| Budget Amount *help |
¥67,470,000 (Direct Cost: ¥51,900,000、Indirect Cost: ¥15,570,000)
Fiscal Year 2017: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2016: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2015: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2014: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2013: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
|
|---|
| Outline of Final Research Achievements |
We have studied to clarity the role of microglia in the formation of functional neural circuit, especially the role in the synaptic pruning by using common marmosets, non-human primate models, because they showed clear synaptic pruning in the brain during developmental phase. In the cerebral cortex of the normal marmosets, we showed the possibility that the microglia was involved in synaptic pruning at the age of 3 months old. Furthermore, we prepared the autism spectrum disorder (ASD) model marmosets and demonstrated the insufficient synaptic pruning observed in the ASD patients. We have also suggested the abnormal function of microglia judged from the morphological changes of the cells. We speculated that the abnormal synaptic pruning observed in the ASD patients might be caused by the abnormal function of microglia.
|
