Visualization and significance of various types of regulated cell death in vivo

• Project Area: Homeostatic Regulation by Various Types of Cell Death
• Project/Area Number: 26110005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hokkaido University (2017-2018); The University of Tokyo (2014-2016)
• Principal Investigator: Yamaguchi Yoshifumi 北海道大学, 低温科学研究所, 教授 (10447443)
• Co-Investigator(Kenkyū-buntansha): 荒川 聡子 東京医科歯科大学, 難治疾患研究所, 講師 (90415159)
• Project Period (FY): 2014-07-10 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥77,090,000 (Direct Cost: ¥59,300,000、Indirect Cost: ¥17,790,000); Fiscal Year 2018: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2017: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2016: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000); Fiscal Year 2015: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2014: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
• Keywords: 細胞死 / 発生生物学 / アポトーシス / パイロトーシス / カスパーゼ / イメージング

Outline of Final Research Achievements

To elucidate dynamics and significance of various types of regulated cell death in vivo, we developed novel fluorescent probes that allow us to detect pyroptosis and necroptosis in a real-time manner (Cell Rep 2014, Nature Commun 2018). To address the roles and regulation of cell death during mouse development, we analyzed mice deficient for genes regulating apoptosis and revealed involvement of apoptotic machinery in cellular movement during and after neural tube closure, during which a lot of cell death occur with dramatic rewiring of energy metabolic pathway (Dev Cell 2015, Development 2017, Genes Cells 2018, BMC Dev Biol 2018). In addition, we also found that alternative autophagic cell death compensates for apoptosis-deficiency during development (Cell Death Differ 2017).

Academic Significance and Societal Importance of the Research Achievements

わたしたちの体の中では日々細胞死が生じている。この細胞死を周辺細胞の挙動とともにリアルタイムに可視化・検出することができれば、細胞が死ぬ際の死細胞のふるまいおよび周辺組織への影響を検討することが可能となり、それにより細胞死の生体内での役割についての理解を深めることができる。本研究では、生体内で生じる様々な細胞死のうち、これまでに構築していたアポトーシスに加え、パイロトーシス、ネクロプトーシスといった細胞死のリアルタイム検出系の構築に成功した。さらにそれらを用いて、哺乳類胎児の神経管形成時の細胞死の役割を明らかにした。これらの成果は、炎症や発ガン、胎児奇形の発生等に様々な洞察を与えるものである。

Research Products

• [Int'l Joint Research] University of Bonn(Germany)
• [Journal Article] Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator (2019)
  • Author(s): Chayama Yuichi、Ando Lisa、Sato Yuya、Shigenobu Shuji、Anegawa Daisuke、Fujimoto Takayuki、Taii Hiroki、Tamura Yutaka、Miura Masayuki、Yamaguchi Yoshifumi
  • Journal Title: Frontiers in Physiology Volume: 9 Pages: 1973-1973
  • DOI: 10.3389/fphys.2018.01973
  • Peer Reviewed / Open Access
• [Journal Article] 冬眠する哺乳類が示す虚血再灌流傷害耐性 (2019)
  • Author(s): 姉川大輔，三浦正幸，山口良文
  • Journal Title: 臨床免疫・アレルギー科 Volume: 71 Pages: 170-176
  • NAID: 40021798120
• [Journal Article] A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs. (2018)
  • Author(s): Murai S, Yamaguchi Y, Shirasaki Y, Yamagishi M, Shindo R, Hildebrand JM, Miura R, Nakabayashi O, Totsuka M, Tomida T, Adachi-Akahane S, Uemura S, Silke J, Yagita H, Miura M, Nakano H
  • Journal Title: Nat Commun Volume: 9 Issue: 1 Pages: 4457-4457
  • DOI: 10.1038/s41467-018-06985-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mammalian embryos show metabolic plasticity toward the surrounding environment during neural tube closure. (2018)
  • Author(s): Miyazawa H, Yamamoto M, Yamaguchi Y, Miura M.
  • Journal Title: Genes to Cells Volume: 23 Issue: 9 Pages: 794-802
  • DOI: 10.1111/gtc.12626
  • Peer Reviewed / Open Access
• [Journal Article] Caspases and matrix metalloproteases facilitate collective behavior of non-neural ectoderm after hindbrain neuropore closure. (2018)
  • Author(s): Shinotsuka N, Yamaguchi Y, Nakazato K, Matsumoto Y, Mochizuki A, Miura M.
