| Budget Amount *help |
¥115,310,000 (Direct Cost: ¥88,700,000、Indirect Cost: ¥26,610,000)
Fiscal Year 2018: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2017: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2016: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2015: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2014: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
|
|---|
| Outline of Final Research Achievements |
To clarify spatiotemporal control of the reactive oxygen-producing NADPH oxidase (Nox), we have performed biochemical and microscopic experiments and obtained many findings including the following results: (1) among the Nox family, Nox2 and Nox5 are recruited to the plasma membrane in different manners; (2) activation of Nox2 requires its interaction with the activation domain of p67phox bound to the small GTPase Rac; and (3) Nox plays a crucial role in maturation of other proteins, especially correct formation of disulfide bonds.
|
