| Budget Amount *help |
¥137,280,000 (Direct Cost: ¥105,600,000、Indirect Cost: ¥31,680,000)
Fiscal Year 2018: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2017: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2015: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2014: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
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| Outline of Final Research Achievements |
Here we applied our new strategy to manipulate specific neural types and pathways and to characterize dynamic changes of the neural circuit and aimed to elucidate the mechanisms underlying the development and transition of neural circuit during learning processes and the functional compensation of the circuit against neural injury. To achieve this purpose, our planned group focused on the development of the technology for the neural circuit control, in particular, through the application of optogenetic and chemogenetic approaches with viral vector system. In addition, we investigated the roles of specific cell types or neural pathways constituting the cortico-basal ganglia-thalamic network in behavioral acquisition, performance, and switching, and challenged to identify the brain regions in which the activity changes during the learning processes to elucidate the mechanisms underlying the functional shift of neural circuit.
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