Elucidation of the mechanisms underlying cellular responses triggered by necroptosis

• Project Area: Homeostatic Regulation by Various Types of Cell Death
• Project/Area Number: 26110003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Toho University
• Principal Investigator: NAKANO Hiroyasu 東邦大学, 医学部, 教授 (70276476)
• Co-Investigator(Kenkyū-buntansha): 大村谷 昌樹 兵庫医科大学, 医学部, 教授 (60398229)
• Research Collaborator: MURAI Shin ; SHINDO Ryodai ; PIAO Xuehua
• Project Period (FY): 2014-07-10 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥131,820,000 (Direct Cost: ¥101,400,000、Indirect Cost: ¥30,420,000); Fiscal Year 2018: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000); Fiscal Year 2017: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000); Fiscal Year 2016: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000); Fiscal Year 2015: ¥31,330,000 (Direct Cost: ¥24,100,000、Indirect Cost: ¥7,230,000); Fiscal Year 2014: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
• Keywords: ネクロプトーシス / アポトーシス / cFLIPs / DAMPs / Reg / FRET / tissue repair / chronic pancreatitis / イメージング / cFLIP / ユビキチン / タンパク質分解 / Reg3 / 膵炎 / トランスジェニックマウス / ユビキチン化 / 全反射顕微鏡 / ユビキチンリガーゼ / 慢性膵炎 / liver progenitor cells / SPINK1 / 腸炎 / Reg3b / IL-22 / 組織修復 / 計画的ネクローシス / CFLIPs / ノックインマウス / SPINK / RIPK3

Outline of Final Research Achievements

In the present study, we aimed to elucidate the mechanisms underlying cellular responses triggered by necroptosis or apoptosis. We identified several danger-associated molecular pattern (DAMP)s released from hepatocytes, keratinocytes, and intestinal epithelial cells that induced variety of cellular responses. Moreover, we developed a sensor for live cell imaging of necroptosis, which was referred to SMART (a Sensor for MLKL Activation by RIPK3 based on FRET). SMART revealed two different modes of the release of DAMPs from necroptotic cells.

Academic Significance and Societal Importance of the Research Achievements

我々の開発したネクロプトーシスをライブセルでイメージングすることを可能にしたバイオセンサーや、それを発現するトランスジェニックマウスを開発することで、ネクロプトーシスが生体のどこで起こっているかをリアルタイムでイメージングすることが可能となり、ネクロプトーシスの様々な病態における役割の理解が飛躍的に進むと考えられる。またネクロプトーシスに伴い放出されるdanger-associated molecular pattern (DAMP)sをいくつかのマウス病態モデルを用いて同定できており、今後は同定したDAMPsの疾患バイオマーカーとしての有用性や、治療の標的にできる可能性が示された。

Research Products

• [Int'l Joint Research] WEHI(オーストリア)
• [Int'l Joint Research] Ghent University(ベルギー)
• [Int'l Joint Research] Cologne University/Kiel University(ドイツ)
• [Int'l Joint Research] Genentech Inc./Duke University/Washington University(米国)
• [Int'l Joint Research] WEHI(Australia)
• [Int'l Joint Research] Cologne University(Germany)
• [Int'l Joint Research] WEHI(Australia)
• [Int'l Joint Research] Cologne University(Germany)
• [Int'l Joint Research] Vrije Universiteit(Netherlands)
• [Int'l Joint Research] Walter Eliza Hall Institute(Australia)
• [Int'l Joint Research] Cologne University(Germany)
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  • NAID: 40020153836
  • Peer Reviewed
• [Journal Article] Impact of postoperative weight loss on survival after resection for pancreatic cancer. (2014)
  • Author(s): Hashimoto D, Chikamoto A, Ohmuraya M, Abe S, Nakagawa S, Beppu T, Takamori H, Hirota M, Baba H.
  • Journal Title: J Parenter Enteral Nutr. Volume: Epub ahead of print Issue: 5 Pages: 598-603
  • DOI: 10.1177/0148607114520992
  • Peer Reviewed
• [Journal Article] Application of oocyte cryopreservation technology in TALEN-mediated mouse genome editing (2014)
  • Author(s): Nakagawa Y, Sakuma T, Nakagata N, Yamasaki S, Takeda N, Ohmuraya M, Yamamoto T.
  • Journal Title: Exp Anim Volume: 63 Pages: 349-355
  • NAID: 130004677827
  • Peer Reviewed
• [Journal Article] Screening methods to identify TALEN-mediated knockout mice. (2014)
  • Author(s): Nakagawa Y, Yamamoto T, Suzuki K, Araki K, Takeda N, Ohmuraya M, Sakuma T.
