Polysulfur metabolome and regulation of anti-oxidative stress responses

• Project Area: Oxygen biology: a new criterion for integrated understanding of life
• Project/Area Number: 26111008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: 赤池 孝章 東北大学, 医学系研究科, 教授 (20231798)
• Co-Investigator(Kenkyū-buntansha): 渡辺 泰男 昭和薬科大学, 薬学部, 教授 (10273228) ; 澤 智裕 熊本大学, 大学院生命科学研究部(医), 教授 (30284756) ; 朽津 和幸 東京理科大学, 理工学部応用生物科学科, 教授 (50211884) ; 上原 孝 岡山大学, 医歯薬学総合研究科, 教授 (00261321) [Withdrawn] ; 井田 智章 東北大学, 医学系研究科, 助教 (70570406)
• Project Period (FY): 2014-07-10 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥105,430,000 (Direct Cost: ¥81,100,000、Indirect Cost: ¥24,330,000); Fiscal Year 2018: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000); Fiscal Year 2017: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000); Fiscal Year 2016: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000); Fiscal Year 2015: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000); Fiscal Year 2014: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
• Keywords: 活性酸素 / 代謝 / ケミカルバイオロジー / メタボローム / 抗酸化

Outline of Annual Research Achievements

本研究では、システインのイオウ付加体であるシステインパースルフィドをはじめとする活性ポリスルフィドの生理機能に注目し、メタボローム解析手法（ポリサルファメタボローム）を駆使して、動物および植物における活性イオウ・ポリサルファ系のユニークな抗酸化制御システムの全貌を解明することを目的としている。昨年度までの研究において活性ポリスルフィドを網羅的かつ定量的に測定するメタボローム解析系を確立して、生体内に存在する様々な活性イオウ分子種の検出と動態解析、代謝経路と生理機能解析を行い、システイン-tRNA合成酵素（CARS）によるタンパク質翻訳に共役した新規ポリスルフィド生成系を同定し、ミトコンドリア型のCARS2が生成するパースルフィドがミトコンドリアの酸素消費速度や膜電位形成の制御に深く関わることが示された。本年度は、ポリスルフィド生成の生理学的機能についての詳細な解析を行った。ミトコンドリア型CARS2のノックアウト細胞の解析から、CARS2由来パースルフィドはミトコンドリア形態形成にも関わっており、哺乳類細胞においてミトコンドリアの分裂に中心的な役割を果たすDrp1 (dynamin-related protein 1)の酵素活性がタンパク質ポリスルフィド化によって制御されていることが分かった。また、CARS2によるイオウ代謝プロファイルを詳細に解析した結果、CARS2により生成されるパースルフィドは電子伝達系から電子を授受し、硫化水素(H2S)へと代謝・還元することが示唆された。さらに、イオウ代謝産物であるH2Sの代謝経路としてSQR (sulfide:quinone oxidoreductase)によるプロトン供与を介したミトコンドリア膜電位形成が認められ、ミトコンドリアの電子伝達およびエネルギー産生における活性ポリスルフィドおよびイオウ代謝経路の関与が示唆された。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] National Institute of Oncology(ハンガリー)
• [Int'l Joint Research] Sonoma State University/University of Vermont/University of Alabama at Birmingham(米国)
• [Int'l Joint Research] University of Southampton/King's College London(英国)
• [Int'l Joint Research] National Institute of Oncology(Hungary)
• [Int'l Joint Research] University of Southampton(UK)
• [Int'l Joint Research] Sonoma State University/University of Vermont(USA)
• [Int'l Joint Research] German Cancer Research Center(Germany)
• [Int'l Joint Research] Sonoma State University/Johons Hopkins University/University of Alabama at Birmingham(USA)
• [Int'l Joint Research] Sonoma State University/University of California, Davis/Washington State University(USA)
• [Int'l Joint Research] King's College London(UK)
• [Journal Article] Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension. (2019)
  • Author(s): Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah MA, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P.
  • Journal Title: Proc Natl Acad Sci USA Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock. (2019)
  • Author(s): Zhang Tianli、Ono Katsuhiko、Tsutsuki Hiroyasu、Ihara Hideshi、Islam Waliul、Akaike Takaaki、Sawa Tomohiro
  • Journal Title: Cell Chem Biol Volume: in press
  • DOI: 10.1016/j.chembiol.2019.02.003
  • Peer Reviewed
• [Journal Article] The active-site cysteine residue of Ca2+/calmodulin-dependent protein kinase I is protected from irreversible modification via generation of polysulfidation. (2019)
  • Author(s): Takata Tsuyoshi、Tsukuda Ayaka、Tsuchiya Yukihiro、Akaike Takaaki、Watanabe Yasuo
  • Journal Title: Nitric Oxide Volume: 86 Pages: 68-75
  • DOI: 10.1016/j.niox.2019.02.008
  • Peer Reviewed
• [Journal Article] 8-Nitro-cGMP attenuates context-dependent fear memory in mice. (2019)
  • Author(s): Yusuke Kishimoto, Shingo Kasamatsu, Shuichi Yanai, Shogo Endo, Takaaki Akaike, & Hideshi Ihara
  • Journal Title: Biochemical and biophysical research communications Volume: 511 Pages: 141-147
  • DOI: 10.1016/j.bbrc.2019.01.138
  • Peer Reviewed
• [Journal Article] The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications. (2019)
  • Author(s): Lin Joseph、Akiyama Masahiro、Bica Iris、Long Faith T.、Henderson Catherine F.、Goddu Robert N.、Suarez Valeria、Baker Blaine、Ida Tomoaki、Shinkai Yasuhiro、Nagy Peter、Akaike Takaaki、Fukuto Jon M.、Kumagai Yoshito
  • Journal Title: Chem Res Toxicol Volume: 32 Pages: 447-455
  • DOI: 10.1021/acs.chemrestox.8b00340
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis. (2019)
  • Author(s): Hamid Hisyam Abdul、Tanaka Akira、Ida Tomoaki、Nishimura Akira、Matsunaga Tetsuro、Fujii Shigemoto、Morita Masanobu、Sawa Tomohiro、Fukuto Jon M.、Nagy Peter、Tsutsumi Ryouhei、Motohashi Hozumi、Ihara Hideshi、Akaike Takaaki
  • Journal Title: Redox Biol. Volume: 21 Pages: 101096-101096
  • DOI: 10.1016/j.redox.2019.101096
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E2 (2019)
  • Author(s): Nagayama K, Miyamoto Y, Kaneko K, Yoshimura K, Sasa K, Akaike T, Fujii S, Izumida E, Uyama R, Chikazu D, Maki K, Kamijo R.
  • Journal Title: In Vitro Cell Dev Biol Anim. Volume: 55 Pages: 45-51
  • DOI: 10.1007/s11626-018-0304-0
  • Peer Reviewed
• [Journal Article] SNAP-25 S-Guanylation and SNARE Complex Formation (2019)
  • Author(s): Kishimoto Y, Akaike T, Ihara H.