  • Journal Title: BMC Developmental Biology Volume: 18 Issue: 1 Pages: 17-17
  • DOI: 10.1186/s12861-018-0175-3
  • NAID: 120006528261
  • Peer Reviewed / Open Access
• [Journal Article] 哺乳類の冬眠を可能とする低体温耐性機構 (2018)
  • Author(s): 姉川大輔，三浦正幸，山口良文
  • Journal Title: 月刊「細胞」８月号 Volume: 50
• [Journal Article] Dram1 regulates DNA damage-induced alternative autophagy (2018)
  • Author(s): Nagata M, Arakawa S, Yamaguchi H, Torii S, Endo H, Tsujioka M, Honda S, Nishida Y, Konishi A, Shimizu S
  • Journal Title: Cell Stress Volume: 2 Issue: 3 Pages: 55-65
  • DOI: 10.15698/cst2018.03.127
  • Peer Reviewed / Open Access
• [Journal Article] The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function (2018)
  • Author(s): Yamaguchi Tomokazu et al
  • Journal Title: Science Signaling Volume: 11 Issue: 516 Pages: 3638-3638
  • DOI: 10.1126/scisignal.aan3638
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos (2017)
  • Author(s): Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T and Kontani K
  • Journal Title: J Cell Sci Volume: 130 Issue: 20 Pages: 3568-3577
  • DOI: 10.1242/jcs.200519
  • Peer Reviewed / Open Access
• [Journal Article] Neural tube closure and embryonic metabolism (2017)
  • Author(s): Yamaguchi Yoshifumi、Miyazawa Hidenobu、Miura Masayuki
  • Journal Title: Congenital Anomalies Volume: 57 Issue: 5 Pages: 134-137
  • DOI: 10.1111/cga.12219
  • NAID: 130008142315
  • Peer Reviewed
• [Journal Article] Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation (2017)
  • Author(s): Yotsumoto Satoshi、Muroi Yuito、Chiba Tatsuya、Ohmura Rio、Yoneyama Maki、Magarisawa Megumi、Dodo Kosuke、Terayama Naoki、Sodeoka Mikiko、Aoyagi Ryohei、Arita Makoto、Arakawa Satoko、Shimizu Shigeomi、Tanaka Masato
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 16026-16026
  • DOI: 10.1038/s41598-017-15668-z
  • Peer Reviewed / Open Access
• [Journal Article] Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice (2017)
  • Author(s): Arakawa S, Tsujioka M, Yoshida T, Tajima-Sakurai H, Nishida Y, Matsuoka Y, Yoshino I, Tsujimoto Y, Shimizu S.
  • Journal Title: Cell death and differ Volume: 9 Issue: 9 Pages: 1598-1608
  • DOI: 10.1038/cdd.2017.84
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Monitoring of Atg5-Independent Mitophagy (2017)
  • Author(s): Arakawa Satoko、Honda Shinya、Torii Satoru、Tsujioka Masatsune、Shimizu Shigeomi
  • Journal Title: Methods Mol Biol. Volume: - Pages: 125-132
  • DOI: 10.1007/7651_2017_16
  • ISBN: 9781493977499, 9781493977505
  • Peer Reviewed
• [Journal Article] Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy (2017)
  • Author(s): Arakawa S, Honda S, Yamaguchi H, Shimizu S.
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 93 Issue: 6 Pages: 378-385
  • DOI: 10.2183/pjab.93.023
  • NAID: 130005696809
  • ISSN: 0386-2208, 1349-2896
  • Peer Reviewed / Open Access
• [Journal Article] Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching (2017)
  • Author(s): Miyazawa, H., Yamaguchi, Y., Sugiura, Y., Honda, K., Kondo, K., Matsuda, F., Yamamoto, T., Suematsu, M., and Miura, M
  • Journal Title: Development Volume: 144 Issue: 1 Pages: 63-73
  • DOI: 10.1242/dev.138545
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity (2016)
  • Author(s): Semba, H., Takeda, N., Isagawa, T., Sugiura, Y., Honda, K., Wake, M., Miyazawa, H., Yamaguchi, Y., Miura, M., Jenkins, DM., Choi, H., Kim, JW., Asagiri, M., Cowburn, AS., Abe, H., Soma, K., Koyama, K., Katoh, M., Sayama, K., Goda, N., Johnson, RS., Manabe, I., Nagai, R., Komuro, I.