  • Journal Title: Exp Anim Volume: 63 Pages: 79-84
  • NAID: 130003391606
  • Peer Reviewed
• [Journal Article] Autophagy regulation in the pancreatic acinar cells is independent of epidermal growth factor receptor signaling. (2014)
  • Author(s): Ozaki, N., Fukuchi, Y., Tomiyoshi, S., Uehara1, H., Ida, S., Wang, J., Kimi Araki, K., Sibilia, M., Baba, H., and Yamamura, K. and Ohmuraya, M.
  • Journal Title: Biochem. Biophysic. Res. Comm. Volume: 446 Issue: 1 Pages: 224-230
  • DOI: 10.1016/j.bbrc.2014.02.111
  • Peer Reviewed / Open Access
• [Journal Article] Generation and analysis of serine protease inhibitor kazal type 3-cre driver mice. (2014)
  • Author(s): Sakata K, Ohmuraya M, Araki K, Suzuki C, Ida S, Hashimoto D, Wang J, Uchiyama Y, Baba H, Yamamura K.
  • Journal Title: Exp Anim Volume: 63 Pages: 45-53
  • NAID: 130003391605
  • Peer Reviewed
• [Journal Article] Clinical features and management of pancreatic solid pseudopapillary tumor. (2014)
  • Author(s): Tsukamoto M, Hashimoto D, Chikamoto A, Abe S, Ohmuraya M, Baba H
  • Journal Title: Am Surg Volume: 80 Pages: 1212-1215
  • Peer Reviewed
• [Journal Article] Pancreaticodigestive anastomosis and the postoperative management strategies to prevent postoperative pancreatic fistula formation after pancreaticoduodenectomy. (2013)
  • Author(s): Hashimoto D, Chikamoto A, Ohmuraya M, Hirota M, Baba H
  • Journal Title: Surg Today Volume: - Issue: 7 Pages: 1207-1213
  • DOI: 10.1007/s00595-013-0662-x
  • Peer Reviewed
• [Journal Article] Pancreatic cancer in the remnant pancreas following primary pancreatic resection. (2013)
  • Author(s): Hashimoto D, Chikamoto A, Ohmuraya M, Sakata K, Miyake K, Kuroki H, Watanabe M, Beppu T, Hirota M, Baba H.
  • Journal Title: Surg Today Volume: - Issue: 7 Pages: 1313-1320
  • DOI: 10.1007/s00595-013-0708-0
  • Peer Reviewed
• [Presentation] インターロイキン（IL）-11は大腸癌形成を促進するstromal fibroblastsのマーカーとなる (2018)
  • Author(s): 仁科隆史、出口裕、竹田若水、中野裕康
  • Organizer: 第27回日本Cell Death学会学術集会
  • Invited
• [Presentation] 腸管上皮バリアにおける転写因子JunBの役割 (2018)
  • Author(s): 片桐 翔治, 山﨑 創, 三上 哲夫, 遠藤 昌吾, 住本 英樹, 亀田 秀人, 中野 裕康
  • Organizer: 第91回日本生化学会大会
• [Presentation] MIND BOMB-2はcFLIPLを安定化することにより細胞死を抑制する (2018)
  • Author(s): 中林修, 高橋宏隆, 澤崎達也, 中野裕康
  • Organizer: 第91回日本生化学会大会
• [Presentation] FRETバイオセンサーによるネクロプトーシス実行の１細胞イメージング (2018)
  • Author(s): 村井 晋, 山口 良文, 白崎 義隆, 進藤 綾大, 中林 修, Hildebrand Joanne, 冨田 太一郎, 赤羽 悟美, Silke John, 三浦 正幸, 中野 裕康
  • Organizer: 第91回日本生化学会大会
• [Presentation] 家族性大腸腺腫症モデルマウスにおけるインターロイキン-11産生細胞の解析 (2018)
  • Author(s): 竹田 若水, 仁科 隆史, 出口 裕, 西山 千春, 中野 裕康
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] Development of a novel FRET biosensor, SMART that monitors necroptosis (2018)
  • Author(s): Hiroyasu Nakano
  • Organizer: 2nd Australia-Japan Meeting on Cell Death
  • Int'l Joint Research / Invited
• [Presentation] Cell Death in Pancreatitis (2018)
  • Author(s): Masaki Ohmuraya
  • Organizer: 2nd Australia-Japan Meeting on Cell Death
  • Int'l Joint Research / Invited
• [Presentation] RIPK3-dependent necroptosis of intestinal epithelial cells results in RORgt+ innate lymphoid cell-dependent lethal ileitis (2018)
  • Author(s): Shindo Ryodai, Ohmuraya Masaki, Komazawa-Sakon Sachiko, Miyake Sanae, Yamazaki Soh, Nishina Takashi, Pasparakis Manolis, Araki Kim, Nakano Hiroyasu.