  • Journal Title: Methods in Molecular Biology Volume: 1860 Pages: 163-173
  • DOI: 10.1007/978-1-4939-8760-3_9
  • Peer Reviewed
• [Journal Article] Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell? (2019)
  • Author(s): Bogdandi Virag、Ida Tomoaki、Sutton Thomas R、Bianco Christopher、Ditroi Tamas、Koster Grielof、Henthorn Hillary A、Minnion Magda、Toscano John P、van der Vliet Albert、Pluth Michael D、Feelisch Martin、Fukuto Jon M、Akaike Takaaki、Nagy Peter
  • Journal Title: Br J Pharmacol Volume: 176 Pages: 646-670
  • DOI: 10.1111/bph.14394
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems. (2019)
  • Author(s): Bianco Christopher L、Akaike Takaaki、Ida Tomoaki、Nagy Peter、Bogdandi Virag、Toscano John P、Kumagai Yoshito、Henderson Catherine F、Goddu Robert N、Lin Joseph、Fukuto Jon M
  • Journal Title: Br. J. Pharmacol. Volume: 176 Pages: 671-683
  • DOI: 10.1111/bph.14372
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells (2019)
  • Author(s): Fujii S, Sawa T, Motohashi H, Akaike T.
  • Journal Title: British Journal of Pharmacology Volume: 176 Pages: 607-615
  • DOI: 10.1111/bph.14356
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence (2018)
  • Author(s): Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.
  • Journal Title: Science Signaling Volume: 11 Pages: 5185-5185
  • DOI: 10.1126/scisignal.aat5185
  • Peer Reviewed / Open Access
• [Journal Article] Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling. (2018)
  • Author(s): Khan Shahzada、Fujii Shigemoto、Matsunaga Tetsuro、Nishimura Akira、Ono Katsuhiko、Ida Tomoaki、Ahmed Khandaker Ahtesham、Okamoto Tatsuya、Tsutsuki Hiroyasu、Sawa Tomohiro、Akaike Takaaki
  • Journal Title: Cell Chem Biol Volume: 25 Pages: 1403-1413
  • DOI: 10.1016/j.chembiol.2018.08.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology. (2018)
  • Author(s): Fukuto Jon M.、Ignarro Louis J.、Nagy Peter、Wink David A.、Kevil Christopher G.、Feelisch Martin、Cortese-Krott Miriam M.、Bianco Christopher L.、Kumagai Yoshito、Hobbs Adrian J.、Lin Joseph、Ida Tomoaki、Akaike Takaaki
  • Journal Title: FEBS Lett Volume: 592 Pages: 2140-2152
  • DOI: 10.1002/1873-3468.13090
  • NAID: 120006502670
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons. (2018)
  • Author(s): Masuda Kumiko、Tsutsuki Hiroyasu、Kasamatsu Shingo、Ida Tomoaki、Takata Tsuyoshi、Sugiura Kikuya、Nishida Motohiro、Watanabe Yasuo、Sawa Tomohiro、Akaike Takaaki、Ihara Hideshi
  • Journal Title: Biochemical and biophysical research communications Volume: 495 Pages: 2165-2170
  • DOI: 10.1016/j.bbrc.2017.12.088
  • Peer Reviewed / Open Access
• [Journal Article] 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL. (2018)
  • Author(s): Kaneko K.、Miyamoto Y.、Tsukuura R.、Sasa K.、Akaike T.、Fujii S.、Yoshimura K.、Nagayama K.、Hoshino M.、Inoue S.、Maki K.、Baba K.、Chikazu D.、Kamijo R.
  • Journal Title: Nitric Oxide Volume: 72 Pages: 46-51
  • DOI: 10.1016/j.niox.2017.11.006
  • Peer Reviewed / Open Access
• [Journal Article] Important role of endothelial caveolin-1 in the protective role of EDH against NO-mediated nitrative stress in microcirculation in mice. (2018)
  • Author(s): ②Hiroki Saito, Shigeo Godo, Saori Sato, Akiyo Ito, Yosuke Ikumi, Shuhei Tanaka, Tomoaki Ida, Shigemoto Fujii, Takaaki Akaike, and Hiroaki Shimokawa.
  • Journal Title: J Cardiovasc Pharmacol. Volume: 71 Pages: 113-126
  • DOI: 10.1097/fjc.0000000000000552
  • Peer Reviewed / Open Access
• [Journal Article] 8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-25 (2018)
  • Author(s): Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H.
  • Journal Title: ACS chemical neuroscience Volume: 9 Pages: 217-223
  • DOI: 10.1021/acschemneuro.7b00363
  • Peer Reviewed / Open Access
• [Journal Article] Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol- based redox signaling? (2018)
  • Author(s): Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdandi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A.
  • Journal Title: Redox Biology Volume: 14 Pages: 379-385
  • DOI: 10.1016/j.redox.2017.10.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Persulfide synthases function coupled with translation and mediate sulfur respiration (2018)
  • Author(s): Fujii S, Sawa T, Motohashi H, Akaike T.
  • Journal Title: Br J Pharmacol Volume: -
  • Peer Reviewed
• [Journal Article] 概論 レドックス疾患学：レドックス制御の破綻による病態と新たな疾患概念 (2018)
  • Author(s): 本橋ほづみ、赤池孝章、内田浩二、末松 誠.
  • Journal Title: 実験医学増刊「レドックス疾患学」 Volume: 36 Pages: 642-648
• [Journal Article] 活性イオウによる生体防御応答、エネルギー代謝と寿命制御 (2018)
  • Author(s): 澤 智裕、赤池孝章.
  • Journal Title: 実験医学増刊「レドックス疾患学」 Volume: 36 Pages: 649-655
• [Journal Article] 硫黄呼吸の発見：ペルスルフィド産生酵素による新しいエネルギー代謝 (2018)
  • Author(s): 西村 明、赤池孝章.
  • Journal Title: 現代化学 Volume: 565 Pages: 55-59
  • NAID: 40021493631
• [Journal Article] Synthesis of l -cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome (2017)
  • Author(s): Ono K, Jung M, Zhang T, Tsutsuki H, Sezaki H, Ihara H, Wei FY, Tomizawa K, Akaike T, Sawa T.
  • Journal Title: Free Radic Biol Med. Volume: 106 Pages: 69-79
  • DOI: 10.1016/j.freeradbiomed.2017.02.023
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach. (2017)
  • Author(s): keda, M. Ishima, Y. Shibata, A. Chuang, V. T. G. Sawa, T. Ihara, H. Watanabe, H. Xian, M. Ouchi, Y. Shimizu, T. Ando, H. Ukawa, M. Ishida, T. Akaike, T. Otagiri, M. Maruyama, T.
  • Journal Title: Anal Chim Acta Volume: 969 Pages: 18-25
  • DOI: 10.1016/j.aca.2017.03.027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reactive sulfur species inactivate Ca 2+ /calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue (2017)
  • Author(s): Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y.
  • Journal Title: Biochem J Volume: 474 Pages: 2547-2562
  • DOI: 10.1042/bcj20170092
  • Peer Reviewed
• [Journal Article] Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells. (2017)
  • Author(s): Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T.
