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;The roles of hypoxia signaling in the pathogenesis of lifestyle related diseases

Planned Research

Project AreaOxygen biology: a new criterion for integrated understanding of life
Project/Area Number 26111003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

Nangaku Masaomi  東京大学, 医学部附属病院, 教授 (90311620)

Co-Investigator(Kenkyū-buntansha) 合田 亘人  早稲田大学, 理工学術院, 教授 (00245549)
武田 憲彦  東京大学, 医学部附属病院, 助教 (40422307)
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥120,250,000 (Direct Cost: ¥92,500,000、Indirect Cost: ¥27,750,000)
Fiscal Year 2018: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2017: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2016: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2015: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2014: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Keywords生活習慣病 / 低酸素 / 慢性腎臓病 / 肝臓病 / 心臓病 / 炎症 / 線維化 / エネルギー / 低酸素応答 / 低酸素センサー / HIF / 内科 / ストレス / 低酸素シグナル
Outline of Final Research Achievements

Kidney, liver or heart consumes a large amount of molecular oxygen to maintain its activity, thus oxygen availability in each organ could influence its function. The molecular link, however, between hypoxic environment and the disease progression has not been fully elucidated.
In this study, we examined the roles of hypoxia inducible factor (HIF)-1alpha; signaling during the pathogenesis of lifestyle related diseases including chronic kidney disease, drug-induced liver injury and heart failure. Based on the in vivo animal models, we identified part of the critical pathways which augment the disease progression. In addition, we established a phosphorescence-based technology where we could measure tissue oxygen concentration quantitatively. These results will help us to gain a novel insight into the pathogenesis of lifestyle related disorders.

Academic Significance and Societal Importance of the Research Achievements

本研究により慢性腎臓病、薬剤性肝障害、心不全の病態進展における低酸素シグナルの役割を明らかにすると共に将来的な治療標的候補を同定した。今後、新たな生活習慣病治療介入への応用が期待される。併せて本研究では腎臓における組織酸素濃度の定量的計測を可能にする新規燐光プローブを用いた解析法を開発した。この手法は腎臓体内の各臓器への応用が可能であり、今後の酸素生物学の進展における重要な技術的基盤になると考えられる。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (208 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (6 results) Journal Article (107 results) (of which Int'l Joint Research: 30 results,  Peer Reviewed: 107 results,  Open Access: 68 results,  Acknowledgement Compliant: 14 results) Presentation (93 results) (of which Int'l Joint Research: 53 results,  Invited: 59 results) Funded Workshop (2 results)

  • [Int'l Joint Research] Alessia Fornoni/University of Miami(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Kai-Uwe Eckardt, Juergen Floege/University of Berlin/University of Aachen(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Roger Evans/Monash University(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Bart Staels/Université de Lille(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Thitinun Anusornvongchai/Lerdsin General Hospital(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Uppsala University(Sweden)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Murine Model of Pulmonary Artery Overflow Vasculopathy Revealed Macrophage Accumulation in the Lung2019

    • Author(s)
      Minatsuki Shun、Takeda Norihiko、Soma Katsura、Katoh Manami、Maki Hisataka、Hatano Masaru、Takimoto Eiki、Manabe Ichiro、Komuro Issei
    • Journal Title

      International Heart Journal

      Volume: 60 Issue: 2 Pages: 451-456

    • DOI

      10.1536/ihj.18-281

    • NAID

      130007617444

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2019-03-30
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/ reperfusion injury in the kidney.2019

    • Author(s)
      Inoue T,Abe C, Kohro T, Tanaka S, Huang L, Yao J, Zheng S, Ye H, Inagi R, Stornetta RL, Rosin DL, Nangaku M, Wada Y, Okusa MD
    • Journal Title

      Kidney International

      Volume: 95(3) Issue: 3 Pages: 563-576

    • DOI

      10.1016/j.kint.2018.09.020

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Placebo-Controlled, Randomized Trial of Enarodustat in Patients with Chronic Kidney Disease Followed by Long-Term Trial2019

    • Author(s)
      Akizawa Tadao、Nangaku Masaomi、Yamaguchi Takuhiro、Arai Masanobu、Koretomo Ryosuke、Matsui Atsushi、Hirakata Hideki
    • Journal Title

      American Journal of Nephrology

      Volume: 49 Issue: 2 Pages: 165-174

    • DOI

      10.1159/000496929

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis2019

    • Author(s)
      Jao Tzu-Ming、Nangaku Masaomi、Wu Chia-Hsien、Sugahara Mai、Saito Hisako、Maekawa Hiroshi、Ishimoto Yu、Aoe Mari、Inoue Tsuyoshi、Tanaka Tetsuhiro、Staels Bart、Mori Kazutoshi、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 95 Issue: 3 Pages: 577-589

    • DOI

      10.1016/j.kint.2018.09.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.2019

    • Author(s)
      Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
    • Journal Title

      Nature Communications

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment of novel cells stably secreting various human IL-18 recombinant proteins.2019

    • Author(s)
      Asuka Kumagai, Kenji Shimizu, Riho Kurata, Xiaofeng Cui, Takayuki Isagawa, Msamitsu Harada, Jun Nagai, Yasuhiro Yoshida, Kei-ichi Ozaki, Norihiko Takeda, Hiroaki Semba and Tomo Yonezawa
    • Journal Title

      Current Pharmaceutical Biotechnology

      Volume: 20 Issue: 1 Pages: 47-55

    • DOI

      10.2174/1389201020666190206203640

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Seasonal Variations in the Achievement of Guideline Targets for HbA1c, Blood Pressure, and Cholesterol Among Patients With Type 2 Diabetes: A Nationwide Population-Based Study (ABC Study JDDM49)2019

    • Author(s)
      Sakamoto Masaya、Matsutani Daisuke、Minato Soichiro、Tsujimoto Yuki、Kayama Yosuke、Takeda Norihiko、Ichikawa Seiichi、Horiuchi Ryuzo、Utsunomiya Kazunori、Nishikawa Masako
    • Journal Title

      Diabetes Care

      Volume: 42 Issue: 5 Pages: 816-823

    • DOI

      10.2337/dc18-1953

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell cycle perturbation induces collagen production in fibroblasts.2019

    • Author(s)
      Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.
    • Journal Title

      Int Heart J.

      Volume: in press

    • NAID

      130007684138

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional profiles in the chicken ductus arteriosus during hatching2019

    • Author(s)
      Akaike T, Shinjo S, Ohmori E, Kajimura I, Goda N, Minamisawa S
    • Journal Title

      PLoS One

      Volume: 14 Issue: 3 Pages: e0214139-e0214139

    • DOI

      10.1371/journal.pone.0214139

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined Surgical and Medical Therapy for <i>Candida</i> Prosthetic Endocarditis in a Patient with Repaired Tetralogy of Fallot2018

    • Author(s)
      Kubota Kana、Soma Katsura、Uehara Masae、Inaba Toshiro、Saito Akihito、Takeda Norihiko、Hatano Masaru、Morita Hiroyuki、Inuzuka Ryo、Hirata Yasutaka、Yao Atsushi、Komuro Issei
    • Journal Title

      International Heart Journal

      Volume: 59 Issue: 4 Pages: 877-880

    • DOI

      10.1536/ihj.17-314

    • NAID

      130007427442

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2018-07-31
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sodium glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice2018

    • Author(s)
      Tanaka Shinji、Sugiura Yuki、Saito Hisako、Sugahara Mai、Higashijima Yoshiki、Yamaguchi Junna、Inagi Reiko、Suematsu Makoto、Nangaku Masaomi、Tanaka Tetsuhiro
    • Journal Title

