.
  • Journal Title: Psychiatry Res. Volume: 260 Pages: 23-28
  • DOI: 10.1016/j.pscychresns.2016.12.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In vivo TSPO and cannabinoid receptor type 2 availability early in poststroke neuroinflammation in rats: a positron emission tomography study study. (2017)
  • Author(s): Hosoya T, Fukumoto D, Kakiuchi T, Nishiyama S, Yamamoto S, Ohba H, Tsukada H, Ueki T, Sato K, Ouchi Y.
  • Journal Title: J Neuroinflammation. Volume: 29 Issue: 1 Pages: 69-78
  • DOI: 10.1186/s12974-017-0851-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A multicenter, randomized, placebo-controlled 1 trial for cilostazol in patients with MCI: the COMCID study protocol (2016)
  • Author(s): Saito S, Kojima S, Oishi N, Kakuta R, Maki T, Yasuno F, Nagatsuka K, Yamamoto H, Fukuyama H, Fukushima M, Ihara M
  • Journal Title: Alzheimer's & Dementia: Translational Research & Clinical Interventions Volume: 2 Issue: 4 Pages: 250-257
  • DOI: 10.1016/j.trci.2016.10.001
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of heterogeneity and regional grading of gliomas by multiple features using magnetic resonance-based clustered images (2016)
  • Author(s): Inano R, Oishi N, Kunieda T, Arakawa Y, Kikuchi T, Fukuyama H, Miyamoto S.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 30344-30344
  • DOI: 10.1038/srep30344
  • NAID: 120005825907
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of Alzheimer's Disease in Amnestic Mild Cognitive Impairment Subtypes: Stratification Based on Imaging Biomarkers (2016)
  • Author(s): Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer's Disease Neuroimaging Initiative
  • Journal Title: J Alzheimers Dis Volume: 52 Issue: 4 Pages: 1385-1401
  • DOI: 10.3233/jad-160145
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ambiguity aversion in schizophrenia: An fMRI study of decision-making under risk and ambiguity. (2016)
  • Author(s): Fujino J, Hirose K, Tei S, Kawada R, Tsurumi K, Matsukawa N, Miyata J,Sugihara G, Yoshihara Y, Ideno T, Aso T, Takemura K, Fukuyama H, Murai T,Takahashi H.
  • Journal Title: Schizophrenia Research Volume: 178(1-3) Issue: 1-3 Pages: 94-101
  • DOI: 10.1016/j.schres.2016.09.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Neural mechanisms and personality correlates of the sunk cost effect. (2016)
  • Author(s): Fujino J, Fujimoto S, Kodaka F, Camerer CF, Kawada R, Tsurumi K, Tei S, Isobe M, Miyata J, Sugihara G, Yamada M, Fukuyama H, Murai T, Takahashi H.
  • Journal Title: Sci Rep Volume: 9 Issue: 1 Pages: 33171-33171
  • DOI: 10.1038/srep33171
  • NAID: 120005842702
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dynamic interactions of the cortical networks during thoughtsuppression. (2016)
  • Author(s): Aso T, Nishimura K, Kiyonaka T, Aoki T, Inagawa M, Matsuhashi M, Tobinaga Y,
  • Journal Title: Brain and Behavior Volume: 16;6(8) Issue: 8
  • DOI: 10.1002/brb3.503
  • Peer Reviewed / Open Access
• [Journal Article] Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1. (2016)
  • Author(s): Fujitsuka N, Asakawa A, Morinaga A, Amitani MS, Amitani H, Katsuura G, Sawada Y, Sudo Y, Uezono Y, Mochiki E, Sakata I, Sakai T, Hanazaki K, Yada T, Yakabi K, Sakuma E, Ueki T, Niijima A, Nakagawa K, Okubo N, Takeda H, Asaka M, Inui A.
  • Journal Title: Mol Psychiatry Volume: 21 Issue: 11 Pages: 1-11
  • DOI: 10.1038/mp.2015.220
  • Peer Reviewed / Open Access
• [Journal Article] Serum- and glucocorticoid-inducible kinases in microglia. (2016)
  • Author(s): Inoue K, Sakuma E, Morimoto H, Asai H, Koide Y, Leng T, Wada I, Xiong ZG, Ueki T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 478 Issue: 1 Pages: 53-59
  • DOI: 10.1016/j.bbrc.2016.07.094
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory. (2016)
  • Author(s): Kitamura A, Saito S, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalaria R, Fukuyama H, Horsburgh K, Takahashi R, Ihara M.
  • Journal Title: Journal of Cerebral Blood Flow & Metabolism Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prediction of Alzheimer’s Disease in Amnestic Mild Cognitive Impairment Subtypes: Stratification Based on Imaging Biomarkers. (2016)
  • Author(s): Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer’s Disease Neuroimaging Initiative.