  • Journal Title: Free radical biology & medicine Volume: 印刷中 Pages: 132-140
  • DOI: 10.1016/j.freeradbiomed.2017.01.024
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke. (2017)
  • Author(s): Takamiya Rina、Uchida Koji、Shibata Takahiro、Maeno Toshitaka、Kato Masaki、Yamaguchi Yoshiki、Ariki Shigeru、Hasegawa Yoshihiro、Saito Atsushi、Miwa Soichi、Takahashi Hiroki、Akaike Takaaki、Kuroki Yoshio、Takahashi Motoko
  • Journal Title: Scientific Reports Volume: 7 Pages: 8304-8304
  • DOI: 10.1038/s41598-017-08588-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage (2017)
  • Author(s): Hoshino Marie、Kaneko Kotaro、Miyamoto Yoichi、Yoshimura Kentaro、Suzuki Dai、Akaike Takaaki、Sawa Tomohiro、Ida Tomoaki、Fujii Shigemoto、Ihara Hideshi、Tanaka Junichi、Tsukuura Risa、Chikazu Daichi、Mishima Kenji、Baba Kazuyoshi、Kamijo Ryutaro
  • Journal Title: Free Radio Bios Med Volume: 110 Pages: 63-71
  • DOI: 10.1016/j.freeradbiomed.2017.05.022
  • Peer Reviewed / Open Access
• [Journal Article] Exposure to Electrophiles Impairs Reactive Persulfide-dependent Redox Signaling in Neuronal Cells (2017)
  • Author(s): Ihara Hideshi、Kasamatsu Shingo、Kitamura Atsushi、Nishimura Akira、Tsutsuki Hiroyasu、Ida Tomoaki、Ishizaki Kento、Toyama Takashi、Yoshida Eiko、Abdul Hamid Hisyam、Jung Minkyung、Matsunaga Tetsuro、Fujii Shigemoto、Sawa Tomohiro、Nishida Motohiro、Kumagai Yoshito、Akaike Takaaki
  • Journal Title: Chemical Research Toxicology Volume: 30 Pages: 1673-1684
  • DOI: 10.1021/acs.chemrestox.7b00120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chemical Biology of Hydropersulfides and Related Species: Possible Roles in Cellular Protection and Redox Signaling (2017)
  • Author(s): Alvarez L, Bianco CL, Toscano JP, Lin J. Akaike T, Fukuto JM.
  • Journal Title: Antioxid Redox Signal Volume: 27 Pages: 622-633
  • DOI: 10.1089/ars.2017.7081
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Diversity and microevolution of CRISPR loci in Helicobacter cinaedi (2017)
  • Author(s): Tomida J, Morita Y, Shibayama K, Kikuchi K, Sawa T, Akaike T, Kawamura Y.
  • Journal Title: PLOS ONE Volume: 12
  • DOI: 10.1371/journal.pone.0186241
  • Peer Reviewed / Open Access
• [Journal Article] Production of reactive persulfide species in chronic obstructive pulmonary disease. (2017)
  • Author(s): Numakura T, Sugiura H, Akaike T, Ida T, Fujii S, Koarai A, Yamada M, Onodera K, Hashimoto Y, Tanaka R, Sato K, Shishikura Y, Hirano T, Yanagisawa S, Fujino N, Okazaki T, Tamada T, Hoshikawa Y, Okada Y, Ichinose M
  • Journal Title: Thorax. Volume: 72 Pages: 1074-1083
  • DOI: 10.1136/thoraxjnl-2016-209359
  • Peer Reviewed / Open Access
• [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. (2017)
  • Author(s): Akaike Takaaki、、、Nishida Motohiro（4）、、、、、、Fujii Shigemoto（20）、、、Motohashi Hozumi（26）
  • Journal Title: Nature Commun Volume: 8 Pages: 1-10
  • DOI: 10.1038/s41467-017-01311-y
  • NAID: 120006365562
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ニトロ化環状ヌクレオチドと活性イオウ分子によるレドックスシグナル制御と生理機能 (2017)
  • Author(s): 藤井重元、赤池孝章.
  • Journal Title: 化学療法の領域 Volume: 33 Pages: 2194-2195
• [Journal Article] 活性イオウ分子：システインパースルフィドの新規生合成経路の発見とその生理機能 (2017)
  • Author(s): 西村 明、赤池孝章.
  • Journal Title: 硫酸と工業 Volume: 70 (11) Pages: 1-9
  • NAID: 40021404464
• [Journal Article] Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion (2017)
  • Author(s): Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
  • Journal Title: Nucleic Acids Research Volume: 45 Pages: 435-445
  • DOI: 10.1093/nar/gkw745
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors (2017)
  • Author(s): Kunikata H, Ida T, Sato K, Aizawa N, Sawa T, Tawarayama H, Murayama N, Fujii S, Akaike T, Nakazawa T.
  • Journal Title: Sci. Rep. Volume: 7 Pages: 41984-41984
  • DOI: 10.1038/srep41984
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides (2017)
  • Author(s): Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.
  • Journal Title: Free Radical Biology & Medicine Volume: 104 Pages: 118-128
  • DOI: 10.1016/j.freeradbiomed.2016.12.047
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Synthesis and Characterization of 8-Nitroguanosine 3′,5′-Cyclic Monophosphorothioate Rp-Isomer as a Potent Inhibitor of Protein Kinase G1α (2017)
  • Author(s): Ahmed KA, Zhang T, Ono K, Tsutsuki H, Ida T, Akashi S, Miyata K, Oike Y, Akaike T, Sawa T.
  • Journal Title: Biol. Pharm. Bull. Volume: 40 Issue: 3 Pages: 365-374
  • DOI: 10.1248/bpb.b16-00880
  • NAID: 130005398514
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation. (2017)
  • Author(s): Ihara H, Kitamura A, Kasamatsu S, Ida T, Kakihana Y, Tsutsuki H, Sawa T, Watanabe Y, Akaike T.
  • Journal Title: Biochem. J. Volume: 474 Pages: 1149-1162
  • DOI: 10.1042/bcj20160999
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Discovery and mechanistic characterization of selective inhibitors of H2S-producing enzyme:: 3-mercaptopyruvate sulfurtransferase (3MST) targeting active-site cysteine persulfide. (2017)
  • Author(s): K. Hanaoka, K. Sasakura, Y. Suwanai, S. Toma-Fukai, K. Shimamoto, Y. Takano, N. Shibuya, T. Terai, T. Komatsu, T. Ueno, Y. Ogasawara, Y. Tsuchiya, Y. Watanabe, H. Kimura, C. Wang, M. Uchiyama, H. Kojima, T. Okabe, Y. Urano, T. Shimizu, T. Nagano
  • Journal Title: Sci. Rep Volume: 7 Pages: 40227-40227
  • DOI: 10.1038/srep40227
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Silver Nanoparticles as Potential Antibiofilm Agents against Human Pathogenic Bacteria (2017)
  • Author(s): Kyaw K, Harada A, Ichimaru H, Kawagoe T, Yahiro K, Morimura S, Ono K, Tsutsuki H, Sawa T, Niidome T.
  • Journal Title: Chem. Lett. Volume: 46 Issue: 4 Pages: 594-596
  • DOI: 10.1246/cl.161198
  • NAID: 130005549076
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  • Author(s): 朽津 和幸
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• [Journal Article] Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides (2016)
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• [Journal Article] Proposal of Helicobacter canicola sp. nov., previously identified as Helicobacter cinaedi, isolated from canines. (2016)
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  • Journal Title: Systematic and Applied Microbiology Volume: 39 Pages: 307-312
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• [Journal Article] The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation. (2016)
  • Author(s): Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM.
  • Journal Title: Free Radic Biol Med. Volume: 97 Pages: 136-147
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  • Journal Title: Biochemical and Biophysical Research Communications Volume: 478 Pages: 7-11
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  • Author(s): 井田智章、松永哲郎、藤井重元、澤 智裕、赤池孝章.
