Signal transduction by redox sensor molecules

• Project Area: Oxygen biology: a new criterion for integrated understanding of life
• Project/Area Number: 26111007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: Miki Hiroaki 大阪大学, 微生物病研究所, 教授 (80302602)
• Co-Investigator(Kenkyū-buntansha): 藤澤 貴央 東京大学, 大学院薬学系研究科(薬学部), 助教 (50636644) ; 服部 一輝 東京大学, 大学院薬学系研究科(薬学部), 助教 (40708575) ; 関根 史織 東京大学, 薬学研究科(研究院), 助教 (70612654)
• Project Period (FY): 2014-07-10 – 2019-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥100,360,000 (Direct Cost: ¥77,200,000、Indirect Cost: ¥23,160,000); Fiscal Year 2018: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2017: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2016: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2015: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2014: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
• Keywords: シグナル伝達 / ストレス

Outline of Final Research Achievements

(1) We performed functional analyses of PRL, a redox sensor molecule. We found a novel regulatory mechanism of the complex formation with its target molecule CNNM and a unique role in the regulation of energy metabolism and blood pressure. (2) We also performed functional analyses of another redox sensor molecule KLHDC10. We found its involvement in systemic inflammation by promoting cell death and the importance of ASK1, which functions downstream of KLHDC10, in cell death induced by the accumulation of peroxidized lipids, which is called ferroptosis.

Academic Significance and Societal Importance of the Research Achievements

活性酸素は酸素呼吸に伴って生じる毒物的なものとして認識されてきたが、生物はそれを積極的に利用して生命機能の調節に役立てている。本研究では、この活性酸素に応答して適切な細胞応答を起こすレドックセンサー分子にフォーカスして解析を進めた。その結果、各レドックスセンサー分子の機能調節の仕組みや、血圧調節・炎症制御などヒト疾患にも密接に関わるマクロな現象との関連も明らかにできた。

Research Products

• [Int'l Joint Research] McGill University(カナダ)
• [Int'l Joint Research] Fudan University(中国)
• [Int'l Joint Research] McGill大学(カナダ)
• [Int'l Joint Research] McGill University(Canada)
• [Int'l Joint Research] University of Oxford(United Kingdom)
• [Int'l Joint Research] McGill University(カナダ)
• [Journal Article] Molecular function and biological importance of CNNM family Mg2+ transporters. (2019)
  • Author(s): Funato Y, Miki H
  • Journal Title: J Biochem Volume: 165 Issue: 3 Pages: 219-225
  • DOI: 10.1093/jb/mvy095
  • Peer Reviewed / Open Access
• [Journal Article] Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains (2019)
  • Author(s): Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uuskula-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC
  • Journal Title: Molecular Cell Volume: 73 Issue: 3 Pages: 1-18
  • DOI: 10.1016/j.molcel.2018.11.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The cyclic nucleotide-binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity. (2018)
  • Author(s): Chen YS, Kozlov G, Fakih R, Funato Y, Miki H, Gehring K
  • Journal Title: J Biol Chem Volume: 293 Issue: 52 Pages: 19998-20007
  • DOI: 10.1074/jbc.ra118.005672
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model (2018)
  • Author(s): Tsuburaya, N., Homma, K., Higuchi, T., Balia, A., Yamakoshi, H., Shibata, N., Nakamura, S., Nakagawa, H., Ikeda, S., Umezawa, N., Kato, N., Yokoshima, S., Shibuya, M., Shimonishi, M., Kojima, H., Okabe, T., Nagano, T., Naguro, I., Imamura, K., Inoue, H., Fujisawa, T., and Ichijo, H.
