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Polysulfur metabolome and regulation of anti-oxidative stress responses

Planned

Project AreaOxygen biology: a new criterion for integrated understanding of life
Project/Area Number 26111008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

赤池 孝章  東北大学, 医学系研究科, 教授 (20231798)

Co-Investigator(Kenkyū-buntansha) 渡辺 泰男  昭和薬科大学, 薬学部, 教授 (10273228)
澤 智裕  熊本大学, 大学院生命科学研究部(医), 教授 (30284756)
朽津 和幸  東京理科大学, 理工学部応用生物科学科, 教授 (50211884)
上原 孝  岡山大学, 医歯薬学総合研究科, 教授 (00261321) [Withdrawn]
井田 智章  東北大学, 医学系研究科, 助教 (70570406)
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Granted (Fiscal Year 2018)
Budget Amount *help
¥105,430,000 (Direct Cost: ¥81,100,000、Indirect Cost: ¥24,330,000)
Fiscal Year 2018: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2017: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2016: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2015: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2014: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Keywords活性酸素 / 代謝 / ケミカルバイオロジー / メタボローム / 抗酸化
Outline of Annual Research Achievements

本研究では、システインのイオウ付加体であるシステインパースルフィドをはじめとする活性ポリスルフィドの生理機能に注目し、メタボローム解析手法(ポリサルファメタボローム)を駆使して、動物および植物における活性イオウ・ポリサルファ系のユニークな抗酸化制御システムの全貌を解明することを目的としている。昨年度までの研究において活性ポリスルフィドを網羅的かつ定量的に測定するメタボローム解析系を確立し、生体内に存在する様々な活性イオウ分子種の検出と動態解析、代謝経路と生理機能解析を行ってきた。本年度は、システイン-tRNA合成酵素(CARS)による翻訳に共役した新規ポリスルフィド生成系について、ポリスルフィド生成の分子メカニズムおよびその生理学的機能についての解析を行った。細菌および哺乳類の各種CARSの解析から、CARSがシステインを基質としてシステインパースルフィドを産生することが分かった。CARSのパースルフィド産生活性は細菌などの原核生物から哺乳類を含めた真核生物まで種横断的に保存されており、パースルフィド合成活性とCARS本来のシステイニルtRNA合成活性とは異なる活性部位が司っていることが明らかになった。さらに、ミトコンドリア型のCARS2のノックアウト細胞の解析から、CARS2が産生するパースルフィドはミトコンドリアの酸素消費速度や膜電位形成の制御に深く関わっており、ミトコンドリアの電子伝達およびエネルギー産生における活性ポリスルフィドの関与が示唆された。ポリスルフィドによるミトコンドリアのエネルギー産生制御の分子機構について今後さらに詳細な解析を進め、生体内ポリスルフィドの生理機能の解明向けた研究を進めていく。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

活性イオウ・ポリサルファの生理機能解明に関する当初の研究目的および研究計画に沿って研究を進めることができており、おおむね予定通りの実験・解析の遂行と研究成果を得ることができているため。

Strategy for Future Research Activity

本研究の当初の目的と計画に沿って順調に研究が進展し研究成果が得られており、研究を進める上で問題となるような事項は特にない。今後は、ひきつづき、新しく発見したシステイン-tRNA合成酵素によるポリスルフィド生成系の役割の解明を中心として、当初計画通り、動物および植物における活性イオウ・ポリサルファ系のユニークな抗酸化制御システムの全貌解明に向けた研究を推進していく。

Report

(4 results)
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(176 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Int'l Joint Research] National Institute of Oncology(Hungary)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Southampton(UK)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Sonoma State University/University of Vermont(USA)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] German Cancer Research Center(Germany)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Sonoma State University/Johons Hopkins University/University of Alabama at Birmingham(USA)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Sonoma State University/University of California, Davis/Washington State University(USA)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] King's College London(UK)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons.2018

    • Author(s)
      Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K,Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 495 Pages: 2165-2170

    • DOI
      10.1016/j.bbrc.2017.12.088
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL2018

    • Author(s)
      Kaneko K.、Miyamoto Y.、Tsukuura R.、Sasa K.、Akaike T.、Fujii S.、Yoshimura K.、Nagayama K.、Hoshino M.、Inoue S.、Maki K.、Baba K.、Chikazu D.、Kamijo R.
    • Journal Title

      Nitric Oxide

      Volume: 72 Pages: 46-51

    • DOI
      10.1016/j.niox.2017.11.006
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Important Role of endothelial caveolin-1 in the protective role of endothelium-dependent hyperpolarization against nitric oxide-mediated nitrative stress in microcirculation in mice2018

    • Author(s)
      Saito H, Godo S, Sato S, Ito A, Ikumi Y, Tanaka S, Ida T, Fujii S, Akaike T, Shimokawa H.
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 71 Pages: 113-126

    • DOI
      10.1097/fjc.0000000000000552
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-252018

    • Author(s)
      Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H.
    • Journal Title

      ACS chemical neuroscience

      Volume: 9 Pages: 217-223

    • DOI
      10.1021/acschemneuro.7b00363
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?2018

    • Author(s)
      Heppner David E.、Hristova Milena、Ida Tomoaki、Mijuskovic Ana、Dustin Christopher M.、Bogdandi Virag、Fukuto Jon M.、Dick Tobias P.、Nagy Peter、Li Jianing、Akaike Takaaki、van der Vliet Albert
    • Journal Title

      Redox Biol

      Volume: 14 Pages: 379-385

    • DOI
      10.1016/j.redox.2017.10.006
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Persulfide synthases function coupled with translation and mediate sulfur respiration2018

    • Author(s)
      Fujii S, Sawa T, Motohashi H, Akaike T.
    • Journal Title

      Br J Pharmacol

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 概論 レドックス疾患学:レドックス制御の破綻による病態と新たな疾患概念2018

    • Author(s)
      本橋ほづみ、赤池孝章、内田浩二、末松 誠.
    • Journal Title

      実験医学増刊「レドックス疾患学」

      Volume: 36 Pages: 642-648

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 活性イオウによる生体防御応答、エネルギー代謝と寿命制御2018

    • Author(s)
      澤 智裕、赤池孝章.
    • Journal Title

      実験医学増刊「レドックス疾患学」

      Volume: 36 Pages: 649-655

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 硫黄呼吸の発見:ペルスルフィド産生酵素による新しいエネルギー代謝2018

    • Author(s)
      西村 明、赤池孝章.
    • Journal Title

      現代化学

      Volume: 565 Pages: 55-59

    • NAID
      40021493631
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Synthesis of l -cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome2017

    • Author(s)
      Ono K, Jung M, Zhang T, Tsutsuki H, Sezaki H, Ihara H, Wei FY, Tomizawa K, Akaike T, Sawa T.
    • Journal Title

      Free Radic Biol Med.

