| Budget Amount *help |
¥80,340,000 (Direct Cost: ¥61,800,000、Indirect Cost: ¥18,540,000)
Fiscal Year 2018: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2017: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2016: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2015: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2014: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
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| Outline of Final Research Achievements |
We identified the strong physical interaction between Nrf2 and ATF4, and demonstrated that they cooperatively regulates gene expression of a set of cytoprotective genes. We also showed that GCN1L1 regulates cell cycle and embryonic development in a GCN2-independent manner as well as GCN2-dependent amino acid starvation and UV response. We also demonstrated thata Keap1 senses a variety of stresses by using multiple cysteine residues and consequently, Nrf2 inducers can be classified into at least 5 subclasses. We also identified novel regulators of proteasome and an Nrf1 activator during proteasome inhibition.
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