  • Journal Title: Folia Pharmacol. Jpn. Volume: 147 Issue: 5 Pages: 278-284
  • DOI: 10.1254/fpj.147.278
  • NAID: 130005150958
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  • Author(s): 笠松真吾、藤井重元、赤池孝章.
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  • NAID: 130005150953
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• [Journal Article] 巻頭言 セレンディピティと抗菌薬の新しい分指標的 (2016)
  • Author(s): 赤池孝章
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  • Author(s): 藤井重元、赤池孝章.
  • Journal Title: 生体の科学 Volume: 67 Pages: 418-419
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• [Journal Article] Activation of Signal Transducer and Activator of Transcription 3 in Endothelial Cells of Chronic Subdural Hematoma Outer Membranes. (2016)
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  • Author(s): Ishikawa M, Ide H, Yamazaki H, Murakawa H, Kuchitsu K, Price WS, Arata Y.
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• [Journal Article] Quantitative live cell imaging of autophagic flux and roles of autophagy in reproductive development in plants (2016)
  • Author(s): Kurusu T, Hanamata S, Kuchitsu K
  • Journal Title: bioimages Volume: 24 Issue: 0 Pages: 1-11
  • DOI: 10.11169/bioimages.24.1
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  • Author(s): 渡邊泰男
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  • Author(s): Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S, Akaike T.
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• [Journal Article] Regulation of xylanase elicitor-induced expression of defense-related genes involved in phytoalexin biosynthesis by a cation channel OsTPC1 in suspension-cultured rice cells (2015)
  • Author(s): Hamada H, Kurusu T, Nokajima H, Kiyoduka M, Yano K, Kuchitsu K
  • Journal Title: Plant Biotechnology Volume: 31 Issue: 4 Pages: 329-334
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  • NAID: 130004713022
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• [Journal Article] Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress. (2015)
  • Author(s): Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
  • Journal Title: Chemical Research in Toxicology Volume: 印刷中 Pages: 838-847
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• [Journal Article] Involvement of reactive persulfides in biological bismethylmercury sulfide formation (2015)
  • Author(s): Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
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  • Journal Title: Plant Cell Physiol Volume: 56 Pages: 1481-1489
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• [Journal Article] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions (2015)
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• [Journal Article] Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides. (2015)
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• [Journal Article] 8-Nitro-cGMP Enhances SNARE Complex Formation through S-Guanylation of Cys90 in SNAP25. (2015)
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• [Journal Article] Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia. (2015)
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• [Journal Article] The development of fluorescent probes for visualizing intracellular hydrogen polysulfides (2015)
  • Author(s): Wei Chen, Ethan W. Rosser, Tetsuro Matsunaga, Armando Pacheco, Takaaki Akaike, and Ming Xian
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• [Journal Article] Regulation of Histone Deacetylase 6 Activity <i>via</i> <i>S</i>-Nitrosylation (2015)
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• [Journal Article] Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress (2015)
  • Author(s): Nakato R, Ohkubo Y, Konishi A, Shibata M, Kaneko Y, Iwawaki T, Nakamura T, Lipton SA, and Uehara T.
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  • Author(s): Wada S, Hayashida Y, Izumi M, Kurusu T, Hanamata S, Kanno K, Kojima S, Yamaya T, Kuchitsu K, Makino A, Ishida H
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• [Journal Article] Establishment of monitoring methods for autophagy in rice reveals autophagic recycling of chloroplasts Ishida II. and root plastids during energy limitation. (2015)
  • Author(s): Izumi M, Hidema J, Wada S, Kondo E, Kurusu T, Kuchitsu K, Makino A, Ishida H.
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• [Journal Article] The chemical biology of hydropersulfides (RSSH): Chemical stability, reactivity and redox roles (2015)
  • Author(s): Saund, S. S., Sosa, V., Henriquez, S., Nguyen, Q. N. N., Soeda, S., Bianco, C. L., Millikin, R., White, C., Le, H., Ono, K., Tantillo, D. J., Kumagai, Y., Akaike, T., Lin, J., Fukuto, J. M.
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  • Author(s): Kurusu T, Kuchitsu K, Tada Y
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• [Journal Article] 感染性微生物：H. cinaedi (2015)
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• [Journal Article] 活性イオウ分子による酸化・ニトロ化ストレス制御 (2015)
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  • Journal Title: Respiratory Medical Research Volume: 3 Pages: 70-75
• [Journal Article] 活性イオウ分子種による酸化ストレス制御 (2015)
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• [Journal Article] Host defense and oxidative stress signaling in bacterial infection (2015)
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  • NAID: 130005094695
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• [Journal Article] Nitric Oxide (NO) (2015)
  • Author(s): 赤池孝章、藤井重元.
  • Journal Title: 生体の科学 Volume: 66 Pages: 396-397
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• [Journal Article] イネの生殖器官発達におけるオートファジーの新たな役割 (2015)
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• [Journal Article] Endogenous S-sulfhydration of PTEN helps protect against modification by nitric oxide (2015)
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• [Journal Article] Correlation between attenuation of protein disulfide isomerase activity through S-Mercuration and neurotoxicity induced by methyl mercury (2015)
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• [Journal Article] Apoplastic ROS production upon pollination by RbohH and RbohJ in Arabidopsis. (2015)
  • Author(s): 1)Kaya H, Iwano M, Takeda S, Kanaoka MM, Kimura S, Higashiyama T, Abe M, Kuchitsu K.
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  • DOI: 10.4161/15592324.2014.989050
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• [Journal Article] Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1. (2015)
  • Author(s): Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M.
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• [Journal Article] H2Sの生体内生成とシグナル機能の正体：システインパースルフィドの再発見と新機能 (2015)
  • Author(s): 赤池孝章.
  • Journal Title: 細胞工学 Volume: 34 Pages: 346-348
• [Journal Article] RSSによる抗酸化・レドックスシグナル制御 (2015)
  • Author(s): 井田智章、藤井重元、赤池孝章.
  • Journal Title: 細胞工学 Volume: 34 Pages: 354-357
• [Journal Article] RSSの生合成系とタンパク質機能制御 (2015)
  • Author(s): 渡邊泰男、石井 功、蕨 栄治.
  • Journal Title: 細胞工学 Volume: 34 Pages: 372-376
• [Journal Article] 細菌の硫化水素・RSSの代謝シグナル制御 (2015)
  • Author(s): 津々木博康、小野勝彦、澤 智裕.
  • Journal Title: 細胞工学 Volume: 34 Pages: 392-395
• [Journal Article] Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons. Biochem J (2014)
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  • Journal Title: Biochem J Volume: 459 Pages: 251-263
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• [Journal Article] SIRT7 controls hepatic lipid metabolism by tegulating the ubiquitin-proteasome pathway. (2014)
  • Author(s): Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
  • Journal Title: Cell metab Volume: 9 Pages: 712-21
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• [Journal Article] Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses (2014)
  • Author(s): Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman M d M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, Akaike T.
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• [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling (2014)
  • Author(s): Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
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• [Journal Article] High ice nucleation activity located in blueberry stem bark is linked to primary freeze initiation and adaptive freezing behaviour of the bark. (2014)
  • Author(s): Kishimoto T, Yamazaki H, Saruwatari A, Murakawa H, Sekozawa Y, Kuchitsu K, Price WS, Ishikawa M.