      Volume: 106 Pages: 69-79

    • DOI
      10.1016/j.freeradbiomed.2017.02.023
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach.2017

    • Author(s)
      keda, M. Ishima, Y. Shibata, A. Chuang, V. T. G. Sawa, T. Ihara, H. Watanabe, H. Xian, M. Ouchi, Y. Shimizu, T. Ando, H. Ukawa, M. Ishida, T. Akaike, T. Otagiri, M. Maruyama, T.
    • Journal Title

      Anal Chim Acta

      Volume: 969 Pages: 18-25

    • DOI
      10.1016/j.aca.2017.03.027
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reactive sulfur species inactivate Ca 2+ /calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue2017

    • Author(s)
      Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y.
    • Journal Title

      Biochem J

      Volume: 474 Pages: 2547-2562

    • DOI
      10.1042/bcj20170092
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.2017

    • Author(s)
      Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T.
    • Journal Title

      Free radical biology & medicine

      Volume: 印刷中 Pages: 132-140

    • DOI
      10.1016/j.freeradbiomed.2017.01.024
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke.2017

    • Author(s)
      Takamiya Rina、Uchida Koji、Shibata Takahiro、Maeno Toshitaka、Kato Masaki、Yamaguchi Yoshiki、Ariki Shigeru、Hasegawa Yoshihiro、Saito Atsushi、Miwa Soichi、Takahashi Hiroki、Akaike Takaaki、Kuroki Yoshio、Takahashi Motoko
    • Journal Title

      Sci. Rep.

      Volume: 7 Pages: 8304-8304

    • DOI
      10.1038/s41598-017-08588-5
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage2017

    • Author(s)
      Hoshino Marie、Kaneko Kotaro、Miyamoto Yoichi、Yoshimura Kentaro、Suzuki Dai、Akaike Takaaki、Sawa Tomohiro、Ida Tomoaki、Fujii Shigemoto、Ihara Hideshi、Tanaka Junichi、Tsukuura Risa、Chikazu Daichi、Mishima Kenji、Baba Kazuyoshi、Kamijo Ryutaro
    • Journal Title

      Free Radio Bios Med

      Volume: 110 Pages: 63-71

    • DOI
      10.1016/j.freeradbiomed.2017.05.022
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exposure to Electrophiles Impairs Reactive Persulfide-dependent Redox Signaling in Neuronal Cells2017

    • Author(s)
      Ihara Hideshi、Kasamatsu Shingo、Kitamura Atsushi、Nishimura Akira、Tsutsuki Hiroyasu、Ida Tomoaki、Ishizaki Kento、Toyama Takashi、Yoshida Eiko、Abdul Hamid Hisyam、Jung Minkyung、Matsunaga Tetsuro、Fujii Shigemoto、Sawa Tomohiro、Nishida Motohiro、Kumagai Yoshito、Akaike Takaaki
    • Journal Title

      Chemical Research Toxicology

      Volume: 30 Pages: 1673-1684

    • DOI
      10.1021/acs.chemrestox.7b00120
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical Biology of Hydropersulfides and Related Species: Possible Roles in Cellular Protection and Redox Signaling2017

    • Author(s)
      Alvarez L, Bianco CL, Toscano JP, Lin J. Akaike T, Fukuto JM.
    • Journal Title

      Antioxid Redox Signal

      Volume: 27 Pages: 622-633

    • DOI
      10.1089/ars.2017.7081
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diversity and microevolution of CRISPR loci in Helicobacter cinaedi2017

    • Author(s)
      Tomida J, Morita Y, Shibayama K, Kikuchi K, Sawa T, Akaike T, Kawamura Y.
    • Journal Title

      PLOS ONE

      Volume: 12

    • DOI
      10.1371/journal.pone.0186241
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Production of reactive persulfide species in chronic obstructive pulmonary disease.2017

    • Author(s)
      Numakura T, Sugiura H, Akaike T, Ida T, Fujii S, Koarai A, Yamada M, Onodera K, Hashimoto Y, Tanaka R, Sato K, Shishikura Y, Hirano T, Yanagisawa S, Fujino N, Okazaki T, Tamada T, Hoshikawa Y, Okada Y, Ichinose M
    • Journal Title

      Thorax.

      Volume: 72 Pages: 1074-1083

    • DOI
      10.1136/thoraxjnl-2016-209359
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.2017

    • Author(s)
      Akaike Takaaki、、、Nishida Motohiro(4)、、、、、、Fujii Shigemoto(20)、、、Motohashi Hozumi(26)
    • Journal Title

      Nature Commun

      Volume: 8 Pages: 1177-1177

    • DOI
      10.1038/s41467-017-01311-y
    • NAID
      120006365562
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ニトロ化環状ヌクレオチドと活性イオウ分子によるレドックスシグナル制御と生理機能2017

    • Author(s)
      藤井重元、赤池孝章.
    • Journal Title

      化学療法の領域

      Volume: 33 Pages: 2194-2195

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 活性イオウ分子:システインパースルフィドの新規生合成経路の発見とその生理機能2017

    • Author(s)
      西村 明、赤池孝章.
    • Journal Title

      硫酸と工業

      Volume: 70 (11) Pages: 1-9

    • NAID
      40021404464
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion2017

    • Author(s)
      Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Pages: 435-445

    • DOI
      10.1093/nar/gkw745
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors2017

    • Author(s)
      Kunikata H, Ida T, Sato K, Aizawa N, Sawa T, Tawarayama H, Murayama N, Fujii S, Akaike T, Nakazawa T.
    • Journal Title

      Sci. Rep.

      Volume: 7 Pages: 41984-41984

    • DOI
      10.1038/srep41984
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides2017

    • Author(s)
      Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 104 Pages: 118-128

    • DOI
      10.1016/j.freeradbiomed.2016.12.047
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Synthesis and Characterization of 8-Nitroguanosine 3′,5′-Cyclic Monophosphorothioate Rp-Isomer as a Potent Inhibitor of Protein Kinase G1α2017

    • Author(s)
      Ahmed KA, Zhang T, Ono K, Tsutsuki H, Ida T, Akashi S, Miyata K, Oike Y, Akaike T, Sawa T.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 40 Issue: 3 Pages: 365-374

    • DOI
      10.1248/bpb.b16-00880
    • NAID
      130005398514
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation.2017

    • Author(s)
      Ihara H, Kitamura A, Kasamatsu S, Ida T, Kakihana Y, Tsutsuki H, Sawa T, Watanabe Y, Akaike T.
    • Journal Title

      Biochem. J.