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 11635-11635
  • DOI: 10.1038/ncomms11635
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Decreases in body temperature and body mass constitute pre-hibernation remodelling in the Syrian golden hamster, a facultative mammalian hibernator (2016)
  • Author(s): Chayama, Y., Ando, L., Tamura, Y., Miura, M., Yamaguchi, Y.
  • Journal Title: Royal Society Open Science, 2016, DOI: 10.1098/rsos.160002 Volume: 3 Issue: 4 Pages: 160002-160002
  • DOI: 10.1098/rsos.160002
  • NAID: 120007007804
  • Peer Reviewed / Open Access
• [Journal Article] Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution. (2016)
  • Author(s): Doura T, Kamiya M, Obata F, Yamaguchi Y, Hiyama TY, Matsuda T, Fukamizu A, Noda M, Miura M, Urano Y
  • Journal Title: Angew Chem Int Ed Volume: 55 Issue: 33 Pages: 9620-9624
  • DOI: 10.1002/anie.201603328
  • NAID: 40021583957
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autophagy controls centrosome number by degrading Cep63. (2016)
  • Author(s): Watanabe Y, Honda S, Konishi A, Satoko Arakawa S, Murohashi M, Yamaguchi H, Torii S, Tanabe M, Tanaka S, Warabi E, Shimizu S.
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 13508-13508
  • DOI: 10.1038/ncomms13508
  • NAID: 120007129257
  • Peer Reviewed / Open Access
• [Journal Article] Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress‐induced autophagy (2016)
  • Author(s): S. Torii, T. Yoshida, S. Arakawa, S. Honda, A. Nakanishi, S. Shimizu
  • Journal Title: EMBO reports Volume: 11 Issue: 11 Pages: 1552-1564
  • DOI: 10.15252/embr.201642565
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Golgi membrane-associated degradation pathway in yeast and mammals (2016)
  • Author(s): H. Yamaguchi, S. Arakawa, T. Kanaseki, T. Miyatsuka, Y. Fujitani, H. Watada, Y. Tsujimoto, S. Shimizu
  • Journal Title: EMBO J. Volume: 35 Issue: 18 Pages: 1991-2007
  • DOI: 10.15252/embj.201593191
  • Peer Reviewed
• [Journal Article] In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy (2016)
  • Author(s): Y. Nasu, A. Benke, S. Arakawa, G. Yoshida, G. Kawamura, S. Manley, S. Shimizu, T. Ozawa
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 27505-27505
  • DOI: 10.1038/srep27505
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis. (2015)
  • Author(s): Arakawa S, Nakanomyo I (equally contribution), Kudo-Sakamoto Y, Akazawa H, Komuro I, and Shimizu S.
  • Journal Title: Biochem Biophys Res Commun Volume: 467 Issue: s2 Pages: 1006-1011
  • DOI: 10.1111/j.1463-1326.2010.01268.x
  • Peer Reviewed
• [Journal Article] Programmed cell death and caspase functions during neural development. (2015)
  • Author(s): Yamaguchi Y, Miura, M.
  • Journal Title: Curr. Topics Dev. Biol. Volume: 114 Pages: 159-184
  • DOI: 10.1016/bs.ctdb.2015.07.016
  • ISBN: 9780124104259
  • Peer Reviewed
• [Journal Article] 単一細胞レベルでの細胞死のイメージング (2015)
  • Author(s): 山口良文
  • Journal Title: 臨床免疫・アレルギー科 Volume: 63 Pages: 415-419
• [Journal Article] Programmed Cell Death in Neurodevelopment. (2015)
  • Author(s): Yamaguchi, Y., and Miura, M.
  • Journal Title: Dev. Cell Volume: 32 Issue: 4 Pages: 478-490
  • DOI: 10.1016/j.devcel.2015.01.019
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response. (2014)
  • Author(s): Liu, T., Yamaguchi, Y., Shirasaki, Y., Shikada, K., Yamagishi, M., Hoshino, K., Kaisho, T., Takemoto, K., Suzuki, T., Kuranaga, E., Ohara, O., Miura, M.
  • Journal Title: Cell Reports Volume: 8 Issue: 4 Pages: 974-982
  • DOI: 10.1016/j.celrep.2014.07.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] In vivo monitoring of caspase activation using a fluorescence resonance energy transfer-based fluorescent probe (2014)
  • Author(s): Yamaguchi, Y., Kuranaga, E., Nakajima, Y., Koto, A., Takemoto, K., and Miura, M.