      Kidney International

      Volume: 94 Issue: 5 Pages: 912-925

    • DOI

      10.1016/j.kint.2018.04.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response2018

    • Author(s)
      Anusornvongchai Thitinun、Nangaku Masaomi、Jao Tzu-Ming、Wu Chia-Hsien、Ishimoto Yu、Maekawa Hiroshi、Tanaka Tetsuhiro、Shimizu Akira、Yamamoto Masayuki、Suzuki Norio、Sassa Ryoji、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 94 Issue: 3 Pages: 536-550

    • DOI

      10.1016/j.kint.2018.03.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Persistent expression of neutrophil gelatinase-associated lipocalin and M2 macrophage markers and chronic fibrosis after acute kidney injury2018

    • Author(s)
      Saito Hisako、Tanaka Tetsuhiro、Tanaka Shinji、Higashijima Yoshiki、Yamaguchi Junna、Sugahara Mai、Ito Marie、Uchida Lisa、Hasegawa Sho、Wakashima Takeshi、Fukui Kenji、Nangaku Masaomi
    • Journal Title

      Physiological Reports

      Volume: 6 Issue: 10 Pages: e13707-e13707

    • DOI

      10.14814/phy2.13707

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intravital phosphorescence lifetime imaging of the renal cortex accurately measures renal hypoxia.2018

    • Author(s)
      Hirakawa Y, Mizukami K, Yoshihara T, Takahashi I, Khulan P, Honda T, Mimura I, Tanaka T, Tobita S, Nangaku M.
    • Journal Title

      Kidney Int.

      Volume: 印刷中 Issue: 6 Pages: 1483-1489

    • DOI

      10.1016/j.kint.2018.01.015

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.2018

    • Author(s)
      Mimura I, Hirakawa Y, Kanki Y, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M.
    • Journal Title

      Sci Rep.

      Volume: 28 Issue: 1 Pages: 3779-3779

    • DOI

      10.1038/s41598-018-22180-5

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia-inducible factor stabilizers for treating anemia of chronic kidney disease2018

    • Author(s)
      Hasegawa Sho、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Current Opinion in Nephrology and Hypertension

      Volume: 27 Issue: 5 Pages: 331-338

    • DOI

      10.1097/mnh.0000000000000431

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis2018

    • Author(s)
      Goodwin J, Choi H, Hsieh MH, Nuegent ML, Ahn JM, Hayenga HN, Singh PK, Shackelford DB, Lee IK, Shulaev V, Dhar S, Takeda N, Kim JW.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 58 Issue: 2 Pages: 216-231

    • DOI

      10.1165/rcmb.2016-0186oc

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment2018

    • Author(s)
      Matsumoto Leona、Hirota Yasushi、Saito-Fujita Tomoko、Takeda Norihiko、Tanaka Tomoki、Hiraoka Takehiro、Akaeda Shun、Fujita Hidetoshi、Shimizu-Hirota Ryoko、Igaue Shota、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128 Issue: 7 Pages: 3186-3197

    • DOI

      10.1172/jci98931

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visit-to-visit HbA1c variability is inversely related to baroreflex sensitivity independently of HbA1c value in type 2 diabetes2018

    • Author(s)
      Matsutani Daisuke、Sakamoto Masaya、Minato Soichiro、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
    • Journal Title

      Cardiovascular Diabetology

      Volume: 17 Issue: 1 Pages: 100-100

    • DOI

      10.1186/s12933-018-0743-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation2018

    • Author(s)
      Fuji H、Ohmae S、Noma N、Takeiri M、Yasutomi H、Izumi K、Ito M、Toyomoto M、Iwaki S、Takemoto K、Seo S、Taura K、Hida S、Aoyama M、Ishihama Y、Hagiwara M、Takeda N、Hatano E、Iwaisako K、Uemoto S、Asagiri M
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 2 Pages: 544-549

    • DOI

      10.1016/j.bbrc.2018.05.153

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of canagliflozin on left ventricular diastolic function in patients with type 2 diabetes2018

    • Author(s)
      Matsutani Daisuke、Sakamoto Masaya、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
    • Journal Title

      Cardiovascular Diabetology

      Volume: 17 Issue: 1 Pages: 73-73

    • DOI

      10.1186/s12933-018-0717-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accelerated Cardiomyocyte Proliferation in the Heart of a Neonate With LEOPARD Syndrome-Associated Fatal Cardiomyopathy.2018

    • Author(s)
      Nakagama Y, Inuzuka R, Ichimura K, Hinata M, Takehara H, Takeda N, Kakiuchi S, Shiraga K, Asakai H, Shindo T, Hirata Y, Saitoh M, Oka A.
    • Journal Title

      Circulation: Heart Failure

      Volume: 11(4) Issue: 4

    • DOI

      10.1161/circheartfailure.117.004660

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells.2018

    • Author(s)
      Yonashiro R, Eguchi K, Wake M, Takeda N, Nakayama K.
    • Journal Title

      Cancer Research

      Volume: 78 Issue: 7 Pages: 1592-1603

    • DOI

      10.1158/0008-5472.can-17-1751

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice2018

    • Author(s)
      Nakai Gaku、Shimura Daisuke、Uesugi Ken、Kajimura Ichige、Jiao Qibin、Kusakari Yoichiro、Soga Tomoyoshi、Goda Nobuhito、Minamisawa Susumu
    • Journal Title

      Heart and Vessels

      Volume: 34 Issue: 3 Pages: 545-555

    • DOI

      10.1007/s00380-018-1293-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver2018

    • Author(s)
      Arai Takatomo、Tanaka Masako、Goda Nobuhito
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 14230-14230

    • DOI

      10.1038/s41598-018-32586-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration2018

    • Author(s)
      Miura Yasushi、Matsui Satoshi、Miyata Naoko、Harada Kenichi、Kikkawa Yamato、Ohmuraya Masaki、Araki Kimi、Tsurusaki Shinya、Okochi Hitoshi、Goda Nobuhito、Miyajima Atsushi、Tanaka Minoru
    • Journal Title

      eLife

      Volume: 7 Pages: 36572-36572

    • DOI

      10.7554/elife.36572

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women2018

    • Author(s)
      Kawanishi Noriaki、Kato Yuki、Yokozeki Kyosuke、Sawada Shuji、Sakurai Ryota、Fujiwara Yoshinori、Shinkai Shoji、Goda Nobuhito、Suzuki Katsuhiko
    • Journal Title

      Lipids in Health and Disease

      Volume: 17 Issue: 1 Pages: 135-135

    • DOI

      10.1186/s12944-018-0785-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of hypoxia inducible factor-1alpha; aggravates gamma,deltaT cell-mediated inflammation during acetaminophen-induced liver injury2018

    • Author(s)
      Suzuki T, Minagawa S, Yamazaki T, Arai T, Kanai M, Shinjo S, Goda N
    • Journal Title

      Hepatol Commun

      Volume: in press Issue: 5 Pages: 571-581

    • DOI

      10.1002/hep4.1175

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report2018

    • Author(s)
      Matsutani Daisuke、Sakamoto Masaya、Iuchi Hiroyuki、Minato Souichirou、Suzuki Hirofumi、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
    • Journal Title

      Cardiovasc Diabetol

      Volume: 17 Issue: 1 Pages: 36-36

    • DOI

      10.1186/s12933-018-0683-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease.2017

    • Author(s)
      Hirakawa Y, Tanaka T, Nangaku M.
    • Journal Title

      J Diabetes Investig.