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 2668-2668
  • DOI: 10.1038/s41467-018-05127-2
  • NAID: 120006546002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phosphatase of regenerating liver maintains cellular magnesium homeostasis (2018)
  • Author(s): Yoshida A, Funato Y, Miki H
  • Journal Title: Biochem J. Volume: 475 Issue: 6 Pages: 1129-1139
  • DOI: 10.1042/bcj20170756
  • Peer Reviewed
• [Journal Article] CrossTalk proposal: CNNM proteins are Na+/Mg2+exchangers playing a central role in transepithelial Mg2+(re)absorption (2018)
  • Author(s): Funato Y, Furutani K, Kurachi Y, Miki H
  • Journal Title: J Physiol. Volume: 596 Issue: 5 Pages: 743-746
  • DOI: 10.1113/jp275248
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Apoptosis signal-regulating kinase 1 in regulated necrosis (2018)
  • Author(s): Hattori Kazuki、Ichijo Hidenori
  • Journal Title: Cell Cycle Volume: 17 Issue: 1 Pages: 5-6
  • DOI: 10.1080/15384101.2017.1397330
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of long-term Mg2+ dynamics in apoptotic cells using a novel targetable fluorescent probe (2017)
  • Author(s): Matsui Y, Funato Y, Imamura H, Miki H, Mizukami S, Kikuchi K
  • Journal Title: Chem Sci. Volume: 8 Issue: 12 Pages: 8255-8264
  • DOI: 10.1039/c7sc03954a
  • Peer Reviewed / Open Access
• [Journal Article] Cold stress‐induced ferroptosis involves the ASK1‐p38 pathway (2017)
  • Author(s): Hattori Kazuki、Ishikawa Hiroyuki、Sakauchi Chihiro、Takayanagi Saki、Naguro Isao、Ichijo Hidenori
  • Journal Title: EMBO reports Volume: 18 Issue: 11 Pages: 2067-2078
  • DOI: 10.15252/embr.201744228
  • Peer Reviewed / Open Access
• [Journal Article] Renal function of cyclin M2 Mg2+ transporter maintains blood pressure. (2017)
  • Author(s): Funato Y, Yamazaki D, Miki H.
  • Journal Title: J Hypertens. Volume: 35 Issue: 3 Pages: 585-592
  • DOI: 10.1097/hjh.0000000000001211
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pleiotropic properties of ASK1. (2017)
  • Author(s): Sakauchi C, Wakatsuki H, Ichijo H, Hattori K.
  • Journal Title: Biochim Biophys Acta. Volume: 1861 Issue: 1 Pages: 3030-3038
  • DOI: 10.1016/j.bbagen.2016.09.028
  • Peer Reviewed
• [Journal Article] Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis. (2016)
  • Author(s): Gulerez I, Funato Y, Wu H, Yang M, Kozlov G, Miki H, Gehring K.
  • Journal Title: EMBO Rep. Volume: 17 Issue: 12 Pages: 1890-1900
  • DOI: 10.15252/embr.201643393
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Mg²⁺ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans (2016)
  • Author(s): Ishii T, Funato Y, Hashizume O, Yamazaki D, Hirata Y, Nishiwaki K, Kono N, Arai H, Miki H.
  • Journal Title: PLoS Genet. Volume: 12 Issue: 8 Pages: e1006276-e1006276
  • DOI: 10.1371/journal.pgen.1006276
  • URL: https://pure.teikyo.jp/en/publications/2815954c-7f3b-43fd-8b95-972e240bc205
  • Peer Reviewed / Open Access
• [Journal Article] Complementary role of CNNM2 in sperm motility and Ca(2+) influx during capacitation. (2016)
  • Author(s): Yamazaki D, Funato Y, Miyata H, Ikawa M, Miki H.