  • Organizer: 2nd Australia-Japan Meeting on Cell Death
  • Int'l Joint Research
• [Presentation] Analysis of Interleukin-11-producing cells in a colitis-associated cancer model using IL-11 reporter mice (2018)
  • Author(s): Takashi Nishina, Yutaka Deguchi, Wakami Takeda, Tetsuo Mikami, Hiroyasu Nakano
  • Organizer: 2nd Australia-Japan Meeting on Cell Death
  • Int'l Joint Research
• [Presentation] Blockade of TNFR1-dependent and -independent cell death is crucial for normal epidermal differentiation (2018)
  • Author(s): Ryosuke Miura, Xuehua Piao, Sanae Miyake, Sachiko Komazawa-Sakon, Chiharu Nishiyama, Hiroyasu Nakano.
  • Organizer: Gordon Research Conference
  • Int'l Joint Research
• [Presentation] A Novel FRET Biosensor for Necroptosis Uncovers Two Different Modes of the Release of DAMPs (2018)
  • Author(s): Murai Shin, Nakano Hiroyasu
  • Organizer: Gordon Research Conference
  • Int'l Joint Research
• [Presentation] IL-11 is a novel marker of stromal fibroblasts that promote tumors in a murine model of colitis-associated cancer (2018)
  • Author(s): Takashi Nishina, Yutaka Deguchi, Wakami Takeda, Tetuo Mikami, Hiroyasu Nakano
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] A crucial role of JunB in attenuating epithelial damage-induced colitis through induction of regulatory T cells. (2018)
  • Author(s): Yamazaki Soh, Katagiri Takaharu, Sumimoto Hideki, Nakano Hiroyasu.
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] Blockade of TNFR1-dependent and -independent cell death is crucial for normal epidermal differentiation (2018)
  • Author(s): Ryosuke Miura, Xuehua Piao, Chiharu Nishiyama, Hiroyasu Nakano.
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] Short form FLICE-inhibitory protein promotes TNFα-induced necroptosis in fibroblasts derived from CFLARs transgenic mice (2017)
  • Author(s): Ryodai Shindoa, Soh Yamazakia, Masaki Ohmuraya, Kimi Araki, Hiroyasu Nakano.
  • Organizer: Keystone Symposia on Molecular and Cellular Biology
  • Place of Presentation: Keystone, Colorado, USA
  • Year and Date: 2017-02-07
  • Int'l Joint Research
• [Presentation] Analysis of Interleukin-11-producing cells in a colitis-associated cancer model using IL-11 reporter mice (2017)
  • Author(s): Takashi Nishina, Yutaka Deguchi, Eri Nakamura, Yuko Kojima, Norihiro Tada, Hiroyasu Nakano
  • Organizer: Keystone Symposia on Molecular and Cellular Biology
  • Place of Presentation: Keystone, Colorado, USA
  • Year and Date: 2017-02-07
  • Int'l Joint Research
• [Presentation] 親電子リガンドによるIL-11産生機構とその生体における役割の解明 (2017)