      Volume: - Issue: 3 Pages: 261-271

    • DOI

      10.1111/jdi.12624

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal Hypoxia in CKD; Pathophysiology and Detecting Methods.2017

    • Author(s)
      Hirakawa Y, Tanaka T, Nangaku M.
    • Journal Title

      Front Physiol

      Volume: 8 Pages: 99-99

    • DOI

      10.3389/fphys.2017.00099

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia.2017

    • Author(s)
      Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M.
    • Journal Title

      Physiol Rep.

      Volume: 5 Issue: 8 Pages: e13203-e13203

    • DOI

      10.14814/phy2.13203

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic Changes in the Acute Kidney Injury-to-Chronic Kidney Disease Transition.2017

    • Author(s)
      Nangaku M, Hirakawa Y, Mimura I, Inagi R, Tanaka T.
    • Journal Title

      Nephron.

      Volume: 137 Issue: 4 Pages: 256-259

    • DOI

      10.1159/000476078

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner.2017

    • Author(s)
      Yamaguchi J, Tanaka T, Saito H, Nomura S, Aburatani H, Waki H, Kadowaki T, Nangaku M.
    • Journal Title

      Sci Rep.

      Volume: 26 Issue: 1 Pages: 6516-6516

    • DOI

      10.1038/s41598-017-06761-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease.2017

    • Author(s)
      Sugahara M, Tanaka T, Nangaku M.
    • Journal Title

      Kidney Int.

      Volume: 92 Issue: 2 Pages: 306-312

    • DOI

      10.1016/j.kint.2017.02.035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury.2017

    • Author(s)
      Tanaka S, Tanaka T, Kawakami T, Takano H, Sugahara M, Saito H, Higashijima Y, Yamaguchi J, Inagi R, Nangaku M.
    • Journal Title

      Kidney Int

      Volume: 印刷中 Issue: 1 Pages: 154-164

    • DOI

      10.1016/j.kint.2017.01.014

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease2017

    • Author(s)
      Ishimoto Y, Inagi R, Yoshihara D, Kugita M, Nagao S, Shimizu A, Takeda N, Wake M, Honda K, Zhou J, Nangaku M
    • Journal Title

      Mol Cell Biol

      Volume: e-Pub Issue: 24

    • DOI

      10.1128/mcb.00337-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time-dependent effects of ipragliflozin on behaviour and energy homeostasis in normal and type 2 diabetic rats: continuous glucose telemetry analysis.2017

    • Author(s)
      Iuchi H, Sakamoto M, Matsutani D, Suzuki H, Kayama Y, Takeda N, Minamisawa S, Utsunomiya K.
    • Journal Title

      Sci Rep

      Volume: 22 Issue: 1 Pages: 351-354

    • DOI

      10.1038/s41598-017-12106-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.2017

    • Author(s)
      Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V, Stockmann C.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 1597-1597

    • DOI

      10.1038/s41467-017-01599-w

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between day-by-day and ambulatory blood pressure variability in type 2 diabetes patients2017

    • Author(s)
      Iuchi H, Sakamoto M, Matsutani D, Suzuki H, Kayama Y, Takeda N, Utsunomiya K
    • Journal Title

      Blood Press Monit

      Volume: 22 Issue: 6 Pages: 351-354

    • DOI

      10.1097/mbp.0000000000000285

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.2017

    • Author(s)
      Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 15503-15503

    • DOI

      10.1038/ncomms15503

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases2017

    • Author(s)
      Abe Hajime、Semba Hiroaki、Takeda Norihiko
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 9 Pages: 884-894

    • DOI

      10.5551/jat.RV17009

    • NAID

      130006038428

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid?induced insulin resistance2017

    • Author(s)
      Shinjo Satoko、Jiang Shuying、Nameta Masaaki、Suzuki Tomohiro、Kanai Mai、Nomura Yuta、Goda Nobuhito
    • Journal Title

      Exp Cell Res

      Volume: 359 Issue: 1 Pages: 86-93

    • DOI

      10.1016/j.yexcr.2017.08.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Previous dropout from diabetic care as a predictor of patients' willingness to use mobile applications for self-management: A cross-sectional study.2017

    • Author(s)
      Yamaguchi S, Waki K, Tomizawa N, Waki H, Nannya Y, Nangaku M, Kadowaki T, Ohe K.
    • Journal Title

      J Diabetes Investig

      Volume: 印刷中 Issue: 4 Pages: 542-549

    • DOI

      10.1111/jdi.12613

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects.2017

    • Author(s)
      Akizawa T, Tsubakihara Y, Nangaku M, Endo Y, Nakajima H, Kohno T, Imai Y, Kawase N, Hara K, Lepore J, Cobitz A.
    • Journal Title

      Am J Nephrol

      Volume: 45 Issue: 2 Pages: 127-135

    • DOI

      10.1159/000454818

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome.2017

    • Author(s)
      Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Sasatomi Y, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y; Refractory Nephrotic Syndrome Study Group.
    • Journal Title

      Clin Exp Nephrol

      Volume: 印刷中

    • NAID

      120006373812

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary N-acetyl-β-glucosaminidase and eGFR may identify patients to be treated with immuno-suppression at diagnosis in idiopathic membranous nephropathy.2017

    • Author(s)
      Bazzi C, Usui T, Rizza V, Casellato D, Gallieni M, Nangaku M.
    • Journal Title

      Nephrology

      Volume: 印刷中 Issue: 2 Pages: 175-182

    • DOI

      10.1111/nep.12952

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Selective plasma exchange can reduce auto-antibodies in patients with bullous pemphigoid without affecting factor XIII and fibrinogen.2017

    • Author(s)
      Nasu K, Hanafusa N, Nangaku M.
    • Journal Title

      J Clin Apher

      Volume: 印刷中 Issue: 6 Pages: 589-591

    • DOI

      10.1002/jca.21513

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of end-stage renal disease on hospital outcomes among patients admitted to intensive care units: A retrospective matched-pair cohort study.2017

    • Author(s)
      Iwagami M, Yasunaga H, Matsui H, Horiguchi H, Fushimi K, Noiri E, Nangaku M, Doi K.
    • Journal Title

      Nephrology

      Volume: 印刷中 Issue: 8 Pages: 617-623

    • DOI

      10.1111/nep.12830

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of quality indicators for care of chronic kidney disease in the primary care setting using electronic health data: a RAND-modified Delphi method.2017

    • Author(s)
      Fukuma S, Shimizu S, Niihata K, Sada KE, Yanagita M, Hatta T, Nangaku M, Katafuchi R, Fujita Y, Koizumi J, Koizumi S, Kimura K, Fukuhara S, Shibagaki Y.
    • Journal Title

      Clin Exp Nephrol

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ulcerative colitis with hepatitis B virus infection treated successfully by granulocyte monocyte apheresis.2017

    • Author(s)
      Saito H, Hanafusa N, Kishikawa J, Noiri E, Sunami E, Ishihara S, Watanabe T, Nangaku M.
    • Journal Title

      J Clin Apher

      Volume: 印刷中 Issue: 6 Pages: 584-586

    • DOI

      10.1002/jca.21450

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type I neuregulin1α is a novel local mediator to suppress hepatic gluconeogenesis in mice.2017

    • Author(s)
      Arai T, Ono Y, Arimura Y, Sayama K, Suzuki T, Shinjo S, Kanai M, Abe S, Semba K, Goda N.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 42959-42959