  • Journal Title: AoB Plants Volume: 6
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• [Journal Article] Expression of suppressor of cytokine signaling 3 in cerebrospinal fluid after subarachnoid hemorrhage. (2014)
  • Author(s): Osuka K, Watanabe Y, Aoyama M, Nakura T, Matsuo N, Takayasu M.
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• [Journal Article] Eotaxin-3 activates the Smad pathway through the transforming growth factor beta 1 in chronic subdural hematoma outer membranes. (2014)
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• [Journal Article] Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling (2014)
  • Author(s): Nishida M, Toyama T and Akaike T
  • Journal Title: J. Mol. Cell. Cardiol. Volume: (In press) Pages: 10-17
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• [Journal Article] Roles of autophagy in male reproductive development in plants (2014)
  • Author(s): Hanamata S, Kurusu T, Kuchitsu K
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• [Journal Article] Clinical and bacteriological characteristics of Helicobacter cinaedi infection. (2014)
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  • DOI: 10.1016/j.jiac.2014.06.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility (2014)
  • Author(s): Ono, K., Akaike T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., Fukuto, J.
  • Journal Title: Free Radic Biol Med Volume: 77 Pages: 82-94
  • DOI: 10.1016/j.freeradbiomed.2014.09.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Helicobacter cinaedi meningitis: a case report and review of previous cases (2014)
  • Author(s): Okubo H, Goto M, Sato M, Sugiyama T, Kawano M, Matsunaga T, Akaike T.
  • Journal Title: J Neurol Sci Volume: 347 Pages: 396-397
  • DOI: 10.1016/j.jns.2014.10.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 活性酸素による多階層シグナル伝達機構とレドックス恒常性制御 (2014)
  • Author(s): 赤池孝章.
  • Journal Title: Yakugaku Zasshi Volume: 134 Pages: 515-519
  • NAID: 130003391199
• [Journal Article] 測定装置としての顕微鏡を用いた生物機能の解析 (2014)
  • Author(s): 村田 隆、稲田のりこ、朽津和幸.
  • Journal Title: バイオイメージング Volume: 23 Pages: 11-11
• [Journal Article] 植物のオートファジー動態の簡便な定量解析 (2014)
  • Author(s): 花俣 繁、来須孝光、朽津和幸.
  • Journal Title: バイオイメージング Volume: 23 Pages: 23-27
• [Journal Article] 活性酸素と炎症 (2014)
  • Author(s): 井田智章、赤池孝章、澤 智裕、藤井重元.
  • Journal Title: 感染・炎症・免疫 Volume: 44 Pages: 104-109
• [Journal Article] システインパースルフィドの生体内生成と生理機能の再発見：活性イオウ分子による抗酸化・レドックスシグナル制御 (2014)
  • Author(s): 赤池孝章.
  • Journal Title: 実験医学 Volume: 32 Pages: 2123-2126
• [Journal Article] 小胞体ストレスによる生と死：細胞応答の新たな役割 (2014)
  • Author(s): 上原 孝.
  • Journal Title: 実験医学 Volume: 32 Pages: 2194-2200
• [Journal Article] 穀物の花粉・種子形成の新たな仕組み (2014)
  • Author(s): 来須孝光、朽津和幸.
  • Journal Title: 科学フォーラム Volume: 31 Pages: 26-29
• [Journal Article] フリーラジカル制御系：硫化水素・活性イオウ分子と炎症 (2014)
  • Author(s): 藤井重元、井田智章、澤 智裕、赤池孝章.
  • Journal Title: 実験医学 Volume: 32 Pages: 2803-2809
• [Presentation] Reactive sulfur species (RSS) mediate sulfur respiration in mitochondria and redox signaling (2019)
  • Author(s): Akaike T.
  • Organizer: 第 7 回 IRG(Inflammation and ReGeneration)Meeting（東京）
  • Invited
• [Presentation] Cysteine persulfide synthases mediate sulfur respiration and energy metabolism (2019)
  • Author(s): Akaike T.
  • Organizer: The Kick-off Symposium of Advanced Graduate Program for Future Medicine and Health Care（仙台）
  • Int'l Joint Research / Invited
• [Presentation] Chemical biology of reactive sulfur species and its metabolome analysis (2018)
  • Author(s): Akaike T.
  • Organizer: 2018 Annual Medical Technology Conference 3rd Annual Conference New Frontiers in Mass Spectrometry Clinical and Biomedical Applications（タイ）
  • Int'l Joint Research / Invited
• [Presentation] ミトコンドリアのイオウ呼吸とイオウストレス (2018)
  • Author(s): 赤池孝章
  • Organizer: 山形分子生物研究会（山形）
  • Invited
• [Presentation] 新しいエネルギー代謝機構：イオウ呼吸の発見と生理機能解明 (2018)
  • Author(s): 赤池孝章
  • Organizer: 平成30年度東北大学医学系病理同窓会特別公演（仙台）
  • Invited
• [Presentation] Translation-coupled persulfide synthases (PERSs) involved critically in sulfur respiration and energy metabolism (2018)
  • Author(s): Akaike T.
  • Organizer: 10th Internatinal Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide（イギリス）
  • Int'l Joint Research / Invited
• [Presentation] Persulfide synthase coupled with translation mediates sulfur respiration in mammals (2018)
  • Author(s): Akaike T.
  • Organizer: KCL Redox Biology & Medicine Symposium（イギリス）
  • Int'l Joint Research / Invited
• [Presentation] Sulfur respiration as a target for mitochondrial disease (2018)
  • Author(s): 赤池孝章
  • Organizer: 7 SEAS PROJECT Research meeting 2018（東京）
  • Invited
• [Presentation] イオウ呼吸：レドックス研究の新たなパラダイム (2018)
  • Author(s): 赤池孝章
  • Organizer: Free Radical Summer School 2018（群馬）
  • Invited
• [Presentation] Cysteine persulfide synthases coupled with translation mediate sulfur respiration and redox signaling (2018)
  • Author(s): Akaike T.
  • Organizer: The 43rd FEBS Congress（トルコ）
  • Int'l Joint Research / Invited
• [Presentation] Cysteinyl-tRNA synthetase (CARS) controls endogenous hydropersulfide production and mitochondrial respiration （ (2018)
  • Author(s): Akaike T.
  • Organizer: The 19th biennial meeting for the Society for Free Radical Research International (SFRRI)（ポルトガル）
  • Int'l Joint Research / Invited
• [Presentation] Sulfur respiration in mammals and its implication for tumor biology (2018)
  • Author(s): Takaaki Akaike, Tomoaki Ida, Md. Morshedul Alam, Akira Nishimura, Masanobu Morita, Tetsuro Matsunaga, Hozumi Motohashi.
  • Organizer: The Cold Spring Harbor Asia Conference on Cancer & Metabolism
  • Int'l Joint Research / Invited
• [Presentation] システインパースルフィド産生酵素（Cysteine Persulfide Synthase, CPERS）の発見 (2017)
  • Author(s): 赤池孝章
  • Organizer: 第17回日本NO学会学術集会
  • Invited
• [Presentation] イオウ呼吸とイオウストレス：ほ乳類における新しいエネルギー代謝とレドックス病態 (2017)
  • Author(s): 赤池孝章、西村 明、井田智章、松永哲郎、守田匡伸、本橋ほづみ.
  • Organizer: 2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
  • Invited
• [Presentation] イオウ呼吸とイオウストレス：新しいエネルギー代謝とレドックス病態の提案 (2017)
  • Author(s): 赤池孝章、西村 明、井田智章、松永哲郎、守田匡伸、藤井重元、本橋ほづみ.