      Volume: 474 Pages: 1149-1162

    • DOI
      10.1042/bcj20160999
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Discovery and mechanistic characterization of selective inhibitors of H2S-producing enzyme:: 3-mercaptopyruvate sulfurtransferase (3MST) targeting active-site cysteine persulfide.2017

    • Author(s)
      K. Hanaoka, K. Sasakura, Y. Suwanai, S. Toma-Fukai, K. Shimamoto, Y. Takano, N. Shibuya, T. Terai, T. Komatsu, T. Ueno, Y. Ogasawara, Y. Tsuchiya, Y. Watanabe, H. Kimura, C. Wang, M. Uchiyama, H. Kojima, T. Okabe, Y. Urano, T. Shimizu, T. Nagano
    • Journal Title

      Sci. Rep

      Volume: 7 Pages: 40227-40227

    • DOI
      10.1038/srep40227
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Silver Nanoparticles as Potential Antibiofilm Agents against Human Pathogenic Bacteria2017

    • Author(s)
      Kyaw K, Harada A, Ichimaru H, Kawagoe T, Yahiro K, Morimura S, Ono K, Tsutsuki H, Sawa T, Niidome T.
    • Journal Title

      Chem. Lett.

      Volume: 46 Issue: 4 Pages: 594-596

    • DOI
      10.1246/cl.161198
    • NAID
      130005549076
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] SAGA complex mediates the transcriptional up-regulation of antiviral RNA silencing.2017

    • Author(s)
      Hyodo K, Hashimoto K, Kuchitsu K, Suzuki N, Okuno T
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 114 Pages: 1282-1290

    • DOI
      10.1073/pnas.1610212114
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 大隅良典先生: オートファジ一(細胞内自食作用)のメカニズム2017

    • Author(s)
      朽津 和幸
    • Journal Title

      科学フォーラム

      Volume: 394 Pages: 44-45

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Prolonged but non-permanent expression of a transgene in ependymal cells of adult rats using an adenovirus-mediated transposon gene transfer system2017

    • Author(s)
      Ito A, Abe N, Fujii T, Hayashi A, Ueno A, Mugikura S, Takahashi S, Mori E.
    • Journal Title

      Brain Res

      Volume: 1464 Pages: 162-173

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides2016

    • Author(s)
      Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, Akaike T.
    • Journal Title

      Arch Biochem Biophys

      Volume: 595 Pages: 140-146

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Proposal of Helicobacter canicola sp. nov., previously identified as Helicobacter cinaedi, isolated from canines.2016

    • Author(s)
      Kawamura Y, Tomida J, Miyoshi-Akiyama T, Okamoto T, Narita M, Hashimoto K, Cnockaert M, Vandamme P, Morita Y, Sawa T, Akaike T.
    • Journal Title

      Systematic and Applied Microbiology

      Volume: 39 Pages: 307-312

    • DOI
      10.1016/j.syapm.2016.06.004
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation.2016

    • Author(s)
      Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM.
    • Journal Title

      Free Radic Biol Med.

      Volume: 97 Pages: 136-147

    • DOI
      10.1016/j.freeradbiomed.2016.05.013
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mice deficient in Angiopoietin-like protein 2 (Angptl2) gene show increased susceptibility to bacterial infection due to attenuated macrophage activity.2016

    • Author(s)
      Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 291 Pages: 18843-18852

    • DOI
      10.1074/jbc.m116.720870
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Endogenous occurrence of protein S-guanylation in Echerichia coli: Target identification and genetic regulation.2016

    • Author(s)
      Tsutsuki H, Jung M, Zhang T, Ono K, Ida T, Kunieda K, Ihara H, Akaike T, Sawa T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 478 Pages: 7-11

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Modification of Tau by 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP): Effects of nitric oxide-linked chemical modification on Tau aggregation2016

    • Author(s)
      Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, Akaike T, Takashima A.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Pages: 22714-22720

    • DOI
      10.1074/jbc.m116.734350
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1.2016

    • Author(s)
      Jung M, Kasamatsu S, Matsunaga T, Akashi S, Ono K, Nishimura A, Morita M, Abdul Hamid H, Fujii S, Kitamura H, Sawa T, Ida T, Motohashi H, Akaike T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 480 Pages: 180-186

    • DOI
      10.1016/j.bbrc.2016.10.022
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox Signaling Regulated by Cysteine Persulfide and Protein Polysulfidation.2016

    • Author(s)
      Kasamatsu S, Nishimura A, Morita M, Matsunaga T, Abdul Hamid H, Akaike T.
    • Journal Title

      Molecules

      Volume: 21 Pages: 1721-1730

    • DOI
      10.3390/molecules21121721
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Re-emerging reactive sulfur-containing compounds and their unique biological functions2016

    • Author(s)
      井田智章、松永哲郎、藤井重元、澤 智裕、赤池孝章.
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 147 Issue: 5 Pages: 278-284

    • DOI
      10.1254/fpj.147.278
    • NAID
      130005150958
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reactive sulfur species-modified protein thiols: new methods for polysulfurated protein analysis2016

    • Author(s)
      笠松真吾、藤井重元、赤池孝章.
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 147 Issue: 5 Pages: 299-302

    • DOI
      10.1254/fpj.147.299
    • NAID
      130005150953
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 巻頭言 セレンディピティと抗菌薬の新しい分指標的2016

    • Author(s)
      赤池孝章
    • Journal Title

      化学療法の領域

      Volume: 32 Pages: 1621-1621

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 酸化ストレス病態とバイオマーカー2016

    • Author(s)
      藤井重元、赤池孝章.
    • Journal Title

      生体の科学

      Volume: 67 Pages: 418-419

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Signal Transducer and Activator of Transcription 3 in Endothelial Cells of Chronic Subdural Hematoma Outer Membranes.2016

    • Author(s)
      Osuka K, Watanabe Y, Usuda N, Aoyama M, Kawaguchi R, Watabe T, Takayasu M.
    • Journal Title

      World Neurosurg

      Volume: 91 Pages: 376-382

    • DOI
      10.1016/j.wneu.2016.04.025
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mitogen-activated protein kinase 4-like carrying an MEY motif instead of a TXY motif is involved in ozone tolerance and regulation of stomatal closure2016

    • Author(s)
      Yanagawa Y, Yoda H, Osaki K, Amano Y, Aono M, Seo S, Kuchitsu K, Mitsuhara I.
    • Journal Title

      J Exp Bot

      Volume: 67 Pages: 3471-3479

    • DOI
      10.1093/jxb/erw173
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum2016

