| Budget Amount *help |
¥91,910,000 (Direct Cost: ¥70,700,000、Indirect Cost: ¥21,210,000)
Fiscal Year 2018: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2016: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
|
|---|
| Outline of Final Research Achievements |
Our aim is to clarify the role and significance of cell death in the process of liver regeneration or fibrosis in the liver diseases. Consequently, we have succeeded in the identification of two novel factors related to cell death, which are involved in the regulation of liver regeneration and fibrosis, respectively. In addition, we revealed their regulatory mechanisms in liver regeneration and fibrosis based on the cell-cell interaction. Especially, we found that bone marrow derived macrophages plays an important role in the progression of liver fibrosis. On the other hand, we have developed the genetically manipulated mice capable of labeling the liver progenitor cells (LPCs) to monitor the liver regeneration mediated by LPCs in vivo. Furthermore, we discovered that ferroptosis plays a crucial role in the pathogenesis of non-alcoholic steatohepatitis (NASH) by cooperating with several units in this research group “Dying Code”.
|