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] Cysteine polysulfidation governed by cysteinyl-tRNA synthetase (CARSs) (2017)
  • Author(s): Takaaki Akaike
  • Organizer: Se2017 - 200 Years of Selenium Research (The 11th International Symposium on Selenium in Biology and Medicine and The 5th International Conference on Selenium in the Environment and Human Health)
  • Int'l Joint Research / Invited
• [Presentation] Cysteinyl-tRNA synthetase (CARS) controls endogenous hydropersulfide production and mediates mitochondrial functions and bioenegetics (2017)
  • Author(s): Takaaki Akaike
  • Organizer: S-Bio 2017 Plant and Human Sulfur Biology Conference 2017
  • Int'l Joint Research / Invited
• [Presentation] Discovery of a novel persulfide synthase that mediates mitochondrial sulfur respiration (2017)
  • Author(s): Takaaki Akaike
  • Organizer: 2nd Karolinska-Tohoku Joint Symposium on Medical Sciences
  • Int'l Joint Research / Invited
• [Presentation] Cysteinyl-tRNA synthetase governs endogenous hydropersulfide production and mediates mitochondrial functions and bioenergetics (2017)
  • Author(s): Takaaki Akaike
  • Organizer: AARS2017: IUBMB Focused Meeting on Aminoacyl-tRNA Synthetase
  • Int'l Joint Research
• [Presentation] Moonlighting functions of cysteinyl-tRNA synthetase: Cysteine hydropersulfide production and regulation of mitochondrial biogenesis and bioenergetics (2017)
  • Author(s): Takaaki Akaike, Akira Nishimura, Tomoaki Ida, Tetsuro Matsunaga, Masanobu Morita, Hozumi Motohashi.
  • Organizer: SfRBM 2017 - 24th Annual Meeting of the Society for Redox Biology and Medicine
  • Int'l Joint Research
• [Presentation] Cysteinyl-tRNA synthetase (CARS) は活性パースルフィド産生とミトコンドリア機能をコントロールしている (2017)
  • Author(s): 赤池孝章
  • Organizer: 2017年度生命科学系学会合同年次大会
  • Invited
• [Presentation] Cysteine persulfide formation via cysteinyl-tRNA synthetase and its involvement in mitochondrial bioenergetics (2017)
  • Author(s): Takaaki Akaike, Tomoaki Ida, Masanobu Morita, Shigemoto Fujii, Akira Nishimura, Tetsuro Matsunaga, Minkyung Jung, Hozumi Motohashi.
  • Organizer: th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10,
  • Int'l Joint Research
• [Presentation] 活性イオウ分子種：システインポリスルフィドの生体機能と代謝制御 (2017)
  • Author(s): 赤池孝章
  • Organizer: 第19回日本質量分析学会北海道談話会講演会
  • Place of Presentation: 旭川医科大学教育推進センター カンファレンスルーム（旭川市）
  • Invited
• [Presentation] Persulfide regulation of mitochondrial number and function (2017)
  • Author(s): Takaaki Akaike
  • Organizer: The 2017 NO Gordon Research Conference
  • Place of Presentation: Ventura Beach Marriott (Venture, CA, USA)
  • Int'l Joint Research / Invited
• [Presentation] 活性イオウ分子種の生体内生成と生理機能 (2016)
  • Author(s): 赤池孝章
  • Organizer: 日本薬学会 第136年会
  • Place of Presentation: パシフィコ横浜（横浜市西区）
  • Year and Date: 2016-03-26
  • Invited
• [Presentation] 細菌の新しいシグナル伝達物質：8-ニトロ-cGMPの生成と機能解析 (2016)
  • Author(s): 井田智章、松永哲郎、赤司壮一郎、ジョン ミンギョン、津々木博康、藤井重元、居原 秀、澤 智裕、赤池孝章.
  • Organizer: 第89回日本細菌学会総会
  • Place of Presentation: 大阪国際交流センター（大阪市天王寺区）
  • Year and Date: 2016-03-23
• [Presentation] 活性システインパースルフィドの生合成機構とレドックス制御機能 (2016)
  • Author(s): 赤池孝章
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜 会議センター（横浜市西区）
  • Year and Date: 2016-03-09
  • Invited
• [Presentation] Polysulfides and redox signaling (2016)
  • Author(s): Takaaki Akaike
  • Organizer: The 2016 Oxygen Radicals Gordon Research Conference
  • Place of Presentation: Ventura Beach Marriott（Ventura, CA, USA）
  • Year and Date: 2016-02-07
  • Int'l Joint Research / Invited
• [Presentation] Development of metabolome analysis for reactive sulfur species (2016)
  • Author(s): Ida T, Kasamatsu S, Fujii S, Sawa T, Ihara H, Akaike T.
  • Organizer: The 2016 Oxygen Radicals Gordon Research Conference
  • Place of Presentation: Ventura Beach Marriott（Ventura, CA, USA）
  • Year and Date: 2016-02-07
  • Int'l Joint Research
• [Presentation] 気道炎症と呼気NO (2016)
  • Author(s): 赤池孝章
  • Organizer: 第56回日本呼吸器学会学術講演会
  • Place of Presentation: 京都国際会館（京都市左京区）
  • Invited
• [Presentation] Host defense and oxidative stress signaling in microbial infections (2016)
  • Author(s): Takaaki Akaike
  • Organizer: The 13th Korea-Japan International Symposium on Microbiology
  • Place of Presentation: The-K Hotel Gyeongju (Gyeongbuk, Korea)
  • Int'l Joint Research / Invited
• [Presentation] Cysteine transfer RNA synthetases moonlighting as novel cysteine persulfide synthases (CPERSs) (2016)
  • Author(s): Takaaki Akaike
  • Organizer: The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: 仙台国際センター会議棟（仙台市青葉区）
  • Int'l Joint Research / Invited
• [Presentation] 生体防御応答のレドックス制御機構 (2016)
  • Author(s): 赤池孝章
  • Organizer: 第27回日本生体防御学会学術総会
  • Place of Presentation: 九州大学病院キャンパス内 コラボステーションI 視聴覚ホール（福岡市東区）
  • Invited
• [Presentation] Helicobacter cinaedi infection and atherosclerosis (2016)
  • Author(s): Takaaki Akaike, Tetsuro Matsunaga, Yoshiaki Kawamura, Shigemoto Fujii.
  • Organizer: 第48回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Int'l Joint Research / Invited
• [Presentation] 新しいCysteine Persulfide Synthaseの発見とそのミトコンドリア機能制御 (2016)
  • Author(s): 赤池孝章
  • Organizer: 生理学研究所研究会「オルガネラネットワークの制御機構とその生理的意義」
  • Place of Presentation: 生理学研究所1F大会議室（岡崎市）
  • Invited
• [Presentation] Cysteinyl-tRNA synthetase controls protein polysulfidation and mitochondrial functions (2016)
  • Author(s): Takaaki Akaike
  • Organizer: The 2016 Thiol-Based Redox Regulation & Signaling Gordon Research Conference
  • Place of Presentation: Stoweflake Conference Center (Stowe, VT, USA)
  • Int'l Joint Research / Invited
• [Presentation] 新しいCysteine Persulfide Synthaseの発見とそのユニークなレドックス制御メカニズム (2016)
  • Author(s): 赤池孝章
  • Organizer: 第12回レドックス・ライフイノベーションシンポジウム
  • Place of Presentation: 熊本大学医学部医学教育図書棟3階第一講義室（熊本市中央区）
  • Invited
• [Presentation] 活性システインパースルフィドによるレドックス制御の分子基盤 (2016)
  • Author(s): 赤池孝章
  • Organizer: 第58回歯科基礎医学会学術大会
  • Place of Presentation: 札幌コンベンションセンター（札幌市白石区）
  • Invited
• [Presentation] 活性イオウ分子種によるミトコンドリア機能制御 (2016)
  • Author(s): 赤池孝章、井田智章.