  • Author(s): 仁科 隆史、出口 裕、三浦 亮介、山﨑 創、新開 泰弘、小島 裕子、奥村 康、熊谷 嘉人、中野 裕康
  • Organizer: 第44回日本毒性学会学術年会
• [Presentation] cFLIPはTNFR1依存的な致死的皮膚炎とTNFR1非依存的な表皮分化障害を防ぐ (2017)
  • Author(s): 三浦 亮介、朴 雪花、三宅 早苗、駒沢 幸子、小池 正人、進藤 綾大、内山 安男、中野 裕康
  • Organizer: 第26回日本Cell Death学会学術集会
• [Presentation] Ⅱ型肺胞上皮細胞障害の障害と再生に関する解析 (2017)
  • Author(s): 三好 嗣臣、黒澤 武介、仁科 隆史、山崎 創、本間 栄、中野 裕康
  • Organizer: 第26回日本Cell Death学会学術集会
• [Presentation] RORγt陽性細胞はRIPK3およびMLKL依存性に小腸炎を誘導する (2017)
  • Author(s): 進藤 綾大、大村谷 昌樹、駒澤 幸子、三宅 早苗、山﨑 創、仁科 隆史、小西 博之、木山 博資、三上 哲夫、荒木 喜美、中野 裕康
  • Organizer: 第26回日本Cell Death学会学術集会
• [Presentation] SMARTによるネクロプトーシス進行の継時的解析 (2017)
  • Author(s): 村井 晋、白崎 善隆、山口 良文、冨田 太一郎、赤羽 悟美、三浦 正幸、中野 裕康
  • Organizer: 第26回日本Cell Death学会学術集会
• [Presentation] 腸上皮特異的cFLIP欠損マウスで見られるTNFR1非依存性腸炎の発症メカニズムの解析 (2017)
  • Author(s): 片桐 翔治、朴 雪花、進藤 綾大、駒沢 幸子、大村谷 昌樹、中野 裕康
  • Organizer: 第26回日本Cell Death学会学術集会
• [Presentation] 肝特異的cFLIP低発現マウスを用いた肝障害モデルの解析 (2017)
  • Author(s): 山﨑 創、朴 雪花、駒澤 幸子、三宅 早苗、中林 修、田中 稔、大村谷 昌樹、及川 彰、角田 宗一郎、内山 安男、 田中 正人, 中野 裕康
  • Organizer: 第26回日本Cell Death学会学術集会
• [Presentation] インターロイキン11の産生制御と産生細胞の同定 (2017)
  • Author(s): 中野裕康
  • Organizer: 第14回レドックス・ライフイノベーションシンポジウム
  • Invited
• [Presentation] ネクロプトーシスをモニターするFRETバイオセンサーによるDAMPs放出メカニズムの解明 (2017)
  • Author(s): 村井 晋、 山口 良文、白崎 善隆、進藤 綾大†、中林 修†、三浦 亮介、冨田 太一郎、赤羽 悟美、三浦 正幸、中野 裕康
  • Organizer: 第40回日本分子生物学会年会 第90回日本生化学会大会
• [Presentation] MIND BOMB-2はcFLIPLをユビキチン化することで細胞死を抑制する (2017)
  • Author(s): 中林 修、 高橋 宏隆、澤崎 達也、吉田 雪子、 佐伯 泰、中野 裕康
  • Organizer: 第40回日本分子生物学会年会 第90回日本生化学会大会
• [Presentation] CFLIPはTNFR1依存的な致死的な皮膚炎とTNFR1非依存的な表皮分化障害を防ぐ (2017)
  • Author(s): 三浦 亮介、朴 雪花、三宅 早苗、駒沢 幸子、小池 正人、進藤 綾大、内山 安男、中野 裕康
  • Organizer: 第40回日本分子生物学会年会 第90回日本生化学会大会
• [Presentation] ネクロプトーシスによる生体応答制御 (2017)
  • Author(s): 中野 裕康
  • Organizer: 第40回日本分子生物学会年会 第90回日本生化学会大会
  • Invited
• [Presentation] RORγt-positive cells mediate RIPK3- and MLKL-dependent lethal ileitis in neonatal mice (2017)
  • Author(s): Ryodai Shindo、Soh Yamazaki、Hiroyasu Nakano
  • Organizer: 第46回日本免疫学会学術集会
• [Presentation] RORγt+ group 3 innate lymphoid cells mediate RIPK3-dependent lethal ileitis (2017)
  • Author(s): Hiroyasu Nakano
  • Organizer: 16th TNF super family meeting
  • Int'l Joint Research / Invited
• [Presentation] Detection of multiple minute genomic deletions by digital MLPA and target NGS in tumors (2017)
  • Author(s): 吉川 良恵、大村谷 昌樹、玉置 知子、江見 充
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] X染色体不活性化による慢性膵炎モデルマウスの解析 (2017)
  • Author(s): 大村谷 昌樹、中野 裕康、荒木 喜美、山村 研一
  • Organizer: 第26回日本Cell Death学会学術集会
• [Presentation] X染色体不活性化による遺伝子改変慢性膵炎モデルマウスの樹立 (2017)
  • Author(s): 大村谷 昌樹、坂田 和也、橋本 大輔、能登原 憲司