  • Journal Title: Methods Enzymol. Volume: 544 Pages: 299-325
  • DOI: 10.1016/b978-0-12-417158-9.00012-1
  • Peer Reviewed / Int'l Joint Research
• [Presentation] シリアンハムスターの冬眠生活環と連動した遺伝子発現変化 (2018)
  • Author(s): Yoshifumi Yamaguchi
  • Organizer: 第41回 日本分子生物学会
  • Int'l Joint Research
• [Presentation] 冬眠する哺乳類シリアンハムスターの細胞自律的な低温耐性 (2018)
  • Author(s): 姉川大輔、茶山由一、安藤理沙、泰井宙輝、重信秀治、佐藤佑哉1、三浦 正幸、山口良文
  • Organizer: 第41回 日本分子生物学会
  • Int'l Joint Research
• [Presentation] 冬眠動物が有する低体温耐性機構の解明にむけて (2018)
  • Author(s): 山口良文
  • Organizer: 第二回冬眠休眠研究会
• [Presentation] 冬眠する哺乳類シリアンハムスターを用いた冬眠能の解析 (2018)
  • Author(s): 山口良文
  • Organizer: モロシヌス研究会2018
• [Presentation] Elucidating the roles and regulation of cell death in mammalian development and physiology (2018)
  • Author(s): Yoshifumi Yamaguchi
  • Organizer: Australia-Japan Meeting on Cell Death
  • Int'l Joint Research / Invited
• [Presentation] ゴルジ体を介したタンパク質分解システムの発見 (2018)
  • Author(s): 荒川聡子、山口啓史、清水重臣
  • Organizer: 第９１回日本生化学会
  • Invited
• [Presentation] Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice. (2018)
  • Author(s): Satoko Arakawa, Shigeomoi Shimizu.
  • Organizer: Australia-Japan Meeting on Cell Death
  • Int'l Joint Research
• [Presentation] カスパーゼ１活性の可視化から明らかになったインフラマソーム活性化様 (2017)
  • Author(s): 山口良文、劉ティン、三浦正幸
  • Organizer: 日本病態プロテアーゼ研究会
  • Invited
• [Presentation] 哺乳類冬眠動物が有する低体温耐性のメカニズムの解析 (2017)
  • Author(s): 姉川大輔、茶山由一、泰井宙輝、安藤理沙、藤本貴之、佐藤佑哉、重信秀治、三浦正幸、山口良文
  • Organizer: 第26回日本Cell Death学会
  • Invited
• [Presentation] Apoptosis is required for maintaining the character of the midbrain roof plate after the neural tube closure (2017)
  • Author(s): Yamaguchi, Y., Matsumoto, Y., Hamachi, M., Yoshida, and Miura, M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research / Invited
• [Presentation] Rewiring of Embryonic Energy Metabolism During Mouse Chorioallantoic Branching (2017)
  • Author(s): Yoshifumi Yamaguchi
  • Organizer: 50th Annual meeting of the Japanese Society of Developmental Biologists
  • Int'l Joint Research / Invited
• [Presentation] 哺乳類の代謝が全身性に変わる二つの局面～「胚発生」と「冬眠」 (2017)
  • Author(s): 山口良文
  • Organizer: がんと代謝研究会
  • Int'l Joint Research / Invited
• [Presentation] ゴルジ体を介したタンパク質分解システムの発見 (2017)
  • Author(s): 荒川聡子、山口啓史、清水重臣
  • Organizer: 生命科学系学会合同年次大会（ConBio2017）（第40回日本分子生物学会年会）
  • Invited
• [Presentation] ゴルジ体を介したタンパク質分解システムの発見 (2016)
  • Author(s): 荒川聡子、山口啓史、金関悳、清水重臣
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川、横浜）
  • Year and Date: 2016-11-30
• [Presentation] オートファジー細胞死の個体での解析 (2016)
  • Author(s): 荒川聡子、辻岡政経、桜井一、山口啓史、吉野育代、清水重臣
  • Organizer: 第２５回日本Cell Death学会学術集会
  • Place of Presentation: きゅりあん（東京、品川区）
  • Year and Date: 2016-09-10
• [Presentation] Investigation of mechanisms for the resistance to ischemia-reperfusion stress during hibernation period in Syrian hamsters (2016)
  • Author(s): Anegawa, D., Chayama, Y., Ando, L., Shigenobu, S., Miura, M. Yamaguchi, Y.