  • Journal Title: J Alzheimers Dis Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Multimodal neuroimaging as a window into the pathological physiology of schizophrenia: Current trends and issues. (2016)
  • Author(s): Isobe M, Miyata J, Hazama M, Fukuyama H, Murai T, Takahashi H.
  • Journal Title: Neurosci Res. Volume: 102 Pages: 29-38
  • DOI: 10.1016/j.neures.2015.07.009
  • Peer Reviewed
• [Journal Article] Effects of imaging modalities, brain atlases and feature selection on prediction of Alzheimer's disease. (2015)
  • Author(s): Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer’s Disease Neuroimaging Initiative.
  • Journal Title: J Neurosci Methods Volume: 256 Pages: 168-183
  • DOI: 10.1016/j.jneumeth.2015.08.020
  • NAID: 120005676653
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Functional heterogeneity in the default mode network edges. (2015)
  • Author(s): Aso T, Fukuyama H
  • Journal Title: Brain Connect Volume: 5(4) Issue: 4 Pages: 203-213
  • DOI: 10.1089/brain.2014.0256
  • Peer Reviewed
• [Journal Article] Anterior cingulate volume predicts response to cognitive behavioral therapy in major depressive disorder. (2015)
  • Author(s): Fujino J, Yamasaki N, Miyata J, Sasaki H, Matsukawa N, Takemura A, Tei S, Sugihara G, Aso T, Fukuyama H, Takahashi H, Inoue K, Murai T.
  • Journal Title: J Affect Disord. Volume: 174 Pages: 397-9
  • DOI: 10.1016/j.jad.2014.12.009
  • Peer Reviewed / Open Access
• [Journal Article] The Uncinate Fasciculus as a Predictor of Conversion from aMCI to Alzheimer Disease (2015)
  • Author(s): Hiyoshi-Taniguchi K, Oishi N, Namiki C, Miyata J, Murai T, Cichocki A, Fukuyama H
  • Journal Title: J Neuroimaging Volume: in press Issue: 5 Pages: 748-753
  • DOI: 10.1111/jon.12196
  • Peer Reviewed
• [Journal Article] Freezing of gait and white matter changes: a tract-based spatial statistics study (2015)
  • Author(s): Iseki K, Fukuyama H, Oishi N, Tomimoto H, Otsuka Y, Nankaku M, Benninger D, Hallett M, Hanakawa T
  • Journal Title: J Clin Mov Disord Volume: in press Issue: 1 Pages: 1-9
  • DOI: 10.1186/s40734-014-0011-2
  • Peer Reviewed / Open Access
• [Journal Article] Creativity and positive symptoms in schizophrenia revisited: Structural connectivity analysis with diffusion tensor imaging (2015)
  • Author(s): Son et al.
  • Journal Title: Schizophrenia Research Volume: in press Issue: 1-3 Pages: 221-6
  • DOI: 10.1016/j.schres.2015.03.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Corpus Callosum Pathology as a Potential Surrogate Marker of Cognitive Impairment in Diffuse Axonal Injury. (2015)
  • Author(s): Ubukata S, Ueda K, Sugihara G, Yassin W, Aso T, Fukuyama H, Murai T.
  • Journal Title: J Neuropsychiatry Clin Neurosci. Volume: 28 Issue: 2 Pages: 97-103
  • DOI: 10.1176/appi.neuropsych.15070159
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Insular Gray Matter Volume and Objective Quality of Life in Schizophrenia. (2015)
  • Author(s): Uwatoko T, Yoshizumi M, Miyata J, Ubukata S, Fujiwara H, Kawada R, Kubota M, Sasamoto A, Sugihara G, Aso T, Urayama S, Fukuyama H, Murai T, Takahashi H.
  • Journal Title: PLoS One Volume: 10 Issue: 11 Pages: e0142018-e0142018
  • DOI: 10.1371/journal.pone.0142018
  • NAID: 120005743645
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Brain rewarding stimulation reduces extracellular glutamate through glial modulation in medial prefrontal cortex of rats (2015)
  • Author(s): Murakami G, Nakamura M, Takita M, Ishida Y, Ueki T, Nakahara D.