    • Author(s)
      Puli MR, Rajsheel P, Aswani V, Agurla S, Kuchitsu K, Raghavendra AS
    • Journal Title

      Planta

      Volume: 244 Pages: 831-841

    • DOI
      10.1007/s00425-016-2545-z
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Freezing behaviours in wintering Cornus florida flower bud tissues revisited using MRI2016

    • Author(s)
      Ishikawa M, Ide H, Yamazaki H, Murakawa H, Kuchitsu K, Price WS, Arata Y.
    • Journal Title

      Plant Cell Environment

      Volume: 39 Pages: 2663-2675

    • DOI
      10.1111/pce.12813
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Quantitative live cell imaging of autophagic flux and roles of autophagy in reproductive development in plants2016

    • Author(s)
      Kurusu T, Hanamata S, Kuchitsu K
    • Journal Title

      bioimages

      Volume: 24 Issue: 0 Pages: 1-11

    • DOI
      10.11169/bioimages.24.1
    • NAID
      130005432499
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Regulation of calcium signals via redox modification2016

    • Author(s)
      渡邊泰男
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 147 Issue: 5 Pages: 285-289

    • DOI
      10.1254/fpj.147.285
    • NAID
      130005150962
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation2016

    • Author(s)
      Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S, Akaike T.
    • Journal Title

      Biochemistry.

      Volume: 55 Pages: 751-61

    • DOI
      10.1021/acs.biochem.5b00774
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox signaling regulated by electrophiles and reactive sulfur species2016

    • Author(s)
      Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
    • Journal Title

      J. Clin. Biochem. Nutr.

      Volume: 58 Issue: 2 Pages: 1-8

    • DOI
      10.3164/jcbn.15-111
    • NAID
      130005132519
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of xylanase elicitor-induced expression of defense-related genes involved in phytoalexin biosynthesis by a cation channel OsTPC1 in suspension-cultured rice cells2015

    • Author(s)
      Hamada H, Kurusu T, Nokajima H, Kiyoduka M, Yano K, Kuchitsu K
    • Journal Title

      Plant Biotechnology

      Volume: 31 Issue: 4 Pages: 329-334

    • DOI
      10.5511/plantbiotechnology.14.0805b
    • NAID
      130004713022
    • Year and Date
      2015-02-05
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress.2015

    • Author(s)
      Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
    • Journal Title

      Chemical Research in Toxicology

      Volume: 印刷中 Pages: 838-847

    • DOI
      10.1021/tx500416y
    • NAID
      130005483607
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of reactive persulfides in biological bismethylmercury sulfide formation2015

    • Author(s)
      Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
    • Journal Title

      Chem Res Toxicol

      Volume: 28 Pages: 1301-1306

    • DOI
      10.1021/acs.chemrestox.5b00101
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 8-Mercapto-cyclic GMP mediates hydrogen sulfide-induced stomatal closure in Arabidopsis2015

    • Author(s)
      Honda K, Yamada N, Yoshida R, Ihara H, Sawa T, Akaike T, Iwai S.
    • Journal Title

      Plant Cell Physiol

      Volume: 56 Pages: 1481-1489

    • DOI
      10.1093/pcp/pcv069
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions2015

    • Author(s)
      Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M.
    • Journal Title

      Journal of Molecular Medicine.

      Volume: 印刷中 Pages: 879-889

    • DOI
      10.1007/s00109-015-1271-5
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides.2015

    • Author(s)
      Abiko Y., Ishii I., Kamata S., Tsuchiya Y., Watanabe Y., Ihara H., Akaike T., Kumagai Y.
    • Journal Title

      Chem Res Toxicol

      Volume: 28 Pages: 1796-1802

    • DOI
      10.1021/acs.chemrestox.5b00245
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 8-Nitro-cGMP Enhances SNARE Complex Formation through S-Guanylation of Cys90 in SNAP25.2015

    • Author(s)
      K. Kunieda, H. Tsutsuki, T. Ida, Y. Kishimoto, S. Kasamatsu, T. Sawa, N. Goshima, M. Itakura, M. Takahashi, T. Akaike, H. Ihara
    • Journal Title

      ACS Chem. Neurosci.

      Volume: 6 Pages: 1715-1725

    • DOI
      10.1021/acschemneuro.5b00196
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia.2015

    • Author(s)
      Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, Shirozu K, Hayashida K, Kosugi S, Hanaoka K, Kaneki M, Akaike T, Ichinose F
    • Journal Title

      J Am Heart Assoc.

      Volume: 4

    • DOI
      10.1161/jaha.115.002125
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The development of fluorescent probes for visualizing intracellular hydrogen polysulfides2015

    • Author(s)
      Wei Chen, Ethan W. Rosser, Tetsuro Matsunaga, Armando Pacheco, Takaaki Akaike, and Ming Xian
    • Journal Title

      Angew Chem Int Ed Engl

      Volume: 54 Pages: 13961-13965

    • DOI
      10.1002/anie.201506887
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Expressions of mitogen-activated protein kinases2015

    • Author(s)
      Aoyama M, Osuka K, Usuda N, Watanabe Y, Kawaguchi R, Nakura T, Takayasu M
    • Journal Title

      J Neurotrauma.

      Volume: 32 Pages: 1064-1070

    • DOI
      10.1089/neu.2014.3594
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regulation of Histone Deacetylase 6 Activity <i>via</i> <i>S</i>-Nitrosylation2015

    • Author(s)
      Okuda K, Ito A, and Uehara T.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 38 Issue: 9 Pages: 1434-1437

    • DOI
      10.1248/bpb.b15-00364
    • NAID
      130005096977
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress2015

    • Author(s)
      Nakato R, Ohkubo Y, Konishi A, Shibata M, Kaneko Y, Iwawaki T, Nakamura T, Lipton SA, and Uehara T.
    • Journal Title

      Sci Rep

      Volume: 5 Pages: 14182-14182

    • DOI
      10.1038/srep14812
    • NAID
      120005661532
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Autophagy supports biomass production and nitrogen use efficiency at the vegetative stage in rice.2015

    • Author(s)
      Wada S, Hayashida Y, Izumi M, Kurusu T, Hanamata S, Kanno K, Kojima S, Yamaya T, Kuchitsu K, Makino A, Ishida H
    • Journal Title

      Plant Physiology

      Volume: in press Pages: 60-73

    • DOI
      10.1104/pp.15.00242
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Establishment of monitoring methods for autophagy in rice reveals autophagic recycling of chloroplasts Ishida II. and root plastids during energy limitation.2015