    • DOI

      10.1038/srep42959

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct Metabolic Phenotypes within Non-small Cell 1 Lung Cancer Define Selective Vulnerability to Glycolytic Inhibition of Lung Squamous Cell Carcinoma.2017

    • Author(s)
      Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
    • Journal Title

      Nat Commun

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Bevacizumab-related microvascular angina and its management with nicorandil.2017

    • Author(s)
      Katoh M, Takeda N, Arimoto T, Abe H, Oda K, Osuga Y, Fujii T, Komuro I.
    • Journal Title

      Int Heart J

      Volume: 印刷中

    • NAID

      130006179206

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac Sarcoidosis Diagnosed by Incidental Lymph Node Biopsy2017

    • Author(s)
      Matsuda J, Fujiu K, Roh S, Tajima M, Maki H, Kojima T, Ushiku T, Nawata K, Takeda N, Watanabe M, Akazawa H, Komuro I.
    • Journal Title

      International Heart Journal

      Volume: 58 Issue: 1 Pages: 140-143

    • DOI

      10.1536/ihj.16-218

    • NAID

      130005330527

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K2017

    • Author(s)
      Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M
    • Journal Title

      Sci Rep

      Volume: - Issue: 1 Pages: 41710-41710

    • DOI

      10.1038/srep41710

    • NAID

      120006313626

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Planimetry of the orifice area in aortic valve stenosis using phase-contrast cardiac magnetic resonance imaging.2017

    • Author(s)
      Abe H., Iguchi N, Utanohara Y, Takada K, Hen Y, Machida H, Takeda N, Sumiyoshi T.
    • Journal Title

      Int Heart J

      Volume: 印刷中

    • NAID

      130006321387

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells.2016

    • Author(s)
      Kushida N, Nomura S, Mimura I, Fujita T, Yamamoto S, Nangaku M, Aburatani H.
    • Journal Title

      Am J Nephrol

      Volume: 44 Pages: 276-285

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis.2016

    • Author(s)
      Sugawara Y, Honda K, Katagiri D, Nakamura M, Kawakami T, Nasu R, Hayashi A, Shintani Y, Tojo A, Noiri E, Kurokawa M, Fukayama M, Nangaku M.
    • Journal Title

      Intern Med

      Volume: 55 Pages: 2831-2836

    • NAID

      130005605877

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of clinical context on acute kidney injury biomarker performances: differences between neutrophil gelatinase-associated lipocalin and L-type fatty acid-binding protein.2016

    • Author(s)
      Asada T, Isshiki R, Hayase N, Sumida M, Inokuchi R, Noiri E, Nangaku M, Yahagi N, Doi K.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 33077-33077

    • DOI

      10.1038/srep33077

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of the V2 Vasopressin Receptor (V2R) Mutations Causing Partial Nephrogenic Diabetes Insipidus Highlights a Sustainable Signaling by a Non-peptide V2R Agonist.2016

    • Author(s)
      Makita N, Sato T, Yajima-Shoji Y, Sato J, Manaka K, Eda-Hashimoto M, Ootaki M, Matsumoto N, Nangaku M, Iiri T.
    • Journal Title

      J Biol Chem

      Volume: 291 Pages: 22460-22471

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DialBetics: Smartphone-Based Self-Management for Type 2 Diabetes Patients on Insulin Injections.2016

    • Author(s)
      Waki K, Fujiu K, Hayashi A, Kimura S, Kobayashi H, Nangaku M, Kadowaki T, Ohe K.
    • Journal Title

      J Diabetes Sci Technol

      Volume: 10 Issue: 3 Pages: 804-805

    • DOI

      10.1177/1932296815619638

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation2016

    • Author(s)
      Okubo K, Kamiya M, Urano Y, Nishi H, Herter JM, Mayadas T, Hirohama D, Suzuki K, Kawakami H, Tanaka M, Kurosawa M, Kagaya S, Hishikawa K, Nangaku M, Fujita T, Hayashi M, Hirahashi J.
    • Journal Title

      EBioMedicine

      Volume: 10 Pages: 204

    • DOI

      10.1016/j.ebiom.2016.07.012

    • URL

      https://localhost/en/publications/8cb82691-23b7-40ca-8ff0-6762123351bd

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Complete remission of thrombotic microangiopathy after treatment with eculizumab in a patient with non-Shiga toxin-associated bacterial enteritis: A case report.2016

    • Author(s)
      Omura T, Watanabe E, Otsuka Y, Yoshida Y, Kato H, Nangaku M, Miyata T, Oda S.
    • Journal Title

      Medicine

      Volume: 95 Issue: 27 Pages: e4104-e4104

    • DOI

      10.1097/md.0000000000004104

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] No association between dysplasminogenemia with p.Ala620Thr mutation and atypical hemolytic uremic syndrome.2016

    • Author(s)
      Miyata T, Uchida Y, Yoshida Y, Kato H, Matsumoto M, Kokame K, Fujimura Y, Nangaku M.
    • Journal Title

      Int J Hematol

      Volume: 104 Pages: 223-227

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential Survival Benefit of Polymyxin B Hemoperfusion in Septic Shock Patients on Continuous Renal Replacement Therapy: A Propensity-Matched Analysis.2016

    • Author(s)
      Iwagami M, Yasunaga H, Noiri E, Horiguchi H, Fushimi K, Matsubara T, Yahagi N, Nangaku M, Doi K.
    • Journal Title

      Blood Purif

      Volume: 42 Pages: 9-17

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythropoietin concentration in acute kidney injury is associated with insulin-like growth factor-binding protein-1.2016

    • Author(s)
      Yamashita T, Noiri E, Hamasaki Y, Matsubara T, Ishii T, Yahagi N, Nangaku M, Doi K.
    • Journal Title

      Nephrology

      Volume: 21 Issue: 8 Pages: 693-9

    • DOI

      10.1111/nep.12656

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Urinary Neutrophil Gelatinase-Associated Lipocalin With Long-Term Renal Outcomes in ICU Survivors: A Retrospective Observational Cohort Study.2016

    • Author(s)
      Isshiki R, Asada T, Sato D, Sumida M, Hamasaki Y, Inokuchi R, Matsubara T, Ishii T, Yahagi N, Nangaku M, Noiri E, Doi K.
    • Journal Title

      Shock

      Volume: 46 Issue: 1 Pages: 44-51

    • DOI

      10.1097/shk.0000000000000580

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition.2016

    • Author(s)
      Katagiri D, Hamasaki Y, Doi K, Negishi K, Sugaya T, Nangaku M, Noiri E.
    • Journal Title

      Kidney Int

      Volume: 89 Pages: 374-85

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The reduced expression of proximal tubular transporters in acquired Fanconi syndrome with κ light chain deposition.2016

    • Author(s)
      Tojo A, Asaba K, Kinugasa S, Ikeda Y, Shintani Y, Fukayama M, Nangaku M.
    • Journal Title

      Med Mol Morphol

      Volume: 49 Pages: 48-52

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correction of Metabolic Alkalosis and Elevated Calcium Levels by Sodium Chloride in a Hemodialysis Patient With Inadequate Chloride Intake2016

    • Author(s)
      Hirakawa Y, Hanafusa N, Nangaku M
    • Journal Title

      Ther Apher Dial

      Volume: 20 Issue: 1 Pages: 86-7

    • DOI

      10.1111/1744-9987.12335

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of continuous renal replacement therapy intensity on septic acute kidney injury.2016

    • Author(s)
      Mayumi K, Yamashita T, Hamasaki Y, Noiri E, Nangaku M, Yahagi N, Doi K.
    • Journal Title