  • Organizer: 第48回日本膵臓学会大会
• [Presentation] X染色体不活性化による遺伝子改変慢性膵炎モデルマウスの樹立と解析 (2017)
  • Author(s): 大村谷 昌樹、中野 裕康、荒木 喜美、山村 研一
  • Organizer: 2017年度モロシヌス研究会
• [Presentation] 電子顕微鏡を用いたネクロプトーシスの微細構造の解析 (2016)
  • Author(s): 三宅早苗, 角田宗一郎, 小池正人, 内山安男, 中野裕康
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市西区パシフィコ横浜
  • Year and Date: 2016-12-02
• [Presentation] アポトーシス細胞は腸内細菌非依存的にReg3βを産生し腸管の恒常性を維持する (2016)
  • Author(s): 進藤綾大、大村谷昌樹、駒澤幸子、三宅早苗、山崎創、仁科隆史、小西博之、木山博資、三上哲夫、荒木喜美、中野裕康
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 宮城県仙台市青葉区仙台国際センター
  • Year and Date: 2016-09-27
• [Presentation] 肝細胞死亢進マウスを用いた肝幹細胞増殖因子同定の試み (2016)
  • Author(s): 土屋勇一, 田中稔, 鶴崎慎也, 及川彰, 駒澤幸子, 三上哲夫, 中野裕康
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 宮城県仙台市青葉区仙台国際センター
  • Year and Date: 2016-09-26
• [Presentation] 細胞死制御因子cFLIPの肝細胞特異的欠損マウスを用いた肝障害モデルにおけるクッパー細胞および骨髄由来細胞の役割 (2016)
  • Author(s): 朴 雪花, 山﨑 創, 駒澤-左近 幸子, 三宅 早苗, 中林 修, 田中 稔, 大村谷 昌樹, 及川 彰, 角田 宗一郎, 内山 安男, 田中 正人, 中野 裕康
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 宮城県仙台市青葉区仙台国際センター
  • Year and Date: 2016-09-26
• [Presentation] 肝細胞死亢進マウスモデルを用いた肝再生や炎症制御のメカニズムの解明 (2016)
  • Author(s): 中野裕康
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 宮城県仙台市青葉区仙台国際センター
  • Year and Date: 2016-09-25
  • Invited
• [Presentation] 親電子リガンドによるIL-11産生機構とその生体における役割の解明 (2016)
  • Author(s): 仁科 隆史、出口 裕、三浦 亮介、新開 泰弘、小島 裕子、熊谷 嘉人、中野 裕康
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 宮城県仙台市青葉区仙台国際センター
  • Year and Date: 2016-09-25
• [Presentation] ネクロプトーシスをモニターするFRETプローブの開発 (2016)
  • Author(s): 村井 晋, 山口 良文, 中林 修, 冨田 太一郎, 赤羽 悟美, 三浦 正幸, 中野 裕康
  • Organizer: 第25回 日本Cell Death学会学術集会
  • Place of Presentation: 東京都品川区きゅりあん
  • Year and Date: 2016-09-10
• [Presentation] ネクロプトーシスと遺伝性膵炎 (2016)
  • Author(s): 大村谷昌樹
  • Organizer: 第25回 Cell Death学会学術集会
  • Place of Presentation: 東京都品川区きゅりあん
  • Year and Date: 2016-09-09
• [Presentation] CD4+ T cell-intrinsic TRAF5 negatively regulates Th17 cell-dependent experimental autoimmune encephalomyelitis (2016)
  • Author(s): Hiroyuki Nagashima, Yuko Okuyama, Takaya Hayashi, Atsuko Asao, Takeshi Kawabe, Satoshi Yamaki, Hiroyasu Nakano, Michael Croft, Naoto Ishii, Takanori So.
  • Organizer: 第16回国際免疫学会議
  • Place of Presentation: オーストラリア、メルボルン
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] TRAF adaptors limit the IL-6 receptor signaling through an unexpected binding to the signaling transducer receptor gp130. (2016)
  • Author(s): Takanori So, Hiroyuki Nagashima, Yuko Okuyama, Takaya Hayahi, Atsuko Asao, Takeshi Kawabe, Satoshi Yamaki, Hiroyasu Nakano, Michael Croft, Naoto Ishii.