  • Organizer: 第69回日本酸化ストレス学会学術集会
  • Place of Presentation: 仙台国際センター会議棟（仙台市青葉区）
  • Invited
• [Presentation] 生体内タンパク質ポリスルフィドの検出とその生成機構 (2016)
  • Author(s): 赤池孝章、笠松真吾.
  • Organizer: 第69回日本酸化ストレス学会学術集会
  • Place of Presentation: 仙台国際センター会議棟（仙台市青葉区）
  • Invited
• [Presentation] 細菌感染におけるレドックスシグナル制御機構 (2016)
  • Author(s): 赤池孝章
  • Organizer: 第28回微生物学シンポジウム
  • Place of Presentation: 愛知学院大学薬学部（名古屋市千種区）
  • Invited
• [Presentation] Cysteinyl-tRNA synthetase is a major source of reactive persulfide and controls mitochondrial biology (2016)
  • Author(s): Takaaki Akaike
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台国際センター会議棟（仙台市青葉区）
  • Int'l Joint Research / Invited
• [Presentation] 活性イオウ生成酵素の発見：ミトコンドリア形態形成とエネルギー代謝の新しいメカニズム (2016)
  • Author(s): 赤池孝章
  • Organizer: 第14回がんとハイポキシア研究会
  • Place of Presentation: 岐阜グランドホテル（岐阜市）
  • Invited
• [Presentation] 活性イオウ分子種：新しい活性酸素制御因子の生合成と制御機構 (2016)
  • Author(s): 赤池孝章
  • Organizer: 昭和大学学士会後援セミナー
  • Place of Presentation: 昭和大学（東京都品川区）
  • Invited
• [Presentation] 活性イオウ分子種：総論 (2016)
  • Author(s): 赤池孝章
  • Organizer: 新学術領域研究「酸素生物学」・「レドックス委員会」合同シンポジウム2016「活性イオウ分子種の科学と生体機能の解明に向けて」
  • Place of Presentation: 名古屋大学シンポジオン（名古屋市千種区）
  • Invited
• [Presentation] 活性イオウメタボライトのLC-MS/MS解析 (2016)
  • Author(s): 井田智章、居原 秀、澤 智裕.
  • Organizer: 新学術領域研究「酸素生物学」・「レドックス委員会」合同シンポジウム2016「活性イオウ分子種の科学と生体機能の解明に向けて」
  • Place of Presentation: 名古屋大学シンポジオン（名古屋市千種区）
  • Invited
• [Presentation] 細菌感染における酸化ストレスシグナル制御と感染防御論 (2016)
  • Author(s): 赤池孝章
  • Organizer: 平成27年度 学校法人北里研究所 第25回学会受賞者特別講演会
  • Place of Presentation: 北里大学白金キャンパス薬学部コンベンションホール（東京都港区）
  • Invited
• [Presentation] Antioxidant electrophilic signaling regulated by reactive sulfur species and its translational biosynthesis (2015)
  • Author(s): 赤池孝章
  • Organizer: 第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド（神戸市中央区)
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] タンパク質ポリサルファ化の分子メカニズムの解明 (2015)
  • Author(s): 井田智章、居原 秀、魏 范研、富澤一仁、長尾翌手可、鈴木 勉、熊谷嘉人、澤 智裕、笠松真吾、本橋ほづみ、赤池孝章.
  • Organizer: 第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド（神戸市中央区)
  • Year and Date: 2015-12-01
• [Presentation] Protein-bound reactive sulfur species and its translational biosynthesis: potential implication for oxidative stress and tumor biology (2015)
  • Author(s): Takaaki Akaike
  • Organizer: The 46th International Symposium of The Princess Takamatsu Cancer Research Fund
  • Place of Presentation: パレスホテル東京（東京都千代田区）
  • Year and Date: 2015-11-17
  • Int'l Joint Research / Invited
• [Presentation] Reactive persulfide species: Its antioxidant redox signaling and translational biosynthesis (2015)
  • Author(s): Takaaki Akaike
  • Organizer: 文部科学省 私立大学戦略的研究基盤形成支援事業 生体分子コバレント修飾の革新的解析拠点形成 第２回国際シンポジウム New Aspects of Covalent modifications from Small to Large Molecules
  • Place of Presentation: 昭和薬科大学（東京都町田市)
  • Year and Date: 2015-08-31
  • Int'l Joint Research / Invited
• [Presentation] 活性イオウ分子システインパースルフィドのタンパク質翻訳機構：タンパク質ポリチオール化 (2015)
  • Author(s): 赤池孝章
  • Organizer: 第42回日本毒性学会学術年会
  • Place of Presentation: 石川県音楽堂、金沢市アートホール、ホテル日航金沢（石川県金沢市）
  • Year and Date: 2015-06-29
  • Invited
• [Presentation] 活性システインパースルフィドのメタボロームおよびプロテオーム解析 (2015)
  • Author(s): 井田智章、居原 秀、澤 智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
  • Organizer: 第15回日本NO学会学術集会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府豊中市）
  • Year and Date: 2015-06-26
• [Presentation] システインパースルフィドの新しいタンパク質翻訳機構：タンパク質ポリチオール化 (2015)
  • Author(s): 赤池孝章
  • Organizer: 第15回日本蛋白質科学会年会
  • Place of Presentation: あわ銀ホール（徳島市）
  • Year and Date: 2015-06-24
  • Invited
• [Presentation] 活性酸素のシグナル伝達機構の解明（学会賞受賞講演） (2015)
  • Author(s): 赤池孝章
  • Organizer: 第68回日本酸化ストレス学会学術集会
  • Place of Presentation: かごしま県民交流センター（鹿児島市）
  • Year and Date: 2015-06-11
  • Invited
• [Presentation] 活性システインパースルフィドのメタボロミクスとプロテオミクス (2015)
  • Author(s): 井田智章、居原 秀、澤 智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
  • Organizer: 第68回日本酸化ストレス学会学術集会
  • Place of Presentation: かごしま県民交流センター（鹿児島市）
  • Year and Date: 2015-06-11
• [Presentation] 細菌感染における酸化ストレスシグナル制御と感染防御論（浅川賞受賞講演） (2015)
  • Author(s): 赤池孝章.
  • Organizer: 第88回日本細菌学会総会
  • Place of Presentation: 長良川国際会議場（岐阜市）
  • Year and Date: 2015-03-26 – 2015-03-28
  • Invited
• [Presentation] 活性イオウ含有分子の再発見とその生物活性 (2015)
  • Author(s): 井田智章、赤池孝章.
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（名古屋市熱田区）
  • Year and Date: 2015-03-18 – 2015-03-20
  • Invited
• [Presentation] Redox-active cysteine polysulfide modulates NO and electrophilic protein modification (2015)
  • Author(s): Takaaki Akaike.