      Shock

      Volume: 45 Issue: 2 Pages: 133-138

    • DOI

      10.1097/shk.0000000000000496

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rationale and study design of a randomized controlled trial to assess the effects of maintaining hemoglobin levels using darbepoetin alfa on prevention of development of end-stage kidney disease in non-diabetic CKD patients (PREDICT Trial).2016

    • Author(s)
      Imai E, Maruyama S, Nangaku M, Hirakata H, Hayashi T, Narita I, Kono H, Nakatani E, Morita S, Tsubakihara Y, Akizawa T.
    • Journal Title

      Clin Exp Nephrol

      Volume: 20 Issue: 1 Pages: 71-76

    • DOI

      10.1007/s10157-015-1133-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High serum ALP level is associated with increased risk of denosumab-related hypocalcemia in patients with bone metastases from solid tumors2016

    • Author(s)
      Kinoshita Y, Arai M, Ito N, Takashi Y, Makita N, Nangaku M, Shinoda Y, Fukumoto S.
    • Journal Title

      Endocrine Journal

      Volume: 63 Issue: 5 Pages: 479-484

    • DOI

      10.1507/endocrj.EJ16-0003

    • NAID

      130005154205

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity2016

    • Author(s)
      Semba, H., Takeda, N., Isagawa, T., Sugiura, Y., Honda, K., Wake, M., Miyazawa, H., Yamaguchi, Y., Miura, M., Jenkins, DM., Choi, H., Kim, JW., Asagiri, M., Cowburn, AS., Abe, H., Soma, K., Koyama, K., Katoh, M., Sayama, K., Goda, N., Johnson, RS., Manabe, I., Nagai, R., Komuro, I.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 11635-11635

    • DOI

      10.1038/ncomms11635

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.2016

    • Author(s)
      Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.
    • Journal Title

      Cell Stem Cell

      Volume: 19 Issue: 2 Pages: 192-204

    • DOI

      10.1016/j.stem.2016.05.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.2016

    • Author(s)
      R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 28845-28845

    • DOI

      10.1038/srep28845

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance.2016

    • Author(s)
      Takikawa A, Mahmood A , Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K.
    • Journal Title

      Diabetes

      Volume: 65 Pages: 3649-3659

    • NAID

      40021380120

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.2016

    • Author(s)
      Yamano, E., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., Soga, T., Watanabe, Y., and Kataoka, Y.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 34990-34990

    • DOI

      10.1038/srep34990

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cardiogenic syncope possibly related to bevacizumab-containing combination chemotherapy for advanced non-small cell lung cancer.2016

    • Author(s)
      Chino H, Amano Y, Yamauchi Y, Matsuda J, Takeda N, Tanaka G, Takai D, Nagase T.
    • Journal Title

      J Thorac Dis

      Volume: 8 Pages: 2646-2650

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atypical hemolytic uremic syndrome (aHUS): essential aspects of an accurate diagnosis.2016

    • Author(s)
      Laurence J, Haller H, Mannucci PM, Nangaku M, Praga M, Rodriguez de Cordoba S.
    • Journal Title

      Clin Adv Hematol Oncol

      Volume: 14 Suppl 11 Pages: 2-15

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] New insights into molecular mechanisms of epigenetic regulation in kidney disease.2016

    • Author(s)
      Mimura I, Tanaka T, Nangaku M.
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 43 Issue: 12 Pages: 1159-1167

    • DOI

      10.1111/1440-1681.12663

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments.2016

    • Author(s)
      Basile DP, Bonventre JV, Mehta R, Nangaku M, Unwin R, Rosner MH, Kellum JA, Ronco C; ADQI XIII Work Group.
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Issue: 3 Pages: 687-697

    • DOI

      10.1681/asn.2015030309

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting Endogenous Repair Pathways after AKI.2016

    • Author(s)
      Humphreys BD, Cantaluppi V, Portilla D, Singbartl K, Yang L, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative (ADQI) XIII Work Group.
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Issue: 4 Pages: 990-998

    • DOI

      10.1681/asn.2015030286

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps.2016

    • Author(s)
      Rabb H, Griffin MD, McKay DB, Swaminathan S, Pickkers P, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative Consensus XIII Work Group.
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Issue: 2 Pages: 371-379

    • DOI

      10.1681/asn.2015030261

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic Targets of Human AKI: Harmonizing Human and Animal AKI.2016

    • Author(s)
      Okusa MD, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative XIII Workgroup.
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Issue: 1 Pages: 44-48

    • DOI

      10.1681/asn.2015030233

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Renal Hemodynamics in AKI: In Search of New Treatment Targets.2016

    • Author(s)
      Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, Ronco C; ADQI XIII Work Group.
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Issue: 1 Pages: 49-58

    • DOI

      10.1681/asn.2015030234

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Circadian clock and the onset of cardiovascular events.2016

    • Author(s)
      Takeda N, Maemura K.
    • Journal Title

      Hypertens Res.

      Volume: in press Issue: 6 Pages: 383-90

    • DOI

      10.1038/hr.2016.9

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats.2016

    • Author(s)
      Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S
    • Journal Title

      PLoS One

      Volume: 11(2) Issue: 2 Pages: e0148666-e0148666

    • DOI

      10.1371/journal.pone.0148666

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016

    • Author(s)
      Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins D, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
    • Journal Title

      Nat commun.

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation.2016

    • Author(s)
      Mori Y, Takahashi N, Polat OK, Kuroakwa T, Takeda N, Inoue M
    • Journal Title

      Pflugers Arch. Eur. J. Physiol.

      Volume: 468 Issue: 1 Pages: 85-97

    • DOI

      10.1007/s00424-015-1716-2

    • NAID

      120005980858

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] nnate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity.2015

    • Author(s)
      Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M.
    • Journal Title

      J Immunol

      Volume: 195 Issue: 4 Pages: 1883-1890

    • DOI

      10.4049/jimmunol.1402103

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heterozygous deletion of sarcolipin maintains normal cardiac function.2015

    • Author(s)
      Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 310(1) Issue: 1 Pages: 92-103

    • DOI

      10.1152/ajpheart.00411.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.2015

    • Author(s)
      Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
    • Journal Title

      Mol Cell Biol.

      Volume: 35 Issue: 15 Pages: 2658-2672

    • DOI

      10.1128/mcb.00161-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitating intracellular oxygen tension in vivo by phosphorescence lifetime measurement2015

    • Author(s)
      Hirakawa Y, Yoshihara T, Kamiya M, Mimura I, Fujikura D, Masuda T, Kikuchi R, Takahashi I, Urano Y, Tobita S, Nangaku M.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 17838-17838

    • DOI

      10.1038/srep17838

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ2015

    • Author(s)
      Yamaguchi J, Tanaka T, Eto N, Nangaku M.
    • Journal Title

      Kidney International

      Volume: 印刷中 Issue: 2 Pages: 262-75

    • DOI

      10.1038/ki.2015.21

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of clock genes and circadian rhythm in the development of cardiovascular diseases.2015

    • Author(s)
      Takeda N, Maemura K.
    • Journal Title

      Cell Mol Life Sci

      Volume: 72 Issue: 17 Pages: 3225-3234

    • DOI

      10.1007/s00018-015-1923-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential biomarkers of fatigue identified by plasma metabolome analysis in rats.2015

    • Author(s)
      Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.
    • Journal Title

      PLOS ONE

      Volume: 10(3) Issue: 3 Pages: e0120106-e0120106

    • DOI

      10.1371/journal.pone.0120106

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of hypoxia-inducible factors prevents diabetic nephropathy.2015