  • Journal Title: NEUROPSYCHOPHARMACOLOGY Volume: 40 Issue: 12 Pages: 2686-2695
  • DOI: 10.1038/npp.2015.115
  • Peer Reviewed / Open Access
• [Journal Article] Water diffusion reveals networks that modulate multiregional morphological plasticity after repetitive brain stimulation (2014)
  • Author(s): Abe, M., H. Fukuyama and T. Mima
  • Journal Title: Proc Natl Acad Sci U S A Volume: 111 Issue: 12 Pages: 4608-4613
  • DOI: 10.1073/pnas.1320223111
  • Peer Reviewed / Open Access
• [Journal Article] Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke (2014)
  • Author(s): Takenobu Y, Hayashi T, Moriwaki H, Nagatsuka, K, Naritomi H, Fukuyama H
  • Journal Title: Neuroimage: Clinical Volume: 4 Pages: 201-208
  • DOI: 10.1016/j.nicl.2013.12.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impaired empathic abilities and reduced white matter integrity in schizophrenia. (2014)
  • Author(s): Fujino, J., Takahashi, H., Miyata, J., Sugihara, G., Kubota, M., Sasamoto, A., Fujiwara, H., Aso, T., Fukuyama, H., & Murai, T.
  • Journal Title: Progress in Neuropsychopharmacology & Biological Psychiatry Volume: 48 Pages: 117-123
  • DOI: 10.1016/j.pnpbp.2013.09.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Topographic representation of an occluded object and the effects of spatiotemporal context in human early visual areas (2013)
  • Author(s): Ban, H., Yamamoto, H., Hanakawa, T., Urayama, S., Aso, T., Fukuyama, H., and Ejima, Y.
  • Journal Title: J Neurosci Volume: 33 Issue: 43 Pages: 16992-17007
  • DOI: 10.1523/jneurosci.1455-12.2013
  • NAID: 120005342659
  • Peer Reviewed
• [Journal Article] A comparison of three brain atlases for MCI prediction. (2013)
  • Author(s): Ota K, Oishi N, Ito K, Fukuyama H.
  • Journal Title: J Neurosci Methods. Volume: 221 Pages: 139-150
  • DOI: 10.1016/j.jneumeth.2013.10.003
  • Peer Reviewed
• [Journal Article] Alterations in α4β2 nicotinic receptors in cognitive decline in Alzheimer's etiopathology (2013)
  • Author(s): Okada H, Ouchi Y, Ueki T, 他 10 人
  • Journal Title: Brain Volume: 136(Pt10) Issue: 10 Pages: 3004-17
  • DOI: 10.1093/brain/awt195
  • Peer Reviewed
• [Presentation] Predicting Motor Recovery at One Week After Ischemic Stroke: a Combined Transcranial Magnetic Stimulation and MRI Study (2017)
  • Author(s): Takahashi Y, Oishi N, Mima T, Fukuyama H, Takahashi R, Toyoda K, Nagatsuka K, Ihara M
  • Organizer: International Stroke Conference 2017
  • Place of Presentation: Houston, USA
  • Year and Date: 2017-02-22
  • Int'l Joint Research
• [Presentation] Cryogen-free 3T-MRI System for Human Brain Research using Bi 2223 High-Temperature Superconducting Taps (2016)
  • Author(s): Fukuyama.H
  • Organizer: International Symposium on Applied Brain Science.
  • Place of Presentation: Beijing Hubei Building, China
  • Year and Date: 2016-12-09
  • Int'l Joint Research / Invited
• [Presentation] Neural basis of cognitive impairments in patients with diffuse axonal injury (2016)
  • Author(s): Ubukata S, Oishi N, Sugihara G, Yassin W, Aso T, Fukuyama H, Murai T, Ueda K
  • Organizer: 46th ANNUAL MEETING NEUROSCIENCE 2016
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 大脳皮質野の可塑性―resting state fMRIによる検討― (2016)
  • Author(s): 福山秀直
  • Organizer: 第9回神経機能回復セミナー
  • Place of Presentation: 仙北市角館町交流センター、秋田県
  • Year and Date: 2016-10-22
  • Invited
• [Presentation] Effect of non-local means denoising on MRI-based structural connectome in Alzheimer's disease (2016)
  • Author(s): Oishi N, Fukuyama H
  • Organizer: 第57回日本神経学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] リン酸化酵素SGKによるミクログリア活性の調節 (2016)
  • Author(s): 井上浩一、植木孝俊
  • Organizer: 第121回日本解剖学会全国学術総会
  • Place of Presentation: 郡山
  • Year and Date: 2016-03-28
• [Presentation] 高温超伝導マグネットを用いたMRI装置の開発 (2016)
  • Author(s): 福山秀直
  • Organizer: 第28回臨床MR脳機能研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-03-19
  • Invited
• [Presentation] 高温超伝導マグネットを用いたMRI装置の開発 (2016)
  • Author(s): 福山秀直
  • Organizer: 第28回臨床MR脳機能研究会
  • Place of Presentation: 東京都
  • Year and Date: 2016-03-19
  • Invited
• [Presentation] Keynote: Optical imaging and cerebral blood flow. (2016)
  • Author(s): Fukuyama H.