  • Journal Title: Biochem Biophys Res Commun. Volume: 474 Issue: 3 Pages: 441-446
  • DOI: 10.1016/j.bbrc.2016.05.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and it is essential for reproduction (2016)
  • Author(s): Daisuke Yamazaki, Haruhiko Miyata, Yosuke Funato, Yoshitaka Fujihara, Masahito Ikawa, Hiroaki Miki
  • Journal Title: Journal of Cell Science Volume: 未定 Issue: 9 Pages: 1940-1949
  • DOI: 10.1242/jcs.182220
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ASK1 signaling regulates brown and beige adipocyte maturation (2016)
  • Author(s): Kazuki H, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, and Ichijo H
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 11158-11158
  • DOI: 10.1038/ncomms11158
  • Peer Reviewed / Open Access
• [Journal Article] The ablation of mitochondrial protein phosphatase pgam5 confers resistance against metabolic stress (2016)
  • Author(s): Sekine S., Yao, A., Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K., Ichijo, H
  • Journal Title: EBioMedicine Volume: 6 Pages: 82-92
  • DOI: 10.1016/j.ebiom.2016.01.031
  • Peer Reviewed / Open Access
• [Journal Article] Apoptosis Signal-regulating Kinase 1(ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for oxidative stress-induced necrosis (2015)
  • Author(s): Watanabe T, Sekine S, Naguro I, Sekine Y, Ichijo H.
  • Journal Title: J Biol Chem Volume: in press Issue: 17 Pages: 10791-10803
  • DOI: 10.1074/jbc.m114.623280
  • NAID: 120007150218
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mitochondrial proteolysis: Its emerging roles in stress responses. (2015)
  • Author(s): Sekine, S. and Ichijo, H.
  • Journal Title: B.B.A. Volume: 1850 Issue: 2 Pages: 274-280
  • DOI: 10.1016/j.bbagen.2014.10.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Basolateral sorting of the Mg2+ transporter CNNM4 requires interaction with AP-1A and AP-1B. (2014)
  • Author(s): Hirata Y, Funato Y, Miki H.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 455 Issue: 3-4 Pages: 184-189
  • DOI: 10.1016/j.bbrc.2014.10.138
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Membrane Protein CNNM4-Dependent Mg2+ Efflux Suppresses Tumor Progression (2014)
  • Author(s): Yosuke Funato, Daisuke Yamazaki, Shin Mizukami, Lisa Du, Kazuya Kikuchi, Hiroaki Miki
  • Journal Title: J. Clin. Invest. Volume: 124 Issue: 12 Pages: 5398-5410
  • DOI: 10.1172/jci76614
  • Peer Reviewed
• [Journal Article] Reconstruction of insulin signal flow from phosphoproteome and metabolome data (2014)
  • Author(s): Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K.I., Kashikura, K., Endo, K., Ikeda, K., Soga, T., Kuroda, S.
  • Journal Title: Cell Rep. Volume: 8 Issue: 4 Pages: 1171-1183
  • DOI: 10.1016/j.celrep.2014.07.021
  • NAID: 120005537752
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporter. (2014)
  • Author(s): Hirata Y, Funato Y, Takano Y, Miki H.
