| Budget Amount *help |
¥72,540,000 (Direct Cost: ¥55,800,000、Indirect Cost: ¥16,740,000)
Fiscal Year 2017: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2016: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2015: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2014: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2013: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
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| Outline of Final Research Achievements |
In this project, focusing on the sparseness of NMR data and structure information of biomolecule, we have aimed to achieve faster and more precise NMR measurement and analysis of biomolecules by solving the issues arising from complexity and complicatedness of NMR analysis with the sparse modeling. In the subproject 1, we have successfully developed the spectrum reconstruction method with high reproducibility. In the subproject 2, decoding process of “SiCode” was dramatically improved by concurrently deconvoluting spectra and identifying amino-acid assignment. In the subproject 3, the method for faster and more precise biomolecular structure calculation was established by using Bayesian inference, and was successfully applied to de novo structure determination of proteins in living eukaryotic cells. In later introduced subproject 4, we have successfully developed a novel method enabling concurrent signal identification and structural dynamics analysis.
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