  • Organizer: 15th International Hibernation Symposium
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2016-08-01
  • Int'l Joint Research
• [Presentation] Elimination of the boundary cells by apoptosis in the dorsal midline of the midbrain after the neural tube closure (2016)
  • Author(s): Yamaguchi, Y., Matsumoto, M., Hamachi, M., Nonomura, K., Shinotsuka, N., Miura, M.
  • Organizer: Gordon Research Conference “Cell Death”
  • Place of Presentation: Girona, Spain.
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] 死細胞のライブイメージング観察から視えるもの (2016)
  • Author(s): 山口良文
  • Organizer: 第８１回日本インターフェロン学会
  • Place of Presentation: 長崎大学（長崎、長崎）
  • Year and Date: 2016-06-23
  • Invited
• [Presentation] Evidence for systemic pre-hibernation remodeling in a mammalian hibernator, Syrian golden hamster. (2016)
  • Author(s): Yamaguchi, Y., Ando, L., Chayama, Y., Anegawa, D., Fujimoto, T., Shigenobu, S., Tamura, Y., Miura, M.
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター、札幌
  • Year and Date: 2016-03-24
• [Presentation] Induction of Atg5-independent alternative macroautophagy by a disturbance of insulin secretion of Pancreatic beta cell (2015)
  • Author(s): Satoko Arakawa, Hirofumi Yamaguchi, Toku Kanaseki, Hirotaka Watada, and Shigeomi Shimizu
  • Organizer: 第38回日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド、神戸
  • Year and Date: 2015-12-02
  • Int'l Joint Research
• [Presentation] What enables hibernation in mammals? ~ Identification of body remodeling for hibernation in the pre-hibernation period (2015)
  • Author(s): 山口良文
  • Organizer: 第３８回日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド、神戸
  • Year and Date: 2015-12-01
  • Int'l Joint Research / Invited
• [Presentation] 冬眠する哺乳類に学ぶ代謝変化 (2015)
  • Author(s): 山口良文
  • Organizer: 脳心血管抗加齢研究会2015
  • Place of Presentation: 梅田スカイビル、大阪
  • Year and Date: 2015-11-28
  • Invited
• [Presentation] Live-imaging analysis of apoptosis and pyroptosis at a single cell resolution (2015)
  • Author(s): Yamaguchi, Y.
  • Organizer: Imaging Cell Death. Japan Australia Meeting on Cell Death
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2015-10-21
  • Int'l Joint Research / Invited
• [Presentation] Evidence for involvement of apoptosis in establishing proper cerebrospinal fluid Hydrodynamics (2015)
  • Author(s): Yamaguchi, Y., Yoshida, A., Kawata, D., Shinotsuka, N., Yoshida, M., Miura, M.
  • Organizer: 第５８回日本神経化学大会
  • Place of Presentation: 大宮ソニックシティ、埼玉
  • Year and Date: 2015-09-11
• [Presentation] アポトーシスとパイロトーシスのライブイメージング観察 (2015)
  • Author(s): 山口良文
  • Organizer: 第2４回日本Cell Death学会学術集会
  • Place of Presentation: 大阪大学、大阪
  • Year and Date: 2015-07-12
  • Invited
• [Presentation] 細胞死のライブイメージング (2015)
  • Author(s): 山口良文
  • Organizer: 第１５回蛋白質科学会年会
  • Place of Presentation: あわぎんホール、徳島
  • Year and Date: 2015-06-24
  • Invited
• [Presentation] 異なる細胞死動態の単一細胞ライブイメージングによる観察 (2014)
  • Author(s): 山口良文、劉霞、篠塚直美、三浦正幸
  • Organizer: 第87回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-18
• [Presentation] Live-imaging of caspase-1 activation reveals an all-or-none response of inflammasome signaling (2014)
  • Author(s): Liu Ting
  • Organizer: The International Symposium on Mechanisms of Innate Immunity, Cell Death and Inflammation
  • Place of Presentation: ゲント（ベルギー）
  • Year and Date: 2014-09-28
• [Remarks] 炎症性細胞死の現場を捉える ～単一細胞イメージングが明らかにした炎症応答のデジタル制御～
  • URL: http://www.u-tokyo.ac.jp/public/public01_260808_j.html