    • Author(s)
      8)Nordquist L, Friederich-Persson M, Fasching A, Liss P, Shoji K, Nangaku M, Hansell P, Palm F.
    • Journal Title

      J Am Soc Nephrol

      Volume: 26 Issue: 2 Pages: 328-338

    • DOI

      10.1681/asn.2013090990

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory role of DPP-4 inhibitors in a non-diabetic model of glomerular injury2015

    • Author(s)
      Higashijima Y, Tanaka T, Yamaguchi J, Tanaka S, Nangaku M
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: ahead of print Issue: 8 Pages: F878-F887

    • DOI

      10.1152/ajprenal.00590.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-invasive diagnosis of coronary artery disease by 123I-BMIPP/201TlCl dual myocardial SPECT in patients with heart failure2014

    • Author(s)
      Abe H, Iguchi N, Utanohara Y, Inoue K, Takamisawa I, Seki A, Tanizaki K, Takeda N, Tohbaru T, Asano R, Nagayama M, Takayama M, Umemura J, Sumiyoshi T, Tomoike H.
    • Journal Title

      Int J Cardiol

      Volume: 176 Issue: 3 Pages: 969-974

    • DOI

      10.1016/j.ijcard.2014.08.129

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure.2014

    • Author(s)
      Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M.
    • Journal Title

      FEBS Open Bio

      Volume: 4 Issue: 1 Pages: 777-787

    • DOI

      10.1016/j.fob.2014.08.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transcription Profiles of the Ductus Arteriosus in Brown-Norway Rats With Irregular Elastic Fiber Formation2014

    • Author(s)
      Hsieh YT, Liu NM, Ohmori E, Yokota T, Kajimura I, Akaike T, Ohshima T, Goda N, Minamisawa S.
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 5 Pages: 1224-1233

    • DOI

      10.1253/circj.CJ-13-1029

    • NAID

      130003391069

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor.2014

    • Author(s)
      Khamaisi M, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, Meidan R, Koesters R, Rosen S, Walkinshaw G, Mimura I, Nangaku M, Heyman SN.
    • Journal Title

      Kidney International

      Volume: 87 Issue: 4 Pages: 761-770

    • DOI

      10.1038/ki.2014.362

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1.2014

    • Author(s)
      Ruthenborg RJ, Ban JJ, Wazir A, Takeda N, Kim JW.
    • Journal Title

      Mol Cells

      Volume: 37 Issue: 9 Pages: 637-643

    • DOI

      10.14348/molcells.2014.0150

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia and fatty liver.2014

    • Author(s)
      Suzuki T, Shinjo S, Arai T, Kanai M, Goda N.
    • Journal Title

      World J Gastroenterol.

      Volume: 20 Issue: 41 Pages: 15087-15097

    • DOI

      10.3748/wjg.v20.i41.15087

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes.2014

    • Author(s)
      Kawakami T, Mimura I, Shoji K, Tanaka T, Nangaku M.
    • Journal Title

      Kidney Int Suppl

      Volume: 4 Pages: 107-112

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] The Role of Hypoxia and HIF in Tubule Injury2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Keystone Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 組織リモデリングにおける低酸素シグナル2019

    • Author(s)
      武田憲彦
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Roles of Ly6Chi macrophages hypoxia signaling in cardiac fibrosis2019

    • Author(s)
      Norihiko Takeda
    • Organizer
      Keystone Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diabetic Nephropathy: What is new?2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Academic Conference of 70th Establishment Anniversary of VMMU
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] AKI to CKD Transition2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Burden of CKD; Challenges and Successes2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mitochondrial DNA Leakage Causes Inflammation via the cGAS-STING Axis in Cisplatin-Mediated Tubular Damage2018

    • Author(s)
      Maekawa H, Jao T-M, Inoue R, Nishi H, Inoue T, Nangaku M, Inagi R.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficacy and Safety of Daprodustat on Anemia Management in Japanese Hemodialysis Patients Not Using Erythropoiesis-Stimulating Agents2018

    • Author(s)
      Fujii T, Tsubakihara Y, Akizawa T, Nangaku M, Onoue T, Yonekawa T, Endo Y, Cobitz AR.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Randomized, Placebo-Controlled Phase 2 Trials of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor (HIF-PHI), to Treat Anemia of CKD2018

    • Author(s)
      Nangaku M, Khawaja Z, Luo W, Garafola S, deGoma E, Komatsu Y.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple, Systemic Effects of PHD Inhibitors Signify an Anti-Fibrotic and Anti-Inflammatory Impact on Cardiovascular Complications in the Remnant Kidney2018

    • Author(s)
      Uchida L, Tanaka T, Saito H, Sugahara M, Fukui K, Wakashima T, Nangaku M.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mitochondrial Morphological Abnormality in Cyst Epithelial Cells of Autosomal Dominant Polycystic Kidney Disease Patients2018

    • Author(s)
      Ishimoto Y, Shimizu A, Kugita M, Nagao S, Honda K, Inagi R, Nangauk M, Nishio S, Kawano H, Horie S, Kasahara T, Osafune K, Hoshino J, Ubara Y.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PHD Inhibition Reduces Reactive Oxidative Stress in In Vitro Ischemia Model2018

    • Author(s)
      Ito M, Tanaka T, Wakashima T, Nangaku M, Fukui K.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hes1, a Newly Identified Downstream Mediator of alpha7nAChR on Macrophages in the Cholinergic Anti-Inflammatory Pathway, Plays a Protective Role in AKI2018

    • Author(s)
      Inoue T, Abe C, Tanaka S, Rosin DL, Nangaku M, Wada Y, Okusa MD.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ATF6alpha and PPARalpha Cross-Talk Provides New Insights into Lipotoxicity-Induced Tubulointerstitial Fibrosis2018

    • Author(s)
      Jao T-M, Inoue T, Sugahara M, Maekawa H, Ishimoto Y, Tanaka T, Nangaku M, Inagi R.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The molecular mechanisms of AKI to CKD transition and its clinical implication2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Asia Pacific AKI CRRT conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The AKI to CKD Continuum: a Clinical Perspective2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Annual Meeting of the Hong Kong Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anemia treatment in CKD: Update2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Annual Meeting of the Malaysian Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 慢性腎臓病における心・血管障害2018

    • Author(s)
      南学正臣
    • Organizer
      日本下肢救済・足病学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 慢性腎不全治療薬の開発 その課題と今後への期待2018

    • Author(s)
      南学正臣
    • Organizer
      日本腎臓学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] New insights into AKI to CKD continuum and the role of maladaptive repair2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Anuual Meeting of the Korean Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The roles of glucose and lactate metabolism in the regulation of mitochondrial respiration2018

    • Author(s)
      武田憲彦
    • Organizer
      第6回低酸素研究会・酸素生物学領域国際シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The roles of glucose and lactate metabolism in the regulation of mitochondrial respiration2018

    • Author(s)
      Norihiko Takeda
    • Organizer
      Hypoxia Research Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pathological role of HIF-1 in the liver2018

    • Author(s)
      合田亘人
    • Organizer
      第6回低酸素研究会・酸素生物学領域国際シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Pathological role of HIF-1 in the liver2018

    • Author(s)
      Nobuhito Goda
    • Organizer
      Hypoxia Research Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自然免疫様T細胞のHIF-1による急性炎症制御機構の解明2018

    • Author(s)
      合田亘人
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新しい糖新生調節因子の探索とその機能解析2018