  • Organizer: The 2015 Nitric Oxide Gordon Research Conference
  • Place of Presentation: Four Points Sheraton/Holiday Inn Express (Ventura, CA, USA)
  • Year and Date: 2015-02-15 – 2015-02-20
  • Invited
• [Presentation] 活性イオウ分子とADH3によるホルムアルデヒド解毒代謝機構 (2015)
  • Author(s): 井田智章、Md. Morshedul Alam、松永哲郎、藤井重元、居原 秀、本橋ほづみ、赤池孝章.
  • Organizer: 第14回分子予防環境医学研究会
  • Place of Presentation: 大阪市立大学医学部（大阪市阿倍野区）
  • Year and Date: 2015-02-13 – 2015-02-14
• [Presentation] 炎症・酸化ストレス応答とフリーラジカル・活性酸素制御 (2014)
  • Author(s): 赤池孝章.
  • Organizer: 第44回日本創傷治癒学会
  • Place of Presentation: ホテルメトロポリタン仙台（仙台市青葉区）
  • Year and Date: 2014-12-02 – 2014-12-03
  • Invited
• [Presentation] 活性イオウ分子種によるレドックスシグナルと酸化ストレス制御 (2014)
  • Author(s): 赤池孝章.
  • Organizer: 第386回東北医学会例会シンポジウム
  • Place of Presentation: 東北大学艮陵会館（仙台市青葉区）
  • Year and Date: 2014-11-21
  • Invited
• [Presentation] 活性システインパーサルファイドとS-ポリチオレーションが酸化ストレスを制御する (2014)
  • Author(s): 井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、末松 誠、本橋ほづみ、藤井重元、松永哲郎、山本雅之、Ming Xian、Jon M Fukuto、赤池孝章.
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館（京都市左京区）
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] ポリサルファ化とタンパク質レドックス制御 (2014)
  • Author(s): 赤池孝章.
  • Organizer: レドックスシンポジウム：酸素生物学の誕生
  • Place of Presentation: 名古屋大学ES総合館ESホール（名古屋市千種区）
  • Year and Date: 2014-10-11
  • Invited
• [Presentation] 活性イオウ分子種による酸化ストレス制御とポリサルファーバイオロジー (2014)
  • Author(s): 赤池孝章.
  • Organizer: フォーラム2014 衛生薬学・環境トキシコロジー
  • Place of Presentation: つくば国際会議場（つくば市）
  • Year and Date: 2014-09-19 – 2014-09-20
  • Invited
• [Presentation] 活性システインパーサルファイドによる酸化ストレス制御 (2014)
  • Author(s): 井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、藤井重元、松永哲郎、Jon M Fukuto、赤池孝章.
  • Organizer: 第67回日本酸化ストレス学会学術集会
  • Place of Presentation: 同志社大学今出川キャンパス良心館（京都市上京区）
  • Year and Date: 2014-09-04 – 2014-09-05
• [Presentation] 活性イオウ分子種システインパースルフィドによる酸化ストレス制御 (2014)
  • Author(s): 井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、本橋ほづみ、藤井重元、松永哲郎、Ming Xian、Jon M Fukuto、赤池孝章.
  • Organizer: 第8回レドックス・ライフイノベーション第170委員会
  • Place of Presentation: シーガイアコンベンションセンター（宮崎市）
  • Year and Date: 2014-08-21 – 2014-08-23
  • Invited
• [Presentation] 細菌の新しいシグナル伝達物質：8-ニトロ-cGMPの同定と機能解析 (2014)
  • Author(s): 井田智章、松永哲郎、赤司壮一郎、ジョン ミンギョン、津々木博康、藤井重元、居原 秀、澤 智裕、赤池孝章.
  • Organizer: 第25回日本生体防御学会学術総会
  • Place of Presentation: 東北大学 片平さくらホール（仙台市青葉区）
  • Year and Date: 2014-07-09 – 2014-07-11
• [Presentation] タンパク質過イオウ化：酸化ストレスの新しい制御システム (2014)
  • Author(s): 赤池孝章.
  • Organizer: 第41回日本毒性学会学術年会
  • Place of Presentation: 神戸コンベンションセンター（神戸市中央区）
  • Year and Date: 2014-07-02 – 2014-07-04
  • Invited
• [Book] 活性イオウ分子によるエネルギー代謝制御 (2019)
  • Author(s): 西村 明、本橋ほづみ、赤池孝章
  • Total Pages: 6
  • Publisher: 基礎老化研究
• [Book] 活性イオウ分子：システインパースルフィドの新規生合成経路の発見とその生理機能 (2018)
  • Author(s): 西村 明、赤池孝章
  • Total Pages: 2
  • Publisher: 化学と生物
• [Book] ポリスルフィド化 (2018)
  • Author(s): 西村 明、井田智章、赤池孝章
  • Total Pages: 2
  • Publisher: 生体の科学
• [Book] SH(ポリスルフィド)の酸化 (2018)
  • Author(s): 西村 明、井田智章、赤池孝章
  • Total Pages: 2
  • Publisher: 生体の科学
• [Book] 哺乳類におけるイオウ呼吸の発見 (2018)
  • Author(s): 西村 明、赤池孝章
  • Total Pages: 2
  • Publisher: 医学のあゆみ
• [Book] Nitric Oxide: Biology and Pathobiology. 3rd ed. (Ignarro LJ, Freeman BA, eds.) (2017)
  • Author(s): Sawa T, Kumagai Y, Akaike T.
  • Total Pages: 403
  • Publisher: Academic Press
• [Book] Chronic Inflammation: Elucidation and Control of the Mechanisms (K. Takatsu and M. Miyasaka eds) (2016)
  • Author(s): Sawa, T.
  • Total Pages: 702
  • Publisher: Springer (Tokyo, Japan)
• [Book] Plant Programmed Cell Death (2015)
  • Author(s): Kurusu T, Higaki T, Kuchitsu K.
  • Total Pages: 306
  • Publisher: Springer International Publishing (Switzerland)
• [Book] 別冊・医学のあゆみ「レドックスUPDATE ― ストレス制御の臨床医学・健康科学」 (2015)
  • Author(s): 赤池孝章、藤井重元.
  • Total Pages: 360
  • Publisher: 医歯薬出版社（東京都）
• [Book] みてわかる薬学 図解 薬理学 (2015)
  • Author(s): 渡邊泰男
  • Total Pages: 873
  • Publisher: 南山堂（東京都）
• [Remarks] 東北大学大学院医学系研究科環境医学分野ホームページ
  • URL: http://www.toxicosci.med.tohoku.ac.jp/
• [Remarks] 東北大学大学院医学系研究科 環境医学分野教室ホームページ
  • URL: http://www.toxicosci.med.tohoku.ac.jp
• [Remarks] 東北大学大学院医学系研究科環境保健医学分野ホームページ
  • URL: http://www.toxicosci.med.tohoku.ac.jp/
• [Remarks] 東北大学大学院医学系研究科 環境保健医学分野ホームページ
  • URL: http://www.toxicosci.med.tohoku.ac.jp/
• [Patent(Industrial Property Rights)] イオウ原子を同位体標識したシステイン及びシステイン誘導体の合成法の確立 (2016)
  • Inventor(s): 小野勝彦、澤智裕
  • Industrial Property Rights Holder: 熊本大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-04-28