  • Organizer: Taiwan Society Of Clinical Neurophysiolgy
  • Place of Presentation: 台大医院国際会議中心 Taiwan
  • Int'l Joint Research / Invited
• [Presentation] Social problems in aged society of Japan. (2015)
  • Author(s): Fukuyama H.
  • Organizer: University of BRISTOL
  • Place of Presentation: USA
  • Year and Date: 2015-11-06
  • Int'l Joint Research / Invited
• [Presentation] Social problems in aged society of Japan. (2015)
  • Author(s): Fukuyama H.
  • Organizer: Healthy living and active ageing programme
  • Place of Presentation: University of BRISTOL
  • Year and Date: 2015-11-06
  • Int'l Joint Research / Invited
• [Presentation] MRIを用いた非侵襲的な神経膠腫の悪性度予測 (2015)
  • Author(s): 稲野理賀、大石直也、國枝武治、荒川芳輝、山尾幸広、芝田純也、菊池隆幸、福山秀直、宮本享
  • Organizer: 日本脳神経外科学会第74回学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-10-14
• [Presentation] Stratification of MCI with Imaging Biomarkers Improves Outcome Prediction (2015)
  • Author(s): Naoya Oishi, Kenichi Ota, Kengo Ito, Hidenao Fukuyama, SEAD-J Study Group
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: 青森
  • Year and Date: 2015-10-02
• [Presentation] Axonal Fiber Connectivity in Schizophrenia: A Graph Theoretical Analysis in a Japanese Sample (2015)
  • Author(s): Yujiro Yoshihara, Naoya Oishi, Genichi Sugihara, Toshiya Murai
  • Organizer: Organization for Human Brain Mapping 2015
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2015-06-14
  • Int'l Joint Research
• [Presentation] Prediction of MCI to AD conversion via gray and white matter structural changes (2015)
  • Author(s): Naoya Oishi, Chihiro Namiki, Hidenao Fukuyama
  • Organizer: 第56回日本神経学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20
• [Presentation] 認知症時代克服への道 (2015)
  • Author(s): 福山秀直
  • Organizer: 第29回日本医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2015-04-12
  • Invited
• [Presentation] 認知症時代克服への道 (2015)
  • Author(s): 福山秀直
  • Organizer: 第29回日本医学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2015-04-12
  • Invited
• [Presentation] Intracortical water diffusion can retain plasticity-induced changes after repetitive transcranial magnetic stimulation through coupling between the stimulated and remote regions. (2014)
  • Author(s): Abe M., Fukuyama H., Mima T.
  • Organizer: 30th International Congress of Clinical Neurophysiology
  • Place of Presentation: Berlin, Germany
• [Presentation] 日本脳機能画像研究の現状と今後 (2014)
  • Author(s): 福山 秀直
  • Organizer: 第16回日本ヒト脳機能マッピング学会
  • Place of Presentation: 仙台市
  • Invited
• [Presentation] 脳機能イメージング ～虚血・神経変性～ (2014)
  • Author(s): 福山 秀直
  • Organizer: STROKE2014
  • Place of Presentation: 大阪市
  • Invited
• [Presentation] ドパミントランスポーターの機能画像 (2014)
  • Author(s): 福山 秀直
  • Organizer: BRAIN IMAGING 2014
  • Place of Presentation: 広島市
  • Invited
• [Presentation] ミクログリアを治療標的とした神経変性疾患治療戦略の構築 (2014)
  • Author(s): 植木 孝俊
  • Organizer: 第119回日本解剖学会総会・全国学術集会
  • Place of Presentation: 下野市
  • Invited
• [Presentation] Default Mode Network,reappraisal. (2013)
  • Author(s): Fukuyama H.
  • Organizer: International Society for the Advancement of Clinical Magnetoencephalography meeting 2013
  • Place of Presentation: Sapporo, Japan
  • Invited
• [Presentation] Neural correlates of multimodal emotional perception: An fMRI study with music and facial expressions. (2013)
  • Author(s): Ishii T., Aso T., Ono K., Fukuyama H.
  • Organizer: The 43rd Annual meeting of Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] 画像統計ソフトの有用性と限界 (2013)
  • Author(s): 福山 秀直
  • Organizer: 第18回認知神経科学会学術集会
  • Place of Presentation: 東京
  • Invited
• [Book] fMRI 原理と実践 (2016)
  • Author(s): 福山秀直
  • Total Pages: 556
  • Publisher: MEDSI
• [Book] 認知症と画像診断（総論）．脳とこころのプライマリケア２知能の衰え (2013)
  • Author(s): 大石直也、福山秀直
  • Publisher: シナジー
• [Remarks] うつ・脳卒中・パーキンソン病の最新電磁気治療法のメカニズムを解明
  • URL: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2013_1/140311_1.htm