    • Author(s)
      合田亘人
    • Organizer
      第5回肝臓と糖尿病・代謝研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] From diabetic nephropathy to diabetic kidney disease2018

    • Author(s)
      Nangaku M.
    • Organizer
      The 16th Asian Pacific Congress of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenetic change in progression of AKI to CKD2018

    • Author(s)
      Nangaku M.
    • Organizer
      The 16th Asian Pacific Congress of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 低酸素シグナルを介する心臓リモデリング2018

    • Author(s)
      武田憲彦
    • Organizer
      第47回日本心脈管作動物質学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The roles of lactate metabolism in cardiac function2018

    • Author(s)
      武田憲彦
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Genomewide analysis of HIF-1α target genes in macrophage adaptation for the microenvironment2018

    • Author(s)
      Isagawa T, Takeda N, Semba H, Morioka M, Maemura K.
    • Organizer
      第1回日本循環器学会基礎研究フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] マクロファージ微小環境適応における転写制御機構2018

    • Author(s)
      砂河孝行, 武田憲彦, 仙波宏章,安部 元, 相馬 桂, 和氣正樹, 加藤愛巳, 森岡勝樹, 魏碩俣, 前村浩二
    • Organizer
      第47回日本心脈管作動物質学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 低酸素誘導性肺血管リモデリングにおける炎症細胞の役割2017

    • Author(s)
      武田憲彦
    • Organizer
      第9回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松、静岡
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The Role of Eosinophils in Pulmonary Arterial Remodelling2017

    • Author(s)
      武田憲彦
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      ホテル日航金沢、金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2017

    • Author(s)
      Takeda N.
    • Organizer
      Keystone Symposium “Adaptaions to Hypoxia in Physiology and Disease”
    • Place of Presentation
      Whistler Conference Centre, Whistler, British Columbia, Canada
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Oxygen biology in the kidney2017

    • Author(s)
      Nangaku M.
    • Organizer
      The 2nd NTU-UTokyo Joint Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenetics and AKI-CKD transition2017

    • Author(s)
      Nangaku M.
    • Organizer
      22nd International Conference on Advances in Critical Care: AKI & CRRT 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of HIF stabilizer in renal fibrosis2017

    • Author(s)
      Nangaku M.
    • Organizer
      The 37th Annual Meeting of the Korean Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Metabolic memory and hypoxic memory: epigenetics in diabetic nephropathy2017

    • Author(s)
      Nangaku M.
    • Organizer
      The 53rd Annual Meeting of the Australia-New Zealand Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Gene Expression Profiles of Glomeruli from BTBR ob/ob Mice Treated with Prolyl Hydroxylase Inhibitor Suggest Involvement of Extracellular Matrix Modulators in Pathogenesis of Diabetic Kidney Disease2017

    • Author(s)
      Sugahara M, Tanaka T, Tanaka S, Fukui K, Shimizu A, Ishimoto Y, Inagi R, Nangaku M
    • Organizer
      The 61st Annual Meeting of the American Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of Glycolysis Attenuates Ischemia-Reperfusion Injury via Metabolic and Redox Changes in Proximal Tubular Cells2017

    • Author(s)
      Shinohara A, Kawakami T, Nangaku M.
    • Organizer
      The 61st Annual Meeting of the American Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of Prolyl Hydroxylase Domain (PHD) Reduces Glomerular Macrophage Infiltration and Improves Albuminuria in Mice with a High Fat Diet2017

    • Author(s)
      Saito H, Tanaka T, Sugahara M, Fukui K, Wakashima T, Nangaku M.
    • Organizer
      The 61st Annual Meeting of the American Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Treatment of anemia in CKD and doping2017

    • Author(s)
      Nangaku M.
    • Organizer
      Cunio Richardson Lecture at University of Miami
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anemia in CKD2017

    • Author(s)
      Nangaku M.
    • Organizer
      Vietnam Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Update of anemia management in CKD patients2017

    • Author(s)
      Nangaku M.
    • Organizer
      The 2nd International Congress of Chinese Nephrologists
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flt-1 in M1 macrophages promotes immature vascular formation2017

    • Author(s)
      Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Kato M, Nakagama Y, Manabe I, Nagai R, Komuro I
    • Organizer
      European society of cardiology, ESC congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-Throughput shRNA Screening of the Molecular Mechanisms in Cardiac Fibroblast Activation2017

    • Author(s)
      Koyama K, Takeda N, Abe H, Semba H, Soma K, Wake M, Katoh M, Nakagama Y, Isagawa T, Komuro I
    • Organizer
      European society of cardiology, ESC congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The roles of hypoxia or inflammatory signals in cardiovascular remodeling2017

    • Author(s)
      Takeda N.
    • Organizer
      Special Research Seminar at 神戸女子薬科大学
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The roles of lactate metabolism in cardiac function2017

    • Author(s)
      Takeda N.
    • Organizer
      Consortium of Biological Sciences 2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] マクロファージ活性化における細胞内グルコース代謝の役割2016

    • Author(s)
      武田憲彦
    • Organizer
      第20回日本適応医学会学術集会
    • Place of Presentation
      東京コンベンションホール、東京
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation.2016

    • Author(s)
      武田憲彦
    • Organizer
      第24回日本血管生物医学会学術集会
    • Place of Presentation
      長崎ブリックホール、長崎
    • Year and Date
      2016-12-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Oxygen biology in the kidney.2016

    • Author(s)
      Nangaku M.
    • Organizer
      2nd NTU-UTokyo Joint Conference
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel therapeutic targets in PKD, DKD, and CKD: mitochondria, ER, and oxygen metabolism.2016

    • Author(s)
      Nangaku M.
    • Organizer
      Yale University Nephrology Seminar
    • Place of Presentation
      New Haven, USA
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Hypoxia-inducible factors in diabetic nephropathy.2016

    • Author(s)
      Nangaku M.
    • Organizer
      50th American Society of Nephrology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 低酸素応答システムが拓く代謝性疾患の新しい病態理解2016

    • Author(s)
      合田亘人
    • Organizer
      第20回酸素ダイナミクス研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] HIF-1alpha-PDK1経路を介した代謝リプログラミングはマクロファージ遊走能を促進する2016

    • Author(s)
      武田憲彦
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京ファッションタウン、東京
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Metabolic diseases and HIF-12016

    • Author(s)
      Goda N.
    • Organizer
      第89回生化学会大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Switching of two HIF-alpha; isforms regulates inflammatory processes and cardiac remodeling2016

    • Author(s)
      武田憲彦
    • Organizer
      第52回高血圧関連疾患モデル学会
    • Place of Presentation
      秋葉原UDX、東京
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Epigenetics of renal disease.2016

    • Author(s)
      Nangaku M.
    • Organizer
      15th Asian Pacific Congress of Nephrology
    • Place of Presentation
      Perth, Australia
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenetics of Renal Disease2016

    • Author(s)
      Nangaku M.
    • Organizer
      15th Asian Pacific Congress of Nephrology
    • Place of Presentation
      Perth, Australia
    • Year and Date
      2016-09-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anemia management update.2016

    • Author(s)
      Nangaku M.
    • Organizer
      15th Asian Pacific Congress of Nephrology
    • Place of Presentation
      Perth, Australia
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 心血管リモデリングにおける炎症細胞・低酸素シグナルの役割2016

    • Author(s)
      武田憲彦
    • Organizer
      第48回日本動脈硬化学会総会学術集会
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016

    • Author(s)
      Takeda N.
    • Organizer
      2016 HDRC International Symposium
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of novel drugs targeting renal hypoxia and anaemia.2016