  • Organizer: 第16回国際免疫学会議
  • Place of Presentation: オーストラリア、メルボルン
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] The Roles of Cathepsin B, D, and L during Acute and Chronic Pancreatitis in Mice (2016)
  • Author(s): Masaki Ohmuraya, Kazuya Sakata, Olga Mareninova, Kenji Notohara, Ilya Gukovsky, Anna Gukovskaya
  • Organizer: 20th meeting of the International Association of Pancreatology
  • Place of Presentation: 宮城県仙台市青葉区仙台国際センター
  • Year and Date: 2016-08-04
  • Int'l Joint Research / Invited
• [Presentation] cFLIPによる細胞死制御 (2016)
  • Author(s): 中野裕康
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 横浜パシフィコ、神奈川県、横浜市
  • Year and Date: 2016-03-28
  • Invited
• [Presentation] 細胞死亢進マウスを用いた新たな代償性増殖に関与する因子の同定 (2015)
  • Author(s): 進藤綾大、大村谷昌樹、駒澤幸子、三宅早苗、小池正人、内山安男、荒木喜美、中野裕康
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド、兵庫県、神戸市
  • Year and Date: 2015-12-02
• [Presentation] 表皮特異的Cflip欠損マウスはTNFa非依存性に皮膚炎を発症する (2015)
  • Author(s): 朴雪花, 三宅早苗, 小池正人, 角田宗一郎, 内山安男, 中野裕康
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド、兵庫県、神戸市
  • Year and Date: 2015-12-02
• [Presentation] がん細胞特異的細胞死誘導分子の局在に着目した分子標的がん治療の新たな展開 (2015)
  • Author(s): 小島裕子, 仁科隆史, 中野裕康, 八木田秀男, 奥村 康, 竹田和由
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド、兵庫県、神戸市
  • Year and Date: 2015-12-02
• [Presentation] 大腸がんの発症と進行におけるInterleukin-11の産生細胞の免疫組織化学的解析 (2015)
  • Author(s): 出口裕, 仁科隆史, 大塚正人, 中村衣里, 小島裕子, 多田昇弘, 三上哲夫, 中野裕康
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド、兵庫県、神戸市
  • Year and Date: 2015-12-02
• [Presentation] インターロイキン-11レポーターマウスを用いた炎症性大腸発がんモデルにおけるIL-11産生細胞の解析 (2015)
  • Author(s): 仁科隆史, 出口裕, 大塚正人, 中村衣里, 小島裕子, 三上哲夫, 多田昇弘, 中野裕康
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド、兵庫県、神戸市
  • Year and Date: 2015-12-02
• [Presentation] Targeted integration of CFLIPs on the X chromosome in mice results in identification of genes that promote compensatory proliferation (2015)
  • Author(s): 中野裕康.
  • Organizer: 第44回日本免疫学会
  • Place of Presentation: 札幌コンベンションセンター、北海道、札幌市
  • Year and Date: 2015-11-20
  • Invited
• [Presentation] オートファジー不全と慢性膵炎発症メカニズムの解明 (2015)
  • Author(s): 大村谷 昌樹
  • Organizer: 第9 回オートファジー研究会
  • Place of Presentation: 淡路夢舞台国際会議場、兵庫県、淡路市
  • Year and Date: 2015-11-16
• [Presentation] Targeted integration of CFLIPs on the X chromosome in mice results in identification of genes that promote compensatory proliferation (2015)
  • Author(s): Nakano H
  • Organizer: Japan Australia Cell Death Meeting
  • Place of Presentation: WEHI, Melbourne, Australia
  • Year and Date: 2015-10-22
  • Int'l Joint Research / Invited
• [Presentation] Deletion of Cflip in the epidermis results in TNFR1-dependent and independent lethal dermatitis (2015)
  • Author(s): Piao X, Miyake S, Komazawa-Sakon S, Koike M, Uchiyama Y, and Nakano H.
  • Organizer: Japan Australia Cell Death Meeting
  • Place of Presentation: WEHI, Melbourne, Australia
  • Year and Date: 2015-10-22
  • Int'l Joint Research
• [Presentation] Impaired Autophagy and Chronic Pancreatitis (2015)
  • Author(s): Ohmuraya M, Sakata K, and Yamamura KI.
  • Organizer: JAPAN AUSTRALIA MEETING ON CELL DEATH
  • Place of Presentation: WEHI, Melbourne, Australia
  • Year and Date: 2015-10-22
  • Int'l Joint Research
• [Presentation] 細胞死亢進マウスを用いた代償性増殖に関与する因子の同定 (2015)
