| Budget Amount *help |
¥98,280,000 (Direct Cost: ¥75,600,000、Indirect Cost: ¥22,680,000)
Fiscal Year 2018: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2014: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
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| Outline of Final Research Achievements |
This study aimed to clarify molecular mechanisms and roles of caspase-1-meidated cell death. Recent studies identified gasdermin D (GSDMD) as the effector molecule of pyroptosis, a caspase-1-dependent inflammatory cell death. However, GSDMD-deficient macrophages are still susceptible to caspase-1 activation. Thus, we investigated the molecular mechanism of caspase-1-dependent GSDMD-independent cell death. We found that GSDMD-deficient cells exhibits Bid-dependent apoptosis in response to caspase-1 activation. We found the same for inherently GSDMD-null/low cells such as neuronal cells and mast cells. These findings may contribute to understanding of the mechanism of caspase-1-related diseases such as neurodegenerative diseases. In addition, we demonstrated that pyroptotic cell death of tumor cells induces stronger anti-tumor immune responses than apoptotic cell death in an animal tumor therapy model. The latter finding may help to develop novel strategy of cancer therapy.
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