  • Journal Title: J. Biol. Chem. Volume: 289 Issue: 21 Pages: 14731-14739
  • DOI: 10.1074/jbc.m114.551176
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Regulation of Mg2+ levels and ROS generation by PRL/CNNM complexes (2019)
  • Author(s): Hiroaki Miki
  • Organizer: The Kick-off Symposium of Advanced Graduate Program for Future Medicine and Health Care
  • Int'l Joint Research / Invited
• [Presentation] がん細胞のエネルギー代謝における細胞の環境pH応答の制御 (2019)
  • Author(s): 船戸洋佑、吉田篤、山崎大輔、三木裕明
  • Organizer: 第1回SGH若手がん研究者ワークショップ
  • Invited
• [Presentation] 過剰なマグネシウムが引き起こすミトコンドリアでの活性酸素種とATPの過剰産生 (2018)
  • Author(s): 橋爪 脩, 船戸 洋佑, 三木 裕明
  • Organizer: 第18回日本ミトコンドリア学会年会
• [Presentation] Regulation of Mg2+ homeostasis and cancer progression by Phosphatase of Regenerating Liver (PRL) (2018)
  • Author(s): Yosuke Funato, Daisuke Yamazaki, Hiroaki Miki
  • Organizer: Workshop on Frontiers in Phosphatase Research and Drug Discovery
  • Int'l Joint Research / Invited
• [Presentation] Overproduction of ATP and Reactive Oxygen Species in Mitochondria by Excessive Magnesium (2018)
  • Author(s): Osamu Hashizume, Yosuke Funato, Hiroaki Miki
  • Organizer: The Joint Symposium of the 13th International Symposium of the Institute Network for Biomedical Sciences and the 28th Hot Spring Harbor International Symposium 2018
  • Int'l Joint Research
• [Presentation] PRL高発現によるMetチロシンリン酸化の亢進と細胞内局在変化 (2018)
  • Author(s): 兒島 卓也, 船戸 洋佑, 三木 裕明
  • Organizer: 第９１回日本生化学会大会
• [Presentation] がん悪性化のドライバー蛋白質PRLによる染色体制御の異常 (2018)
  • Author(s): Kajung Ryu, 吉田 篤, 船戸 洋佑, 山崎 大輔, 三木 裕明
  • Organizer: 第９１回日本生化学会大会
• [Presentation] 過剰なマグネシウムが引き起こすミトコンドリアでのATPとROSの過剰産生 (2018)
  • Author(s): 橋爪 脩, 船戸 洋佑, 三木 裕明
  • Organizer: 第９１回日本生化学会大会
• [Presentation] 酸化・還元依存的なマグネシウム恒常性の維持機構とその破綻による疾患・老化 (2018)
  • Author(s): 船戸 洋佑, 橋爪 脩, 山崎 大輔, 三木 裕明
  • Organizer: 第９１回日本生化学会大会
  • Invited
• [Presentation] Mg2+トランスポーターCNNM4は大腸での発がんを抑制する (2018)
  • Author(s): 山崎 大輔, 長谷川 綾郁, 船戸 洋佑, 三木 裕明
  • Organizer: 第９１回日本生化学会大会
• [Presentation] PRL/CNNM複合体によるマグネシウムイオン排出の調節とミトコンドリアでの活性酸素産生 (2018)
  • Author(s): 船戸 洋佑, 橋爪 脩, 山崎 大輔, 三木 裕明
  • Organizer: 第９１回日本生化学会大会
  • Invited
• [Presentation] PRLによる細胞外pH環境依存的な細胞死 (2018)
  • Author(s): 船戸洋佑、吉田篤、柳嘉晶、山崎大輔、三木裕明
  • Organizer: 第27回日本Cell death学会学術集会
  • Invited
• [Presentation] Mg2+排出タンパク質CNNMによる マグネシウム恒常性維持と寿命制御 (2018)
  • Author(s): 船戸洋佑、 橋爪脩、山崎大輔、三木裕明
  • Organizer: 第13回トランスポーター研究会年会
  • Invited
• [Presentation] マグネシウム再吸収と共役した血圧調節機構の解明 (2018)
  • Author(s): 船戸洋佑、山崎大輔、三木裕明
  • Organizer: ソルト・サイエンス研究財団 第30回 助成研究発表会
  • Invited
• [Presentation] Overproduction of ATP and reactive oxygen species in mitochondria by excessive magnesium (2018)
  • Author(s): Hiroaki Miki
  • Organizer: WCP2018 KYOTO Satellite Symposia "Regulating cell homeostasis: from small molecules (drugs, O2, ROS, and NO) to ion channels, receptors, and systems.”