    • Author(s)
      Izumi M, Hidema J, Wada S, Kondo E, Kurusu T, Kuchitsu K, Makino A, Ishida H.
    • Journal Title

      Plant Physiology

      Volume: 169 Pages: 1307-1320

    • DOI
      10.1104/pp.114.254078
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The chemical biology of hydropersulfides (RSSH): Chemical stability, reactivity and redox roles2015

    • Author(s)
      Saund, S. S., Sosa, V., Henriquez, S., Nguyen, Q. N. N., Soeda, S., Bianco, C. L., Millikin, R., White, C., Le, H., Ono, K., Tantillo, D. J., Kumagai, Y., Akaike, T., Lin, J., Fukuto, J. M.
    • Journal Title

      Arch Biochem Biophys

      Volume: 588 Pages: 15-24

    • DOI
      10.1016/j.abb.2015.10.016
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Plant signaling networks involving Ca2+ and Rboh/Nox-mediated ROS production under salinity stress.2015

    • Author(s)
      Kurusu T, Kuchitsu K, Tada Y
    • Journal Title

      Front Plant Sci

      Volume: 6 Pages: 427-427

    • DOI
      10.3389/fpls.2015.00427
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 感染性微生物:H. cinaedi2015

    • Author(s)
      松永哲郎, 藤井重元, 赤池孝章.
    • Journal Title

      動脈硬化予防

      Volume: 14 Pages: 66-71

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 活性イオウ分子による酸化・ニトロ化ストレス制御2015

    • Author(s)
      笠松真吾、井田智章、藤井重元、赤池孝章.
    • Journal Title

      Respiratory Medical Research

      Volume: 3 Pages: 70-75

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 活性イオウ分子種による酸化ストレス制御2015

    • Author(s)
      赤池孝章、藤井重元.
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 502-506

    • NAID
      40020484751
    • Related Report
      2015 Annual Research Report
  • [Journal Article] Host defense and oxidative stress signaling in bacterial infection2015

    • Author(s)
      赤池孝章.
    • Journal Title

      JAPANESE JOURNAL OF BACTERIOLOGY

      Volume: 70 Issue: 3 Pages: 339-349

    • DOI
      10.3412/jsb.70.339
    • NAID
      130005094695
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nitric Oxide (NO)2015

    • Author(s)
      赤池孝章、藤井重元.
    • Journal Title

      生体の科学

      Volume: 66 Pages: 396-397

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] イネの生殖器官発達におけるオートファジーの新たな役割2015

    • Author(s)
      来須孝光、小谷野智子、花俣繁、朽津和幸.
    • Journal Title

      バイオイメージング

      Volume: 24 Pages: 7-11

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Endogenous S-sulfhydration of PTEN helps protect against modification by nitric oxide2015

    • Author(s)
      Kazuki Ohno, Kosaku Okuda, Takashi Uehara
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 456 Pages: 245-249

    • DOI
      10.1016/j.bbrc.2014.11.066
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Correlation between attenuation of protein disulfide isomerase activity through S-Mercuration and neurotoxicity induced by methyl mercury2015

    • Author(s)
      Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T.
    • Journal Title

      Neurotoxicity Research

      Volume: 27 Pages: 99-105

    • DOI
      10.1007/s12640-014-9494-8
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Apoplastic ROS production upon pollination by RbohH and RbohJ in Arabidopsis.2015

    • Author(s)
      1)Kaya H, Iwano M, Takeda S, Kanaoka MM, Kimura S, Higashiyama T, Abe M, Kuchitsu K.
    • Journal Title

      Plant Signal Behav.

      Volume: 0 Pages: 0-0

    • DOI
      10.4161/15592324.2014.989050
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1.2015

    • Author(s)
      Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M.
    • Journal Title

      Mol Ther.

      Volume: 23 Pages: 549-560

    • DOI
      10.1038/mt.2014.217
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] H2Sの生体内生成とシグナル機能の正体:システインパースルフィドの再発見と新機能2015

    • Author(s)
      赤池孝章.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 346-348

    • Related Report
      2014 Annual Research Report
  • [Journal Article] RSSによる抗酸化・レドックスシグナル制御2015

    • Author(s)
      井田智章、藤井重元、赤池孝章.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 354-357

    • Related Report
      2014 Annual Research Report
  • [Journal Article] RSSの生合成系とタンパク質機能制御2015

    • Author(s)
      渡邊泰男、石井 功、蕨 栄治.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 372-376

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 細菌の硫化水素・RSSの代謝シグナル制御2015

    • Author(s)
      津々木博康、小野勝彦、澤 智裕.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 392-395

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons. Biochem J2014

    • Author(s)
      Kasamats S, Watanabe Y, Sawa T, Akaike T, Ihara H.
    • Journal Title

      Biochem J

      Volume: 459 Pages: 251-263

    • DOI
      10.1042/bj20131262
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] SIRT7 controls hepatic lipid metabolism by tegulating the ubiquitin-proteasome pathway.2014

    • Author(s)
      Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
    • Journal Title

      Cell metab

      Volume: 9 Pages: 712-21

    • DOI
      10.1016/j.cmet.2014.03.006
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses2014

    • Author(s)
      Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman M d M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, Akaike T.
    • Journal Title

      Scientific Reports

      Volume: (印刷中) Pages: 4680-4680

    • DOI
      10.1038/srep04680
    • NAID
      120005649608
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling2014

    • Author(s)
      Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: (印刷中) Pages: 7606-7611

    • DOI
      10.1073/pnas.1321232111
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High ice nucleation activity located in blueberry stem bark is linked to primary freeze initiation and adaptive freezing behaviour of the bark.2014

    • Author(s)
      Kishimoto T, Yamazaki H, Saruwatari A, Murakawa H, Sekozawa Y, Kuchitsu K, Price WS, Ishikawa M.
    • Journal Title

      AoB Plants

      Volume: 6

    • DOI
      10.1093/aobpla/plu044
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of suppressor of cytokine signaling 3 in cerebrospinal fluid after subarachnoid hemorrhage.2014

    • Author(s)
      Osuka K, Watanabe Y, Aoyama M, Nakura T, Matsuo N, Takayasu M.
    • Journal Title

      Journal of Neuroinflammation

      Volume: 11 Pages: 142-142

    • DOI
      10.1186/s12974-014-0142-2
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Eotaxin-3 activates the Smad pathway through the transforming growth factor beta 1 in chronic subdural hematoma outer membranes.2014

    • Author(s)
      Osuka K, Watanabe Y, Usuda N, Aoyama M, Takeuchi M, Takayasu M.
    • Journal Title

      Journal of Neurotrauma

      Volume: 31 Pages: 1451-1456

    • DOI
      10.1089/neu.2013.3195
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling2014

    • Author(s)
      Nishida M, Toyama T and Akaike T
    • Journal Title

      J. Mol. Cell. Cardiol.

      Volume: (In press) Pages: 10-17

    • DOI
      10.1016/j.yjmcc.2014.02.003
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Roles of autophagy in male reproductive development in plants2014

    • Author(s)
      Hanamata S, Kurusu T, Kuchitsu K
    • Journal Title

      Front Plant Sci

      Volume: 5 Pages: 457-457

    • DOI
      10.3389/fpls.2014.00457
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical and bacteriological characteristics of Helicobacter cinaedi infection.2014

    • Author(s)
      Kawamura Y, Tomida J, Morita Y, Fujii S, Okamoto T, Akaike T.
    • Journal Title

      J Infect Chemother.