  • Author(s): 中野裕康
  • Organizer: 第24回日本Cell Death学会学術集会
  • Place of Presentation: 大阪大学会館、大阪府、大阪市
  • Year and Date: 2015-07-11
• [Presentation] 表皮特異的cFlip欠損マウスの表皮細胞はアポトーシスが亢進するとともに分化異常を呈する (2015)
  • Author(s): 三宅早苗, 朴雪花, 小池正人, 角田宗一郎, 内山安男, 中野裕康
  • Organizer: 第24回日本Cell Death学会学術集会
  • Place of Presentation: 大阪大学会館、大阪府、大阪市
  • Year and Date: 2015-07-11
• [Presentation] インターロイキン(IL)-11 を介した生体の恒常性維持機構の解析 (2015)
  • Author(s): 仁科隆史, 出口裕, 大塚正人, 中村衣里, 小島裕子, 多田昇弘, 中野裕康
  • Organizer: 第15回日本蛋白質科学学会年会
  • Place of Presentation: あわぎんホール、徳島県、徳島市
  • Year and Date: 2015-06-24
  • Invited
• [Presentation] 膵分泌性トリプシンインヒビター；SPINK1の異常がもたらすオートファジー不全、ネクロプトーシスと膵炎発症メカニズムの解明 (2015)
  • Author(s): 大村谷昌樹
  • Organizer: 第15回日本蛋白質科学会年会
  • Place of Presentation: あわぎんホール、徳島県、徳島市
  • Year and Date: 2015-06-24
• [Presentation] 慢性膵炎発症過程におけるアポトーシスとネクロプトーシスの役割 (2015)
  • Author(s): 大村谷昌樹、高城克暢、坂田和也、橋本大輔、能登原憲司、廣田昌彦
  • Organizer: 第46回日本膵臓学会大会
  • Place of Presentation: 名古屋国際会議場、愛知県、名古屋市
  • Year and Date: 2015-06-19
• [Presentation] 慢性膵炎におけるKras変異の意義 (2015)
  • Author(s): 髙城 克暢、大村谷 昌樹、橋本 大輔、能登原憲司、有馬浩太、甲斐田剛圭、東 孝暁、岡部弘尚、新田 英利、林 洋光、近本 亮、別府 透、馬場 秀夫
  • Organizer: 第46回日本膵臓学会大会
  • Place of Presentation: 名古屋国際会議場、愛知県、名古屋市
  • Year and Date: 2015-06-19
• [Presentation] 変異GNAS導入マウス遺伝子改変膵管内乳頭粘液性腫瘍モデルの開発 (2015)
  • Author(s): 古川徹、髙城 克暢、大村谷昌樹
  • Organizer: 第46回日本膵臓学会大会
  • Place of Presentation: 名古屋国際会議場、愛知県、名古屋市
  • Year and Date: 2015-06-19
• [Presentation] 遺伝子改変慢性膵炎モデルマウスではオートファジー不全とネクロプトーシスが誘導される (2015)
  • Author(s): 大村谷昌樹、荒木喜美、山村研一
  • Organizer: 第62回日本実験動物学会総会
  • Place of Presentation: 京都テルサ、京都府、京都市
  • Year and Date: 2015-05-28
• [Presentation] Targeted integration of human cFLIPs gene on X chromosome results in RIPK3-dependent apoptosis and necroptosis (2015)
  • Author(s): Nakano H, Ohmuraya M, Komazawa-Sakon S, Miyake S, Murai S, Araki K, and Shindo R.
  • Organizer: 15th International TNF conference
  • Place of Presentation: Ghent, Belgium
  • Year and Date: 2015-05-21
  • Int'l Joint Research
• [Presentation] Impaired Autophagy and Pancreatitis (2015)
  • Author(s): Ohmuraya M, Bukovsky I, Notohara K, and Gukovskaya AS.
  • Organizer: The 10th JSGE-AGA Joint Meeting
  • Place of Presentation: 仙台国際センター、宮城県、仙台市
  • Year and Date: 2015-04-25
  • Int'l Joint Research / Invited
• [Presentation] 早期慢性膵炎から慢性膵炎を発症するモデルマウスの開発 (2015)
  • Author(s): 大村谷昌樹、能登原憲司
  • Organizer: 第101回日本消化器病学会
  • Place of Presentation: 仙台国際センター、宮城県、仙台市
  • Year and Date: 2015-04-23
• [Presentation] Autophagy and Pancreatitis (2014)
  • Author(s): Masaki Ohmuraya, Kazuya Sakata, Ken-ichi Yamamura
  • Organizer: The16th Northeastern Asian Symposiumon Autophagy
  • Place of Presentation: 釜山, 韓国
  • Year and Date: 2014-12-18
• [Presentation] Impaired Autophagy induced by Serine Protease Inhibitor Kazal (SPINK) Insufficiency Causes Chronic Pancreatitis in Mice (2014)
  • Author(s): Masaki Ohmuraya, Kazuya Sakata, Katsunobu Taki, Miyuki Matsumoto, Kimi Araki, and Ken-ichi Yamamura
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川県、横浜市
  • Year and Date: 2014-11-25
• [Presentation] 計画的ネクローシスの担う生体応答機構の解明 (2014)
  • Author(s): 中野 裕康
  • Organizer: 新学術領域「ダイイングコード」キックオフシンポジウム
  • Place of Presentation: 東京大学、東京都、文京区
  • Year and Date: 2014-11-13
  • Invited