    • Author(s)
      Nangaku M.
    • Organizer
      53rd European Renal Association/European Dialysis and Transplantation Association
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hypoxia and persistent inflammation in CKD.2016

    • Author(s)
      Nangaku M.
    • Organizer
      XVIII International Congress on Nutrition and Metabolism in Renal Disease
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HIF-1α - Pdk1 axis induced metabolic reprogramming critically regulates macrophage function in inflammatory conditions2016

    • Author(s)
      Semba H, Takeda N, Isagawa T, Wake M, Abe H, Soma K, Koyama K, Katoh M, Manabe I, Nagai R, Takeshi Yamashita, Komuro I
    • Organizer
      第80回日本循環器学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] HIF-1α - PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity2016

    • Author(s)
      Takeda N, Semba H, Isagawa T, Abe H, Sugiura Y, Honda K, Wake M, Kim JW, Soma K, Koyama K, Katoh M, Johnson RS, Manabe I, Nagai R, Komuro I
    • Organizer
      Keystone symposium; Immunometabolism in immune function and inflammatory disease
    • Place of Presentation
      Alberta, Canada
    • Year and Date
      2016-02-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of Ly6Chi monocytes hypoxia signaling in cardiac remodeling2016

    • Author(s)
      Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
    • Organizer
      Keystone symposium; Immunometabolism in immune function and inflammatory disease
    • Place of Presentation
      Alberta, Canada
    • Year and Date
      2016-02-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] M1マクロファージの集積遷延は腫瘍内血管の未熟化を引き起こす2015

    • Author(s)
      相馬桂 武田憲彦 砂河孝行 安部元 仙波宏章 小山雄広 和氣正樹 加藤愛巳 真鍋一郎 永井良三 小室一成
    • Organizer
      第23回日本血管生物医学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Roles of macrophages hypoxia signaling in pressure overload-induced cardiac remodeling2015

    • Author(s)
      Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
    • Organizer
      第32回国際心臓研究学会日本部会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] りん光寿命測定を用いた腎臓尿細管細胞内分圧の測定2015

    • Author(s)
      平川陽亮、吉原利忠、神谷真子、三村維真理、田中真司、田中哲洋、浦野泰照、飛田成史、南学正臣
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] HIF-1α;-PDK1を介する解糖系代謝シフトがマクロファージ遊走能を促進する2015

    • Author(s)
      武田憲彦
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 低酸素とTGF-βは、下流にある IGFBP3 を介して、尿細管上皮細胞に apoptosis を誘導する.2015

    • Author(s)
      串田夏樹、野村征太郎、藤田隆教、三村維真理、南学正臣、油谷浩幸
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 炎症プロセスにおけるマクロファージ細胞内代謝調節機構の役割2015

    • Author(s)
      武田憲彦
    • Organizer
      脳心血管抗加齢研究会2015
    • Place of Presentation
      大阪梅田スカイビル(大阪府大阪市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Quantitating Intracellular Oxygen Tension in Kidney by Phosphorescence Lifetime Measurement.2015

    • Author(s)
      Yosuke Hirakawa, Imari Mimura, Toshitada Yoshihara, Mako Kamiya, Yasuteru Urano, Seiji Tobita, Masaomi Nangaku.
    • Organizer
      The 49th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oxidative Stres and Kidney Injury.2015

    • Author(s)
      Nangaku M.
    • Organizer
      The 49th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Palmitate Exacerbates Renal Anemia: Suppression of Renal Erythropoietin Production via Endoplasmic Reticulum Stress.2015

    • Author(s)
      Reiko Inagi, Thitinun Anusornvongchai, Yu Ishimoto, Akira Okada, Norio Suzuki, Masayuki Yamamoto, Masaomi Nangaku.
    • Organizer
      The 49th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estimation of intracellular oxygen concentration in diabetic kidney by phosphorescence lifetime measurement.2015

    • Author(s)
      Hirakawa Y, Mimura I, Yoshihara T, Kamiya M, Tanaka S, Tanaka T, Inagi R, Urano Y, Tobita S, Nangaku M.
    • Organizer
      Keystone Symposia: Diabetes: New insights into molecular mechanisms and therapeutic strategies.
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Palmitate suppresses EPO production via ER stress in renal EPO producing cells.2015

    • Author(s)
      Anusomvongchai T, Tanaka S, Hirakawa Y, Suzuki n, Yamamoto M, Nangaku M, Inagi R.
    • Organizer
      Keystone Symposia: Diabetes: New insights into molecular mechanisms and therapeutic strategies.
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腎不全に至る共通経路と高血圧の役割2015

    • Author(s)
      南学正臣
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛県県民文化会館(愛媛県松山市)
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] HIF-1αを介する解糖系代謝シフトはマクロファージ遊走能を促進する2015

    • Author(s)
      武田憲彦
    • Organizer
      第19回酸素ダイナミクス研究会
    • Place of Presentation
      東京女子医科大学 健保会館(東京都新宿区)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation.2015

    • Author(s)
      Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Manabe I, Nagai R, Komuro I
    • Organizer
      ESC Congress2015
    • Place of Presentation
      London, UK
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hypoxia induced metabolic reprograming in macrophages.2015

    • Author(s)
      Takeda N.
    • Organizer
      An International Symposium on Oxygen Biology
    • Place of Presentation
      早稲田大学 先端生命医科学センター/TWIns(東京都新宿区)
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 低酸素シグナルを介する心血管病態治療の可能性2015

    • Author(s)
      武田憲彦
    • Organizer
      第47回日本動脈硬化学会総会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] AKI-to-CKD: epidemiology and pathogenesis.2015

    • Author(s)
      Nangaku M.
    • Organizer
      Shanghai International AKI-CRRT Forum
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 腎性貧血とHIF2015

    • Author(s)
      南学正臣
    • Organizer
      第60回日本透析医学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Hypoxia as a new therapeutic target in CKD.2015

    • Author(s)
      南学正臣
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Development of novel drugs targeting CKD: hypoxia, oxidative stress, and epigenetics.2015

    • Author(s)
      Nangaku M.
    • Organizer
      52nd European Renal Association/European Dialysis and Transplantation Association
    • Place of Presentation
      London, UK
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Roles of Macrophages Hypoxia Signaling in Pressure Overload Induced Cardiac Remodeling2015

    • Author(s)
      Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Manabe I, Nagai R, Komuro I.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Hypoxia and Renal Disease2015

    • Author(s)
      Nangaku M
    • Organizer
      第8回国際腎臓学会
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2015-03-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マクロファージの代謝リプログラミングにおける細胞内低酸素センサー2014

    • Author(s)
      仙波宏章, 武田憲彦, 砂河孝行, 杉浦悠毅, 安部元, 相馬桂, 小山雄広, 和氣正樹, 真鍋一郎, 小室一成, 永井良三
    • Organizer
      第37回日本分子生物学会年会ワークショップ
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 慢性腎臓病の進展とエピゲノム~低酸素刺激によるクロマチン立体構造変化2014

    • Author(s)
      三村維真理
    • Organizer
      第37回日本分子生物学会年会ワークショップ
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hypoxic HIF, Fibrosis, and CKD.2014

    • Author(s)
      Nangaku M
    • Organizer
      第47回アメリカ腎臓学会
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Funded Workshop] Hypoxia Research Meeting 20182018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] 国際低酸素シンポジウム(CARPEDIEMと共催)2015

    • Place of Presentation
      東京
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report

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Published: 2014-11-20   Modified: 2020-03-30  

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