      Volume: 20 Pages: 517-526

    • DOI
      10.1016/j.jiac.2014.06.007
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility2014

    • Author(s)
      Ono, K., Akaike T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., Fukuto, J.
    • Journal Title

      Free Radic Biol Med

      Volume: 77 Pages: 82-94

    • DOI
      10.1016/j.freeradbiomed.2014.09.007
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Helicobacter cinaedi meningitis: a case report and review of previous cases2014

    • Author(s)
      Okubo H, Goto M, Sato M, Sugiyama T, Kawano M, Matsunaga T, Akaike T.
    • Journal Title

      J Neurol Sci

      Volume: 347 Pages: 396-397

    • DOI
      10.1016/j.jns.2014.10.011
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 活性酸素による多階層シグナル伝達機構とレドックス恒常性制御2014

    • Author(s)
      赤池孝章.
    • Journal Title

      Yakugaku Zasshi

      Volume: 134 Pages: 515-519

    • NAID
      130003391199
    • Related Report
      2014 Annual Research Report
  • [Journal Article] 測定装置としての顕微鏡を用いた生物機能の解析2014

    • Author(s)
      村田 隆、稲田のりこ、朽津和幸.
    • Journal Title

      バイオイメージング

      Volume: 23 Pages: 11-11

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 植物のオートファジー動態の簡便な定量解析2014

    • Author(s)
      花俣 繁、来須孝光、朽津和幸.
    • Journal Title

      バイオイメージング

      Volume: 23 Pages: 23-27

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 活性酸素と炎症2014

    • Author(s)
      井田智章、赤池孝章、澤 智裕、藤井重元.
    • Journal Title

      感染・炎症・免疫

      Volume: 44 Pages: 104-109

    • Related Report
      2014 Annual Research Report
  • [Journal Article] システインパースルフィドの生体内生成と生理機能の再発見:活性イオウ分子による抗酸化・レドックスシグナル制御2014

    • Author(s)
      赤池孝章.
    • Journal Title

      実験医学

      Volume: 32 Pages: 2123-2126

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 小胞体ストレスによる生と死:細胞応答の新たな役割2014

    • Author(s)
      上原 孝.
    • Journal Title

      実験医学

      Volume: 32 Pages: 2194-2200

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 穀物の花粉・種子形成の新たな仕組み2014

    • Author(s)
      来須孝光、朽津和幸.
    • Journal Title

      科学フォーラム

      Volume: 31 Pages: 26-29

    • Related Report
      2014 Annual Research Report
  • [Journal Article] フリーラジカル制御系:硫化水素・活性イオウ分子と炎症2014

    • Author(s)
      藤井重元、井田智章、澤 智裕、赤池孝章.
    • Journal Title

      実験医学

      Volume: 32 Pages: 2803-2809

    • Related Report
      2014 Annual Research Report
  • [Presentation] Sulfur respiration in mammals and its implication for tumor biology2018

    • Author(s)
      Takaaki Akaike, Tomoaki Ida, Md. Morshedul Alam, Akira Nishimura, Masanobu Morita, Tetsuro Matsunaga, Hozumi Motohashi.
    • Organizer
      The Cold Spring Harbor Asia Conference on Cancer & Metabolism
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] システインパースルフィド産生酵素(Cysteine Persulfide Synthase, CPERS)の発見2017

    • Author(s)
      赤池孝章
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] イオウ呼吸とイオウストレス:ほ乳類における新しいエネルギー代謝とレドックス病態2017

    • Author(s)
      赤池孝章、西村 明、井田智章、松永哲郎、守田匡伸、本橋ほづみ.
    • Organizer
      2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] イオウ呼吸とイオウストレス:新しいエネルギー代謝とレドックス病態の提案2017

    • Author(s)
      赤池孝章、西村 明、井田智章、松永哲郎、守田匡伸、藤井重元、本橋ほづみ.
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cysteine polysulfidation governed by cysteinyl-tRNA synthetase (CARSs)2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      Se2017 - 200 Years of Selenium Research (The 11th International Symposium on Selenium in Biology and Medicine and The 5th International Conference on Selenium in the Environment and Human Health)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteinyl-tRNA synthetase (CARS) controls endogenous hydropersulfide production and mediates mitochondrial functions and bioenegetics2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      S-Bio 2017 Plant and Human Sulfur Biology Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Discovery of a novel persulfide synthase that mediates mitochondrial sulfur respiration2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      2nd Karolinska-Tohoku Joint Symposium on Medical Sciences
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteinyl-tRNA synthetase governs endogenous hydropersulfide production and mediates mitochondrial functions and bioenergetics2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      AARS2017: IUBMB Focused Meeting on Aminoacyl-tRNA Synthetase
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Moonlighting functions of cysteinyl-tRNA synthetase: Cysteine hydropersulfide production and regulation of mitochondrial biogenesis and bioenergetics2017

    • Author(s)
      Takaaki Akaike, Akira Nishimura, Tomoaki Ida, Tetsuro Matsunaga, Masanobu Morita, Hozumi Motohashi.
    • Organizer
      SfRBM 2017 - 24th Annual Meeting of the Society for Redox Biology and Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cysteinyl-tRNA synthetase (CARS) は活性パースルフィド産生とミトコンドリア機能をコントロールしている2017

    • Author(s)
      赤池孝章
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cysteine persulfide formation via cysteinyl-tRNA synthetase and its involvement in mitochondrial bioenergetics2017

    • Author(s)
      Takaaki Akaike, Tomoaki Ida, Masanobu Morita, Shigemoto Fujii, Akira Nishimura, Tetsuro Matsunaga, Minkyung Jung, Hozumi Motohashi.
    • Organizer
      th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 活性イオウ分子種:システインポリスルフィドの生体機能と代謝制御2017

