| Budget Amount *help |
¥152,880,000 (Direct Cost: ¥117,600,000、Indirect Cost: ¥35,280,000)
Fiscal Year 2018: ¥31,330,000 (Direct Cost: ¥24,100,000、Indirect Cost: ¥7,230,000)
Fiscal Year 2017: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2016: ¥31,460,000 (Direct Cost: ¥24,200,000、Indirect Cost: ¥7,260,000)
Fiscal Year 2015: ¥31,070,000 (Direct Cost: ¥23,900,000、Indirect Cost: ¥7,170,000)
Fiscal Year 2014: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
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| Outline of Final Research Achievements |
Urano developed novel hROS bioluminescence probes, hydrogen peroxide fluorogenic probes, and reversible fluorescent probes capable of detecting sulfane sulfurs, glutathione, and hydropersulfides with high selectivity, and succeeded to apply these probes to living cells and in vivo animals. Tobita developed iridium complexes for detecting oxygen concentration in cells based on their phosphorescence lifetime, and succeeded to monitor oxygen concentration in kidney and liver of living mice. Nakagawa developed photo-releasable H2S and NO compounds and probes capable of light-dependent oxygen depletion. We underwent various collaborative works among researchers in and out of this Grant-in-Aid for Scientific Research on Innovative Areas, and obtained various new results and knowledge about oxygen biology.
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