• [Presentation] SPINK insufficiency causes impaired autophagy resulting in chronic pancreatitis (2014)
  • Author(s): Masaki Ohmuraya, Kazuya Sakata, Olga Mareninova, Kenji Notohara, Ilya Gukovsky, Anna Gukovskaya
  • Organizer: APA/JPS, 45th Anniversary Meeting
  • Place of Presentation: ハワイ, 米国
  • Year and Date: 2014-11-05
• [Presentation] cFLIPによる細胞死と炎症の制御 (2014)
  • Author(s): 中野 裕康
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館、京都府、京都市
  • Year and Date: 2014-10-16
  • Invited
• [Presentation] X染色体の不活性化を利用したcFLIPsトランスジェニックマウスの樹立 (2014)
  • Author(s): 進藤綾大、駒澤幸子、小池正人、内山安男、大村谷昌樹、中野裕康
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館、京都府、京都市
  • Year and Date: 2014-10-16
• [Presentation] IL-11を介した腸管の恒常性維持機構の解明 (2014)
  • Author(s): 仁科隆史、大塚正人、中村衣里、多田昇弘、中野裕康
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館、京都府、京都市
  • Year and Date: 2014-10-16
• [Presentation] cFLIPによる生と死の運命決定機構 (2014)
  • Author(s): 中野 裕康
  • Organizer: 第67回日本酸化ストレス学会
  • Place of Presentation: 同志社大学、京都府、京都市
  • Year and Date: 2014-09-05
  • Invited
• [Presentation] 皮膚の恒常性維持におけるcFLIPの役割 (2014)
  • Author(s): 中野 裕康
  • Organizer: 第23回日本Cell Death学会
  • Place of Presentation: 東京医科歯科大学、東京都、文京区
  • Year and Date: 2014-07-18
  • Invited
• [Presentation] オートファジー不全と慢性膵炎発症メカニズムの解明 (2014)
  • Author(s): 大村谷昌樹
  • Organizer: 第23回日本Cell Death学会学術集会
  • Place of Presentation: 東京医科歯科大学、東京都、文京区
  • Year and Date: 2014-07-18
• [Presentation] CHOP欠損による慢性膵炎からの膵線維化進展 (2014)
  • Author(s): 髙城克暢、大村谷昌樹、橋本大輔、坂田和也、阿部真也、新田英利、林 洋光、近本 亮、別府 透、馬場秀夫
  • Organizer: 第69回日本消化器外科学会総会
  • Place of Presentation: 郡山市民文化センター、福島県、郡山市
  • Year and Date: 2014-07-16
• [Presentation] 慢性膵炎におけるオートファジーの解析 (2014)
  • Author(s): 坂田和也、大村谷昌樹、髙城克暢、橋本大輔、阿部真也、新田英利、林洋光、近本亮、別府透、馬場秀夫
  • Organizer: 第45回日本膵臓学会.
  • Place of Presentation: 北九州国際会議場、福岡県、北九州市
  • Year and Date: 2014-07-11
• [Presentation] 急性膵炎におけるオートファジー選択的基質p62の役割. (2014)
  • Author(s): 大村谷昌樹、能登原憲司、廣田昌彦
  • Organizer: 第45回日本膵臓学会
  • Place of Presentation: 北九州国際会議場、福岡県、北九州市
  • Year and Date: 2014-07-11
• [Book] Apoptotic and Non-apoptotic cell death (2017)
  • Author(s): Nagata Shigekazu、Nakano Hiroyasu
  • Total Pages: 183
  • Publisher: Springer
• [Book] Apoptotic and non-apoptotic cell death (2017)
  • Author(s): Shigekazu Nagata, Hiroyasu Nakano
  • Total Pages: 183
  • Publisher: Springer International Publishing AG
• [Book] 新膵臓病学 (2017)
  • Author(s): 下瀬川徹 編集（大村谷昌樹 分担執筆）
  • Total Pages: 515
  • Publisher: 南江堂
• [Book] Current Topics in Microbiology and Immunology "Apoptosis" (2015)
  • Author(s): Nakano H, Piao X, Shindo R, Komazawa-Sakon S.
  • Publisher: Springer International Publishing AG
• [Remarks] 東邦大学医学部生化学講座
  • URL: http://tohobiochemi.jp/
• [Remarks] 表皮細胞の環境変化が重篤な皮膚炎を引き起こすことを発見
  • URL: https://research-er.jp/articles/view/69260
• [Remarks] 東邦大学医学部研究グループが制御された細胞死「ネクロプトーシス」の可視化を世界で初めて実現
  • URL: https://research-er.jp/articles/view/74848
• [Remarks] 東邦大学医学部生化学講座ホームページ
  • URL: http://tohobiochemi.jp/
• [Remarks] 東邦大学医学部生化学講座ホームページ
  • URL: http://tohobiochemi.jp
• [Patent(Industrial Property Rights)] 非アルコール性脂肪性肝炎（NASH）の検出方法 (2018)
  • Inventor(s): 土屋勇一、中野裕康、長井英成、五十嵐良典
  • Industrial Property Rights Holder: 土屋勇一、中野裕康、長井英成、五十嵐良典
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-245036
  • Filing Date: 2018