    • Author(s)
      赤池孝章
    • Organizer
      第19回日本質量分析学会北海道談話会講演会
    • Place of Presentation
      旭川医科大学教育推進センター カンファレンスルーム(旭川市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Persulfide regulation of mitochondrial number and function2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 2017 NO Gordon Research Conference
    • Place of Presentation
      Ventura Beach Marriott (Venture, CA, USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 活性イオウ分子種の生体内生成と生理機能2016

    • Author(s)
      赤池孝章
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細菌の新しいシグナル伝達物質:8-ニトロ-cGMPの生成と機能解析2016

    • Author(s)
      井田智章、松永哲郎、赤司壮一郎、ジョン ミンギョン、津々木博康、藤井重元、居原 秀、澤 智裕、赤池孝章.
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪市天王寺区)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性システインパースルフィドの生合成機構とレドックス制御機能2016

    • Author(s)
      赤池孝章
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜 会議センター(横浜市西区)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Polysulfides and redox signaling2016

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 2016 Oxygen Radicals Gordon Research Conference
    • Place of Presentation
      Ventura Beach Marriott(Ventura, CA, USA)
    • Year and Date
      2016-02-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of metabolome analysis for reactive sulfur species2016

    • Author(s)
      Ida T, Kasamatsu S, Fujii S, Sawa T, Ihara H, Akaike T.
    • Organizer
      The 2016 Oxygen Radicals Gordon Research Conference
    • Place of Presentation
      Ventura Beach Marriott(Ventura, CA, USA)
    • Year and Date
      2016-02-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 気道炎症と呼気NO2016

    • Author(s)
      赤池孝章
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      京都国際会館(京都市左京区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Host defense and oxidative stress signaling in microbial infections2016

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 13th Korea-Japan International Symposium on Microbiology
    • Place of Presentation
      The-K Hotel Gyeongju (Gyeongbuk, Korea)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteine transfer RNA synthetases moonlighting as novel cysteine persulfide synthases (CPERSs)2016

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      仙台国際センター会議棟(仙台市青葉区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体防御応答のレドックス制御機構2016

    • Author(s)
      赤池孝章
    • Organizer
      第27回日本生体防御学会学術総会
    • Place of Presentation
      九州大学病院キャンパス内 コラボステーションI 視聴覚ホール(福岡市東区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Helicobacter cinaedi infection and atherosclerosis2016

    • Author(s)
      Takaaki Akaike, Tetsuro Matsunaga, Yoshiaki Kawamura, Shigemoto Fujii.
    • Organizer
      第48回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新しいCysteine Persulfide Synthaseの発見とそのミトコンドリア機能制御2016

    • Author(s)
      赤池孝章
    • Organizer
      生理学研究所研究会「オルガネラネットワークの制御機構とその生理的意義」
    • Place of Presentation
      生理学研究所1F大会議室(岡崎市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cysteinyl-tRNA synthetase controls protein polysulfidation and mitochondrial functions2016

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 2016 Thiol-Based Redox Regulation & Signaling Gordon Research Conference
    • Place of Presentation
      Stoweflake Conference Center (Stowe, VT, USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新しいCysteine Persulfide Synthaseの発見とそのユニークなレドックス制御メカニズム2016

    • Author(s)
      赤池孝章
    • Organizer
      第12回レドックス・ライフイノベーションシンポジウム
    • Place of Presentation
      熊本大学医学部医学教育図書棟3階第一講義室(熊本市中央区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 活性システインパースルフィドによるレドックス制御の分子基盤2016

    • Author(s)
      赤池孝章
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市白石区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種によるミトコンドリア機能制御2016

    • Author(s)
      赤池孝章、井田智章.
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター会議棟(仙台市青葉区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生体内タンパク質ポリスルフィドの検出とその生成機構2016

    • Author(s)
      赤池孝章、笠松真吾.
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター会議棟(仙台市青葉区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 細菌感染におけるレドックスシグナル制御機構2016

    • Author(s)
      赤池孝章
    • Organizer
      第28回微生物学シンポジウム
    • Place of Presentation
      愛知学院大学薬学部(名古屋市千種区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cysteinyl-tRNA synthetase is a major source of reactive persulfide and controls mitochondrial biology2016

    • Author(s)
      Takaaki Akaike
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター会議棟(仙台市青葉区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 活性イオウ生成酵素の発見:ミトコンドリア形態形成とエネルギー代謝の新しいメカニズム2016

    • Author(s)
      赤池孝章
    • Organizer
      第14回がんとハイポキシア研究会
    • Place of Presentation
      岐阜グランドホテル(岐阜市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種:新しい活性酸素制御因子の生合成と制御機構2016

    • Author(s)
      赤池孝章
    • Organizer
      昭和大学学士会後援セミナー
    • Place of Presentation
      昭和大学(東京都品川区)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種:総論2016

    • Author(s)
      赤池孝章
    • Organizer
      新学術領域研究「酸素生物学」・「レドックス委員会」合同シンポジウム2016「活性イオウ分子種の科学と生体機能の解明に向けて」
    • Place of Presentation
      名古屋大学シンポジオン(名古屋市千種区)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性イオウメタボライトのLC-MS/MS解析2016

    • Author(s)
      井田智章、居原 秀、澤 智裕.
    • Organizer
      新学術領域研究「酸素生物学」・「レドックス委員会」合同シンポジウム2016「活性イオウ分子種の科学と生体機能の解明に向けて」
    • Place of Presentation
      名古屋大学シンポジオン(名古屋市千種区)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細菌感染における酸化ストレスシグナル制御と感染防御論2016

    • Author(s)
      赤池孝章
    • Organizer
      平成27年度 学校法人北里研究所 第25回学会受賞者特別講演会
    • Place of Presentation
      北里大学白金キャンパス薬学部コンベンションホール(東京都港区)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Antioxidant electrophilic signaling regulated by reactive sulfur species and its translational biosynthesis2015

    • Author(s)
      赤池孝章
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市中央区)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] タンパク質ポリサルファ化の分子メカニズムの解明2015

    • Author(s)
      井田智章、居原 秀、魏 范研、富澤一仁、長尾翌手可、鈴木 勉、熊谷嘉人、澤 智裕、笠松真吾、本橋ほづみ、赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市中央区)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protein-bound reactive sulfur species and its translational biosynthesis: potential implication for oxidative stress and tumor biology2015

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 46th International Symposium of The Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      パレスホテル東京(東京都千代田区)
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Reactive persulfide species: Its antioxidant redox signaling and translational biosynthesis2015

