| Budget Amount *help |
¥85,670,000 (Direct Cost: ¥65,900,000、Indirect Cost: ¥19,770,000)
Fiscal Year 2017: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2015: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2014: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2013: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
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| Outline of Final Research Achievements |
Patients with learning deficits due to hippocampal damage cannot recognize "passage of time", indicating that memory is the source of "mind of time". In this study, we explored the mechanism of time compression and the operation of time progression mainly in hippocampal ripple waves and obtained the following two main findings.
(1) When memory engrams are reactivated during the hippocampal ripples, the excitation/inhibition balance of the neural circuit transiently shifts toward excitation. These results were published in Nature Neurosciencee.
(2) Hippocampal ripples down-regulate the excitability of the neural circuit during slow-wave sleep, thereby purifying memory engrams and securing the storage capacity for future memories. These results were published in Science and were also highlighted in a newspaper and other media.
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