  • Int'l Joint Research / Invited
• [Presentation] 細胞内マグネシウムイオンの調節とミトコンドリアでの活性酸素産生 (2018)
  • Author(s): 三木裕明
  • Organizer: 第71回日本酸化ストレス学会/第18回日本NO学会 合同学術集会
  • Invited
• [Presentation] SOD1-Derlin-1結合を標的とした低分子化合物によるALS病態モデルの改善 (2018)
  • Author(s): 藤澤貴央、圓谷奈保美、本間謙吾、一條秀憲
  • Organizer: 第91回日本生化学会大会
• [Presentation] PRL/CNNM複合体によるMg2+排出の調節とPRLのCysリン酸化 (2018)
  • Author(s): 三木裕明
  • Organizer: 生体分子コバレント修飾の革新的解析拠点形成 シンポジウム
  • Invited
• [Presentation] Cold stress evokes ferroptosis through ASK1-p38 axis (2018)
  • Author(s): Hattori K, Ichijo H
  • Organizer: Keystone Symposia: Cell Death, Inflammation and Adaptation to Tissue Stress
  • Int'l Joint Research
• [Presentation] ASK1 signaling regulates brown adipocyte maturation. (2017)
  • Author(s): Hattori K, Wakatsuki H, Naguro I, Ichijo H.
  • Organizer: Keystone Symposia
  • Place of Presentation: Colorado, USA
  • Year and Date: 2017-03-05
  • Int'l Joint Research
• [Presentation] Mg2+の不足によるPRLの転写活性化 (2017)
  • Author(s): Yoshida A, Funato Y, Miki H
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Mg2+トランスポーターCNNM4は大腸での発がんを抑制する (2017)
  • Author(s): Yamazaki D, Hasegawa A, Funato Y, Miki H
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Mg2+トランスポーターCNNMは線虫でROSレベルと寿命を調節する (2017)
  • Author(s): Hashizume O, Funato Y, Miki H
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] PRLによる酸性微小環境への適応 (2017)
  • Author(s): Funato Y, Yoshida A, Yamazaki D, Miki H
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] がんの浸潤運動におけるPRLの役割 (2017)
  • Author(s): 船戸洋佑, 山崎大輔, 吉田篤, 三木裕明
  • Organizer: 第69回日本細胞生物学会大会
  • Invited
• [Presentation] がんの悪性化と酸性環境適応の分子機構 (2017)
  • Author(s): 船戸洋佑, 山崎大輔, 吉田篤, 三木裕明
  • Organizer: 第44回日本毒性学会学術年
  • Invited
• [Presentation] CNNM magnesium transporters in health and disease (2017)
  • Author(s): Yosuke Funato, Daisuke Yamazaki, Hiroaki Miki
  • Organizer: IUPS 38th world congress
  • Int'l Joint Research / Invited
• [Presentation] ASK1 signaling regulates brown adipocyte function (2017)
  • Author(s): Hattori K, Wakatsuki H, Ichijo H
  • Organizer: Cell Symposia: Exercise Metabolism
  • Int'l Joint Research
• [Presentation] 褐色脂肪組織におけるASK1シグナルを介したエネルギー代謝制御 (2017)
  • Author(s): 服部一輝、一條秀憲
  • Organizer: 第44回日本毒性学会学術年会
• [Presentation] ネクローシスにおけるASK1シグナル (2017)
  • Author(s): 服部一輝、名黒功、一條秀憲
  • Organizer: 第26回日本Cell Death学会学術集会
• [Presentation] 低温ストレスはASK1-p38経路を介してフェロトーシス様細胞死を導く (2017)
  • Author(s): 服部一輝、一條秀憲
  • Organizer: ConBio2017
• [Presentation] ASK1シグナルは褐色脂肪細胞の成熟化を制御し、個体の代謝に寄与する (2016)
  • Author(s): 服部 一輝、名黒 功、一條 秀憲
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-11-30
• [Presentation] ASK1シグナルは褐色脂肪細胞の成熟化を導く (2016)
  • Author(s): 服部 一輝、一條 秀憲
  • Organizer: 第37回日本肥満学会
  • Place of Presentation: 東京
  • Year and Date: 2016-10-07
• [Presentation] PRLによる細胞内Mg2+量の調節とその破綻によるがん悪性化 (2016)
  • Author(s): 船戸 洋佑、山崎 大輔、三木 裕明
  • Organizer: 第89回日本生化学会大会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
  • Invited
• [Presentation] PRLによるがん悪性化とpH依存性の細胞死 (2016)
  • Author(s): 三木 裕明
  • Organizer: 第25回日本Cell Death学会学術集会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2016-09-09
  • Invited
• [Presentation] ASK1-p38 axis regulates cold stress-induced cell death. (2016)
  • Author(s): Hattori K, Sakauchi C, Naguro I, Ichijo H.