    • Author(s)
      Takaaki Akaike
    • Organizer
      文部科学省 私立大学戦略的研究基盤形成支援事業 生体分子コバレント修飾の革新的解析拠点形成 第2回国際シンポジウム New Aspects of Covalent modifications from Small to Large Molecules
    • Place of Presentation
      昭和薬科大学(東京都町田市)
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 活性イオウ分子システインパースルフィドのタンパク質翻訳機構:タンパク質ポリチオール化2015

    • Author(s)
      赤池孝章
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県音楽堂、金沢市アートホール、ホテル日航金沢(石川県金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性システインパースルフィドのメタボロームおよびプロテオーム解析2015

    • Author(s)
      井田智章、居原 秀、澤 智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第15回日本NO学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] システインパースルフィドの新しいタンパク質翻訳機構:タンパク質ポリチオール化2015

    • Author(s)
      赤池孝章
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわ銀ホール(徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性酸素のシグナル伝達機構の解明(学会賞受賞講演)2015

    • Author(s)
      赤池孝章
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性システインパースルフィドのメタボロミクスとプロテオミクス2015

    • Author(s)
      井田智章、居原 秀、澤 智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細菌感染における酸化ストレスシグナル制御と感染防御論(浅川賞受賞講演)2015

    • Author(s)
      赤池孝章.
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ含有分子の再発見とその生物活性2015

    • Author(s)
      井田智章、赤池孝章.
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Redox-active cysteine polysulfide modulates NO and electrophilic protein modification2015

    • Author(s)
      Takaaki Akaike.
    • Organizer
      The 2015 Nitric Oxide Gordon Research Conference
    • Place of Presentation
      Four Points Sheraton/Holiday Inn Express (Ventura, CA, USA)
    • Year and Date
      2015-02-15 – 2015-02-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子とADH3によるホルムアルデヒド解毒代謝機構2015

    • Author(s)
      井田智章、Md. Morshedul Alam、松永哲郎、藤井重元、居原 秀、本橋ほづみ、赤池孝章.
    • Organizer
      第14回分子予防環境医学研究会
    • Place of Presentation
      大阪市立大学医学部(大阪市阿倍野区)
    • Year and Date
      2015-02-13 – 2015-02-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 炎症・酸化ストレス応答とフリーラジカル・活性酸素制御2014

    • Author(s)
      赤池孝章.
    • Organizer
      第44回日本創傷治癒学会
    • Place of Presentation
      ホテルメトロポリタン仙台(仙台市青葉区)
    • Year and Date
      2014-12-02 – 2014-12-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種によるレドックスシグナルと酸化ストレス制御2014

    • Author(s)
      赤池孝章.
    • Organizer
      第386回東北医学会例会シンポジウム
    • Place of Presentation
      東北大学艮陵会館(仙台市青葉区)
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性システインパーサルファイドとS-ポリチオレーションが酸化ストレスを制御する2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、末松 誠、本橋ほづみ、藤井重元、松永哲郎、山本雅之、Ming Xian、Jon M Fukuto、赤池孝章.
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポリサルファ化とタンパク質レドックス制御2014

    • Author(s)
      赤池孝章.
    • Organizer
      レドックスシンポジウム:酸素生物学の誕生
    • Place of Presentation
      名古屋大学ES総合館ESホール(名古屋市千種区)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種による酸化ストレス制御とポリサルファーバイオロジー2014

    • Author(s)
      赤池孝章.
    • Organizer
      フォーラム2014 衛生薬学・環境トキシコロジー
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Year and Date
      2014-09-19 – 2014-09-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性システインパーサルファイドによる酸化ストレス制御2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、藤井重元、松永哲郎、Jon M Fukuto、赤池孝章.
    • Organizer
      第67回日本酸化ストレス学会学術集会
    • Place of Presentation
      同志社大学今出川キャンパス良心館(京都市上京区)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 活性イオウ分子種システインパースルフィドによる酸化ストレス制御2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、本橋ほづみ、藤井重元、松永哲郎、Ming Xian、Jon M Fukuto、赤池孝章.
    • Organizer
      第8回レドックス・ライフイノベーション第170委員会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎市)
    • Year and Date
      2014-08-21 – 2014-08-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細菌の新しいシグナル伝達物質:8-ニトロ-cGMPの同定と機能解析2014

    • Author(s)
      井田智章、松永哲郎、赤司壮一郎、ジョン ミンギョン、津々木博康、藤井重元、居原 秀、澤 智裕、赤池孝章.
    • Organizer
      第25回日本生体防御学会学術総会
    • Place of Presentation
      東北大学 片平さくらホール(仙台市青葉区)
    • Year and Date
      2014-07-09 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] タンパク質過イオウ化:酸化ストレスの新しい制御システム2014

    • Author(s)
      赤池孝章.
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター(神戸市中央区)
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] Nitric Oxide: Biology and Pathobiology. 3rd ed. (Ignarro LJ, Freeman BA, eds.)2017

    • Author(s)
      Sawa T, Kumagai Y, Akaike T.
    • Total Pages
      403
    • Publisher
      Academic Press
    • Related Report
      2017 Annual Research Report
  • [Book] Chronic Inflammation: Elucidation and Control of the Mechanisms (K. Takatsu and M. Miyasaka eds)2016

    • Author(s)
      Sawa, T.
    • Total Pages
      702
    • Publisher
      Springer (Tokyo, Japan)
    • Related Report
      2016 Annual Research Report
  • [Book] Plant Programmed Cell Death2015

    • Author(s)
      Kurusu T, Higaki T, Kuchitsu K.
    • Total Pages
      306
    • Publisher
      Springer International Publishing (Switzerland)
    • Related Report
      2015 Annual Research Report
  • [Book] 別冊・医学のあゆみ「レドックスUPDATE ― ストレス制御の臨床医学・健康科学」2015

    • Author(s)
      赤池孝章、藤井重元.
    • Total Pages
      360
    • Publisher
      医歯薬出版社(東京都)
    • Related Report
      2015 Annual Research Report
  • [Book] みてわかる薬学 図解 薬理学2015

    • Author(s)
      渡邊泰男
    • Total Pages
      873
    • Publisher
      南山堂(東京都)
    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科 環境医学分野教室ホームページ

    • URL
      http://www.toxicosci.med.tohoku.ac.jp
    • Related Report
      2017 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科環境保健医学分野ホームページ

    • URL
      http://www.toxicosci.med.tohoku.ac.jp/
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科 環境保健医学分野ホームページ

    • URL
      http://www.toxicosci.med.tohoku.ac.jp/
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] イオウ原子を同位体標識したシステイン及びシステイン誘導体の合成法の確立2016

    • Inventor(s)
      小野勝彦、澤智裕
    • Industrial Property Rights Holder
      熊本大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-28
    • Application Year
      2016
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2018-12-17  

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