  • Organizer: Gordon Research Conference
  • Place of Presentation: Girona, Spain
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] PRLによる細胞内マグネシウムイオン量のレドックス制御 (2016)
  • Author(s): 船戸 洋佑、山崎 大輔、三木 裕明
  • Organizer: 第43回日本毒性学会学術年会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2016-06-29
  • Invited
• [Presentation] PRLによるがん悪性化と上皮組織内の細胞間相互作用 (2016)
  • Author(s): 船戸 洋佑、山崎 大輔、 三木 裕明
  • Organizer: 第68回日本細胞生物学会大会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2016-06-15
  • Invited
• [Presentation] 細胞内マグネシウム調節の異常とがん悪性化 (2016)
  • Author(s): 三木 裕明
  • Organizer: タイムシグナルと制御シンポジウム
  • Place of Presentation: 下田
  • Year and Date: 2016-06-11
  • Invited
• [Presentation] 細胞内マグネシウム調節とがん悪性化 (2016)
  • Author(s): 三木 裕明
  • Organizer: 第53回日本臨床分子医学会学術集会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2016-04-15
  • Invited
• [Presentation] ミトコンドリアにおけるストレス応答シグナル解析 (2016)
  • Author(s): 関根 史織、一條 秀憲
  • Organizer: 第８９回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] Redox regulation of magnesium-ion transporter MagEx/CNNM (2015)
  • Author(s): Yosuke Funato, Daisuke Yamazaki, Hiroaki Miki
  • Organizer: BMB2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] ミトコンドリア内膜局在型プロテインホスファターゼPGAM5の個体レベルでの生理機能解析 (2015)
  • Author(s): 関根 史織、一條 秀憲
  • Organizer: BMB2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] MgイオントランスポーターCNNM/MagExの分子機能とがん悪性化 (2015)
  • Author(s): 三木 裕明
  • Organizer: 生理学研究所研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2015-09-15
  • Invited
• [Presentation] ミトコンドリア局在ホスファターゼPGAM5欠損マウスの表現型解析 (2015)
  • Author(s): 関根史織
  • Organizer: Young Mito2015
  • Place of Presentation: 千葉
  • Year and Date: 2015-07-09
• [Presentation] マグネシウムイオン輸送のレドックス制御 (2015)
  • Author(s): 船戸 洋佑、山崎 大輔、三木 裕明
  • Organizer: 第１５回日本蛋白質科学会年会
  • Place of Presentation: 徳島
  • Year and Date: 2015-06-24
  • Invited
• [Presentation] Mg2+ efflux by CNNM4 Mediates Intestinal Magnesium Absorption and Suppresses Malignant Progression of Tumors. (2015)
  • Author(s): Miki H.
  • Organizer: Ion Channels, transporters, and small molecules as key regulators of homeostatic systems
  • Place of Presentation: Nagoya Congress Center
  • Year and Date: 2015-03-17
  • Invited
• [Presentation] ケルヒリピートタンパク質 KLHDC10 の全身炎症反応症候群 (SIRS) における新規機能の解析 (2014)
  • Author(s): 山口奈美子、関根悠介、関根史織、一條秀憲
  • Organizer: 第 23 回 日本 Cell Death 学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-18